TY  - JOUR
AU  - Jantsch, Michael F.
AU  - Quattrone, Alessandro
AU  - O'Connell, Mary
AU  - Helm, Mark
AU  - Frye, Michaela
AU  - Macias-Gonzales, Manuel
AU  - Ohman, Marie
AU  - Ameres, Stefan
AU  - Willems, Luc
AU  - Fuks, Francois
AU  - Oulas, Anastasis
AU  - Vanacova, Stepanka
AU  - Nielsen, Henrik
AU  - Bousquet-Antonelli, Cecile
AU  - Motorin, Yuri
AU  - Roignant, Jean-Yves
AU  - Balatsos, Nikolaos
AU  - Dinnyes, Andras
AU  - Baranov, Pavel
AU  - Kelly, Vincent
AU  - Lamm, Ayelet
AU  - Rechavi, Gideon
AU  - Pelizzola, Mattia
AU  - Liepins, Janis
AU  - Holodnuka Kholodnyuk, Irina
AU  - Zammit, Vanessa
AU  - Ayers, Duncan
AU  - Drablos, Finn
AU  - Dahl, John Arne
AU  - Bujnicki, Janusz
AU  - Jeronimo, Carmen
AU  - Almeida, Raquel
AU  - Neagu, Monica
AU  - Costache, Marieta
AU  - Banković, Jasna
AU  - Banović, Bojana
AU  - Kyselovic, Jan
AU  - Valor, Luis Miguel
AU  - Selbert, Stefan
AU  - Pir, Pinar
AU  - Demircan, Turan
AU  - Cowling, Victoria
AU  - Schäfer, Matthias
AU  - Rossmanith, Walter
AU  - Lafontaine, Denis
AU  - David, Alexandre
AU  - Carre, Clement
AU  - Lyko, Frank
AU  - Schaffrath, Raffael
AU  - Schwartz, Schraga
AU  - Verdel, Andre
AU  - Klungland, Arne
AU  - Purta, Elzbieta
AU  - Timotijevic, Gordana
AU  - Cardona, Fernando
AU  - Davalos, Alberto
AU  - Ballana, Ester
AU  - O Carroll, Donal
AU  - Ule, Jernej
AU  - Fray, Rupert
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/15476286.2018.1460996
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3063
AB  - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
T2  - RNA Biology
T1  - Positioning Europe for the EPITRANSCRIPTOMICS challenge.
DO  - 10.1080/15476286.2018.1460996
ER  - 

@article{
author = "Jantsch, Michael F. and Quattrone, Alessandro and O'Connell, Mary and Helm, Mark and Frye, Michaela and Macias-Gonzales, Manuel and Ohman, Marie and Ameres, Stefan and Willems, Luc and Fuks, Francois and Oulas, Anastasis and Vanacova, Stepanka and Nielsen, Henrik and Bousquet-Antonelli, Cecile and Motorin, Yuri and Roignant, Jean-Yves and Balatsos, Nikolaos and Dinnyes, Andras and Baranov, Pavel and Kelly, Vincent and Lamm, Ayelet and Rechavi, Gideon and Pelizzola, Mattia and Liepins, Janis and Holodnuka Kholodnyuk, Irina and Zammit, Vanessa and Ayers, Duncan and Drablos, Finn and Dahl, John Arne and Bujnicki, Janusz and Jeronimo, Carmen and Almeida, Raquel and Neagu, Monica and Costache, Marieta and Banković, Jasna and Banović, Bojana and Kyselovic, Jan and Valor, Luis Miguel and Selbert, Stefan and Pir, Pinar and Demircan, Turan and Cowling, Victoria and Schäfer, Matthias and Rossmanith, Walter and Lafontaine, Denis and David, Alexandre and Carre, Clement and Lyko, Frank and Schaffrath, Raffael and Schwartz, Schraga and Verdel, Andre and Klungland, Arne and Purta, Elzbieta and Timotijevic, Gordana and Cardona, Fernando and Davalos, Alberto and Ballana, Ester and O Carroll, Donal and Ule, Jernej and Fray, Rupert",
year = "2018",
abstract = "The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.",
journal = "RNA Biology",
title = "Positioning Europe for the EPITRANSCRIPTOMICS challenge.",
doi = "10.1080/15476286.2018.1460996"
}

Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J., Balatsos, N., Dinnyes, A., Baranov, P., Kelly, V., Lamm, A., Rechavi, G., Pelizzola, M., Liepins, J., Holodnuka Kholodnyuk, I., Zammit, V., Ayers, D., Drablos, F., Dahl, J. A., Bujnicki, J., Jeronimo, C., Almeida, R., Neagu, M., Costache, M., Banković, J., Banović, B., Kyselovic, J., Valor, L. M., Selbert, S., Pir, P., Demircan, T., Cowling, V., Schäfer, M., Rossmanith, W., Lafontaine, D., David, A., Carre, C., Lyko, F., Schaffrath, R., Schwartz, S., Verdel, A., Klungland, A., Purta, E., Timotijevic, G., Cardona, F., Davalos, A., Ballana, E., O Carroll, D., Ule, J.,& Fray, R.. (2018). Positioning Europe for the EPITRANSCRIPTOMICS challenge.. in RNA Biology.
https://doi.org/10.1080/15476286.2018.1460996

Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant J, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Banković J, Banović B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R. Positioning Europe for the EPITRANSCRIPTOMICS challenge.. in RNA Biology. 2018;.
doi:10.1080/15476286.2018.1460996 .

Jantsch, Michael F., Quattrone, Alessandro, O'Connell, Mary, Helm, Mark, Frye, Michaela, Macias-Gonzales, Manuel, Ohman, Marie, Ameres, Stefan, Willems, Luc, Fuks, Francois, Oulas, Anastasis, Vanacova, Stepanka, Nielsen, Henrik, Bousquet-Antonelli, Cecile, Motorin, Yuri, Roignant, Jean-Yves, Balatsos, Nikolaos, Dinnyes, Andras, Baranov, Pavel, Kelly, Vincent, Lamm, Ayelet, Rechavi, Gideon, Pelizzola, Mattia, Liepins, Janis, Holodnuka Kholodnyuk, Irina, Zammit, Vanessa, Ayers, Duncan, Drablos, Finn, Dahl, John Arne, Bujnicki, Janusz, Jeronimo, Carmen, Almeida, Raquel, Neagu, Monica, Costache, Marieta, Banković, Jasna, Banović, Bojana, Kyselovic, Jan, Valor, Luis Miguel, Selbert, Stefan, Pir, Pinar, Demircan, Turan, Cowling, Victoria, Schäfer, Matthias, Rossmanith, Walter, Lafontaine, Denis, David, Alexandre, Carre, Clement, Lyko, Frank, Schaffrath, Raffael, Schwartz, Schraga, Verdel, Andre, Klungland, Arne, Purta, Elzbieta, Timotijevic, Gordana, Cardona, Fernando, Davalos, Alberto, Ballana, Ester, O Carroll, Donal, Ule, Jernej, Fray, Rupert, "Positioning Europe for the EPITRANSCRIPTOMICS challenge." in RNA Biology (2018),
https://doi.org/10.1080/15476286.2018.1460996 . .

TY  - JOUR
AU  - Jevtić, Bojan
AU  - Timotijevic, Gordana
AU  - Stanisavljević, Suzana
AU  - Momčilović, Miljana
AU  - Stojkovic, Marija Mostarica
AU  - Miljković, Đorđe
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1919
AB  - MicroRNAs (miR) are small non-coding RNAs involved in the immune
   response regulation. miR-155 has been attributed a major
   pro-inflammatory role in the pathogenesis of multiple sclerosis and its
   animal model experimental autoimmune encephalomyelitis (EAE). Here, a
   role of miR-155 in re-activation of encephalitogenic CD4(+) T cells was
   investigated. Dark Agouti rats were immunized with myelin basic protein
   (MBP) emulsified in complete Freund's adjuvant. CD4(+) T cells were
   purified from draining lymph node cells (DLNC) obtained in the inductive
   phase and from spinal cord immune cells (SCIC) isolated at the peak of
   EAE. CD4(+) T cells obtained from SCIC (i.e., in vivo re-activated
   cells) had markedly higher expression of miR-155 in comparison to those
   purified from DLNC (not re-activated). Likewise, in vitro re-activation
   of DLNC with MBP led to increase in miR-155 expression. Further, DLNC
   and DLNC CD4(+) T cells were transfected with an inhibitor of miR-155
   during in vitro re-activation. As a result, expression of important
   CD4(+) T cell effector cytokines IFN-gamma and IL-17, but not of
   regulatory cytokines IL-10 and TGF-beta, was reduced. These results
   imply that miR-155 supports re-activation of encephalitogenic CD4+ T
   cells. Our results contribute to a view that miR-155 might be a valuable
   target in multiple sclerosis therapy. (C) 2015 Elsevier Masson SAS. All
   rights reserved.
T2  - Biomedicine & Pharmacotherapy
T1  - Micro RNA-155 participates in re-activation of encephalitogenic T cells
VL  - 74
DO  - 10.1016/j.biopha.2015.08.011
SP  - 206
EP  - 210
ER  - 

@article{
author = "Jevtić, Bojan and Timotijevic, Gordana and Stanisavljević, Suzana and Momčilović, Miljana and Stojkovic, Marija Mostarica and Miljković, Đorđe",
year = "2015",
abstract = "MicroRNAs (miR) are small non-coding RNAs involved in the immune
   response regulation. miR-155 has been attributed a major
   pro-inflammatory role in the pathogenesis of multiple sclerosis and its
   animal model experimental autoimmune encephalomyelitis (EAE). Here, a
   role of miR-155 in re-activation of encephalitogenic CD4(+) T cells was
   investigated. Dark Agouti rats were immunized with myelin basic protein
   (MBP) emulsified in complete Freund's adjuvant. CD4(+) T cells were
   purified from draining lymph node cells (DLNC) obtained in the inductive
   phase and from spinal cord immune cells (SCIC) isolated at the peak of
   EAE. CD4(+) T cells obtained from SCIC (i.e., in vivo re-activated
   cells) had markedly higher expression of miR-155 in comparison to those
   purified from DLNC (not re-activated). Likewise, in vitro re-activation
   of DLNC with MBP led to increase in miR-155 expression. Further, DLNC
   and DLNC CD4(+) T cells were transfected with an inhibitor of miR-155
   during in vitro re-activation. As a result, expression of important
   CD4(+) T cell effector cytokines IFN-gamma and IL-17, but not of
   regulatory cytokines IL-10 and TGF-beta, was reduced. These results
   imply that miR-155 supports re-activation of encephalitogenic CD4+ T
   cells. Our results contribute to a view that miR-155 might be a valuable
   target in multiple sclerosis therapy. (C) 2015 Elsevier Masson SAS. All
   rights reserved.",
journal = "Biomedicine & Pharmacotherapy",
title = "Micro RNA-155 participates in re-activation of encephalitogenic T cells",
volume = "74",
doi = "10.1016/j.biopha.2015.08.011",
pages = "206-210"
}

Jevtić, B., Timotijevic, G., Stanisavljević, S., Momčilović, M., Stojkovic, M. M.,& Miljković, Đ.. (2015). Micro RNA-155 participates in re-activation of encephalitogenic T cells. in Biomedicine & Pharmacotherapy, 74, 206-210.
https://doi.org/10.1016/j.biopha.2015.08.011

Jevtić B, Timotijevic G, Stanisavljević S, Momčilović M, Stojkovic MM, Miljković Đ. Micro RNA-155 participates in re-activation of encephalitogenic T cells. in Biomedicine & Pharmacotherapy. 2015;74:206-210.
doi:10.1016/j.biopha.2015.08.011 .

Jevtić, Bojan, Timotijevic, Gordana, Stanisavljević, Suzana, Momčilović, Miljana, Stojkovic, Marija Mostarica, Miljković, Đorđe, "Micro RNA-155 participates in re-activation of encephalitogenic T cells" in Biomedicine & Pharmacotherapy, 74 (2015):206-210,
https://doi.org/10.1016/j.biopha.2015.08.011 . .