TY  - CONF
AU  - Jovanović, Aleksandra
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Vidaković, Melita
AU  - Mihailović, Mirjana
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5255
AB  - The aim of the present study was the characterization of silymarin and silibinin loaded liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-days stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from -27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -29.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to -2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 µmcm/Vs to -2.110±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products.
PB  - Banja Luka: University of Banja Luka
C3  - XIV conference of chemists, technologists and environmentalists of Republic of Srpska; 2022 Oct 21-2; Banja Luka, Bosnia and Herzegovinia
T1  - The characterisation of silymarin and silibinin loaded liposomes
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5255
ER  - 

@conference{
editor = "Malinović, Borislav",
author = "Jovanović, Aleksandra and Dinić, Svetlana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Vidaković, Melita and Mihailović, Mirjana",
year = "2022",
abstract = "The aim of the present study was the characterization of silymarin and silibinin loaded liposomes via determination of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, mobility, and conductivity, as well as storage stability during 28 days at 4ºC and stability after UV irradiation. Encapsulation efficiency of silymarin and silibinin were 92.05±1.41% and 87.86±2.06%, respectively. Particle size and PDI of the liposomes with silymarin were changed from 3541.3±62.5 nm to 2677.0±44.2 nm and from 0.346±0.044 to 0.228±0.036, respectively, during the 28-days stability study; particle size and PDI of the liposomes with silibinin were changed from 2074.7±19.4 nm to 2704.0±35.0 nm and from 0.328±0.030 to 0.456±0.026, respectively. Zeta potential of the silymarin-liposomes and silibinin-liposomes was changed from -27.0±0.7 mV to -26.4±0.4 mV and from -29.4±0.6 mV to -29.0±0.4 mV, respectively. Mobility and conductivity of the liposomes with silymarin were changed from -2.120±0.057 µmcm/Vs to -2.067±0.028 µmcm/Vs and from 0.017±0.005 mS/cm to 0.009±0.004 mS/cm, respectively. Mobility and conductivity of the liposomal particles with silibinin were changed from -2.307±0.053 µmcm/Vs to -2.110±0.033 µmcm/Vs and from 0.018±0.003 mS/cm to 0.060±0.001 mS/cm, respectively. UV irradiation did not affect particle size and PDI of all liposomes, but it caused a decrease in zeta potential: -23.9±0.8 mV for silymarin and -24.5±0.7 mV for silibinin, in mobility: -1.874±0.064 µmcm/Vs for silymarin and -1.920±0.057 µmcm/Vs for silibinin, and in conductivity: 0.014±0.001 mS/cm for silymarin and 0.007±0.003 mS/cm for silibinin. Overall, the obtained results qualify liposomes to be used as silymarin and silibinin carriers for application in functional foods and pharmaceutical products.",
publisher = "Banja Luka: University of Banja Luka",
journal = "XIV conference of chemists, technologists and environmentalists of Republic of Srpska; 2022 Oct 21-2; Banja Luka, Bosnia and Herzegovinia",
title = "The characterisation of silymarin and silibinin loaded liposomes",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5255"
}

Malinović, B., Jovanović, A., Dinić, S., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Vidaković, M.,& Mihailović, M.. (2022). The characterisation of silymarin and silibinin loaded liposomes. in XIV conference of chemists, technologists and environmentalists of Republic of Srpska; 2022 Oct 21-2; Banja Luka, Bosnia and Herzegovinia
Banja Luka: University of Banja Luka..
https://hdl.handle.net/21.15107/rcub_ibiss_5255

Malinović B, Jovanović A, Dinić S, Uskoković A, Arambašić Jovanović J, Grdović N, Vidaković M, Mihailović M. The characterisation of silymarin and silibinin loaded liposomes. in XIV conference of chemists, technologists and environmentalists of Republic of Srpska; 2022 Oct 21-2; Banja Luka, Bosnia and Herzegovinia. 2022;.
https://hdl.handle.net/21.15107/rcub_ibiss_5255 .

Malinović, Borislav, Jovanović, Aleksandra, Dinić, Svetlana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Vidaković, Melita, Mihailović, Mirjana, "The characterisation of silymarin and silibinin loaded liposomes" in XIV conference of chemists, technologists and environmentalists of Republic of Srpska; 2022 Oct 21-2; Banja Luka, Bosnia and Herzegovinia (2022),
https://hdl.handle.net/21.15107/rcub_ibiss_5255 .