TY  - DATA
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Poznanović, Goran
AU  - Franić, Aida
AU  - Đorđević, Marija
AU  - Vidaković, Melita
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3715
AB  - Supplementary Table S1. The  effects  of administration  of  extracts  of Castanea  sativa, Lactarius deterrimusand the combination of theseextracts on the change in body weight and biochemical parameters in seraof diabetic rats.
T2  - Archives of Biological Sciences
T1  - Supplementary data for the article: Mihailović M, Uskoković A, Arambašić-Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. Arch Biol Sci. 2020;72(2):233-42.
IS  - 2
VL  - 72
SP  - 233
EP  - 242
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3715
ER  - 

@misc{
author = "Mihailović, Mirjana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Dinić, Svetlana and Poznanović, Goran and Franić, Aida and Đorđević, Marija and Vidaković, Melita",
year = "2020",
abstract = "Supplementary Table S1. The  effects  of administration  of  extracts  of Castanea  sativa, Lactarius deterrimusand the combination of theseextracts on the change in body weight and biochemical parameters in seraof diabetic rats.",
journal = "Archives of Biological Sciences",
title = "Supplementary data for the article: Mihailović M, Uskoković A, Arambašić-Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. Arch Biol Sci. 2020;72(2):233-42.",
number = "2",
volume = "72",
pages = "233-242",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3715"
}

Mihailović, M., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Dinić, S., Poznanović, G., Franić, A., Đorđević, M.,& Vidaković, M.. (2020). Supplementary data for the article: Mihailović M, Uskoković A, Arambašić-Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. Arch Biol Sci. 2020;72(2):233-42.. in Archives of Biological Sciences, 72(2), 233-242.
https://hdl.handle.net/21.15107/rcub_ibiss_3715

Mihailović M, Uskoković A, Arambašić Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Supplementary data for the article: Mihailović M, Uskoković A, Arambašić-Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. Arch Biol Sci. 2020;72(2):233-42.. in Archives of Biological Sciences. 2020;72(2):233-242.
https://hdl.handle.net/21.15107/rcub_ibiss_3715 .

Mihailović, Mirjana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Dinić, Svetlana, Poznanović, Goran, Franić, Aida, Đorđević, Marija, Vidaković, Melita, "Supplementary data for the article: Mihailović M, Uskoković A, Arambašić-Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. Arch Biol Sci. 2020;72(2):233-42." in Archives of Biological Sciences, 72, no. 2 (2020):233-242,
https://hdl.handle.net/21.15107/rcub_ibiss_3715 .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Poznanović, Goran
AU  - Franić, Aida
AU  - Đorđević, Marija
AU  - Vidaković, Melita
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3658
AB  - Diabetes is the most important non-infectious disease affecting 5% of the general population. Different plant and mushroom extracts with hypoglycemic and antioxidant properties have been used traditionally as antidiabetic herbal medicines. The aim of this study was to study the in vivo effect of extracts obtained from the edible mushroom, Lactarius deterrimus (Ld), and chestnut, Castanea sativa (Cs), on the alleviation of liver damage in streptozotocin (STZ)-induced diabetic rats. The extracts were applied, either alone or in combination, for four weeks, starting from the last day of STZ administration. Diabetic rats treated with the extracts exhibited reduced hyperglycemia and lower hepatic oxidative stress. Extract treatment decreased the level of O-linkage of N-acetylglucosamine modified superoxide dismutase, catalase and NF-κB. Masson trichrome staining showed a decrease in collagen fiber deposition in the liver. Immunoblot analysis revealed the activation of the prosurvival Akt kinase after extract application. The obtained results revealed that the hyperglycemia-reducing and antioxidant effects of the Ld and Cs extracts suppressed cytotoxic signaling pathways, attenuating the negative effects of diabetes on the liver. The examined extracts are beneficial in the prevention of liver damage and could be considered for prediabetes and diabetes management after a definitive phytochemical description of extract constituents and subsequent evaluation in preclinical and clinical studies.
T2  - Archives of Biological Sciences
T1  - Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase
IS  - 2
VL  - 72
DO  - 10.2298/ABS200410017M
SP  - 233
EP  - 242
ER  - 

@article{
author = "Mihailović, Mirjana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Grdović, Nevena and Dinić, Svetlana and Poznanović, Goran and Franić, Aida and Đorđević, Marija and Vidaković, Melita",
year = "2020",
abstract = "Diabetes is the most important non-infectious disease affecting 5% of the general population. Different plant and mushroom extracts with hypoglycemic and antioxidant properties have been used traditionally as antidiabetic herbal medicines. The aim of this study was to study the in vivo effect of extracts obtained from the edible mushroom, Lactarius deterrimus (Ld), and chestnut, Castanea sativa (Cs), on the alleviation of liver damage in streptozotocin (STZ)-induced diabetic rats. The extracts were applied, either alone or in combination, for four weeks, starting from the last day of STZ administration. Diabetic rats treated with the extracts exhibited reduced hyperglycemia and lower hepatic oxidative stress. Extract treatment decreased the level of O-linkage of N-acetylglucosamine modified superoxide dismutase, catalase and NF-κB. Masson trichrome staining showed a decrease in collagen fiber deposition in the liver. Immunoblot analysis revealed the activation of the prosurvival Akt kinase after extract application. The obtained results revealed that the hyperglycemia-reducing and antioxidant effects of the Ld and Cs extracts suppressed cytotoxic signaling pathways, attenuating the negative effects of diabetes on the liver. The examined extracts are beneficial in the prevention of liver damage and could be considered for prediabetes and diabetes management after a definitive phytochemical description of extract constituents and subsequent evaluation in preclinical and clinical studies.",
journal = "Archives of Biological Sciences",
title = "Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase",
number = "2",
volume = "72",
doi = "10.2298/ABS200410017M",
pages = "233-242"
}

Mihailović, M., Uskoković, A., Arambašić Jovanović, J., Grdović, N., Dinić, S., Poznanović, G., Franić, A., Đorđević, M.,& Vidaković, M.. (2020). Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. in Archives of Biological Sciences, 72(2), 233-242.
https://doi.org/10.2298/ABS200410017M

Mihailović M, Uskoković A, Arambašić Jovanović J, Grdović N, Dinić S, Poznanović G, Franić A, Đorđević M, Vidaković M. Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase. in Archives of Biological Sciences. 2020;72(2):233-242.
doi:10.2298/ABS200410017M .

Mihailović, Mirjana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Grdović, Nevena, Dinić, Svetlana, Poznanović, Goran, Franić, Aida, Đorđević, Marija, Vidaković, Melita, "Treatment of streptozotocin-induced diabetic rats with Castanea sativa and Lactarius deterrimus extracts decreases liver damage by initiating activation of the Akt prosurvival kinase" in Archives of Biological Sciences, 72, no. 2 (2020):233-242,
https://doi.org/10.2298/ABS200410017M . .