TY  - JOUR
AU  - Ruskovska, Tatjana
AU  - Budić-Leto, Irena
AU  - Corral-Jara, Karla Fabiola
AU  - Ajdžanović, Vladimir
AU  - Arola-Arnal, Anna
AU  - Bravo, Francisca Isabel
AU  - Deligiannidou, Georgia-Eirini
AU  - Havlik, Jaroslav
AU  - Janeva, Milkica
AU  - Kistanova, Elena
AU  - Kontogiorgis, Christos
AU  - Krga, Irena
AU  - Massaro, Marika
AU  - Miler, Marko
AU  - Harnafi, Hicham
AU  - Milošević, Verica
AU  - Morand, Christine
AU  - Scoditti, Egeria
AU  - Suárez, Manuel
AU  - Vauzour, David
AU  - Milenkovic, Dragan
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4977
AB  - Cardiovascular and metabolic disorders present major causes of mortality in the ageing population. Polyphenols present in human diets possess cardiometabolic protective properties, however their underlying molecular mechanisms in humans are still not well identified. Even though preclinical and in vitro studies advocate that these bioactives can modulate gene expression, most studies were performed using targeted approaches. With the objective to decipher the molecular mechanisms underlying polyphenols cardiometabolic preventive properties in humans, we performed integrative multi-omic bioinformatic analyses of published studies which reported improvements of cardiometabolic risk factors following polyphenol intake, together with genomic analyses performed using untargeted approach. We identified 5 studies within our criteria and nearly 5000 differentially expressed genes, both mRNAs and miRNAs, in peripheral blood cells. Integrative bioinformatic analyses (e.g. pathway and gene network analyses, identification of transcription factors, correlation of gene expression profiles with those associated with diseases and drug intake) revealed that these genes are involved in the processes such as cell adhesion and mobility, immune system, metabolism, or cell signaling. We also identified 27 miRNAs known to regulate processes such as cell cytoskeleton, chemotaxis, cell signaling, or cell metabolism. Gene expression profiles negatively correlated with expression profiles of cardiovascular disease patients, while a positive correlation was observed with gene expression profiles following intake of drugs against cardiometabolic disorders. These analyses further advocate for health protective effects of these bioactives against age-associated diseases. In conclusion, polyphenols can exert multi-genomic modifications in humans and use of untargeted methods coupled with bioinformatic analyses represent the best approach to decipher molecular mechanisms underlying healthy-ageing effects of these bioactives.
PB  - Elsevier B.V.
T2  - Ageing Research Reviews
T1  - Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies
VL  - 79:101649
DO  - 10.1016/j.arr.2022.101649
ER  - 

@article{
author = "Ruskovska, Tatjana and Budić-Leto, Irena and Corral-Jara, Karla Fabiola and Ajdžanović, Vladimir and Arola-Arnal, Anna and Bravo, Francisca Isabel and Deligiannidou, Georgia-Eirini and Havlik, Jaroslav and Janeva, Milkica and Kistanova, Elena and Kontogiorgis, Christos and Krga, Irena and Massaro, Marika and Miler, Marko and Harnafi, Hicham and Milošević, Verica and Morand, Christine and Scoditti, Egeria and Suárez, Manuel and Vauzour, David and Milenkovic, Dragan",
year = "2022",
abstract = "Cardiovascular and metabolic disorders present major causes of mortality in the ageing population. Polyphenols present in human diets possess cardiometabolic protective properties, however their underlying molecular mechanisms in humans are still not well identified. Even though preclinical and in vitro studies advocate that these bioactives can modulate gene expression, most studies were performed using targeted approaches. With the objective to decipher the molecular mechanisms underlying polyphenols cardiometabolic preventive properties in humans, we performed integrative multi-omic bioinformatic analyses of published studies which reported improvements of cardiometabolic risk factors following polyphenol intake, together with genomic analyses performed using untargeted approach. We identified 5 studies within our criteria and nearly 5000 differentially expressed genes, both mRNAs and miRNAs, in peripheral blood cells. Integrative bioinformatic analyses (e.g. pathway and gene network analyses, identification of transcription factors, correlation of gene expression profiles with those associated with diseases and drug intake) revealed that these genes are involved in the processes such as cell adhesion and mobility, immune system, metabolism, or cell signaling. We also identified 27 miRNAs known to regulate processes such as cell cytoskeleton, chemotaxis, cell signaling, or cell metabolism. Gene expression profiles negatively correlated with expression profiles of cardiovascular disease patients, while a positive correlation was observed with gene expression profiles following intake of drugs against cardiometabolic disorders. These analyses further advocate for health protective effects of these bioactives against age-associated diseases. In conclusion, polyphenols can exert multi-genomic modifications in humans and use of untargeted methods coupled with bioinformatic analyses represent the best approach to decipher molecular mechanisms underlying healthy-ageing effects of these bioactives.",
publisher = "Elsevier B.V.",
journal = "Ageing Research Reviews",
title = "Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies",
volume = "79:101649",
doi = "10.1016/j.arr.2022.101649"
}

Ruskovska, T., Budić-Leto, I., Corral-Jara, K. F., Ajdžanović, V., Arola-Arnal, A., Bravo, F. I., Deligiannidou, G., Havlik, J., Janeva, M., Kistanova, E., Kontogiorgis, C., Krga, I., Massaro, M., Miler, M., Harnafi, H., Milošević, V., Morand, C., Scoditti, E., Suárez, M., Vauzour, D.,& Milenkovic, D.. (2022). Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies. in Ageing Research Reviews
Elsevier B.V.., 79:101649.
https://doi.org/10.1016/j.arr.2022.101649

Ruskovska T, Budić-Leto I, Corral-Jara KF, Ajdžanović V, Arola-Arnal A, Bravo FI, Deligiannidou G, Havlik J, Janeva M, Kistanova E, Kontogiorgis C, Krga I, Massaro M, Miler M, Harnafi H, Milošević V, Morand C, Scoditti E, Suárez M, Vauzour D, Milenkovic D. Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies. in Ageing Research Reviews. 2022;79:101649.
doi:10.1016/j.arr.2022.101649 .

Ruskovska, Tatjana, Budić-Leto, Irena, Corral-Jara, Karla Fabiola, Ajdžanović, Vladimir, Arola-Arnal, Anna, Bravo, Francisca Isabel, Deligiannidou, Georgia-Eirini, Havlik, Jaroslav, Janeva, Milkica, Kistanova, Elena, Kontogiorgis, Christos, Krga, Irena, Massaro, Marika, Miler, Marko, Harnafi, Hicham, Milošević, Verica, Morand, Christine, Scoditti, Egeria, Suárez, Manuel, Vauzour, David, Milenkovic, Dragan, "Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies" in Ageing Research Reviews, 79:101649 (2022),
https://doi.org/10.1016/j.arr.2022.101649 . .

TY  - JOUR
AU  - Ruskovska, Tatjana
AU  - Budić-Leto, Irena
AU  - Corral-Jara, Karla Fabiola
AU  - Ajdžanović, Vladimir
AU  - Arola-Arnal, Anna
AU  - Bravo, Francisca Isabel
AU  - Deligiannidou, Georgia-Eirini
AU  - Havlik, Jaroslav
AU  - Janeva, Milkica
AU  - Kistanova, Elena
AU  - Kontogiorgis, Christos
AU  - Krga, Irena
AU  - Massaro, Marika
AU  - Miler, Marko
AU  - Milošević, Verica
AU  - Morand, Christine
AU  - Scoditti, Egeria
AU  - Suárez, Manuel
AU  - Vauzour, David
AU  - Milenković, Dragan
PY  - 2021
UR  - https://www.mdpi.com/2072-6643/13/7/2326
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4435
AB  - Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
PB  - Basel: MDPI
T2  - Nutrients
T1  - Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies.
IS  - 7
VL  - 13
DO  - 10.3390/nu13072326
SP  - 2326
ER  - 

@article{
author = "Ruskovska, Tatjana and Budić-Leto, Irena and Corral-Jara, Karla Fabiola and Ajdžanović, Vladimir and Arola-Arnal, Anna and Bravo, Francisca Isabel and Deligiannidou, Georgia-Eirini and Havlik, Jaroslav and Janeva, Milkica and Kistanova, Elena and Kontogiorgis, Christos and Krga, Irena and Massaro, Marika and Miler, Marko and Milošević, Verica and Morand, Christine and Scoditti, Egeria and Suárez, Manuel and Vauzour, David and Milenković, Dragan",
year = "2021",
abstract = "Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.",
publisher = "Basel: MDPI",
journal = "Nutrients",
title = "Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies.",
number = "7",
volume = "13",
doi = "10.3390/nu13072326",
pages = "2326"
}

Ruskovska, T., Budić-Leto, I., Corral-Jara, K. F., Ajdžanović, V., Arola-Arnal, A., Bravo, F. I., Deligiannidou, G., Havlik, J., Janeva, M., Kistanova, E., Kontogiorgis, C., Krga, I., Massaro, M., Miler, M., Milošević, V., Morand, C., Scoditti, E., Suárez, M., Vauzour, D.,& Milenković, D.. (2021). Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies.. in Nutrients
Basel: MDPI., 13(7), 2326.
https://doi.org/10.3390/nu13072326

Ruskovska T, Budić-Leto I, Corral-Jara KF, Ajdžanović V, Arola-Arnal A, Bravo FI, Deligiannidou G, Havlik J, Janeva M, Kistanova E, Kontogiorgis C, Krga I, Massaro M, Miler M, Milošević V, Morand C, Scoditti E, Suárez M, Vauzour D, Milenković D. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies.. in Nutrients. 2021;13(7):2326.
doi:10.3390/nu13072326 .

Ruskovska, Tatjana, Budić-Leto, Irena, Corral-Jara, Karla Fabiola, Ajdžanović, Vladimir, Arola-Arnal, Anna, Bravo, Francisca Isabel, Deligiannidou, Georgia-Eirini, Havlik, Jaroslav, Janeva, Milkica, Kistanova, Elena, Kontogiorgis, Christos, Krga, Irena, Massaro, Marika, Miler, Marko, Milošević, Verica, Morand, Christine, Scoditti, Egeria, Suárez, Manuel, Vauzour, David, Milenković, Dragan, "Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies." in Nutrients, 13, no. 7 (2021):2326,
https://doi.org/10.3390/nu13072326 . .

TY  - JOUR
AU  - Monfoulet, Laurent‐Emmanuel
AU  - Ruskovska, Tatjana
AU  - Ajdžanović, Vladimir
AU  - Havlik, Jaroslav
AU  - Vauzour, David
AU  - Bayram, Banu
AU  - Krga, Irena
AU  - Corral-Jara, Karla-Fabiola
AU  - Kistanova, Elena
AU  - Abadjieva, Desislava
AU  - Massaro, Marika
AU  - Scoditti, Egeria
AU  - Deligiannidou, Eirini
AU  - Kontogiorgis, Christos
AU  - Arola-Arnal, Anna
AU  - van Schothorst, Evert M
AU  - Morand, Christine
AU  - Milenkovic, Dragan
PY  - 2021
UR  - https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100227
UR  - http://www.ncbi.nlm.nih.gov/pubmed/34048642
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4437
AB  - SCOPE Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.
PB  - John Wiley and Sons
T2  - Molecular Nutrition & Food Research
T2  - Molecular Nutrition & Food Research
T1  - Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.
IS  - 16
VL  - 65
DO  - 10.1002/mnfr.202100227
SP  - e2100227
ER  - 

@article{
author = "Monfoulet, Laurent‐Emmanuel and Ruskovska, Tatjana and Ajdžanović, Vladimir and Havlik, Jaroslav and Vauzour, David and Bayram, Banu and Krga, Irena and Corral-Jara, Karla-Fabiola and Kistanova, Elena and Abadjieva, Desislava and Massaro, Marika and Scoditti, Egeria and Deligiannidou, Eirini and Kontogiorgis, Christos and Arola-Arnal, Anna and van Schothorst, Evert M and Morand, Christine and Milenkovic, Dragan",
year = "2021",
abstract = "SCOPE Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.",
publisher = "John Wiley and Sons",
journal = "Molecular Nutrition & Food Research, Molecular Nutrition & Food Research",
title = "Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.",
number = "16",
volume = "65",
doi = "10.1002/mnfr.202100227",
pages = "e2100227"
}

Monfoulet, L., Ruskovska, T., Ajdžanović, V., Havlik, J., Vauzour, D., Bayram, B., Krga, I., Corral-Jara, K., Kistanova, E., Abadjieva, D., Massaro, M., Scoditti, E., Deligiannidou, E., Kontogiorgis, C., Arola-Arnal, A., van Schothorst, E. M., Morand, C.,& Milenkovic, D.. (2021). Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.. in Molecular Nutrition & Food Research
John Wiley and Sons., 65(16), e2100227.
https://doi.org/10.1002/mnfr.202100227

Monfoulet L, Ruskovska T, Ajdžanović V, Havlik J, Vauzour D, Bayram B, Krga I, Corral-Jara K, Kistanova E, Abadjieva D, Massaro M, Scoditti E, Deligiannidou E, Kontogiorgis C, Arola-Arnal A, van Schothorst EM, Morand C, Milenkovic D. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.. in Molecular Nutrition & Food Research. 2021;65(16):e2100227.
doi:10.1002/mnfr.202100227 .

Monfoulet, Laurent‐Emmanuel, Ruskovska, Tatjana, Ajdžanović, Vladimir, Havlik, Jaroslav, Vauzour, David, Bayram, Banu, Krga, Irena, Corral-Jara, Karla-Fabiola, Kistanova, Elena, Abadjieva, Desislava, Massaro, Marika, Scoditti, Egeria, Deligiannidou, Eirini, Kontogiorgis, Christos, Arola-Arnal, Anna, van Schothorst, Evert M, Morand, Christine, Milenkovic, Dragan, "Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies." in Molecular Nutrition & Food Research, 65, no. 16 (2021):e2100227,
https://doi.org/10.1002/mnfr.202100227 . .

TY  - JOUR
AU  - Egea, Javier
AU  - Fabregat, Isabel
AU  - Frapart, Yves M.
AU  - Ghezzi, Pietro
AU  - Görlach, Agnes
AU  - Kietzmann, Thomas
AU  - Kubaichuk, Kateryna
AU  - Knaus, Ulla G.
AU  - Lopez, Manuela G.
AU  - Olaso-Gonzalez, Gloria
AU  - Petry, Andreas
AU  - Schulz, Rainer
AU  - Vina, Jose
AU  - Winyard, Paul
AU  - Abbas, Kahina
AU  - Ademowo, Opeyemi S.
AU  - Afonso, Catarina B.
AU  - Andreadou, Ioanna
AU  - Antelmann, Haike
AU  - Antunes, Fernando
AU  - Aslan, Mutay
AU  - Bachschmid, Markus M.
AU  - Barbosa, Rui M.
AU  - Belousov, Vsevolod
AU  - Berndt, Carsten
AU  - Bernlohr, David
AU  - Bertrán, Esther
AU  - Bindoli, Alberto
AU  - Bottari, Serge P.
AU  - Brito, Paula M.
AU  - Carrara, Guia
AU  - Casas, Ana I.
AU  - Chatzi, Afroditi
AU  - Chondrogianni, Niki
AU  - Conrad, Marcus
AU  - Cooke, Marcus S.
AU  - Costa, João G.
AU  - Cuadrado, Antonio
AU  - My-Chan Dang, Pham
AU  - De Smet, Barbara
AU  - Debelec-Butuner, Bilge
AU  - Dias, Irundika H.K.
AU  - Dunn, Joe Dan
AU  - Edson, Amanda J.
AU  - El Assar, Mariam
AU  - El-Benna, Jamel
AU  - Ferdinandy, Péter
AU  - Fernandes, Ana S.
AU  - Fladmark, Kari E.
AU  - Förstermann, Ulrich
AU  - Giniatullin, Rashid
AU  - Giricz, Zoltán
AU  - Görbe, Anikó
AU  - Griffiths, Helen
AU  - Hampl, Vaclav
AU  - Hanf, Alina
AU  - Herget, Jan
AU  - Hernansanz-Agustín, Pablo
AU  - Hillion, Melanie
AU  - Huang, Jingjing
AU  - Ilikay, Serap
AU  - Jansen-Dürr, Pidder
AU  - Jaquet, Vincent
AU  - Joles, Jaap A.
AU  - Kalyanaraman, Balaraman
AU  - Kaminskyy, Danylo
AU  - Karbaschi, Mahsa
AU  - Kleanthous, Marina
AU  - Klotz, Lars-Oliver
AU  - Korać, Bato
AU  - Korkmaz, Kemal Sami
AU  - Koziel, Rafal
AU  - Kračun, Damir
AU  - Krause, Karl-Heinz
AU  - Křen, Vladimír
AU  - Krieg, Thomas
AU  - Laranjinha, João
AU  - Lazou, Antigone
AU  - Li, Huige
AU  - Martínez-Ruiz, Antonio
AU  - Matsui, Reiko
AU  - McBean, Gethin J.
AU  - Meredith, Stuart P.
AU  - Messens, Joris
AU  - Miguel, Verónica
AU  - Mikhed, Yuliya
AU  - Milisav, Irina
AU  - Milković, Lidija
AU  - Miranda-Vizuete, Antonio
AU  - Mojović, Miloš
AU  - Monsalve, María
AU  - Mouthuy, Pierre-Alexis
AU  - Mulvey, John
AU  - Münzel, Thomas
AU  - Muzykantov, Vladimir
AU  - Nguyen, Isabel T.N.
AU  - Oelze, Matthias
AU  - Oliveira, Nuno G.
AU  - Palmeira, Carlos M.
AU  - Papaevgeniou, Nikoletta
AU  - Pavićević, Aleksandra
AU  - Pedre, Brandán
AU  - Peyrot, Fabienne
AU  - Phylactides, Marios
AU  - Pircalabioru, Gratiela G.
AU  - Pitt, Andrew R.
AU  - Poulsen, Henrik E.
AU  - Prieto, Ignacio
AU  - Rigobello, Maria Pia
AU  - Robledinos-Antón, Natalia
AU  - Rodríguez-Mañas, Leocadio
AU  - Rolo, Anabela P.
AU  - Rousset, Francis
AU  - Ruskovska, Tatjana
AU  - Saraiva, Nuno
AU  - Sasson, Shlomo
AU  - Schröder, Katrin
AU  - Semen, Khrystyna
AU  - Seredenina, Tamara
AU  - Shakirzyanova, Anastasia
AU  - Smith, Geoffrey L.
AU  - Soldati, Thierry
AU  - Sousa, Bebiana C.
AU  - Spickett, Corinne M.
AU  - Stančić, Ana
AU  - Stasia, Marie José
AU  - Steinbrenner, Holger
AU  - Stepanić, Višnja
AU  - Steven, Sebastian
AU  - Tokatlidis, Kostas
AU  - Tuncay, Erkan
AU  - Turan, Belma
AU  - Ursini, Fulvio
AU  - Vacek, Jan
AU  - Vajnerova, Olga
AU  - Valentová, Kateřina
AU  - Van Breusegem, Frank
AU  - Varisli, Lokman
AU  - Veal, Elizabeth A.
AU  - Yalçın, A. Suha
AU  - Yelisyeyeva, Olha
AU  - Žarković, Neven
AU  - Zatloukalová, Martina
AU  - Zielonka, Jacek
AU  - Touyz, Rhian M.
AU  - Papapetropoulos, Andreas
AU  - Grune, Tilman
AU  - Lamas, Santiago
AU  - Schmidt, Harald H.H.W.
AU  - Di Lisa, Fabio
AU  - Daiber, Andreas
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S2213231717303373
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2778
AB  - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.
T2  - Redox Biology
T1  - European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
VL  - 13
DO  - 10.1016/j.redox.2017.05.007
SP  - 94
EP  - 162
ER  - 

@article{
author = "Egea, Javier and Fabregat, Isabel and Frapart, Yves M. and Ghezzi, Pietro and Görlach, Agnes and Kietzmann, Thomas and Kubaichuk, Kateryna and Knaus, Ulla G. and Lopez, Manuela G. and Olaso-Gonzalez, Gloria and Petry, Andreas and Schulz, Rainer and Vina, Jose and Winyard, Paul and Abbas, Kahina and Ademowo, Opeyemi S. and Afonso, Catarina B. and Andreadou, Ioanna and Antelmann, Haike and Antunes, Fernando and Aslan, Mutay and Bachschmid, Markus M. and Barbosa, Rui M. and Belousov, Vsevolod and Berndt, Carsten and Bernlohr, David and Bertrán, Esther and Bindoli, Alberto and Bottari, Serge P. and Brito, Paula M. and Carrara, Guia and Casas, Ana I. and Chatzi, Afroditi and Chondrogianni, Niki and Conrad, Marcus and Cooke, Marcus S. and Costa, João G. and Cuadrado, Antonio and My-Chan Dang, Pham and De Smet, Barbara and Debelec-Butuner, Bilge and Dias, Irundika H.K. and Dunn, Joe Dan and Edson, Amanda J. and El Assar, Mariam and El-Benna, Jamel and Ferdinandy, Péter and Fernandes, Ana S. and Fladmark, Kari E. and Förstermann, Ulrich and Giniatullin, Rashid and Giricz, Zoltán and Görbe, Anikó and Griffiths, Helen and Hampl, Vaclav and Hanf, Alina and Herget, Jan and Hernansanz-Agustín, Pablo and Hillion, Melanie and Huang, Jingjing and Ilikay, Serap and Jansen-Dürr, Pidder and Jaquet, Vincent and Joles, Jaap A. and Kalyanaraman, Balaraman and Kaminskyy, Danylo and Karbaschi, Mahsa and Kleanthous, Marina and Klotz, Lars-Oliver and Korać, Bato and Korkmaz, Kemal Sami and Koziel, Rafal and Kračun, Damir and Krause, Karl-Heinz and Křen, Vladimír and Krieg, Thomas and Laranjinha, João and Lazou, Antigone and Li, Huige and Martínez-Ruiz, Antonio and Matsui, Reiko and McBean, Gethin J. and Meredith, Stuart P. and Messens, Joris and Miguel, Verónica and Mikhed, Yuliya and Milisav, Irina and Milković, Lidija and Miranda-Vizuete, Antonio and Mojović, Miloš and Monsalve, María and Mouthuy, Pierre-Alexis and Mulvey, John and Münzel, Thomas and Muzykantov, Vladimir and Nguyen, Isabel T.N. and Oelze, Matthias and Oliveira, Nuno G. and Palmeira, Carlos M. and Papaevgeniou, Nikoletta and Pavićević, Aleksandra and Pedre, Brandán and Peyrot, Fabienne and Phylactides, Marios and Pircalabioru, Gratiela G. and Pitt, Andrew R. and Poulsen, Henrik E. and Prieto, Ignacio and Rigobello, Maria Pia and Robledinos-Antón, Natalia and Rodríguez-Mañas, Leocadio and Rolo, Anabela P. and Rousset, Francis and Ruskovska, Tatjana and Saraiva, Nuno and Sasson, Shlomo and Schröder, Katrin and Semen, Khrystyna and Seredenina, Tamara and Shakirzyanova, Anastasia and Smith, Geoffrey L. and Soldati, Thierry and Sousa, Bebiana C. and Spickett, Corinne M. and Stančić, Ana and Stasia, Marie José and Steinbrenner, Holger and Stepanić, Višnja and Steven, Sebastian and Tokatlidis, Kostas and Tuncay, Erkan and Turan, Belma and Ursini, Fulvio and Vacek, Jan and Vajnerova, Olga and Valentová, Kateřina and Van Breusegem, Frank and Varisli, Lokman and Veal, Elizabeth A. and Yalçın, A. Suha and Yelisyeyeva, Olha and Žarković, Neven and Zatloukalová, Martina and Zielonka, Jacek and Touyz, Rhian M. and Papapetropoulos, Andreas and Grune, Tilman and Lamas, Santiago and Schmidt, Harald H.H.W. and Di Lisa, Fabio and Daiber, Andreas",
year = "2017",
abstract = "The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.",
journal = "Redox Biology",
title = "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)",
volume = "13",
doi = "10.1016/j.redox.2017.05.007",
pages = "94-162"
}

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-Butuner, B., Dias, I. H.K., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L., Korać, B., Korkmaz, K. S., Koziel, R., Kračun, D., Krause, K., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., McBean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I. T.N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Rigobello, M. P., Robledinos-Antón, N., Rodríguez-Mañas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stančić, A., Stasia, M. J., Steinbrenner, H., Stepanić, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., Van Breusegem, F., Varisli, L., Veal, E. A., Yalçın, A. S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H.H.W., Di Lisa, F.,& Daiber, A.. (2017). European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). in Redox Biology, 13, 94-162.
https://doi.org/10.1016/j.redox.2017.05.007

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IH, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz L, Korać B, Korkmaz KS, Koziel R, Kračun D, Krause K, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy P, Mulvey J, Münzel T, Muzykantov V, Nguyen IT, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stančić A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HH, Di Lisa F, Daiber A. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). in Redox Biology. 2017;13:94-162.
doi:10.1016/j.redox.2017.05.007 .

Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec-Butuner, Bilge, Dias, Irundika H.K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korać, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stančić, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., Di Lisa, Fabio, Daiber, Andreas, "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" in Redox Biology, 13 (2017):94-162,
https://doi.org/10.1016/j.redox.2017.05.007 . .