TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Li, Shuo
AU  - Stojilković, Stanko S.
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0005273617301098
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2745
AB  - Pannexins are a three-member family of vertebrate plasma membrane spanning molecules that have homology to the invertebrate gap junction forming proteins, the innexins. However, pannexins do not form gap junctions but operate as plasma membrane channels. The best-characterized member of these proteins, Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling. Two potentiation concepts have been suggested: enhancement of the current responses and/or sustained receptor channel activation by ATP released through Panx1 pore and adenosine generated by ectonucleotidase-dependent dephosphorylation of ATP. Here we summarize the current knowledge and hypotheses about interactions of Panx1 channels with P2X and NMDA receptor channels. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.
T2  - Biochimica et Biophysica Acta (BBA) - Biomembranes
T1  - Interactions of Pannexin1 channels with purinergic and NMDA receptor channels
IS  - 1
VL  - 1860
DO  - 10.1016/j.bbamem.2017.03.025
SP  - 166
EP  - 173
ER  - 

@article{
author = "Bjelobaba, Ivana and Li, Shuo and Stojilković, Stanko S.",
year = "2018",
abstract = "Pannexins are a three-member family of vertebrate plasma membrane spanning molecules that have homology to the invertebrate gap junction forming proteins, the innexins. However, pannexins do not form gap junctions but operate as plasma membrane channels. The best-characterized member of these proteins, Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling. Two potentiation concepts have been suggested: enhancement of the current responses and/or sustained receptor channel activation by ATP released through Panx1 pore and adenosine generated by ectonucleotidase-dependent dephosphorylation of ATP. Here we summarize the current knowledge and hypotheses about interactions of Panx1 channels with P2X and NMDA receptor channels. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.",
journal = "Biochimica et Biophysica Acta (BBA) - Biomembranes",
title = "Interactions of Pannexin1 channels with purinergic and NMDA receptor channels",
number = "1",
volume = "1860",
doi = "10.1016/j.bbamem.2017.03.025",
pages = "166-173"
}

Bjelobaba, I., Li, S.,& Stojilković, S. S.. (2018). Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. in Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(1), 166-173.
https://doi.org/10.1016/j.bbamem.2017.03.025

Bjelobaba I, Li S, Stojilković SS. Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. in Biochimica et Biophysica Acta (BBA) - Biomembranes. 2018;1860(1):166-173.
doi:10.1016/j.bbamem.2017.03.025 .

Bjelobaba, Ivana, Li, Shuo, Stojilković, Stanko S., "Interactions of Pannexin1 channels with purinergic and NMDA receptor channels" in Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860, no. 1 (2018):166-173,
https://doi.org/10.1016/j.bbamem.2017.03.025 . .

TY  - JOUR
AU  - Li, Shuo
AU  - Bjelobaba, Ivana
AU  - Yan, Zonghe
AU  - Kucka, Marek
AU  - Tomić, Melanija
AU  - Stojilković, Stanko S
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1120
AB  - Pannexins are a newly discovered three-member family of proteins expressed in the brain and peripheral tissues that belong to the superfamily of gap junction proteins. However, in mammals pannexins do not form gap junctions, and their expression and function in the pituitary gland have not been studied. Here we show that the rat pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3. Pannexin 1 was more abundantly expressed in the anterior lobe, whereas pannexin 2 was more abundantly expressed in the intermediate and posterior pituitary. Pannexin 1 was identified in corticotrophs and a fraction of somatotrophs, the S100-positive pituicytes of the posterior pituitary and AtT-20 (mouse pituitary adrenocorticotropin-secreting cells) and rat immortalized pituitary cells secreting prolactin, whereas pannexin 2 was detected in the S100-positive folliculostellate cells of the anterior pituitary, melanotrophs of the intermediate lobe, and vasopressin-containing axons and nerve endings in the posterior lobe. Overexpression of pannexins 1 and 2 in AtT-20 pituitary cells enhanced the release of ATP in the extracellular medium, which was blocked by the gap junction inhibitor carbenoxolone. Basal ATP release in At-T20 cells was also suppressed by down-regulating the expression of endogenous pannexin 1 but not pannexin 2 with their short interfering RNAs. These results indicate that pannexins may provide a pathway for delivery of ATP, which is a native agonist for numerous P2X cationic channels and G protein-coupled P2Y receptors endogenously expressed in the pituitary gland. (Endocrinology 152: 2342-2352, 2011)
T2  - Endocrinology
T1  - Expression and Roles of Pannexins in ATP Release in the Pituitary Gland
IS  - 6
VL  - 152
SP  - 83
EP  - 2352
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1120
ER  - 

@article{
author = "Li, Shuo and Bjelobaba, Ivana and Yan, Zonghe and Kucka, Marek and Tomić, Melanija and Stojilković, Stanko S",
year = "2011",
abstract = "Pannexins are a newly discovered three-member family of proteins expressed in the brain and peripheral tissues that belong to the superfamily of gap junction proteins. However, in mammals pannexins do not form gap junctions, and their expression and function in the pituitary gland have not been studied. Here we show that the rat pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3. Pannexin 1 was more abundantly expressed in the anterior lobe, whereas pannexin 2 was more abundantly expressed in the intermediate and posterior pituitary. Pannexin 1 was identified in corticotrophs and a fraction of somatotrophs, the S100-positive pituicytes of the posterior pituitary and AtT-20 (mouse pituitary adrenocorticotropin-secreting cells) and rat immortalized pituitary cells secreting prolactin, whereas pannexin 2 was detected in the S100-positive folliculostellate cells of the anterior pituitary, melanotrophs of the intermediate lobe, and vasopressin-containing axons and nerve endings in the posterior lobe. Overexpression of pannexins 1 and 2 in AtT-20 pituitary cells enhanced the release of ATP in the extracellular medium, which was blocked by the gap junction inhibitor carbenoxolone. Basal ATP release in At-T20 cells was also suppressed by down-regulating the expression of endogenous pannexin 1 but not pannexin 2 with their short interfering RNAs. These results indicate that pannexins may provide a pathway for delivery of ATP, which is a native agonist for numerous P2X cationic channels and G protein-coupled P2Y receptors endogenously expressed in the pituitary gland. (Endocrinology 152: 2342-2352, 2011)",
journal = "Endocrinology",
title = "Expression and Roles of Pannexins in ATP Release in the Pituitary Gland",
number = "6",
volume = "152",
pages = "83-2352",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1120"
}

Li, S., Bjelobaba, I., Yan, Z., Kucka, M., Tomić, M.,& Stojilković, S. S.. (2011). Expression and Roles of Pannexins in ATP Release in the Pituitary Gland. in Endocrinology, 152(6), 83-2352.
https://hdl.handle.net/21.15107/rcub_ibiss_1120

Li S, Bjelobaba I, Yan Z, Kucka M, Tomić M, Stojilković SS. Expression and Roles of Pannexins in ATP Release in the Pituitary Gland. in Endocrinology. 2011;152(6):83-2352.
https://hdl.handle.net/21.15107/rcub_ibiss_1120 .

Li, Shuo, Bjelobaba, Ivana, Yan, Zonghe, Kucka, Marek, Tomić, Melanija, Stojilković, Stanko S, "Expression and Roles of Pannexins in ATP Release in the Pituitary Gland" in Endocrinology, 152, no. 6 (2011):83-2352,
https://hdl.handle.net/21.15107/rcub_ibiss_1120 .