TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Belij, Sandra
AU  - Subota, Vesna S
AU  - Zolotarevski, Lidija D
AU  - Mirkov, Ivana
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1061
AB  - Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including anti-tumor and immunomodulating activity. With respect to the latter, both immune stimulating and suppressive effects have been noted in different experimental systems. To explore the in vivo immunomodulatory potential of warfarin on one type of activity (i.e., cytokine production) in two different immune cell populations (i.e., mononuclear or polymorphonuclear cells), effects of subchronic oral warfarin intake in rats on pro-inflammatory cytokine (i.e., TNF alpha, IL-6) production by peripheral blood mononuclear and polymorphonuclear cells (granulocytes) was examined. Differential effects of warfarin intake on TNF alpha and IL-6 were noted, depending on the type of peripheral blood leukocytes and on the cytokine examined. Specifically, a lack of effect on TNF alpha and a priming of IL-6 production by mononuclear cells along with a decrease in TNF alpha and a lack of effect on IL-6 in polymorphonuclear cells were seen in warfarin-exposed hosts. The cell-and cytokine-dependent effects from subchronic oral warfarin intake on peripheral blood leukocytes demonstrated in this study could, possibly, differentially affect reactions mediated by these cells. Ultimately, the observed effects in rats might have implications for those humans who are on long-term/prolonged warfarin therapy.
T2  - Journal of Immunotoxicology
T1  - Oral warfarin affects peripheral blood leukocyte IL-6 and TNF alpha production in rats
IS  - 1
VL  - 10
SP  - 375
EP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1061
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Belij, Sandra and Subota, Vesna S and Zolotarevski, Lidija D and Mirkov, Ivana and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2013",
abstract = "Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including anti-tumor and immunomodulating activity. With respect to the latter, both immune stimulating and suppressive effects have been noted in different experimental systems. To explore the in vivo immunomodulatory potential of warfarin on one type of activity (i.e., cytokine production) in two different immune cell populations (i.e., mononuclear or polymorphonuclear cells), effects of subchronic oral warfarin intake in rats on pro-inflammatory cytokine (i.e., TNF alpha, IL-6) production by peripheral blood mononuclear and polymorphonuclear cells (granulocytes) was examined. Differential effects of warfarin intake on TNF alpha and IL-6 were noted, depending on the type of peripheral blood leukocytes and on the cytokine examined. Specifically, a lack of effect on TNF alpha and a priming of IL-6 production by mononuclear cells along with a decrease in TNF alpha and a lack of effect on IL-6 in polymorphonuclear cells were seen in warfarin-exposed hosts. The cell-and cytokine-dependent effects from subchronic oral warfarin intake on peripheral blood leukocytes demonstrated in this study could, possibly, differentially affect reactions mediated by these cells. Ultimately, the observed effects in rats might have implications for those humans who are on long-term/prolonged warfarin therapy.",
journal = "Journal of Immunotoxicology",
title = "Oral warfarin affects peripheral blood leukocyte IL-6 and TNF alpha production in rats",
number = "1",
volume = "10",
pages = "375-24",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1061"
}

Popov Aleksandrov, A., Belij, S., Subota, V. S., Zolotarevski, L. D., Mirkov, I., Kataranovski, D. S.,& Kataranovski, M.. (2013). Oral warfarin affects peripheral blood leukocyte IL-6 and TNF alpha production in rats. in Journal of Immunotoxicology, 10(1), 375-24.
https://hdl.handle.net/21.15107/rcub_ibiss_1061

Popov Aleksandrov A, Belij S, Subota VS, Zolotarevski LD, Mirkov I, Kataranovski DS, Kataranovski M. Oral warfarin affects peripheral blood leukocyte IL-6 and TNF alpha production in rats. in Journal of Immunotoxicology. 2013;10(1):375-24.
https://hdl.handle.net/21.15107/rcub_ibiss_1061 .

Popov Aleksandrov, Aleksandra, Belij, Sandra, Subota, Vesna S, Zolotarevski, Lidija D, Mirkov, Ivana, Kataranovski, Dragan S., Kataranovski, Milena, "Oral warfarin affects peripheral blood leukocyte IL-6 and TNF alpha production in rats" in Journal of Immunotoxicology, 10, no. 1 (2013):375-24,
https://hdl.handle.net/21.15107/rcub_ibiss_1061 .

TY  - CONF
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Miljković, Đorđe
AU  - Belij, Sandra
AU  - Đokić, Jelena
AU  - Zolotarevski, Lidija D
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1113
C3  - Immunology
T1  - Contribution of sensitization phase to intensity of contact hypersensitivity reaction in rats
IS  - null
VL  - 137
SP  - 349
EP  - 442
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1113
ER  - 

@conference{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Miljković, Đorđe and Belij, Sandra and Đokić, Jelena and Zolotarevski, Lidija D and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2012",
journal = "Immunology",
title = "Contribution of sensitization phase to intensity of contact hypersensitivity reaction in rats",
number = "null",
volume = "137",
pages = "349-442",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1113"
}

Popov Aleksandrov, A., Mirkov, I., Miljković, Đ., Belij, S., Đokić, J., Zolotarevski, L. D., Kataranovski, D. S.,& Kataranovski, M.. (2012). Contribution of sensitization phase to intensity of contact hypersensitivity reaction in rats. in Immunology, 137(null), 349-442.
https://hdl.handle.net/21.15107/rcub_ibiss_1113

Popov Aleksandrov A, Mirkov I, Miljković Đ, Belij S, Đokić J, Zolotarevski LD, Kataranovski DS, Kataranovski M. Contribution of sensitization phase to intensity of contact hypersensitivity reaction in rats. in Immunology. 2012;137(null):349-442.
https://hdl.handle.net/21.15107/rcub_ibiss_1113 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Miljković, Đorđe, Belij, Sandra, Đokić, Jelena, Zolotarevski, Lidija D, Kataranovski, Dragan S., Kataranovski, Milena, "Contribution of sensitization phase to intensity of contact hypersensitivity reaction in rats" in Immunology, 137, no. null (2012):349-442,
https://hdl.handle.net/21.15107/rcub_ibiss_1113 .

TY  - JOUR
AU  - Belij, Sandra
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Zolotarevski, Lidija D
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1207
AB  - Contact hypersensitivity reaction (CHS) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. While the significance of local inflammatory skin response to the hapten application in CHS induction and expression is known, there is paucity of data concerning systemic inflammation in CHS. In this study, changes in cellular (peripheral blood granulocytes) and humoral (plasma tumor necrosis factor (TNF)-alpha levels) components of inflammation during sensitization of rats with two consecutive applications of dinitrochlorobenzene (DNCB) were examined. The impact of sensitization on these parameters was determined by employing low (0.4%) and high (4%) hapten doses and by examining the dynamics (i.e. one and three days following the last application of DNCB) of these changes. Dose-dependent increase in relative numbers and priming (for respiratory burst and adhesion) effect of skin sensitization with DNCB on peripheral blood neutrophils in rats were noted. No changes in circulating TNF-alpha levels were observed following the sensitization. The increase in lung myeloperoxidase content and histologically evident presence of neutrophils was observed in lungs of the sensitized rats. The changes in granulocyte priming for adhesion might have accounted for the observed increase in lung neutrophil content in the sensitized rats.
T2  - Cutaneous and Ocular Toxicology
T1  - Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats
IS  - 1
VL  - 31
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1207
ER  - 

@article{
author = "Belij, Sandra and Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Zolotarevski, Lidija D and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2012",
abstract = "Contact hypersensitivity reaction (CHS) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. While the significance of local inflammatory skin response to the hapten application in CHS induction and expression is known, there is paucity of data concerning systemic inflammation in CHS. In this study, changes in cellular (peripheral blood granulocytes) and humoral (plasma tumor necrosis factor (TNF)-alpha levels) components of inflammation during sensitization of rats with two consecutive applications of dinitrochlorobenzene (DNCB) were examined. The impact of sensitization on these parameters was determined by employing low (0.4%) and high (4%) hapten doses and by examining the dynamics (i.e. one and three days following the last application of DNCB) of these changes. Dose-dependent increase in relative numbers and priming (for respiratory burst and adhesion) effect of skin sensitization with DNCB on peripheral blood neutrophils in rats were noted. No changes in circulating TNF-alpha levels were observed following the sensitization. The increase in lung myeloperoxidase content and histologically evident presence of neutrophils was observed in lungs of the sensitized rats. The changes in granulocyte priming for adhesion might have accounted for the observed increase in lung neutrophil content in the sensitized rats.",
journal = "Cutaneous and Ocular Toxicology",
title = "Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats",
number = "1",
volume = "31",
pages = "13",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1207"
}

Belij, S., Popov Aleksandrov, A., Mirkov, I., Zolotarevski, L. D., Kataranovski, D. S.,& Kataranovski, M.. (2012). Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology, 31(1).
https://hdl.handle.net/21.15107/rcub_ibiss_1207

Belij S, Popov Aleksandrov A, Mirkov I, Zolotarevski LD, Kataranovski DS, Kataranovski M. Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology. 2012;31(1):null-13.
https://hdl.handle.net/21.15107/rcub_ibiss_1207 .

Belij, Sandra, Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Zolotarevski, Lidija D, Kataranovski, Dragan S., Kataranovski, Milena, "Percutaneous toxicity of dinitrochlorobenzene (DNCB) in rats" in Cutaneous and Ocular Toxicology, 31, no. 1 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1207 .

TY  - JOUR
AU  - Belij, Sandra
AU  - Popov Aleksandrov, Aleksandra
AU  - Zolotarevski, Lidija D
AU  - Mirkov, Ivana
AU  - Đokić, Jelena
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1203
AB  - Topical application of dinitrochlorobenzene (DNCB) is employed in the immunotherapy of skin diseases. Activation of T-cell mediated immune responses (Th1/type1) is the supposed mechanism of the clinical effect of DNCB, but there are no data concerning innate/inflammatory mechanisms. In this study, the effect of repeated topical DNCB application on peripheral blood polymorphonuclear (PMN) leukocytes has been examined in two rat strains which differ in the propensity to mount Th1/type1 or Th2/type2 responses. The dynamics of changes in PMN numbers and effector activities (respiratory burst, nitric oxide production and myeloperoxidase content), as well as in adhesion and TNF-alpha production following the rat skin sensitization with low (0.4%) and high (4%) DNCB doses were measured. Both priming and activation of PMNs were observed following skin sensitization with DNCB, with dose-dependent as well as time-dependent differences in some PMN activities. Obtained data might be relevant for understanding the immune mechanisms of topical DNCB therapy. (C) 2011 Published by Elsevier B.V.
T2  - Environmental Toxicology and Pharmacology
T1  - Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells
IS  - 2
VL  - 33
EP  - 180
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1203
ER  - 

@article{
author = "Belij, Sandra and Popov Aleksandrov, Aleksandra and Zolotarevski, Lidija D and Mirkov, Ivana and Đokić, Jelena and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2012",
abstract = "Topical application of dinitrochlorobenzene (DNCB) is employed in the immunotherapy of skin diseases. Activation of T-cell mediated immune responses (Th1/type1) is the supposed mechanism of the clinical effect of DNCB, but there are no data concerning innate/inflammatory mechanisms. In this study, the effect of repeated topical DNCB application on peripheral blood polymorphonuclear (PMN) leukocytes has been examined in two rat strains which differ in the propensity to mount Th1/type1 or Th2/type2 responses. The dynamics of changes in PMN numbers and effector activities (respiratory burst, nitric oxide production and myeloperoxidase content), as well as in adhesion and TNF-alpha production following the rat skin sensitization with low (0.4%) and high (4%) DNCB doses were measured. Both priming and activation of PMNs were observed following skin sensitization with DNCB, with dose-dependent as well as time-dependent differences in some PMN activities. Obtained data might be relevant for understanding the immune mechanisms of topical DNCB therapy. (C) 2011 Published by Elsevier B.V.",
journal = "Environmental Toxicology and Pharmacology",
title = "Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells",
number = "2",
volume = "33",
pages = "180",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1203"
}

Belij, S., Popov Aleksandrov, A., Zolotarevski, L. D., Mirkov, I., Đokić, J., Kataranovski, D. S.,& Kataranovski, M.. (2012). Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells. in Environmental Toxicology and Pharmacology, 33(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1203

Belij S, Popov Aleksandrov A, Zolotarevski LD, Mirkov I, Đokić J, Kataranovski DS, Kataranovski M. Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells. in Environmental Toxicology and Pharmacology. 2012;33(2):null-180.
https://hdl.handle.net/21.15107/rcub_ibiss_1203 .

Belij, Sandra, Popov Aleksandrov, Aleksandra, Zolotarevski, Lidija D, Mirkov, Ivana, Đokić, Jelena, Kataranovski, Dragan S., Kataranovski, Milena, "Systemic immunomodulatory effects of topical dinitrochlorobenzene (DNCB) in rats. Activity of peripheral blood polymorphonuclear cells" in Environmental Toxicology and Pharmacology, 33, no. 2 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1203 .

TY  - JOUR
AU  - Belij, Sandra
AU  - Miljković, Đorđe
AU  - Popov Aleksandrov, Aleksandra
AU  - Subota, Vesna S
AU  - Timotijević, Gordana S
AU  - Slavić, Marija
AU  - Mirkov, Ivana
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1185
AB  - Warfarin affects mainly vitamin K dependent (VKD) processes, but the effects on some non-VKD-related activities such as tumor growth inhibition and mononuclear cell-mediated immune reactions were shown as well. In this study, the effect of subchronic (30 days) oral warfarin (0.35 mg/l and 3.5 mg/l) intake on peripheral blood granulocytes in rats was investigated. Increase in prothrombin and partial thromboplastin time at high warfarin dose reflected its basic activity. Priming effect for respiratory burst was noted at both warfarin doses, while only high warfarin dose resulted in priming for adhesion, the rise in intracellular myeloperoxidase content/release and stimulation of nitric oxide production. Differential effects of high warfarin dose were noted on granulocyte cytokines IL-6 (lack of the effect), TNF-alpha (decreased release and mRNA expression) and IL-12 (increase in mRNA for IL-12 subunits p35 and p40). Changes in granulocytes seems not to rely on mitogen activated kinases p38 and ERK. Warfarin intake was associated with an increase in circulating IL-6, fibrinogen and haptoglobin and with changes in the activity of erythrocyte antioxidant enzymes superoxide dismutase and catalase. The effects of oral warfarin intake on peripheral blood granulocytes demonstrated in this study might be relevant for oral anticoagulant therapy strategies in humans. (C) 2012 Elsevier Ltd. All rights reserved.
T2  - Food and Chemical Toxicology
T1  - Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats
IS  - 5
VL  - 50
EP  - 1507
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1185
ER  - 

@article{
author = "Belij, Sandra and Miljković, Đorđe and Popov Aleksandrov, Aleksandra and Subota, Vesna S and Timotijević, Gordana S and Slavić, Marija and Mirkov, Ivana and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2012",
abstract = "Warfarin affects mainly vitamin K dependent (VKD) processes, but the effects on some non-VKD-related activities such as tumor growth inhibition and mononuclear cell-mediated immune reactions were shown as well. In this study, the effect of subchronic (30 days) oral warfarin (0.35 mg/l and 3.5 mg/l) intake on peripheral blood granulocytes in rats was investigated. Increase in prothrombin and partial thromboplastin time at high warfarin dose reflected its basic activity. Priming effect for respiratory burst was noted at both warfarin doses, while only high warfarin dose resulted in priming for adhesion, the rise in intracellular myeloperoxidase content/release and stimulation of nitric oxide production. Differential effects of high warfarin dose were noted on granulocyte cytokines IL-6 (lack of the effect), TNF-alpha (decreased release and mRNA expression) and IL-12 (increase in mRNA for IL-12 subunits p35 and p40). Changes in granulocytes seems not to rely on mitogen activated kinases p38 and ERK. Warfarin intake was associated with an increase in circulating IL-6, fibrinogen and haptoglobin and with changes in the activity of erythrocyte antioxidant enzymes superoxide dismutase and catalase. The effects of oral warfarin intake on peripheral blood granulocytes demonstrated in this study might be relevant for oral anticoagulant therapy strategies in humans. (C) 2012 Elsevier Ltd. All rights reserved.",
journal = "Food and Chemical Toxicology",
title = "Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats",
number = "5",
volume = "50",
pages = "1507",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1185"
}

Belij, S., Miljković, Đ., Popov Aleksandrov, A., Subota, V. S., Timotijević, G. S., Slavić, M., Mirkov, I., Kataranovski, D. S.,& Kataranovski, M.. (2012). Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats. in Food and Chemical Toxicology, 50(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1185

Belij S, Miljković Đ, Popov Aleksandrov A, Subota VS, Timotijević GS, Slavić M, Mirkov I, Kataranovski DS, Kataranovski M. Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats. in Food and Chemical Toxicology. 2012;50(5):null-1507.
https://hdl.handle.net/21.15107/rcub_ibiss_1185 .

Belij, Sandra, Miljković, Đorđe, Popov Aleksandrov, Aleksandra, Subota, Vesna S, Timotijević, Gordana S, Slavić, Marija, Mirkov, Ivana, Kataranovski, Dragan S., Kataranovski, Milena, "Effects of subacute oral warfarin administration on peripheral blood granulocytes in rats" in Food and Chemical Toxicology, 50, no. 5 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1185 .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Kataranovski, Milena
AU  - Zolotarevski, Lidija D
AU  - Glamočlija, Jasmina
AU  - Stojanović, Ivana D.
AU  - Stošić-Grujičić, Stanislava
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1170
AB  - We recently demonstrated that macrophage migration inhibitory factor deficient (MIF-/-) mice exhibited a higher susceptibility to lethal systemic Aspergillus fumigatus infections than genetically matched, wild-type (WT) C57BL/6 mice, and displayed altered cytokine profiles in the spleen when challenged by sublethal infections. In this report we focused on the potential involvement of MIF in the response of mice to sublethal systemic A. fumigatus infections in tissues other than spleen. Impaired fungal clearance from lungs, kidneys, liver and brain in MIF-/- mice was noted and was associated with histologically-evident differences in signs of inflammation in these organs. Higher values of some indicators of pathologic changes in urine parameters (increases in bilirubin, glucose and ketones), as well as a greater degree of brain tissue damage, pointed to multiple organs being affected in MIF-/- mice. Analysis of the lung response revealed differences in the composition of infiltrated cells between MIF-sufficient and MIF-deficient mice. MPO activity and reactive oxygen species production were impaired, as well as production of IL-17 and IFN-gamma in MIF-/- mice as compared to WT counterparts. Lower systemic IL-1 beta and IL-6 levels in infected MIF-/- mice coincided with reduced blood neutrophil counts and organ infiltration. Collectively, this study identifies MIF as a resistance factor that orchestrates events in several non-lymphoid areas which provide a milieu that accomplishes anti-fungal A. fumigatus defense.
T2  - Medical Mycology
T1  - The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection
IS  - 5
VL  - 50
EP  - 487
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1170
ER  - 

@article{
author = "Mirkov, Ivana and Belij, Sandra and Kataranovski, Milena and Zolotarevski, Lidija D and Glamočlija, Jasmina and Stojanović, Ivana D. and Stošić-Grujičić, Stanislava",
year = "2012",
abstract = "We recently demonstrated that macrophage migration inhibitory factor deficient (MIF-/-) mice exhibited a higher susceptibility to lethal systemic Aspergillus fumigatus infections than genetically matched, wild-type (WT) C57BL/6 mice, and displayed altered cytokine profiles in the spleen when challenged by sublethal infections. In this report we focused on the potential involvement of MIF in the response of mice to sublethal systemic A. fumigatus infections in tissues other than spleen. Impaired fungal clearance from lungs, kidneys, liver and brain in MIF-/- mice was noted and was associated with histologically-evident differences in signs of inflammation in these organs. Higher values of some indicators of pathologic changes in urine parameters (increases in bilirubin, glucose and ketones), as well as a greater degree of brain tissue damage, pointed to multiple organs being affected in MIF-/- mice. Analysis of the lung response revealed differences in the composition of infiltrated cells between MIF-sufficient and MIF-deficient mice. MPO activity and reactive oxygen species production were impaired, as well as production of IL-17 and IFN-gamma in MIF-/- mice as compared to WT counterparts. Lower systemic IL-1 beta and IL-6 levels in infected MIF-/- mice coincided with reduced blood neutrophil counts and organ infiltration. Collectively, this study identifies MIF as a resistance factor that orchestrates events in several non-lymphoid areas which provide a milieu that accomplishes anti-fungal A. fumigatus defense.",
journal = "Medical Mycology",
title = "The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection",
number = "5",
volume = "50",
pages = "487",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1170"
}

Mirkov, I., Belij, S., Kataranovski, M., Zolotarevski, L. D., Glamočlija, J., Stojanović, I. D.,& Stošić-Grujičić, S.. (2012). The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection. in Medical Mycology, 50(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1170

Mirkov I, Belij S, Kataranovski M, Zolotarevski LD, Glamočlija J, Stojanović ID, Stošić-Grujičić S. The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection. in Medical Mycology. 2012;50(5):null-487.
https://hdl.handle.net/21.15107/rcub_ibiss_1170 .

Mirkov, Ivana, Belij, Sandra, Kataranovski, Milena, Zolotarevski, Lidija D, Glamočlija, Jasmina, Stojanović, Ivana D., Stošić-Grujičić, Stanislava, "The relevance of the migration inhibitory factor (MIF) for peripheral tissue response in murine sublethal systemic Aspergillus fumigatus infection" in Medical Mycology, 50, no. 5 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1170 .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Zolotarevski, Lidija D
AU  - Jović, Milena
AU  - Belij, Sandra
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1299
AB  - Objective: To evaluate the effects of epicutaneous application of anticoagulant warfarin, by examining the presence of tissue injury and immune/inflammatory activity in exposed skin. Methods: Rats were exposed to warfarin by applying 10 mu g of warfarin-sodium to 10-12 cm(2) skin (range 0.8-1 mu g per 1 cm(2)) for 3 consecutive days. Tissue injury was evaluated by lipid peroxidation, histomorphological changes and signs of reparative activity in skin. T cell infiltration and selected aspects of epidermal cell activity were examined as indicators of immune/inflammatory skin response to warfarin application. Results: Repeated warfarin application exerted no effect on skin metabolic viability, but resulted in tissue injury (increased malondialdehyde, MDA, production, evident histo-morphological changes in epidermis and dermis depicting cell injury and death). Increased numbers of proliferating cell nuclear antigen (PCNA(+)) cells indicated reparative processes in injured skin. Infiltration of CD3(+) cells (T lymphocytes) along with the increased production of tumor necrosis factor-alpha (TNF-alpha) by epidermal cells from warfarin-treated skin and their co-stimulatory effect in an in vitro T-cell activation assay demonstrated immunomodulatory effects of epicutaneous warfarin. Conclusion: Presented data have documented tissue damage associated with immune/inflammatory activity in skin exposed to warfarin. Observed effects are relevant to immunotoxic potential of this anticoagulant in settings of external exposure.
T2  - Biomedical and Environmental Sciences
T1  - Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats
IS  - 2
VL  - 24
EP  - 189
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1299
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Zolotarevski, Lidija D and Jović, Milena and Belij, Sandra and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2011",
abstract = "Objective: To evaluate the effects of epicutaneous application of anticoagulant warfarin, by examining the presence of tissue injury and immune/inflammatory activity in exposed skin. Methods: Rats were exposed to warfarin by applying 10 mu g of warfarin-sodium to 10-12 cm(2) skin (range 0.8-1 mu g per 1 cm(2)) for 3 consecutive days. Tissue injury was evaluated by lipid peroxidation, histomorphological changes and signs of reparative activity in skin. T cell infiltration and selected aspects of epidermal cell activity were examined as indicators of immune/inflammatory skin response to warfarin application. Results: Repeated warfarin application exerted no effect on skin metabolic viability, but resulted in tissue injury (increased malondialdehyde, MDA, production, evident histo-morphological changes in epidermis and dermis depicting cell injury and death). Increased numbers of proliferating cell nuclear antigen (PCNA(+)) cells indicated reparative processes in injured skin. Infiltration of CD3(+) cells (T lymphocytes) along with the increased production of tumor necrosis factor-alpha (TNF-alpha) by epidermal cells from warfarin-treated skin and their co-stimulatory effect in an in vitro T-cell activation assay demonstrated immunomodulatory effects of epicutaneous warfarin. Conclusion: Presented data have documented tissue damage associated with immune/inflammatory activity in skin exposed to warfarin. Observed effects are relevant to immunotoxic potential of this anticoagulant in settings of external exposure.",
journal = "Biomedical and Environmental Sciences",
title = "Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats",
number = "2",
volume = "24",
pages = "189",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1299"
}

Popov Aleksandrov, A., Mirkov, I., Zolotarevski, L. D., Jović, M., Belij, S., Kataranovski, D. S.,& Kataranovski, M.. (2011). Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats. in Biomedical and Environmental Sciences, 24(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1299

Popov Aleksandrov A, Mirkov I, Zolotarevski LD, Jović M, Belij S, Kataranovski DS, Kataranovski M. Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats. in Biomedical and Environmental Sciences. 2011;24(2):null-189.
https://hdl.handle.net/21.15107/rcub_ibiss_1299 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Zolotarevski, Lidija D, Jović, Milena, Belij, Sandra, Kataranovski, Dragan S., Kataranovski, Milena, "Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats" in Biomedical and Environmental Sciences, 24, no. 2 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1299 .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Popov Aleksandrov, Aleksandra
AU  - Petrović, Z
AU  - Gacić, Zoran M
AU  - Kataranovski, Dragan S.
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1291
AB  - Gastrointestinal helminths of Norway rat (Rattus norvegicus) from the Belgrade area were studied as a part of a wider ecological research of rats in Serbia (data on the distribution, population ecology, economic and epizoothiological-epidemiological importance, and density control). Rats were captured from May 2005 to July 2009 at both urban and suburban-rural sites. Of a total of 302 trapped rats 48 % were males and 52 % females, with 36.5 % and 38.8 % of juvenile-subadult individuals, per sex respectively. Intestinal helminth infection was noted in 68.5 % of rats, with a higher prevalence in male hosts and in adult individuals. Higher numbers of infected juveniles-subadults were noted in suburban-rural habitats, while an opposite tendency was noted in adult rats. Seven helminth species were recovered, of which five were nematode (Heterakis spumosa, Nippostrongylus brasiliensis, Capillaria sp., Trichuris muris and Syphacia muris) and two cestode species (Hymenolepis diminuta and Rodentolepis fraterna). The most prevalent parasites were Heterakis spumosa (36.7 %) and Hymenolepis diminuta (30.5 %). Sex and habitat-related differences were noted in the prevalence of infection with Capillaria sp. and Trichuris muris, while there were no age-related differences in the prevalence of infection with any individual helminth species. Significantly higher prevalence of infection was noted in summer as compared to spring or winter, with a tendency to be higher in autumn as compared to spring. The only significant difference in the prevalence of infection between habitat-related was noted during spring. H. spumosa was most prevalent in summer, while H. diminuta and N. brasiliensis in autumn. The mean intensity of infection with H. spumosa, R. fraterna, S. muris and I muris was higher in autumn than in the other seasons, while N. brasiliensis and Capillaria sp. occured in winter. No more than four helminth species were found in one host.
T2  - Parasite-Journal de La Societe Francaise de Parasitologie
T1  - Intestinal Helminths Infection of Rats (Ratus Norvegicus) in the Belgrade Area (Serbia): the Effect of Sex, Age and Habitat
IS  - 2
VL  - 18
EP  - 196
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1291
ER  - 

@article{
author = "Kataranovski, Milena and Mirkov, Ivana and Belij, Sandra and Popov Aleksandrov, Aleksandra and Petrović, Z and Gacić, Zoran M and Kataranovski, Dragan S.",
year = "2011",
abstract = "Gastrointestinal helminths of Norway rat (Rattus norvegicus) from the Belgrade area were studied as a part of a wider ecological research of rats in Serbia (data on the distribution, population ecology, economic and epizoothiological-epidemiological importance, and density control). Rats were captured from May 2005 to July 2009 at both urban and suburban-rural sites. Of a total of 302 trapped rats 48 % were males and 52 % females, with 36.5 % and 38.8 % of juvenile-subadult individuals, per sex respectively. Intestinal helminth infection was noted in 68.5 % of rats, with a higher prevalence in male hosts and in adult individuals. Higher numbers of infected juveniles-subadults were noted in suburban-rural habitats, while an opposite tendency was noted in adult rats. Seven helminth species were recovered, of which five were nematode (Heterakis spumosa, Nippostrongylus brasiliensis, Capillaria sp., Trichuris muris and Syphacia muris) and two cestode species (Hymenolepis diminuta and Rodentolepis fraterna). The most prevalent parasites were Heterakis spumosa (36.7 %) and Hymenolepis diminuta (30.5 %). Sex and habitat-related differences were noted in the prevalence of infection with Capillaria sp. and Trichuris muris, while there were no age-related differences in the prevalence of infection with any individual helminth species. Significantly higher prevalence of infection was noted in summer as compared to spring or winter, with a tendency to be higher in autumn as compared to spring. The only significant difference in the prevalence of infection between habitat-related was noted during spring. H. spumosa was most prevalent in summer, while H. diminuta and N. brasiliensis in autumn. The mean intensity of infection with H. spumosa, R. fraterna, S. muris and I muris was higher in autumn than in the other seasons, while N. brasiliensis and Capillaria sp. occured in winter. No more than four helminth species were found in one host.",
journal = "Parasite-Journal de La Societe Francaise de Parasitologie",
title = "Intestinal Helminths Infection of Rats (Ratus Norvegicus) in the Belgrade Area (Serbia): the Effect of Sex, Age and Habitat",
number = "2",
volume = "18",
pages = "196",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1291"
}

Kataranovski, M., Mirkov, I., Belij, S., Popov Aleksandrov, A., Petrović, Z., Gacić, Z. M.,& Kataranovski, D. S.. (2011). Intestinal Helminths Infection of Rats (Ratus Norvegicus) in the Belgrade Area (Serbia): the Effect of Sex, Age and Habitat. in Parasite-Journal de La Societe Francaise de Parasitologie, 18(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1291

Kataranovski M, Mirkov I, Belij S, Popov Aleksandrov A, Petrović Z, Gacić ZM, Kataranovski DS. Intestinal Helminths Infection of Rats (Ratus Norvegicus) in the Belgrade Area (Serbia): the Effect of Sex, Age and Habitat. in Parasite-Journal de La Societe Francaise de Parasitologie. 2011;18(2):null-196.
https://hdl.handle.net/21.15107/rcub_ibiss_1291 .

Kataranovski, Milena, Mirkov, Ivana, Belij, Sandra, Popov Aleksandrov, Aleksandra, Petrović, Z, Gacić, Zoran M, Kataranovski, Dragan S., "Intestinal Helminths Infection of Rats (Ratus Norvegicus) in the Belgrade Area (Serbia): the Effect of Sex, Age and Habitat" in Parasite-Journal de La Societe Francaise de Parasitologie, 18, no. 2 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1291 .

TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Miljković, Đorđe
AU  - Belij, Sandra
AU  - Zolotarevski, Lidija D
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1278
AB  - Contact hypersensitivity (CHS) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. Majority of CHS studies were conducted in mice and there is paucity of data in other experimental animals. In the present study, characteristics of contact hypersensitivity reaction to dinitrochlorobenzene (DNCB) were determined in Th1-prone Dark Agouti (DA) rats by evaluating sensitization phase as a function of time-dependent changes in draining lymph nodes (DLN). Apart from basic indices of DLN activity (cellularity and proliferation), the production of cytokines relevant for CHS induction, interleukin-6 (IL-6), interferon-gamma (IFN-gamma), interleukin-17 (IL-17) and interleukin-4 (IL-4) was analyzed. Anti-inflammatory cytokine interleukin-10 (IL-10) production by DLN cells was determined as well. Highest production of IL-6, IFN-gamma and IL-17 in sensitized animals was observed at day 3 after DNCB application, with a decrease at day 5. Increased messages for IFN-gamma and IL-17 were noted at this time point. In contrast to inflammatory cytokines, anti-inflammatory cytokine interleukin-4 (IL-4) was undetectable during the entire sensitization phase. Differential pattern (IL-6 and IFN-gamma) and level (IFN-gamma and IL-17) of inflammatory cytokine production was noted in sensitized Th2-prone Albino Oxford (AO) rats. Similarly to DA rats, no changes in IL-4 were noted in AO rats. Strain-dependent differences in inflammatory cytokine production seem to be based on anti-inflammatory cytokine interleukin-10 (IL-10). Production of IFN-gamma concomitantly with undetectable IL-4 in both strains classify rat CHS to DNCB as Th1/type 1 reaction. Detection of IL-17 in sensitized DLN cells points to the involvement of T(IL-17) cells in rat contact hypersensitivity. (C) 2011 Elsevier GmbH. All rights reserved.
T2  - Immunobiology
T1  - Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase
IS  - 7
VL  - 216
EP  - 770
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1278
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Miljković, Đorđe and Belij, Sandra and Zolotarevski, Lidija D and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2011",
abstract = "Contact hypersensitivity (CHS) is a T-cell-mediated skin inflammatory reaction to cutaneous exposure to small sensitizing chemicals, haptens. Majority of CHS studies were conducted in mice and there is paucity of data in other experimental animals. In the present study, characteristics of contact hypersensitivity reaction to dinitrochlorobenzene (DNCB) were determined in Th1-prone Dark Agouti (DA) rats by evaluating sensitization phase as a function of time-dependent changes in draining lymph nodes (DLN). Apart from basic indices of DLN activity (cellularity and proliferation), the production of cytokines relevant for CHS induction, interleukin-6 (IL-6), interferon-gamma (IFN-gamma), interleukin-17 (IL-17) and interleukin-4 (IL-4) was analyzed. Anti-inflammatory cytokine interleukin-10 (IL-10) production by DLN cells was determined as well. Highest production of IL-6, IFN-gamma and IL-17 in sensitized animals was observed at day 3 after DNCB application, with a decrease at day 5. Increased messages for IFN-gamma and IL-17 were noted at this time point. In contrast to inflammatory cytokines, anti-inflammatory cytokine interleukin-4 (IL-4) was undetectable during the entire sensitization phase. Differential pattern (IL-6 and IFN-gamma) and level (IFN-gamma and IL-17) of inflammatory cytokine production was noted in sensitized Th2-prone Albino Oxford (AO) rats. Similarly to DA rats, no changes in IL-4 were noted in AO rats. Strain-dependent differences in inflammatory cytokine production seem to be based on anti-inflammatory cytokine interleukin-10 (IL-10). Production of IFN-gamma concomitantly with undetectable IL-4 in both strains classify rat CHS to DNCB as Th1/type 1 reaction. Detection of IL-17 in sensitized DLN cells points to the involvement of T(IL-17) cells in rat contact hypersensitivity. (C) 2011 Elsevier GmbH. All rights reserved.",
journal = "Immunobiology",
title = "Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase",
number = "7",
volume = "216",
pages = "770",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1278"
}

Popov Aleksandrov, A., Mirkov, I., Miljković, Đ., Belij, S., Zolotarevski, L. D., Kataranovski, D. S.,& Kataranovski, M.. (2011). Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase. in Immunobiology, 216(7).
https://hdl.handle.net/21.15107/rcub_ibiss_1278

Popov Aleksandrov A, Mirkov I, Miljković Đ, Belij S, Zolotarevski LD, Kataranovski DS, Kataranovski M. Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase. in Immunobiology. 2011;216(7):null-770.
https://hdl.handle.net/21.15107/rcub_ibiss_1278 .

Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Miljković, Đorđe, Belij, Sandra, Zolotarevski, Lidija D, Kataranovski, Dragan S., Kataranovski, Milena, "Contact allergic response to dinitrochlorobenzene (DNCB) in rats: Insight from sensitization phase" in Immunobiology, 216, no. 7 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1278 .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Zolotarevski, Lidija
AU  - Belij, Sandra
AU  - Mirkov, Ivana
AU  - Stošić, Jelena
AU  - Popov Aleksandrov, Aleksandra
AU  - Kataranovski, D.
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/257
AB  - The nematode Calodium hepaticum and the cestode Taenia taeniaeformis are zoonotic helminths primarly found in the liver of common wild rats. Most reports on these helminth species with cosmopolitan distribution are from Asia, and there is paucity of data for Europe. Wild Norway rats (Rattus norvegicus) from urban and suburban habitats of the Belgrade area were examined for the presence of Calodium hepaticum and Taenia taeniaeformis larvae liver infections. The presence of visible cysts and a histomorphology of parasite-related inflammatory liver responses were sought as signs of infection. The total prevalence of infection was 10.9% (C. hepaticum) and 29.9% (T. taeniaeformis), with no differences between the sexes. No difference in the annual prevalence of both helminth species was noted. Data obtained in this study provide new information relevant to wild Norway rats as sources of C. hepaticum and T. taeniaeformis liver infection in this geographic area, and, in a wider context, in Europe. .
T2  - Archives of Biological Sciences
T1  - Prvi nalazi infekcije jetre parazitima Calodium hepaticum i Taenia taeniaeformis kod sivog pacova (Rattus norvegicus) u Srbiji
T1  - First record of Calodium hepaticum and Taenia taeniaeformis liver infection in wild Norway rats (Rattus norvegicus) in Serbia
IS  - 2
VL  - 62
SP  - 431
EP  - 440
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_257
ER  - 

@article{
author = "Kataranovski, Milena and Zolotarevski, Lidija and Belij, Sandra and Mirkov, Ivana and Stošić, Jelena and Popov Aleksandrov, Aleksandra and Kataranovski, D.",
year = "2010, 2010",
abstract = "The nematode Calodium hepaticum and the cestode Taenia taeniaeformis are zoonotic helminths primarly found in the liver of common wild rats. Most reports on these helminth species with cosmopolitan distribution are from Asia, and there is paucity of data for Europe. Wild Norway rats (Rattus norvegicus) from urban and suburban habitats of the Belgrade area were examined for the presence of Calodium hepaticum and Taenia taeniaeformis larvae liver infections. The presence of visible cysts and a histomorphology of parasite-related inflammatory liver responses were sought as signs of infection. The total prevalence of infection was 10.9% (C. hepaticum) and 29.9% (T. taeniaeformis), with no differences between the sexes. No difference in the annual prevalence of both helminth species was noted. Data obtained in this study provide new information relevant to wild Norway rats as sources of C. hepaticum and T. taeniaeformis liver infection in this geographic area, and, in a wider context, in Europe. .",
journal = "Archives of Biological Sciences",
title = "Prvi nalazi infekcije jetre parazitima Calodium hepaticum i Taenia taeniaeformis kod sivog pacova (Rattus norvegicus) u Srbiji, First record of Calodium hepaticum and Taenia taeniaeformis liver infection in wild Norway rats (Rattus norvegicus) in Serbia",
number = "2",
volume = "62",
pages = "431-440",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_257"
}

Kataranovski, M., Zolotarevski, L., Belij, S., Mirkov, I., Stošić, J., Popov Aleksandrov, A.,& Kataranovski, D.. (2010). Prvi nalazi infekcije jetre parazitima Calodium hepaticum i Taenia taeniaeformis kod sivog pacova (Rattus norvegicus) u Srbiji. in Archives of Biological Sciences, 62(2), 431-440.
https://hdl.handle.net/21.15107/rcub_ibiss_257

Kataranovski M, Zolotarevski L, Belij S, Mirkov I, Stošić J, Popov Aleksandrov A, Kataranovski D. Prvi nalazi infekcije jetre parazitima Calodium hepaticum i Taenia taeniaeformis kod sivog pacova (Rattus norvegicus) u Srbiji. in Archives of Biological Sciences. 2010;62(2):431-440.
https://hdl.handle.net/21.15107/rcub_ibiss_257 .

Kataranovski, Milena, Zolotarevski, Lidija, Belij, Sandra, Mirkov, Ivana, Stošić, Jelena, Popov Aleksandrov, Aleksandra, Kataranovski, D., "Prvi nalazi infekcije jetre parazitima Calodium hepaticum i Taenia taeniaeformis kod sivog pacova (Rattus norvegicus) u Srbiji" in Archives of Biological Sciences, 62, no. 2 (2010):431-440,
https://hdl.handle.net/21.15107/rcub_ibiss_257 .

TY  - JOUR
AU  - Stošić, Jelena
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Nikolić, Miroslav
AU  - Popov Aleksandrov, Aleksandra
AU  - Kataranovski, Dragan S.
AU  - Kataranovski, Milena
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1355
AB  - Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA) stimulation was noted in cells recovered from lungs of male rats. Rise in intracellular content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6 levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.
T2  - Biomedical and Environmental Sciences
T1  - Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats
IS  - 4
VL  - 23
EP  - 299
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1355
ER  - 

@article{
author = "Stošić, Jelena and Mirkov, Ivana and Belij, Sandra and Nikolić, Miroslav and Popov Aleksandrov, Aleksandra and Kataranovski, Dragan S. and Kataranovski, Milena",
year = "2010",
abstract = "Objective To examine the presence of gender differences in pulmonary inflammation evoked by acute systemic cadmium administration in rats. Methods Presence of basic indicators of lung inflammation (inflammatory cytokine lung content, leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed and compared in animals of the two sexes. Results Intraperitoneal administration of cadmium (1.0 mg/kg) resulted in higher cadmium content in lungs of female rats. Higher tumor necrosis factor (TNF) content was noted in lung homogenates of male rats, while interleukin-6 (IL-6) content was slightly, but signifaicantly greater in lungs of female rats. Increased leukocyte infiltration was observed in lungs of male rats, mainly due to neutrophils. Increased responsiveness to phorbol myristate acetate (PMA) stimulation was noted in cells recovered from lungs of male rats. Rise in intracellular content of myeloperoxidase (MPO) was noted in lung cells from cadmium-treated rats of both sexes, but higher in cells from male rats. Conclusion Presented data documented a more intense pulmonary inflammatory response to systemic cadmium administration in males, with higher IL-6 levels in lungs of female individuals. These sex differences in proinflamatory activity of cadmium in lungs should be taken into consideration in studying the remote toxicity of this heavy metal.",
journal = "Biomedical and Environmental Sciences",
title = "Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats",
number = "4",
volume = "23",
pages = "299",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1355"
}

Stošić, J., Mirkov, I., Belij, S., Nikolić, M., Popov Aleksandrov, A., Kataranovski, D. S.,& Kataranovski, M.. (2010). Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats. in Biomedical and Environmental Sciences, 23(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1355

Stošić J, Mirkov I, Belij S, Nikolić M, Popov Aleksandrov A, Kataranovski DS, Kataranovski M. Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats. in Biomedical and Environmental Sciences. 2010;23(4):null-299.
https://hdl.handle.net/21.15107/rcub_ibiss_1355 .

Stošić, Jelena, Mirkov, Ivana, Belij, Sandra, Nikolić, Miroslav, Popov Aleksandrov, Aleksandra, Kataranovski, Dragan S., Kataranovski, Milena, "Gender Differences in Pulmonary Inflammation Following Systemic Cadmium Administration in Rats" in Biomedical and Environmental Sciences, 23, no. 4 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1355 .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
AU  - Zolotarevski, Lidija
AU  - Popov Aleksandrov, Aleksandra
AU  - Belij, Sandra
AU  - Stošić, Jelena
AU  - Kataranovski, D.
PY  - 2009
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/239
AB  - Basic parameters of spleen immune activity (spleen weight, histomorphology of splenic compartments, and mitogen-induced splenocyte proliferative capacity in vitro) were evaluated in adult individuals of wild Norway rats from urban habitats and compared to the same data obtained in laboratory rat strains. A wider range of relative spleen mass and differential histomorphological characteristics, together with differences in the level and pattern of responsiveness of splenocytes to exogenous stimulation, were noted in spleens of wild Norway rats. Evidence of both enhanced and low-level immune-relevant spleen activity in wild rats demonstrates the complexity of changes in spleen immune activity in rats from natural populations.
AB  - Ispitivani su osnovni parametri imunske aktivnosti u slezini (masa slezine, histomorfologija i sposobnost ćelija slezine da profilerišu u odgovoru na mitogen u in vitro uslovima) kod adultnih jedinki sivog pacova iz urbanih staništa i poređeni sa podacima dobijenim kod laboratorijskih sojeva pacova. Kod jedinki iz prirodnih populacija je zapažen veći opseg relativnih masa slezine, različite histomorfološke karakteristike i razlike u nivou i načinu odgovara ćelija slezine na egzogenu stimulaciju u poređenju sa jedinkama laboratorijskih sojeva. Ovi podaci ukazuju na kompleksne promene u imunskoj aktivnosti slezine kod jedinki iz prirodnih populacija.
T2  - Archives of Biological Sciences
T1  - Parametri imunske aktivnosti u slezini kod jedinki sivog pacova iz prirodnih populacija (Rattus norvegicus berkenhout, 1769) iz Srbije
T1  - Basic indices of spleen immune activity in natural populations of Norway rats (Rattus norvegicus berkenhout, 1769) in Serbia
IS  - 4
VL  - 61
SP  - 723
EP  - 732
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_239
ER  - 

@article{
author = "Kataranovski, Milena and Mirkov, Ivana and Zolotarevski, Lidija and Popov Aleksandrov, Aleksandra and Belij, Sandra and Stošić, Jelena and Kataranovski, D.",
year = "2009, 2009",
abstract = "Basic parameters of spleen immune activity (spleen weight, histomorphology of splenic compartments, and mitogen-induced splenocyte proliferative capacity in vitro) were evaluated in adult individuals of wild Norway rats from urban habitats and compared to the same data obtained in laboratory rat strains. A wider range of relative spleen mass and differential histomorphological characteristics, together with differences in the level and pattern of responsiveness of splenocytes to exogenous stimulation, were noted in spleens of wild Norway rats. Evidence of both enhanced and low-level immune-relevant spleen activity in wild rats demonstrates the complexity of changes in spleen immune activity in rats from natural populations., Ispitivani su osnovni parametri imunske aktivnosti u slezini (masa slezine, histomorfologija i sposobnost ćelija slezine da profilerišu u odgovoru na mitogen u in vitro uslovima) kod adultnih jedinki sivog pacova iz urbanih staništa i poređeni sa podacima dobijenim kod laboratorijskih sojeva pacova. Kod jedinki iz prirodnih populacija je zapažen veći opseg relativnih masa slezine, različite histomorfološke karakteristike i razlike u nivou i načinu odgovara ćelija slezine na egzogenu stimulaciju u poređenju sa jedinkama laboratorijskih sojeva. Ovi podaci ukazuju na kompleksne promene u imunskoj aktivnosti slezine kod jedinki iz prirodnih populacija.",
journal = "Archives of Biological Sciences",
title = "Parametri imunske aktivnosti u slezini kod jedinki sivog pacova iz prirodnih populacija (Rattus norvegicus berkenhout, 1769) iz Srbije, Basic indices of spleen immune activity in natural populations of Norway rats (Rattus norvegicus berkenhout, 1769) in Serbia",
number = "4",
volume = "61",
pages = "723-732",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_239"
}

Kataranovski, M., Mirkov, I., Zolotarevski, L., Popov Aleksandrov, A., Belij, S., Stošić, J.,& Kataranovski, D.. (2009). Parametri imunske aktivnosti u slezini kod jedinki sivog pacova iz prirodnih populacija (Rattus norvegicus berkenhout, 1769) iz Srbije. in Archives of Biological Sciences, 61(4), 723-732.
https://hdl.handle.net/21.15107/rcub_ibiss_239

Kataranovski M, Mirkov I, Zolotarevski L, Popov Aleksandrov A, Belij S, Stošić J, Kataranovski D. Parametri imunske aktivnosti u slezini kod jedinki sivog pacova iz prirodnih populacija (Rattus norvegicus berkenhout, 1769) iz Srbije. in Archives of Biological Sciences. 2009;61(4):723-732.
https://hdl.handle.net/21.15107/rcub_ibiss_239 .

Kataranovski, Milena, Mirkov, Ivana, Zolotarevski, Lidija, Popov Aleksandrov, Aleksandra, Belij, Sandra, Stošić, Jelena, Kataranovski, D., "Parametri imunske aktivnosti u slezini kod jedinki sivog pacova iz prirodnih populacija (Rattus norvegicus berkenhout, 1769) iz Srbije" in Archives of Biological Sciences, 61, no. 4 (2009):723-732,
https://hdl.handle.net/21.15107/rcub_ibiss_239 .

TY  - JOUR
AU  - Kataranovski, Milena
AU  - Mirkov, Ivana
AU  - Belij, Sandra
AU  - Nikolić, Miroslav
AU  - Zolotarevski, Lidija D
AU  - Ćirić, Danica
AU  - Kataranovski, Dragan S.
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1433
AB  - Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal. (C) 2009 Elsevier B.V. All rights reserved.
T2  - Environmental Toxicology and Pharmacology
T1  - Lungs: Remote inflammatory target of systemic cadmium administration in rats
IS  - 2
VL  - 28
EP  - 231
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1433
ER  - 

@article{
author = "Kataranovski, Milena and Mirkov, Ivana and Belij, Sandra and Nikolić, Miroslav and Zolotarevski, Lidija D and Ćirić, Danica and Kataranovski, Dragan S.",
year = "2009",
abstract = "Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal. (C) 2009 Elsevier B.V. All rights reserved.",
journal = "Environmental Toxicology and Pharmacology",
title = "Lungs: Remote inflammatory target of systemic cadmium administration in rats",
number = "2",
volume = "28",
pages = "231",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1433"
}

Kataranovski, M., Mirkov, I., Belij, S., Nikolić, M., Zolotarevski, L. D., Ćirić, D.,& Kataranovski, D. S.. (2009). Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology, 28(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1433

Kataranovski M, Mirkov I, Belij S, Nikolić M, Zolotarevski LD, Ćirić D, Kataranovski DS. Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology. 2009;28(2):null-231.
https://hdl.handle.net/21.15107/rcub_ibiss_1433 .

Kataranovski, Milena, Mirkov, Ivana, Belij, Sandra, Nikolić, Miroslav, Zolotarevski, Lidija D, Ćirić, Danica, Kataranovski, Dragan S., "Lungs: Remote inflammatory target of systemic cadmium administration in rats" in Environmental Toxicology and Pharmacology, 28, no. 2 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1433 .