TY  - JOUR
AU  - Slavić, Marija
AU  - Đorđević, Aleksandar N
AU  - Radojičić, Ratko M.
AU  - Milovanović, Slobodan R
AU  - Oreščanin Dušić, Zorana
AU  - Rakocević, Zlatko Lj
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1012
AB  - Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
IS  - 5
VL  - 15
SP  - 235
EP  - na
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1012
ER  - 

@article{
author = "Slavić, Marija and Đorđević, Aleksandar N and Radojičić, Ratko M. and Milovanović, Slobodan R and Oreščanin Dušić, Zorana and Rakocević, Zlatko Lj and Spasić, Mihajlo and Blagojević, Duško",
year = "2013",
abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction",
number = "5",
volume = "15",
pages = "235-na",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1012"
}

Slavić, M., Đorđević, A. N., Radojičić, R. M., Milovanović, S. R., Oreščanin Dušić, Z., Rakocević, Z. L., Spasić, M.,& Blagojević, D.. (2013). Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research, 15(5), 235-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1012

Slavić M, Đorđević AN, Radojičić RM, Milovanović SR, Oreščanin Dušić Z, Rakocević ZL, Spasić M, Blagojević D. Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research. 2013;15(5):235-na.
https://hdl.handle.net/21.15107/rcub_ibiss_1012 .

Slavić, Marija, Đorđević, Aleksandar N, Radojičić, Ratko M., Milovanović, Slobodan R, Oreščanin Dušić, Zorana, Rakocević, Zlatko Lj, Spasić, Mihajlo, Blagojević, Duško, "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction" in Journal of Nanoparticle Research, 15, no. 5 (2013):235-na,
https://hdl.handle.net/21.15107/rcub_ibiss_1012 .

TY  - JOUR
AU  - Bogdanović, Visnja V
AU  - Stankov, Karmen
AU  - Icević, Ivana D
AU  - Zikić, Dragan R
AU  - Nikolić, Aleksandra L.
AU  - Solajić, Slavica V
AU  - Đorđević, Aleksandar N
AU  - Bogdanović, Gordana M
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1532
AB  - Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pretreatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismulase and glutathione peroxidase in irradiated K562 cells.
T2  - Journal of Radiation Research
T1  - Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line
IS  - 3
VL  - 49
EP  - 327
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1532
ER  - 

@article{
author = "Bogdanović, Visnja V and Stankov, Karmen and Icević, Ivana D and Zikić, Dragan R and Nikolić, Aleksandra L. and Solajić, Slavica V and Đorđević, Aleksandar N and Bogdanović, Gordana M",
year = "2008",
abstract = "Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its ROS/RNS scavenger properties in vitro and radioprotective efficiency in vivo. Therefore we were interested to evaluate its radioprotective properties in vitro in the human erythroleukemia cell line. Pretreatment of irradiated cells by fullerenol exerted statistically significant effects on cell numbers and the response of antioxidative enzymes to X-ray irradiation-induced oxidative stress in cells. Our study provides evidence that the pre-treatment with fullerenol enhanced the enzymatic activity of superoxide dismulase and glutathione peroxidase in irradiated K562 cells.",
journal = "Journal of Radiation Research",
title = "Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line",
number = "3",
volume = "49",
pages = "327",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1532"
}

Bogdanović, V. V., Stankov, K., Icević, I. D., Zikić, D. R., Nikolić, A. L., Solajić, S. V., Đorđević, A. N.,& Bogdanović, G. M.. (2008). Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. in Journal of Radiation Research, 49(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1532

Bogdanović VV, Stankov K, Icević ID, Zikić DR, Nikolić AL, Solajić SV, Đorđević AN, Bogdanović GM. Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line. in Journal of Radiation Research. 2008;49(3):null-327.
https://hdl.handle.net/21.15107/rcub_ibiss_1532 .

Bogdanović, Visnja V, Stankov, Karmen, Icević, Ivana D, Zikić, Dragan R, Nikolić, Aleksandra L., Solajić, Slavica V, Đorđević, Aleksandar N, Bogdanović, Gordana M, "Fullerenol C-60(OH)(24) effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line" in Journal of Radiation Research, 49, no. 3 (2008),
https://hdl.handle.net/21.15107/rcub_ibiss_1532 .