Ćirić, Miloš D.

Link to this page

https://radar.ibiss.bg.ac.rs/APP/faces/author.xhtml?author_id=0134f786-3585-40fa-93c7-79068d15b88b&item_offset=0&project_offset=0&sort_by=dc.date.issued
Authority KeyName Variants
0134f786-3585-40fa-93c7-79068d15b88b
  • Ćirić, Miloš D. (2)
Projects

Author's Bibliography

Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.

Gavrilović, Branka; Petrović, Tamara; Radovanović, Tijana; Despotović, Svetlana; Gavrić, Jelena; Krizmanić, Imre I.; Ćirić, Miloš D.; Prokić, Marko

(Elsevier B.V., 2021) 

TY  - JOUR
AU  - Gavrilović, Branka
AU  - Petrović, Tamara
AU  - Radovanović, Tijana
AU  - Despotović, Svetlana
AU  - Gavrić, Jelena
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš D.
AU  - Prokić, Marko
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32853936
UR  - https://radar.ibiss.bg.ac.rs/123456789/3856
UR  - https://radar.ibiss.bg.ac.rs/123456789/3857
AB  - Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.
VL  - 750
DO  - 10.1016/j.scitotenv.2020.141569
SP  - 141569
ER  - 
@article{
author = "Gavrilović, Branka and Petrović, Tamara and Radovanović, Tijana and Despotović, Svetlana and Gavrić, Jelena and Krizmanić, Imre I. and Ćirić, Miloš D. and Prokić, Marko",
year = "2021",
abstract = "Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.",
volume = "750",
doi = "10.1016/j.scitotenv.2020.141569",
pages = "141569"
}
Gavrilović, B., Petrović, T., Radovanović, T., Despotović, S., Gavrić, J., Krizmanić, I. I., Ćirić, M. D.,& Prokić, M.. (2021). Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.. in Science of the Total Environment
Elsevier B.V.., 750, 141569.
https://doi.org/10.1016/j.scitotenv.2020.141569
Gavrilović B, Petrović T, Radovanović T, Despotović S, Gavrić J, Krizmanić II, Ćirić MD, Prokić M. Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.. in Science of the Total Environment. 2021;750:141569.
doi:10.1016/j.scitotenv.2020.141569 .
Gavrilović, Branka, Petrović, Tamara, Radovanović, Tijana, Despotović, Svetlana, Gavrić, Jelena, Krizmanić, Imre I., Ćirić, Miloš D., Prokić, Marko, "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom." in Science of the Total Environment, 750 (2021):141569,
https://doi.org/10.1016/j.scitotenv.2020.141569 . .
13
5
11

Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.

Gavrilović, Branka; Petrović, Tamara; Radovanović, Tijana; Despotović, Svetlana; Gavrić, Jelena; Krizmanić, Imre I.; Ćirić, Miloš D.; Prokić, Marko

(Elsevier B.V., 2021) 

TY  - JOUR
AU  - Gavrilović, Branka
AU  - Petrović, Tamara
AU  - Radovanović, Tijana
AU  - Despotović, Svetlana
AU  - Gavrić, Jelena
AU  - Krizmanić, Imre I.
AU  - Ćirić, Miloš D.
AU  - Prokić, Marko
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/32853936
UR  - https://radar.ibiss.bg.ac.rs/123456789/3856
AB  - Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.
VL  - 750
DO  - 10.1016/j.scitotenv.2020.141569
SP  - 141569
ER  - 
@article{
author = "Gavrilović, Branka and Petrović, Tamara and Radovanović, Tijana and Despotović, Svetlana and Gavrić, Jelena and Krizmanić, Imre I. and Ćirić, Miloš D. and Prokić, Marko",
year = "2021",
abstract = "Although the long-term exposure of aquatic organisms to cyanobacterial blooms is a regular occurrence in the environment, the prooxidant and neurotoxic effects of such conditions are still insufficiently investigated in situ. We examined the temporal dynamics of the biochemical parameters in the liver of Pelophylax kl. esculentus frogs that inhabit the northern (N) side of Lake Ludaš (Serbia) with microcystins (MCs) produced in a cyanobacterial bloom over three summer months. The obtained data were compared with data on frogs that live on the southern (S), MC-free side of the same lake. Our results showed that the MC-producing bloom induced oxidative damage to proteins and lipids, observed as a decrease in the concentration of protein -SH groups and increased lipid peroxidation (LPO) in the liver of N frogs in comparison to S frogs. Glutathione (GSH) played a key role in the transient defense against the MC-induced development of LPO. The low glutathione peroxidase (GPx) activity detected in all groups of frogs from the N site was crucial for the observed prooxidant consequences. The bloom impaired cholinergic homeostasis as a result of a decrease in ChE activity. A delayed neurotoxic effect in relation to the prooxidant outcomes was observed. Our results also showed that even though the integrated biomarker response (IBR) of the antioxidant biomarkers increased during exposure, the individual biochemical parameters did not exhibit a well-defined time-dependent pattern because of specific adaptation dynamics and/or additional effects of the physicochemical parameters of the water. This comprehensive environmental ecotoxicological evaluation of the cyanobacterial bloom-induced biochemical alterations in the liver of frogs provides a new basis for further investigations of the prolonged, real-life ecotoxicity of the blooms.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.",
volume = "750",
doi = "10.1016/j.scitotenv.2020.141569",
pages = "141569"
}
Gavrilović, B., Petrović, T., Radovanović, T., Despotović, S., Gavrić, J., Krizmanić, I. I., Ćirić, M. D.,& Prokić, M.. (2021). Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.. in Science of the Total Environment
Elsevier B.V.., 750, 141569.
https://doi.org/10.1016/j.scitotenv.2020.141569
Gavrilović B, Petrović T, Radovanović T, Despotović S, Gavrić J, Krizmanić II, Ćirić MD, Prokić M. Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom.. in Science of the Total Environment. 2021;750:141569.
doi:10.1016/j.scitotenv.2020.141569 .
Gavrilović, Branka, Petrović, Tamara, Radovanović, Tijana, Despotović, Svetlana, Gavrić, Jelena, Krizmanić, Imre I., Ćirić, Miloš D., Prokić, Marko, "Hepatic oxidative stress and neurotoxicity in Pelophylax kl. esculentus frogs: Influence of long-term exposure to a cyanobacterial bloom." in Science of the Total Environment, 750 (2021):141569,
https://doi.org/10.1016/j.scitotenv.2020.141569 . .
13
5
11