TY  - JOUR
AU  - Paunović, Verica
AU  - Vukovič Petrović, Irena
AU  - Milenković, Marina
AU  - Janjetović, Kristina
AU  - Pravica, Vera
AU  - Dujmović, Irena
AU  - Milošević, Emina
AU  - Martinović, Vanja
AU  - Mesaroš, Šarlota
AU  - Drulović, Jelena
AU  - Trajković, Vladimir
PY  - 2018
UR  - http://www.jni-journal.com/article/S0165-5728(17)30538-6/abstract
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3014
AB  - Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis.
T2  - Journal of Neuroimmunology
T1  - Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.
VL  - 319
DO  - 10.1016/j.jneuroim.2018.03.001
SP  - 100
EP  - 105
ER  - 

@article{
author = "Paunović, Verica and Vukovič Petrović, Irena and Milenković, Marina and Janjetović, Kristina and Pravica, Vera and Dujmović, Irena and Milošević, Emina and Martinović, Vanja and Mesaroš, Šarlota and Drulović, Jelena and Trajković, Vladimir",
year = "2018",
abstract = "Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis.",
journal = "Journal of Neuroimmunology",
title = "Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.",
volume = "319",
doi = "10.1016/j.jneuroim.2018.03.001",
pages = "100-105"
}

Paunović, V., Vukovič Petrović, I., Milenković, M., Janjetović, K., Pravica, V., Dujmović, I., Milošević, E., Martinović, V., Mesaroš, Š., Drulović, J.,& Trajković, V.. (2018). Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.. in Journal of Neuroimmunology, 319, 100-105.
https://doi.org/10.1016/j.jneuroim.2018.03.001

Paunović V, Vukovič Petrović I, Milenković M, Janjetović K, Pravica V, Dujmović I, Milošević E, Martinović V, Mesaroš Š, Drulović J, Trajković V. Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.. in Journal of Neuroimmunology. 2018;319:100-105.
doi:10.1016/j.jneuroim.2018.03.001 .

Paunović, Verica, Vukovič Petrović, Irena, Milenković, Marina, Janjetović, Kristina, Pravica, Vera, Dujmović, Irena, Milošević, Emina, Martinović, Vanja, Mesaroš, Šarlota, Drulović, Jelena, Trajković, Vladimir, "Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients." in Journal of Neuroimmunology, 319 (2018):100-105,
https://doi.org/10.1016/j.jneuroim.2018.03.001 . .

TY  - JOUR
AU  - Drulović, Jelena
AU  - Popadić, Dušan
AU  - Mesaroš, Šarlota
AU  - Dujmović, Irena
AU  - Stojanović, Ivana D.
AU  - Miljković, Djordje
AU  - Stojsavljević, Nebojša
AU  - Pravica, Vera
AU  - Pekmezović, Tatjana
AU  - Bogdanović, Gradimir
AU  - Jarebinski, Mirjana
AU  - Mostarica Stojković, Marija
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5924
AB  - Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high TNFalpha production. We investigated the TNFalpha -308 polymorphism in 143 unrelated Serbian patients with MS and 123 ethnically matched, healthy individuals using the allele-specific restriction fragment length polymorphism polymerase chain reaction technique. The frequency of the TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients. The result suggests that in the Serbian population polymorphism at position -308 of TNFalpha or at an adjacent locus might have a role in MS susceptibility.
PB  - Basel: Krager AG
T2  - European Neurology
T1  - Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis
IS  - 1
VL  - 50
DO  - 10.1159/000070855
SP  - 25
EP  - 29
ER  - 

@article{
author = "Drulović, Jelena and Popadić, Dušan and Mesaroš, Šarlota and Dujmović, Irena and Stojanović, Ivana D. and Miljković, Djordje and Stojsavljević, Nebojša and Pravica, Vera and Pekmezović, Tatjana and Bogdanović, Gradimir and Jarebinski, Mirjana and Mostarica Stojković, Marija",
year = "2003",
abstract = "Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high TNFalpha production. We investigated the TNFalpha -308 polymorphism in 143 unrelated Serbian patients with MS and 123 ethnically matched, healthy individuals using the allele-specific restriction fragment length polymorphism polymerase chain reaction technique. The frequency of the TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients. The result suggests that in the Serbian population polymorphism at position -308 of TNFalpha or at an adjacent locus might have a role in MS susceptibility.",
publisher = "Basel: Krager AG",
journal = "European Neurology",
title = "Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis",
number = "1",
volume = "50",
doi = "10.1159/000070855",
pages = "25-29"
}

Drulović, J., Popadić, D., Mesaroš, Š., Dujmović, I., Stojanović, I. D., Miljković, D., Stojsavljević, N., Pravica, V., Pekmezović, T., Bogdanović, G., Jarebinski, M.,& Mostarica Stojković, M.. (2003). Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis. in European Neurology
Basel: Krager AG., 50(1), 25-29.
https://doi.org/10.1159/000070855

Drulović J, Popadić D, Mesaroš Š, Dujmović I, Stojanović ID, Miljković D, Stojsavljević N, Pravica V, Pekmezović T, Bogdanović G, Jarebinski M, Mostarica Stojković M. Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis. in European Neurology. 2003;50(1):25-29.
doi:10.1159/000070855 .

Drulović, Jelena, Popadić, Dušan, Mesaroš, Šarlota, Dujmović, Irena, Stojanović, Ivana D., Miljković, Djordje, Stojsavljević, Nebojša, Pravica, Vera, Pekmezović, Tatjana, Bogdanović, Gradimir, Jarebinski, Mirjana, Mostarica Stojković, Marija, "Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis" in European Neurology, 50, no. 1 (2003):25-29,
https://doi.org/10.1159/000070855 . .

TY  - JOUR
AU  - Miljković, Đorđe
AU  - Drulović, Jelena S
AU  - Trajković, Vladimir S
AU  - Mesaros, Sarlota
AU  - Dujmović, Irena
AU  - Maksimović-Ivanić, Danijela
AU  - Samardžić, Tatjana S.
AU  - Stojsavljević, Nebojsa
AU  - Lević, Zvonimir
AU  - Mostarica-Stojković, Marija B
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1791
AB  - Interleukin-6 (IL-6) and nitric oxide (NO) are implicated in the pathology of multiple sclerosis (MS). We have investigated the levels of these mediators in the cerebrospinal fluid (CSF) from 50 patients with MS and 23 control subjects. Mean CSF IL-6 level was higher in the total MS group in comparison with controls, but not significantly, whilst the difference between patients with stable MS and controls reached the level of statistical significance. Mean CSF nitrite/nitrate level was significantly higher in the total MS group compared with the control group, as well as in active MS patients versus controls. There was significant difference neither in the mean CSF IL-6 nor in nitrite/nitrate levels between active and stable MS patients. Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Such a trend existed in both subgroups with active and stable MS, but without reaching the level of statistical significance. Our data further support the involvement of IL-6 and NO in ongoing pathological processes in MS, suggesting their potential interplay within the central nervous system in this disease.
PB  - John Wiley and Sons
T2  - European Journal of Neurology
T1  - Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients
IS  - 4
VL  - 9
DO  - 10.1046/j.1468-1331.2002.00437.x
SP  - 413
EP  - 418
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1791
ER  - 

@article{
author = "Miljković, Đorđe and Drulović, Jelena S and Trajković, Vladimir S and Mesaros, Sarlota and Dujmović, Irena and Maksimović-Ivanić, Danijela and Samardžić, Tatjana S. and Stojsavljević, Nebojsa and Lević, Zvonimir and Mostarica-Stojković, Marija B",
year = "2002",
abstract = "Interleukin-6 (IL-6) and nitric oxide (NO) are implicated in the pathology of multiple sclerosis (MS). We have investigated the levels of these mediators in the cerebrospinal fluid (CSF) from 50 patients with MS and 23 control subjects. Mean CSF IL-6 level was higher in the total MS group in comparison with controls, but not significantly, whilst the difference between patients with stable MS and controls reached the level of statistical significance. Mean CSF nitrite/nitrate level was significantly higher in the total MS group compared with the control group, as well as in active MS patients versus controls. There was significant difference neither in the mean CSF IL-6 nor in nitrite/nitrate levels between active and stable MS patients. Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Such a trend existed in both subgroups with active and stable MS, but without reaching the level of statistical significance. Our data further support the involvement of IL-6 and NO in ongoing pathological processes in MS, suggesting their potential interplay within the central nervous system in this disease.",
publisher = "John Wiley and Sons",
journal = "European Journal of Neurology",
title = "Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients",
number = "4",
volume = "9",
doi = "10.1046/j.1468-1331.2002.00437.x",
pages = "413-418",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1791"
}

Miljković, Đ., Drulović, J. S., Trajković, V. S., Mesaros, S., Dujmović, I., Maksimović-Ivanić, D., Samardžić, T. S., Stojsavljević, N., Lević, Z.,& Mostarica-Stojković, M. B.. (2002). Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients. in European Journal of Neurology
John Wiley and Sons., 9(4), 413-418.
https://doi.org/10.1046/j.1468-1331.2002.00437.x
https://hdl.handle.net/21.15107/rcub_ibiss_1791

Miljković Đ, Drulović JS, Trajković VS, Mesaros S, Dujmović I, Maksimović-Ivanić D, Samardžić TS, Stojsavljević N, Lević Z, Mostarica-Stojković MB. Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients. in European Journal of Neurology. 2002;9(4):413-418.
doi:10.1046/j.1468-1331.2002.00437.x
https://hdl.handle.net/21.15107/rcub_ibiss_1791 .

Miljković, Đorđe, Drulović, Jelena S, Trajković, Vladimir S, Mesaros, Sarlota, Dujmović, Irena, Maksimović-Ivanić, Danijela, Samardžić, Tatjana S., Stojsavljević, Nebojsa, Lević, Zvonimir, Mostarica-Stojković, Marija B, "Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients" in European Journal of Neurology, 9, no. 4 (2002):413-418,
https://doi.org/10.1046/j.1468-1331.2002.00437.x .,
https://hdl.handle.net/21.15107/rcub_ibiss_1791 .

TY  - JOUR
AU  - Drulović, Jelena
AU  - Dujmović, Irena
AU  - Stojsavljević, Nebojša
AU  - Mesaroš, Šarlota
AU  - Anđelković, Slobodanka
AU  - Miljković, Đorđe
AU  - Perić, Vesna
AU  - Dragutinović, Gradimir
AU  - Marinković, Jelena
AU  - Lević, Zvonimir
AU  - Mostarica Stojković, Marija
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5995
AB  - The levels of uric acid (UA), a natural peroxynitrite scavenger, were measured in sera from 240 patients with multiple sclerosis (MS) and 104 sex- and age-matched control patients with other neurological diseases (OND). The mean serum UA concentration was lower in the MS than in the OND group, but the difference did not reach the level of statistical significance (P = 0.068). However, the mean serum UA level from patients with active MS (202.6 + 67.1 mumol/l) was significantly lower than that in inactive MS patients (226.5 + 78.6 mumol/l; P = 0.046) and OND controls (P = 0.007). We found a significant inverse correlation of serum UA concentration with female gender (P = 0.0001), disease activity (P = 0.012) and duration (P = 0.017), and a trend towards an inverse correlation with disability as assessed by EDSS score, which did not reach statistical significance (P = 0.067). Finally, multivariate linear regression analyses showed that UA concentration was independently correlated with gender (P = 0.0001), disease activity (P = 0.014) and duration of the disease (P = 0.043) in MS patients. These findings suggest that serum UA might serve as a possible marker of disease activity in MS. They also provide support to the potential beneficial therapeutic effect of radical-scavenging substances in MS.
PB  - Heidelberg: Springer
T2  - Journal of Neurology
T1  - Uric acid levels in sera from patients with multiple sclerosis
IS  - 2
VL  - 248
DO  - 10.1007/s004150170246
SP  - 121
EP  - 126
ER  - 

@article{
author = "Drulović, Jelena and Dujmović, Irena and Stojsavljević, Nebojša and Mesaroš, Šarlota and Anđelković, Slobodanka and Miljković, Đorđe and Perić, Vesna and Dragutinović, Gradimir and Marinković, Jelena and Lević, Zvonimir and Mostarica Stojković, Marija",
year = "2001",
abstract = "The levels of uric acid (UA), a natural peroxynitrite scavenger, were measured in sera from 240 patients with multiple sclerosis (MS) and 104 sex- and age-matched control patients with other neurological diseases (OND). The mean serum UA concentration was lower in the MS than in the OND group, but the difference did not reach the level of statistical significance (P = 0.068). However, the mean serum UA level from patients with active MS (202.6 + 67.1 mumol/l) was significantly lower than that in inactive MS patients (226.5 + 78.6 mumol/l; P = 0.046) and OND controls (P = 0.007). We found a significant inverse correlation of serum UA concentration with female gender (P = 0.0001), disease activity (P = 0.012) and duration (P = 0.017), and a trend towards an inverse correlation with disability as assessed by EDSS score, which did not reach statistical significance (P = 0.067). Finally, multivariate linear regression analyses showed that UA concentration was independently correlated with gender (P = 0.0001), disease activity (P = 0.014) and duration of the disease (P = 0.043) in MS patients. These findings suggest that serum UA might serve as a possible marker of disease activity in MS. They also provide support to the potential beneficial therapeutic effect of radical-scavenging substances in MS.",
publisher = "Heidelberg: Springer",
journal = "Journal of Neurology",
title = "Uric acid levels in sera from patients with multiple sclerosis",
number = "2",
volume = "248",
doi = "10.1007/s004150170246",
pages = "121-126"
}

Drulović, J., Dujmović, I., Stojsavljević, N., Mesaroš, Š., Anđelković, S., Miljković, Đ., Perić, V., Dragutinović, G., Marinković, J., Lević, Z.,& Mostarica Stojković, M.. (2001). Uric acid levels in sera from patients with multiple sclerosis. in Journal of Neurology
Heidelberg: Springer., 248(2), 121-126.
https://doi.org/10.1007/s004150170246

Drulović J, Dujmović I, Stojsavljević N, Mesaroš Š, Anđelković S, Miljković Đ, Perić V, Dragutinović G, Marinković J, Lević Z, Mostarica Stojković M. Uric acid levels in sera from patients with multiple sclerosis. in Journal of Neurology. 2001;248(2):121-126.
doi:10.1007/s004150170246 .

Drulović, Jelena, Dujmović, Irena, Stojsavljević, Nebojša, Mesaroš, Šarlota, Anđelković, Slobodanka, Miljković, Đorđe, Perić, Vesna, Dragutinović, Gradimir, Marinković, Jelena, Lević, Zvonimir, Mostarica Stojković, Marija, "Uric acid levels in sera from patients with multiple sclerosis" in Journal of Neurology, 248, no. 2 (2001):121-126,
https://doi.org/10.1007/s004150170246 . .

TY  - JOUR
AU  - Drulović, Jelena
AU  - Dujmović, Irena
AU  - Mesaroš, Šarlota
AU  - Samardžić, Tatjana
AU  - Maksimović-Ivanić, Danijela
AU  - Stojsavljević, Nebojša
AU  - Lević, Zvonimir
AU  - Mostarica Stojković, Marija
PY  - 2001
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3842
AB  - A growing body of evidence implicates excessive generation of nitric oxide (NO) within the central nervous system (CNS) in multiple sclerosis (MS). The aim of our study is to analyse nitrite and nitrate as end products of NO in the cerebrospinal fluid (CSF) from MS patients and correlate the concentrations with clinicol characteristics of the disease. CSF nitrite and nitrate concentrations were measured after reduction of nitrate, by Griess reaction, in 105 MS potients, 27 patients with non-inflammatory neurological disorders (NIND) and 13 individuals without neurological disorder (Co). Mean CSF nitrite and nitrate concentrations were significantly higher in patients with MS and NIND compared with the Co patients (9.44 and 8.68, respectively, versus 6.85 microM; P=0.0001 and P=0.031, respectively). There was no significant correlation between CSF nitrite and nitrate concentrations and activity, phase, severity and duration of MS. Our data are in agreement with the results of previous studies which have demonstrated raised concentrations of CSF NO metabolites in MS patients, providing further evidence for NO involvement in MS. The lack of correlation between NO metabolites and disease activity speaks in favour of the possible dual role of NO, as both immunoregulatory and pro-inflammatory molecule, in the pathogenesis of MS.
PB  - Newbury Park: SAGE Publishing
T2  - Multiple Sclerosis Journal
T1  - Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity
IS  - 1
VL  - 7
DO  - 10.1177/135245850100700104
SP  - 19
EP  - 22
ER  - 

@article{
author = "Drulović, Jelena and Dujmović, Irena and Mesaroš, Šarlota and Samardžić, Tatjana and Maksimović-Ivanić, Danijela and Stojsavljević, Nebojša and Lević, Zvonimir and Mostarica Stojković, Marija",
year = "2001",
abstract = "A growing body of evidence implicates excessive generation of nitric oxide (NO) within the central nervous system (CNS) in multiple sclerosis (MS). The aim of our study is to analyse nitrite and nitrate as end products of NO in the cerebrospinal fluid (CSF) from MS patients and correlate the concentrations with clinicol characteristics of the disease. CSF nitrite and nitrate concentrations were measured after reduction of nitrate, by Griess reaction, in 105 MS potients, 27 patients with non-inflammatory neurological disorders (NIND) and 13 individuals without neurological disorder (Co). Mean CSF nitrite and nitrate concentrations were significantly higher in patients with MS and NIND compared with the Co patients (9.44 and 8.68, respectively, versus 6.85 microM; P=0.0001 and P=0.031, respectively). There was no significant correlation between CSF nitrite and nitrate concentrations and activity, phase, severity and duration of MS. Our data are in agreement with the results of previous studies which have demonstrated raised concentrations of CSF NO metabolites in MS patients, providing further evidence for NO involvement in MS. The lack of correlation between NO metabolites and disease activity speaks in favour of the possible dual role of NO, as both immunoregulatory and pro-inflammatory molecule, in the pathogenesis of MS.",
publisher = "Newbury Park: SAGE Publishing",
journal = "Multiple Sclerosis Journal",
title = "Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity",
number = "1",
volume = "7",
doi = "10.1177/135245850100700104",
pages = "19-22"
}

Drulović, J., Dujmović, I., Mesaroš, Š., Samardžić, T., Maksimović-Ivanić, D., Stojsavljević, N., Lević, Z.,& Mostarica Stojković, M.. (2001). Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity. in Multiple Sclerosis Journal
Newbury Park: SAGE Publishing., 7(1), 19-22.
https://doi.org/10.1177/135245850100700104

Drulović J, Dujmović I, Mesaroš Š, Samardžić T, Maksimović-Ivanić D, Stojsavljević N, Lević Z, Mostarica Stojković M. Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity. in Multiple Sclerosis Journal. 2001;7(1):19-22.
doi:10.1177/135245850100700104 .

Drulović, Jelena, Dujmović, Irena, Mesaroš, Šarlota, Samardžić, Tatjana, Maksimović-Ivanić, Danijela, Stojsavljević, Nebojša, Lević, Zvonimir, Mostarica Stojković, Marija, "Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity" in Multiple Sclerosis Journal, 7, no. 1 (2001):19-22,
https://doi.org/10.1177/135245850100700104 . .