TY  - JOUR
AU  - Zengin, Gokhan
AU  - Cvetanović, Aleksandra
AU  - Gašić, Uroš
AU  - Stupar, Alena
AU  - Bulut, Gizem
AU  - Senkardes, Ismail
AU  - Dogan, Ahmet
AU  - Sinan, Kouadio Ibrahime
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahiri
AU  - Aktumsek, Abdurrahman
AU  - Mahomoodally, Mohamad Fawzi
PY  - 2020
UR  - https://doi.org/10.1016/j.indcrop.2020.112202
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3609
AB  - Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and bio- logical propensities of extracts prepared from this plant. This study endeavors to highlight the biological po- tential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was es- tablished via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non- communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium ex- tracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.
T2  - Industrial Crops & Products
T1  - Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip
IS  - April 2020
VL  - 146
DO  - 10.1016/j.indcrop.2020.112202
SP  - 112202
ER  - 

@article{
author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš and Stupar, Alena and Bulut, Gizem and Senkardes, Ismail and Dogan, Ahmet and Sinan, Kouadio Ibrahime and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahiri and Aktumsek, Abdurrahman and Mahomoodally, Mohamad Fawzi",
year = "2020",
abstract = "Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and bio- logical propensities of extracts prepared from this plant. This study endeavors to highlight the biological po- tential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was es- tablished via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non- communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium ex- tracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.",
journal = "Industrial Crops & Products",
title = "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip",
number = "April 2020",
volume = "146",
doi = "10.1016/j.indcrop.2020.112202",
pages = "112202"
}

Zengin, G., Cvetanović, A., Gašić, U., Stupar, A., Bulut, G., Senkardes, I., Dogan, A., Sinan, K. I., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Mahomoodally, M. F.. (2020). Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. in Industrial Crops & Products, 146(April 2020), 112202.
https://doi.org/10.1016/j.indcrop.2020.112202

Zengin G, Cvetanović A, Gašić U, Stupar A, Bulut G, Senkardes I, Dogan A, Sinan KI, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Mahomoodally MF. Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. in Industrial Crops & Products. 2020;146(April 2020):112202.
doi:10.1016/j.indcrop.2020.112202 .

Zengin, Gokhan, Cvetanović, Aleksandra, Gašić, Uroš, Stupar, Alena, Bulut, Gizem, Senkardes, Ismail, Dogan, Ahmet, Sinan, Kouadio Ibrahime, Uysal, Sengul, Aumeeruddy-Elalfi, Zaahiri, Aktumsek, Abdurrahman, Mahomoodally, Mohamad Fawzi, "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip" in Industrial Crops & Products, 146, no. April 2020 (2020):112202,
https://doi.org/10.1016/j.indcrop.2020.112202 . .

TY  - JOUR
AU  - Uysal, Sengul
AU  - Senkardes, Ismail
AU  - Mollica, Adriano
AU  - Zengin, Gokhan
AU  - Bulut, Gizem
AU  - Dogan, Ahmet
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Lobine, Devina
AU  - Mahomoodally, Fawzi M
PY  - 2019
UR  - https://www.tandfonline.com/doi/full/10.1080/07391102.2018.1506361
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3194
AB  - Tragopogon dubius and Tussilago farfara are consumed as vegetables and used in folk medicine to manage common diseases. Herein, the chemical compositions and biological activities of different leaf extracts (ethyl acetate, methanol, and water) of T. dubius and T. farfara were evaluated. The antibacterial, antifungal, and antioxidant abilities of the extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating assays. Enzyme inhibitory potentials were evaluated against cholinesterases, tyrosinase, α-amylase and α-glucosidase. Complexes of bioactive compounds (chlorogenic and rosmarinic acid) were docked into the enzymatic cavity of α-glucosidase and subjected to molecular dynamic calculation, enzyme conformational stability, and flexibility analysis. T. dubius and T. farfara extracts showed remarkable antioxidant potentials. Ethyl acetate extracts of T. dubius and T. farfara were the most potent inhibitors of acetylcholinesterase and butyrylcholinesterase. T. dubius ethyl acetate extract and T. farfara methanolic extract showed noteworthy activity against α-glucosidase. High performance liquid chromatography analysis revealed the abundance of some phenolic compounds including chlorogenic and rosmarinic acids. Ethyl acetate extract of T. dubius showed notable antifungal activity against all strains. Docking studies showed best pose for chlorogenic acid was stabilized by a network of hydrogen bonds with residues Asp1157, Asp1279, whereas rosmarinic acid showed several hydrogen bonds with Asp1157, Asp1420, Asp1526, Lys1460 and Trp1369. This study further validates the use of T. dubius and T. farfara in traditional medicine, as well as act as a stimulus for further studies for future biomedicine development. Communicated by Ramaswamy H. Sarma.
T2  - Journal of Biomolecular Structure and Dynamics
T1  - Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
IS  - 12
VL  - 37
DO  - 10.1080/07391102.2018.1506361
SP  - 3269
EP  - 3281
ER  - 

@article{
author = "Uysal, Sengul and Senkardes, Ismail and Mollica, Adriano and Zengin, Gokhan and Bulut, Gizem and Dogan, Ahmet and Glamočlija, Jasmina and Soković, Marina and Lobine, Devina and Mahomoodally, Fawzi M",
year = "2019",
abstract = "Tragopogon dubius and Tussilago farfara are consumed as vegetables and used in folk medicine to manage common diseases. Herein, the chemical compositions and biological activities of different leaf extracts (ethyl acetate, methanol, and water) of T. dubius and T. farfara were evaluated. The antibacterial, antifungal, and antioxidant abilities of the extracts were tested using different assays including free radical scavenging, reducing power, phosphomolybdenum, and metal chelating assays. Enzyme inhibitory potentials were evaluated against cholinesterases, tyrosinase, α-amylase and α-glucosidase. Complexes of bioactive compounds (chlorogenic and rosmarinic acid) were docked into the enzymatic cavity of α-glucosidase and subjected to molecular dynamic calculation, enzyme conformational stability, and flexibility analysis. T. dubius and T. farfara extracts showed remarkable antioxidant potentials. Ethyl acetate extracts of T. dubius and T. farfara were the most potent inhibitors of acetylcholinesterase and butyrylcholinesterase. T. dubius ethyl acetate extract and T. farfara methanolic extract showed noteworthy activity against α-glucosidase. High performance liquid chromatography analysis revealed the abundance of some phenolic compounds including chlorogenic and rosmarinic acids. Ethyl acetate extract of T. dubius showed notable antifungal activity against all strains. Docking studies showed best pose for chlorogenic acid was stabilized by a network of hydrogen bonds with residues Asp1157, Asp1279, whereas rosmarinic acid showed several hydrogen bonds with Asp1157, Asp1420, Asp1526, Lys1460 and Trp1369. This study further validates the use of T. dubius and T. farfara in traditional medicine, as well as act as a stimulus for further studies for future biomedicine development. Communicated by Ramaswamy H. Sarma.",
journal = "Journal of Biomolecular Structure and Dynamics",
title = "Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.",
number = "12",
volume = "37",
doi = "10.1080/07391102.2018.1506361",
pages = "3269-3281"
}

Uysal, S., Senkardes, I., Mollica, A., Zengin, G., Bulut, G., Dogan, A., Glamočlija, J., Soković, M., Lobine, D.,& Mahomoodally, F. M.. (2019). Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.. in Journal of Biomolecular Structure and Dynamics, 37(12), 3269-3281.
https://doi.org/10.1080/07391102.2018.1506361

Uysal S, Senkardes I, Mollica A, Zengin G, Bulut G, Dogan A, Glamočlija J, Soković M, Lobine D, Mahomoodally FM. Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.. in Journal of Biomolecular Structure and Dynamics. 2019;37(12):3269-3281.
doi:10.1080/07391102.2018.1506361 .

Uysal, Sengul, Senkardes, Ismail, Mollica, Adriano, Zengin, Gokhan, Bulut, Gizem, Dogan, Ahmet, Glamočlija, Jasmina, Soković, Marina, Lobine, Devina, Mahomoodally, Fawzi M, "Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L." in Journal of Biomolecular Structure and Dynamics, 37, no. 12 (2019):3269-3281,
https://doi.org/10.1080/07391102.2018.1506361 . .

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Mahomoodally, M. Fawzi
AU  - Aktumsek, Abdurrahman
AU  - Ceylan, Ramazan
AU  - Uysal, Sengul
AU  - Mocan, Andrei
AU  - Yilmaz, Mustafa Abdullah
AU  - Picot-Allain, Carene Marie Nancy
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S2212429217305473?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3090
AB  - Six wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p-coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma). Antifungal agents, bifonazole (MIC 0.10–0.20 mg/mL and MFC 0.20–0.30 mg/mL) and ketoconazole (MIC 0.15–2.30 mg/mL and MFC 0.20–3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases.
T2  - Food Bioscience
T1  - Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
VL  - 23
DO  - 10.1016/J.FBIO.2018.03.010
SP  - 75
EP  - 82
ER  - 

@article{
author = "Zengin, Gokhan and Mahomoodally, M. Fawzi and Aktumsek, Abdurrahman and Ceylan, Ramazan and Uysal, Sengul and Mocan, Andrei and Yilmaz, Mustafa Abdullah and Picot-Allain, Carene Marie Nancy and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina",
year = "2018",
abstract = "Six wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p-coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma). Antifungal agents, bifonazole (MIC 0.10–0.20 mg/mL and MFC 0.20–0.30 mg/mL) and ketoconazole (MIC 0.15–2.30 mg/mL and MFC 0.20–3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases.",
journal = "Food Bioscience",
title = "Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties",
volume = "23",
doi = "10.1016/J.FBIO.2018.03.010",
pages = "75-82"
}

Zengin, G., Mahomoodally, M. F., Aktumsek, A., Ceylan, R., Uysal, S., Mocan, A., Yilmaz, M. A., Picot-Allain, C. M. N., Ćirić, A., Glamočlija, J.,& Soković, M.. (2018). Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties. in Food Bioscience, 23, 75-82.
https://doi.org/10.1016/J.FBIO.2018.03.010

Zengin G, Mahomoodally MF, Aktumsek A, Ceylan R, Uysal S, Mocan A, Yilmaz MA, Picot-Allain CMN, Ćirić A, Glamočlija J, Soković M. Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties. in Food Bioscience. 2018;23:75-82.
doi:10.1016/J.FBIO.2018.03.010 .

Zengin, Gokhan, Mahomoodally, M. Fawzi, Aktumsek, Abdurrahman, Ceylan, Ramazan, Uysal, Sengul, Mocan, Andrei, Yilmaz, Mustafa Abdullah, Picot-Allain, Carene Marie Nancy, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, "Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties" in Food Bioscience, 23 (2018):75-82,
https://doi.org/10.1016/J.FBIO.2018.03.010 . .

TY  - JOUR
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Zengin, Gokhan
AU  - Aktumsek, Abdurrahman
AU  - Mocan, Andrei
AU  - Custodio, Luisa
AU  - Neng, Nuno R.
AU  - Nogueira, José M.F.
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Mahomoodally, M.Fawzi
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0926669018300013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2965
AB  - Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive compounds that would justify its use as a folk remedy. Aerial part of B. macrodonta was assessed for its antioxidant, antimicrobial, and enzymatic inhibitory potential using different extraction solvents. The total bioactive components determination and compound identification using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were used to correlate the biological properties. HPLC-DAD profile showed the presence of 19 components (e.g. hydroxybenzoic acid, catechin hydrate, vanillic acid, caffeic acid, syringic acid, epicatechin, coumaric acid, ferulic acid, luteolin-7-O-glucoside, rutin, and quercetin). The water and methanolic extracts showed high total phenolic and flavonoid contents, respectively. The overall antioxidant capacity of the water extract was higher than the one of the methanol extract. The extracts showed inhibitory activity against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The extracts also presented antimicrobial activity against eight Gram positive/negative bacteria (MIC – 0.05–0.15 mg/mL) and eight fungi (MIC – 0.0125–0.20 mg/mL). The presence of active biomolecules with multi-pharmacological properties makes B. macrodonta a potential source of health-promoting compounds that can be exploited as a novel medicinal herbal product.
T2  - Industrial Crops and Products
T1  - Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey
VL  - 113
DO  - 10.1016/j.indcrop.2018.01.001
SP  - 422
EP  - 428
ER  - 

@article{
author = "Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Zengin, Gokhan and Aktumsek, Abdurrahman and Mocan, Andrei and Custodio, Luisa and Neng, Nuno R. and Nogueira, José M.F. and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Mahomoodally, M.Fawzi",
year = "2018",
abstract = "Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive compounds that would justify its use as a folk remedy. Aerial part of B. macrodonta was assessed for its antioxidant, antimicrobial, and enzymatic inhibitory potential using different extraction solvents. The total bioactive components determination and compound identification using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were used to correlate the biological properties. HPLC-DAD profile showed the presence of 19 components (e.g. hydroxybenzoic acid, catechin hydrate, vanillic acid, caffeic acid, syringic acid, epicatechin, coumaric acid, ferulic acid, luteolin-7-O-glucoside, rutin, and quercetin). The water and methanolic extracts showed high total phenolic and flavonoid contents, respectively. The overall antioxidant capacity of the water extract was higher than the one of the methanol extract. The extracts showed inhibitory activity against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The extracts also presented antimicrobial activity against eight Gram positive/negative bacteria (MIC – 0.05–0.15 mg/mL) and eight fungi (MIC – 0.0125–0.20 mg/mL). The presence of active biomolecules with multi-pharmacological properties makes B. macrodonta a potential source of health-promoting compounds that can be exploited as a novel medicinal herbal product.",
journal = "Industrial Crops and Products",
title = "Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey",
volume = "113",
doi = "10.1016/j.indcrop.2018.01.001",
pages = "422-428"
}

Uysal, S., Aumeeruddy-Elalfi, Z., Zengin, G., Aktumsek, A., Mocan, A., Custodio, L., Neng, N. R., Nogueira, J. M.F., Ćirić, A., Glamočlija, J., Soković, M.,& Mahomoodally, M.Fawzi. (2018). Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey. in Industrial Crops and Products, 113, 422-428.
https://doi.org/10.1016/j.indcrop.2018.01.001

Uysal S, Aumeeruddy-Elalfi Z, Zengin G, Aktumsek A, Mocan A, Custodio L, Neng NR, Nogueira JM, Ćirić A, Glamočlija J, Soković M, Mahomoodally M. Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey. in Industrial Crops and Products. 2018;113:422-428.
doi:10.1016/j.indcrop.2018.01.001 .

Uysal, Sengul, Aumeeruddy-Elalfi, Zaahira, Zengin, Gokhan, Aktumsek, Abdurrahman, Mocan, Andrei, Custodio, Luisa, Neng, Nuno R., Nogueira, José M.F., Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Mahomoodally, M.Fawzi, "Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey" in Industrial Crops and Products, 113 (2018):422-428,
https://doi.org/10.1016/j.indcrop.2018.01.001 . .

TY  - JOUR
AU  - Zengin, Gokhan
AU  - Aktumsek, Abdurrahman
AU  - Ceylan, Ramazan
AU  - Uysal, Sengul
AU  - Mocan, Andrei
AU  - Guler, Gokalp Ozmen
AU  - Mahomoodally, M. Fawzi
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Soković, Marina
PY  - 2017
UR  - http://xlink.rsc.org/?DOI=C6FO01847E
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2728
AB  - Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles. Moreover, the total phenolic and flavonoid contents were determined and LC-MS analysis was performed for the chemical profile of the investigated extracts. The LC-MS analysis revealed the presence of several caffeoylquinic acids in these extracts. Generally, the methanol and water extracts exhibited stronger antioxidant abilities, which correlated with the higher levels of phenolic compounds when compared to the ethyl acetate extracts. In addition, the best antimicrobial activities were obtained for the ethyl acetate and methanolic extracts. However, the ethyl acetate extract had remarkable enzyme inhibitory potential. On the basis of our results, Achillea species may be promoted as promising sources of natural agents and used for the development of nutraceuticals or functional food ingredients.
T2  - Food and Function
T1  - Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia)
IS  - 3
VL  - 8
DO  - 10.1039/C6FO01847E
SP  - 1152
EP  - 1165
ER  - 

@article{
author = "Zengin, Gokhan and Aktumsek, Abdurrahman and Ceylan, Ramazan and Uysal, Sengul and Mocan, Andrei and Guler, Gokalp Ozmen and Mahomoodally, M. Fawzi and Glamočlija, Jasmina and Ćirić, Ana and Soković, Marina",
year = "2017",
abstract = "Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles. Moreover, the total phenolic and flavonoid contents were determined and LC-MS analysis was performed for the chemical profile of the investigated extracts. The LC-MS analysis revealed the presence of several caffeoylquinic acids in these extracts. Generally, the methanol and water extracts exhibited stronger antioxidant abilities, which correlated with the higher levels of phenolic compounds when compared to the ethyl acetate extracts. In addition, the best antimicrobial activities were obtained for the ethyl acetate and methanolic extracts. However, the ethyl acetate extract had remarkable enzyme inhibitory potential. On the basis of our results, Achillea species may be promoted as promising sources of natural agents and used for the development of nutraceuticals or functional food ingredients.",
journal = "Food and Function",
title = "Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia)",
number = "3",
volume = "8",
doi = "10.1039/C6FO01847E",
pages = "1152-1165"
}

Zengin, G., Aktumsek, A., Ceylan, R., Uysal, S., Mocan, A., Guler, G. O., Mahomoodally, M. F., Glamočlija, J., Ćirić, A.,& Soković, M.. (2017). Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). in Food and Function, 8(3), 1152-1165.
https://doi.org/10.1039/C6FO01847E

Zengin G, Aktumsek A, Ceylan R, Uysal S, Mocan A, Guler GO, Mahomoodally MF, Glamočlija J, Ćirić A, Soković M. Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). in Food and Function. 2017;8(3):1152-1165.
doi:10.1039/C6FO01847E .

Zengin, Gokhan, Aktumsek, Abdurrahman, Ceylan, Ramazan, Uysal, Sengul, Mocan, Andrei, Guler, Gokalp Ozmen, Mahomoodally, M. Fawzi, Glamočlija, Jasmina, Ćirić, Ana, Soković, Marina, "Shedding light on the biological and chemical fingerprints of three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia)" in Food and Function, 8, no. 3 (2017):1152-1165,
https://doi.org/10.1039/C6FO01847E . .