TY  - JOUR
AU  - Garcia-Manieri, Jéssica A.A
AU  - Correa, Vanesa Gesser
AU  - Corrêa, Rúbia Carvalho Gomes
AU  - Dias, Maria Inês
AU  - Calhelha, Ricardo C.
AU  - Ivanov, Marija
AU  - Soković, Marina
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
AU  - Bracht, Adelar
AU  - Peralta, Rosane M.
PY  - 2022
UR  - https://linkinghub.elsevier.com/retrieve/pii/S1878818122002572
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5341
AB  - Leaves and barks of Luehea divaricata (Malvaceae) are used in folk medicine for the treatment of infectious diseases, tumors, rheumatism and diabetes. This work presents in vivo experiments (rats and mice) supported by in vitro and chemical analyses in order to address the above mentioned folk medicinal uses. The phenolic constituents of both aqueous and hydroalcoholic extracts are mainly catechin derivatives (135.4 and 215.9 mg/g, respectively). Both extracts displayed strong antioxidant activity. They also showed antiproliferative activities against tumor cells, nitric oxide synthesis inhibition (indicative of anti-inflammatory activity) and antimicrobial activity against a variety of infectious agents. Paracetamol-induced liver injury in rats, which has a high inflammatory component, was substantially attenuated in animals treated with the hydro-alcoholic extract (200 mg kg−1 day−1). This was deduced from aspartate aminotransferase and alanine aminotransferase measurements in plasma as well as from the hepatic activities of catalase and superoxide dismutase. Both extracts inhibited the pancreatic α-amylase with IC50 values of 11.50 ± 0.05 and 18.70 ± 3.87 μg/mL for the hydro-alcoholic and aqueous extract, respectively. Both extracts inhibited starch digestion in mice at the doses of 200 and 400 mg/kg. In general terms the results confirm several of the vox populi notions about the therapeutic potential of L. divaricata, the antidiabetic action, combined with the hepatoprotective effect, being the most relevant observations. Not less important is the economical perspective for the rural producers which may eventually increase their revenue by selling increasingly valued raw materials derived from L. divaricata based on its therapeutic properties.
PB  - Amsterdam: Elsevier
T2  - Biocatalysis and Agricultural Biotechnology
T1  - Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems
VL  - 45
DO  - 10.1016/j.bcab.2022.102530
SP  - 102530
ER  - 

@article{
author = "Garcia-Manieri, Jéssica A.A and Correa, Vanesa Gesser and Corrêa, Rúbia Carvalho Gomes and Dias, Maria Inês and Calhelha, Ricardo C. and Ivanov, Marija and Soković, Marina and Barros, Lillian and Ferreira, Isabel C.F.R. and Bracht, Adelar and Peralta, Rosane M.",
year = "2022",
abstract = "Leaves and barks of Luehea divaricata (Malvaceae) are used in folk medicine for the treatment of infectious diseases, tumors, rheumatism and diabetes. This work presents in vivo experiments (rats and mice) supported by in vitro and chemical analyses in order to address the above mentioned folk medicinal uses. The phenolic constituents of both aqueous and hydroalcoholic extracts are mainly catechin derivatives (135.4 and 215.9 mg/g, respectively). Both extracts displayed strong antioxidant activity. They also showed antiproliferative activities against tumor cells, nitric oxide synthesis inhibition (indicative of anti-inflammatory activity) and antimicrobial activity against a variety of infectious agents. Paracetamol-induced liver injury in rats, which has a high inflammatory component, was substantially attenuated in animals treated with the hydro-alcoholic extract (200 mg kg−1 day−1). This was deduced from aspartate aminotransferase and alanine aminotransferase measurements in plasma as well as from the hepatic activities of catalase and superoxide dismutase. Both extracts inhibited the pancreatic α-amylase with IC50 values of 11.50 ± 0.05 and 18.70 ± 3.87 μg/mL for the hydro-alcoholic and aqueous extract, respectively. Both extracts inhibited starch digestion in mice at the doses of 200 and 400 mg/kg. In general terms the results confirm several of the vox populi notions about the therapeutic potential of L. divaricata, the antidiabetic action, combined with the hepatoprotective effect, being the most relevant observations. Not less important is the economical perspective for the rural producers which may eventually increase their revenue by selling increasingly valued raw materials derived from L. divaricata based on its therapeutic properties.",
publisher = "Amsterdam: Elsevier",
journal = "Biocatalysis and Agricultural Biotechnology",
title = "Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems",
volume = "45",
doi = "10.1016/j.bcab.2022.102530",
pages = "102530"
}

Garcia-Manieri, J. A.A, Correa, V. G., Corrêa, R. C. G., Dias, M. I., Calhelha, R. C., Ivanov, M., Soković, M., Barros, L., Ferreira, I. C.F.R., Bracht, A.,& Peralta, R. M.. (2022). Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems. in Biocatalysis and Agricultural Biotechnology
Amsterdam: Elsevier., 45, 102530.
https://doi.org/10.1016/j.bcab.2022.102530

Garcia-Manieri JA, Correa VG, Corrêa RCG, Dias MI, Calhelha RC, Ivanov M, Soković M, Barros L, Ferreira IC, Bracht A, Peralta RM. Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems. in Biocatalysis and Agricultural Biotechnology. 2022;45:102530.
doi:10.1016/j.bcab.2022.102530 .

Garcia-Manieri, Jéssica A.A, Correa, Vanesa Gesser, Corrêa, Rúbia Carvalho Gomes, Dias, Maria Inês, Calhelha, Ricardo C., Ivanov, Marija, Soković, Marina, Barros, Lillian, Ferreira, Isabel C.F.R., Bracht, Adelar, Peralta, Rosane M., "Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems" in Biocatalysis and Agricultural Biotechnology, 45 (2022):102530,
https://doi.org/10.1016/j.bcab.2022.102530 . .