TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Marković, Snezana D
AU  - Đorđević, Natasa Z
AU  - Trbojević, Ivana S
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1393
AB  - The aim of this study was to investigate the protective role of coenzyme Q(10) (CoQ(10), 20 mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4 mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ(10) and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ(10), and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQic, and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. (C) 2009 Elsevier Inc. All rights reserved.
T2  - Reproductive Toxicology
T1  - Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E
IS  - 2
VL  - 29
EP  - 197
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1393
ER  - 

@article{
author = "Ognjanović, Branka I and Marković, Snezana D and Đorđević, Natasa Z and Trbojević, Ivana S and Stajn, Andras S and Saičić, Zorica",
year = "2010",
abstract = "The aim of this study was to investigate the protective role of coenzyme Q(10) (CoQ(10), 20 mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4 mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ(10) and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ(10), and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQic, and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. (C) 2009 Elsevier Inc. All rights reserved.",
journal = "Reproductive Toxicology",
title = "Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E",
number = "2",
volume = "29",
pages = "197",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1393"
}

Ognjanović, B. I., Marković, S. D., Đorđević, N. Z., Trbojević, I. S., Stajn, A. S.,& Saičić, Z.. (2010). Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E. in Reproductive Toxicology, 29(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1393

Ognjanović BI, Marković SD, Đorđević NZ, Trbojević IS, Stajn AS, Saičić Z. Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E. in Reproductive Toxicology. 2010;29(2):null-197.
https://hdl.handle.net/21.15107/rcub_ibiss_1393 .

Ognjanović, Branka I, Marković, Snezana D, Đorđević, Natasa Z, Trbojević, Ivana S, Stajn, Andras S, Saičić, Zorica, "Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E" in Reproductive Toxicology, 29, no. 2 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1393 .