TY  - JOUR
AU  - Uysal, Sengul
AU  - Aumeeruddy-Elalfi, Zaahira
AU  - Zengin, Gokhan
AU  - Aktumsek, Abdurrahman
AU  - Mocan, Andrei
AU  - Custodio, Luisa
AU  - Neng, Nuno R.
AU  - Nogueira, José M.F.
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Mahomoodally, M.Fawzi
PY  - 2018
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0926669018300013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2965
AB  - Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive compounds that would justify its use as a folk remedy. Aerial part of B. macrodonta was assessed for its antioxidant, antimicrobial, and enzymatic inhibitory potential using different extraction solvents. The total bioactive components determination and compound identification using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were used to correlate the biological properties. HPLC-DAD profile showed the presence of 19 components (e.g. hydroxybenzoic acid, catechin hydrate, vanillic acid, caffeic acid, syringic acid, epicatechin, coumaric acid, ferulic acid, luteolin-7-O-glucoside, rutin, and quercetin). The water and methanolic extracts showed high total phenolic and flavonoid contents, respectively. The overall antioxidant capacity of the water extract was higher than the one of the methanol extract. The extracts showed inhibitory activity against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The extracts also presented antimicrobial activity against eight Gram positive/negative bacteria (MIC – 0.05–0.15 mg/mL) and eight fungi (MIC – 0.0125–0.20 mg/mL). The presence of active biomolecules with multi-pharmacological properties makes B. macrodonta a potential source of health-promoting compounds that can be exploited as a novel medicinal herbal product.
T2  - Industrial Crops and Products
T1  - Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey
VL  - 113
DO  - 10.1016/j.indcrop.2018.01.001
SP  - 422
EP  - 428
ER  - 

@article{
author = "Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Zengin, Gokhan and Aktumsek, Abdurrahman and Mocan, Andrei and Custodio, Luisa and Neng, Nuno R. and Nogueira, José M.F. and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Mahomoodally, M.Fawzi",
year = "2018",
abstract = "Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant used to manage a plethora of diseases in Turkey. Nonetheless, few studies have endeavoured to highlight its therapeutic potential and its phytochemical profile. We hypothesized that B. macrodonta would possess multi-pharmacological propensities and bioactive compounds that would justify its use as a folk remedy. Aerial part of B. macrodonta was assessed for its antioxidant, antimicrobial, and enzymatic inhibitory potential using different extraction solvents. The total bioactive components determination and compound identification using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were used to correlate the biological properties. HPLC-DAD profile showed the presence of 19 components (e.g. hydroxybenzoic acid, catechin hydrate, vanillic acid, caffeic acid, syringic acid, epicatechin, coumaric acid, ferulic acid, luteolin-7-O-glucoside, rutin, and quercetin). The water and methanolic extracts showed high total phenolic and flavonoid contents, respectively. The overall antioxidant capacity of the water extract was higher than the one of the methanol extract. The extracts showed inhibitory activity against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The extracts also presented antimicrobial activity against eight Gram positive/negative bacteria (MIC – 0.05–0.15 mg/mL) and eight fungi (MIC – 0.0125–0.20 mg/mL). The presence of active biomolecules with multi-pharmacological properties makes B. macrodonta a potential source of health-promoting compounds that can be exploited as a novel medicinal herbal product.",
journal = "Industrial Crops and Products",
title = "Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey",
volume = "113",
doi = "10.1016/j.indcrop.2018.01.001",
pages = "422-428"
}

Uysal, S., Aumeeruddy-Elalfi, Z., Zengin, G., Aktumsek, A., Mocan, A., Custodio, L., Neng, N. R., Nogueira, J. M.F., Ćirić, A., Glamočlija, J., Soković, M.,& Mahomoodally, M.Fawzi. (2018). Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey. in Industrial Crops and Products, 113, 422-428.
https://doi.org/10.1016/j.indcrop.2018.01.001

Uysal S, Aumeeruddy-Elalfi Z, Zengin G, Aktumsek A, Mocan A, Custodio L, Neng NR, Nogueira JM, Ćirić A, Glamočlija J, Soković M, Mahomoodally M. Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey. in Industrial Crops and Products. 2018;113:422-428.
doi:10.1016/j.indcrop.2018.01.001 .

Uysal, Sengul, Aumeeruddy-Elalfi, Zaahira, Zengin, Gokhan, Aktumsek, Abdurrahman, Mocan, Andrei, Custodio, Luisa, Neng, Nuno R., Nogueira, José M.F., Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Mahomoodally, M.Fawzi, "Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey" in Industrial Crops and Products, 113 (2018):422-428,
https://doi.org/10.1016/j.indcrop.2018.01.001 . .