TY  - JOUR
AU  - Adžić, Miroslav
AU  - Đorđević, Jelena D
AU  - Mitić, Milos Z
AU  - Simić, Iva
AU  - Rackov, Gorjana
AU  - Đorđević, Ana
AU  - Elaković, Ivana
AU  - Matić, Gordana
AU  - Radojcić, Marija B
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1319
AB  - Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.
T2  - Acta Chimica Slovenica
T1  - Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats
IS  - 4
VL  - 58
EP  - 791
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1319
ER  - 

@article{
author = "Adžić, Miroslav and Đorđević, Jelena D and Mitić, Milos Z and Simić, Iva and Rackov, Gorjana and Đorđević, Ana and Elaković, Ivana and Matić, Gordana and Radojcić, Marija B",
year = "2011",
abstract = "Alterations in the antioxidative defense parameters upon chronic stress are considered critical for pathophysiology of stress related psychiatric disorders, and their status in blood serves as biomarker for effects of pharmacological treatments. The present study was designed to investigate the modulation of erythrocyte antioxidant enzymes (AOEs): CuZn superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR) activities and their protein expression in Wistar male rats subjected to chronic psychosocial isolation and/or to pharmacological treatment with fluoxetine. Chronically isolated animals exhibited decreased levels of serum corticosterone, as opposed to other chronic stress paradigms. In addition to that, SOD, CAT and GPx status was not altered either by chronic psychosocial isolation or by fluoxetine treatment. In contrast, GLR activity and its protein level were both markedly reduced by fluoxetine. Since, GLR is crucial for overall oxido-reductive balance through maintaining optimal ratio of reduced/oxidized glutathione level (GSH/GSSG) in erythrocytes, these results could indicate that in spite of numerous beneficial effects of fluoxetine, it may compromise both haemoglobin function and oxygen transport.",
journal = "Acta Chimica Slovenica",
title = "Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats",
number = "4",
volume = "58",
pages = "791",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1319"
}

Adžić, M., Đorđević, J. D., Mitić, M. Z., Simić, I., Rackov, G., Đorđević, A., Elaković, I., Matić, G.,& Radojcić, M. B.. (2011). Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats. in Acta Chimica Slovenica, 58(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1319

Adžić M, Đorđević JD, Mitić MZ, Simić I, Rackov G, Đorđević A, Elaković I, Matić G, Radojcić MB. Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats. in Acta Chimica Slovenica. 2011;58(4):null-791.
https://hdl.handle.net/21.15107/rcub_ibiss_1319 .

Adžić, Miroslav, Đorđević, Jelena D, Mitić, Milos Z, Simić, Iva, Rackov, Gorjana, Đorđević, Ana, Elaković, Ivana, Matić, Gordana, Radojcić, Marija B, "Fluoxetine Decreases Glutathione Reductase in Erythrocytes of Chronically Isolated Wistar Rats" in Acta Chimica Slovenica, 58, no. 4 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1319 .