TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Đorđević, Natasa Z
AU  - Matić, Milos M
AU  - Obradović, Jasmina M
AU  - Mladenović, Jelena M
AU  - Stajn, Andras S
AU  - Saičić, Zorica
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1209
AB  - Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage.
T2  - International Journal of Molecular Sciences
T1  - Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium
IS  - 2
VL  - 13
EP  - 1803
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1209
ER  - 

@article{
author = "Ognjanović, Branka I and Đorđević, Natasa Z and Matić, Milos M and Obradović, Jasmina M and Mladenović, Jelena M and Stajn, Andras S and Saičić, Zorica",
year = "2012",
abstract = "Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of several cancers, but with several side effects such as nephrotoxicity. The present study investigated the possible protective effect of selenium (Se) against CP-induced oxidative stress in the rat kidneys. Male Wistar albino rats were injected with a single dose of cisplatin (7 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.), alone or in combination. The obtained results showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations, suggesting the CP-induced oxidative stress, while Se treatment reversed this change to control values. Acute intoxication of rats with CP was followed by statistically significant decreased activity of antioxidant defense enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione-S-transferase (GST). Treatment with Se reversed CP-induced alterations of antioxidant defense enzyme activities and significantly prevented the CP-induced kidney damage.",
journal = "International Journal of Molecular Sciences",
title = "Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium",
number = "2",
volume = "13",
pages = "1803",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1209"
}

Ognjanović, B. I., Đorđević, N. Z., Matić, M. M., Obradović, J. M., Mladenović, J. M., Stajn, A. S.,& Saičić, Z.. (2012). Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium. in International Journal of Molecular Sciences, 13(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1209

Ognjanović BI, Đorđević NZ, Matić MM, Obradović JM, Mladenović JM, Stajn AS, Saičić Z. Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium. in International Journal of Molecular Sciences. 2012;13(2):null-1803.
https://hdl.handle.net/21.15107/rcub_ibiss_1209 .

Ognjanović, Branka I, Đorđević, Natasa Z, Matić, Milos M, Obradović, Jasmina M, Mladenović, Jelena M, Stajn, Andras S, Saičić, Zorica, "Lipid Peroxidative Damage on Cisplatin Exposure and Alterations in Antioxidant Defense System in Rat Kidneys: A Possible Protective Effect of Selenium" in International Journal of Molecular Sciences, 13, no. 2 (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1209 .