TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Đorđević, Nataša
AU  - Pavlović, Slađan
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5999
AB  - The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea
SP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5999
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Đorđević, Nataša and Pavlović, Slađan and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2007",
abstract = "The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea",
pages = "69",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5999"
}

Ognjanović, B., Marković, S., Đorđević, N., Pavlović, S., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2007). Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999

Ognjanović B, Marković S, Đorđević N, Pavlović S, Štajn AŠ, Žikić RV, Saičić Z. Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

Ognjanović, Branka, Marković, Snežana, Đorđević, Nataša, Pavlović, Slađan, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):69,
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

TY  - CONF
AU  - Đorđević, Nataša
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5998
AB  - Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea
SP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5998
ER  - 

@conference{
author = "Đorđević, Nataša and Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea",
pages = "55",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5998"
}

Đorđević, N., Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998

Đorđević N, Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

Đorđević, Nataša, Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):55,
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5971
AB  - Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
T1  - Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5971
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia",
title = "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5971"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
Belgrade: Serbian Physiology Society., 112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia. 2007;:112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart." in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia (2007):112,
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Filipović, Jasmina
AU  - Nikolić, Dubravka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5966
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea
SP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5966
ER  - 

@conference{
author = "Ognjanović, Branka and Filipović, Jasmina and Nikolić, Dubravka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea",
pages = "91",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5966"
}

Ognjanović, B., Filipović, J., Nikolić, D., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2006). Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966

Ognjanović B, Filipović J, Nikolić D, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

Ognjanović, Branka, Filipović, Jasmina, Nikolić, Dubravka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):91,
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2005
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5953
AB  - Cadmium (Cd) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the tissues. Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element which ·plays an important role in a number of biological processess. The effect of cadmium on the activity of glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) which play an important role in the detoxification of xenobiotics, was studied in the liver, kidney and heart of rats. Furthermore, the role of selenium in the modulation of Cd toxicity with respect to GSH-Px and GST was also evaluated. In our experiments, cadmium exposure (15 mg Cd/kg body wt./day as CdCh for 4 weeks) to rats (n=30, male Wistar rats, age 8 weeks) resulted in decreased GSH-Px and GST activity in all organs  present  in  the  order  liver  >  kidney  >  heart.  Oral  administration  of  Se
(0.5 mg Se/kg body wt./day as Na2Se0 3 for 4 weeks) caused a significant increase in
 
IJ,,
Cl

It ra as
SC
at cc ef
ra w ar S1
Ir
 
GSH-Px activity in the order liver> heart> kidney. Selenium  administration caused	d,
an   increase   in  total  GST  activity  in  liver  but  a  decrease   in  kidney    and  heart.	Sf
Simultaneous  administration of Cd  and Se resulted  in  an  increase  GSH-Px and GST	p,
activity  in all  tissues  under study. Thus,  the mechanism  by which Se    decreases Cd	b,
toxicity in rats seems to rely on the protection of the enzyme systems   GSH-Px and	aJ GST in the three organs, possibly by forming non-toxic cadmium selenide. Selenium	th efficiently protects tissues from cadmium-induced oxidative damage
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
T1  - Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium
SP  - 202
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5953
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2005",
abstract = "Cadmium (Cd) is an ubiquitous toxic metal that may induce oxidative damage by disturbing the prooxidant-antioxidant balance in the tissues. Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element which ·plays an important role in a number of biological processess. The effect of cadmium on the activity of glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) which play an important role in the detoxification of xenobiotics, was studied in the liver, kidney and heart of rats. Furthermore, the role of selenium in the modulation of Cd toxicity with respect to GSH-Px and GST was also evaluated. In our experiments, cadmium exposure (15 mg Cd/kg body wt./day as CdCh for 4 weeks) to rats (n=30, male Wistar rats, age 8 weeks) resulted in decreased GSH-Px and GST activity in all organs  present  in  the  order  liver  >  kidney  >  heart.  Oral  administration  of  Se
(0.5 mg Se/kg body wt./day as Na2Se0 3 for 4 weeks) caused a significant increase in
 
IJ,,
Cl

It ra as
SC
at cc ef
ra w ar S1
Ir
 
GSH-Px activity in the order liver> heart> kidney. Selenium  administration caused	d,
an   increase   in  total  GST  activity  in  liver  but  a  decrease   in  kidney    and  heart.	Sf
Simultaneous  administration of Cd  and Se resulted  in  an  increase  GSH-Px and GST	p,
activity  in all  tissues  under study. Thus,  the mechanism  by which Se    decreases Cd	b,
toxicity in rats seems to rely on the protection of the enzyme systems   GSH-Px and	aJ GST in the three organs, possibly by forming non-toxic cadmium selenide. Selenium	th efficiently protects tissues from cadmium-induced oxidative damage",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia",
title = "Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium",
pages = "202",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5953"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2005). Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
Belgrade: Serbian Physiology Society., 202.
https://hdl.handle.net/21.15107/rcub_ibiss_5953

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia. 2005;:202.
https://hdl.handle.net/21.15107/rcub_ibiss_5953 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Effect of chronic cadmium exposure on glutathione peroxidase and glutathione s-transferase activities in rat: the  role  of selenium" in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia (2005):202,
https://hdl.handle.net/21.15107/rcub_ibiss_5953 .