TY  - CONF
AU  - Marković, Marija
AU  - Skorić, Marijana
AU  - Živković, Suzana
AU  - Jadranin, Milka
AU  - Dragićević, Milan
AU  - Tešević, Vele
AU  - Gligorijević, Nevenka
AU  - Janković, Radmila
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Todorović, Slađana
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6184
AB  - Inula oculus-christi L. is a perennial species distributed in Asia, Central Europe and the Balkan Peninsula. In this study a potential cytotoxic and antimicrobial activity of ethanol extracts obtained from different parts of I. oculus-christi plants was investigated. Cytotoxic activity of extracts was determined on three tumor cell lines (HeLa, FemX and LS-174) by MTT assay. The extracts of leaves and flowers showed significant cytotoxic activity against all investigated cell lines, while rhizome, root and trunk extracts had no cytotoxic activity. The IC50 values for flower extract were 68.70 ± 2.79 μg mL-1 for HeLa cells, 88.91 ± 1.66 μg mL-1 for FemX cells and 81.46 ± 8.45 μg mL-1 for LS-174 cells, whereas the IC50 values for leaf extract were 73.69 ± 5.35 μg mL-1 for He-La cells, 71.58 ± 4.25 μg mL-1 for FemX cells and 96.37 ± 4.92 μg mL-1 for LS-174 cells. The observed cytotoxic activity could be attributed to several bioactive sesquiterpenoids and flavonoids which were more abundant in leaf and flower extracts according to LC-DAD/MS non-targeted screening. In the antimicrobial bioassays against eight bacteria and microfungi, all tested extracts exhibited higher antimicrobial activity in comparison with commercial antimicrobial agents used as control. These results indicate the possibility of application of I. oculus-christi extracts as valuable natural products in medicine, agronomy and food industry.
PB  - Belgrade: Serbian Plant Physiology Society
C3  - Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia
T1  - Cytotoxic and antimicrobial activities of different plant part extracts of Inula oculus-christi
SP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6184
ER  - 

@conference{
author = "Marković, Marija and Skorić, Marijana and Živković, Suzana and Jadranin, Milka and Dragićević, Milan and Tešević, Vele and Gligorijević, Nevenka and Janković, Radmila and Glamočlija, Jasmina and Soković, Marina and Todorović, Slađana",
year = "2015",
abstract = "Inula oculus-christi L. is a perennial species distributed in Asia, Central Europe and the Balkan Peninsula. In this study a potential cytotoxic and antimicrobial activity of ethanol extracts obtained from different parts of I. oculus-christi plants was investigated. Cytotoxic activity of extracts was determined on three tumor cell lines (HeLa, FemX and LS-174) by MTT assay. The extracts of leaves and flowers showed significant cytotoxic activity against all investigated cell lines, while rhizome, root and trunk extracts had no cytotoxic activity. The IC50 values for flower extract were 68.70 ± 2.79 μg mL-1 for HeLa cells, 88.91 ± 1.66 μg mL-1 for FemX cells and 81.46 ± 8.45 μg mL-1 for LS-174 cells, whereas the IC50 values for leaf extract were 73.69 ± 5.35 μg mL-1 for He-La cells, 71.58 ± 4.25 μg mL-1 for FemX cells and 96.37 ± 4.92 μg mL-1 for LS-174 cells. The observed cytotoxic activity could be attributed to several bioactive sesquiterpenoids and flavonoids which were more abundant in leaf and flower extracts according to LC-DAD/MS non-targeted screening. In the antimicrobial bioassays against eight bacteria and microfungi, all tested extracts exhibited higher antimicrobial activity in comparison with commercial antimicrobial agents used as control. These results indicate the possibility of application of I. oculus-christi extracts as valuable natural products in medicine, agronomy and food industry.",
publisher = "Belgrade: Serbian Plant Physiology Society",
journal = "Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia",
title = "Cytotoxic and antimicrobial activities of different plant part extracts of Inula oculus-christi",
pages = "85",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6184"
}

Marković, M., Skorić, M., Živković, S., Jadranin, M., Dragićević, M., Tešević, V., Gligorijević, N., Janković, R., Glamočlija, J., Soković, M.,& Todorović, S.. (2015). Cytotoxic and antimicrobial activities of different plant part extracts of Inula oculus-christi. in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia
Belgrade: Serbian Plant Physiology Society., 85.
https://hdl.handle.net/21.15107/rcub_ibiss_6184

Marković M, Skorić M, Živković S, Jadranin M, Dragićević M, Tešević V, Gligorijević N, Janković R, Glamočlija J, Soković M, Todorović S. Cytotoxic and antimicrobial activities of different plant part extracts of Inula oculus-christi. in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia. 2015;:85.
https://hdl.handle.net/21.15107/rcub_ibiss_6184 .

Marković, Marija, Skorić, Marijana, Živković, Suzana, Jadranin, Milka, Dragićević, Milan, Tešević, Vele, Gligorijević, Nevenka, Janković, Radmila, Glamočlija, Jasmina, Soković, Marina, Todorović, Slađana, "Cytotoxic and antimicrobial activities of different plant part extracts of Inula oculus-christi" in Book of Abstracts: 2nd International Conference on Plant Biology, 21th Symposium of the Serbian Plant Physiology Society, and CОST Action FA1106 Quality Fruit Workshop; 2015 Jun 17-20; Petnica, Serbia (2015):85,
https://hdl.handle.net/21.15107/rcub_ibiss_6184 .