TY  - JOUR
AU  - Stefanovic, Ivan S.
AU  - Djonlagic, Jasna
AU  - Tovilović-Kovačević, Gordana
AU  - Brkljačić, Jelena
AU  - Antic, Vesna V.
AU  - Ostojic, Sanja
AU  - Pergal, Marija V.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1983
AB  - Polyurethane copolymers based on ,-dihydroxypropyl
   poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were
   prepared by two-stage polymerization, and their microstructures,
   thermal, thermomechanical, and surface properties, as well as in vitro
   hemo- and cytocompatibility were evaluated. All utilized
   characterization methods confirmed the existence of moderately
   microphase separated structures with the appearance of some microphase
   mixing between segments as the PDMS (i.e., soft segment) content
   increased. Copolymers showed higher crystallinity, storage moduli,
   surface roughness, and surface free energy, but less hydrophobicity with
   decreasing PDMS content. Biocompatibility of copolymers was evaluated
   using an endothelial EA.hy926 cell line by direct contact, an extraction
   method and after pretreatment of copolymers with multicomponent protein
   mixture, as well as by a competitive protein adsorption assay.
   Copolymers showed no toxic effect to endothelial cells and all
   copolymers, except that with the lowest PDMS content, exhibited
   resistance to endothelial cell adhesion, suggesting their unsuitability
   for long-term biomedical devices which particularly require
   re-endothelialization. All copolymers exhibited excellent resistance to
   fibrinogen adsorption and adsorbed more albumin than fibrinogen in the
   competitive adsorption assay, suggesting their good hemocompatibility.
   The noncytotoxic chemistry of these synthesized materials, combined with
   their nonadherent properties which are inhospitable to cell attachment
   and growth, underlie the need for further investigations to clarify
   their potential for use in short-term biomedical devices. (c) 2014 Wiley
   Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1459-1475, 2015.
T2  - Journal of Biomedical Materials Research Part A
T1  - Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells
IS  - 4
VL  - 103
DO  - 10.1002/jbm.a.35285
SP  - 1459
EP  - 1475
ER  - 

@article{
author = "Stefanovic, Ivan S. and Djonlagic, Jasna and Tovilović-Kovačević, Gordana and Brkljačić, Jelena and Antic, Vesna V. and Ostojic, Sanja and Pergal, Marija V.",
year = "2015",
abstract = "Polyurethane copolymers based on ,-dihydroxypropyl
   poly(dimethylsiloxane) (PDMS) with a range of soft segment contents were
   prepared by two-stage polymerization, and their microstructures,
   thermal, thermomechanical, and surface properties, as well as in vitro
   hemo- and cytocompatibility were evaluated. All utilized
   characterization methods confirmed the existence of moderately
   microphase separated structures with the appearance of some microphase
   mixing between segments as the PDMS (i.e., soft segment) content
   increased. Copolymers showed higher crystallinity, storage moduli,
   surface roughness, and surface free energy, but less hydrophobicity with
   decreasing PDMS content. Biocompatibility of copolymers was evaluated
   using an endothelial EA.hy926 cell line by direct contact, an extraction
   method and after pretreatment of copolymers with multicomponent protein
   mixture, as well as by a competitive protein adsorption assay.
   Copolymers showed no toxic effect to endothelial cells and all
   copolymers, except that with the lowest PDMS content, exhibited
   resistance to endothelial cell adhesion, suggesting their unsuitability
   for long-term biomedical devices which particularly require
   re-endothelialization. All copolymers exhibited excellent resistance to
   fibrinogen adsorption and adsorbed more albumin than fibrinogen in the
   competitive adsorption assay, suggesting their good hemocompatibility.
   The noncytotoxic chemistry of these synthesized materials, combined with
   their nonadherent properties which are inhospitable to cell attachment
   and growth, underlie the need for further investigations to clarify
   their potential for use in short-term biomedical devices. (c) 2014 Wiley
   Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1459-1475, 2015.",
journal = "Journal of Biomedical Materials Research Part A",
title = "Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells",
number = "4",
volume = "103",
doi = "10.1002/jbm.a.35285",
pages = "1459-1475"
}

Stefanovic, I. S., Djonlagic, J., Tovilović-Kovačević, G., Brkljačić, J., Antic, V. V., Ostojic, S.,& Pergal, M. V.. (2015). Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells. in Journal of Biomedical Materials Research Part A, 103(4), 1459-1475.
https://doi.org/10.1002/jbm.a.35285

Stefanovic IS, Djonlagic J, Tovilović-Kovačević G, Brkljačić J, Antic VV, Ostojic S, Pergal MV. Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells. in Journal of Biomedical Materials Research Part A. 2015;103(4):1459-1475.
doi:10.1002/jbm.a.35285 .

Stefanovic, Ivan S., Djonlagic, Jasna, Tovilović-Kovačević, Gordana, Brkljačić, Jelena, Antic, Vesna V., Ostojic, Sanja, Pergal, Marija V., "Poly(urethane-dimethylsiloxane) copolymers displaying a range of soft
 segment contents, noncytotoxic chemistry, and nonadherent properties
 toward endothelial cells" in Journal of Biomedical Materials Research Part A, 103, no. 4 (2015):1459-1475,
https://doi.org/10.1002/jbm.a.35285 . .