TY  - JOUR
AU  - Mileski, Ksenija S.
AU  - Džamić, Ana M.
AU  - Ćirić, Ana
AU  - Ristic, Mihailo S.
AU  - Grujic, Slavica M.
AU  - Matevski, Vlado S.
AU  - Marin, Petar D.
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2083
AB  - Ferulago macedonica Micevski \& E. Mayer (Apiaceae), an endemic species
   from Macedonia, was evaluated for its essential oil composition and
   biological activity for the first time. The essential oil composition
   from inflorescence and aerial parts, analyzed by gas chromatography and
   gas chromatography-mass spectrometry (GC and GC-MS), indicated a-pinene
   (43.10\% and 22.78\%) and sabinene (26.73\% and 15.46\%) as the main
   components. The antioxidant activities of extracts was determinated
   spectrophotometrically using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The
   strongest activity had methanol extracts of inflorescence and aerial
   parts (IC50= 490 mg/mL and IC50= 630 mg/mL of solution, respectively).
   According to 2,2'-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid)
   (ABTS) test, the most effective were ethanol and methanol extracts of F.
   macedonica inflorescence (1.69 and 1.63 mg Vit.C/g dw). Total phenolic
   and flavonoid contents evaluation indicated that their amounts were
   ranged between 34.12-59.68 mg gallic acid (GA)/g dw for phenols and
   9.08-23.73 mg quercetin hydrate (QE)/g dw for flavonoids. Antimicrobial
   activity of extracts and essential oils was investigated by micro-well
   dilution assay. Minimum inhibitory (MIC) and minimum
   bactericidal/fungicidal concentrations (MBC/MFC) were defined. The
   methanol extract of inflorescence has shown to be the strongest in both,
   antibacterial (MICs= 4-8 mg/mL; MBCs= 9-13 mg/mL) and antifungal
   activity (MICs= 2-12 mg/mL; MFCs= 6-18 mg/mL). Essential oil from
   inflorescence and aerial parts of F. macedonica manifested stronger
   inhibition on growth of pathogenic bacteria and fungy compared to tested
   extracts and positive standards.
T2  - Records of Natural Products
T1  - Composition, Antimicrobial and Antioxidant Properties of Endemic Species
 Ferulago macedonica Micevski \& E. Mayer
IS  - 2
VL  - 9
SP  - 208
EP  - 223
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2083
ER  - 

@article{
author = "Mileski, Ksenija S. and Džamić, Ana M. and Ćirić, Ana and Ristic, Mihailo S. and Grujic, Slavica M. and Matevski, Vlado S. and Marin, Petar D.",
year = "2015",
abstract = "Ferulago macedonica Micevski \& E. Mayer (Apiaceae), an endemic species
   from Macedonia, was evaluated for its essential oil composition and
   biological activity for the first time. The essential oil composition
   from inflorescence and aerial parts, analyzed by gas chromatography and
   gas chromatography-mass spectrometry (GC and GC-MS), indicated a-pinene
   (43.10\% and 22.78\%) and sabinene (26.73\% and 15.46\%) as the main
   components. The antioxidant activities of extracts was determinated
   spectrophotometrically using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The
   strongest activity had methanol extracts of inflorescence and aerial
   parts (IC50= 490 mg/mL and IC50= 630 mg/mL of solution, respectively).
   According to 2,2'-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid)
   (ABTS) test, the most effective were ethanol and methanol extracts of F.
   macedonica inflorescence (1.69 and 1.63 mg Vit.C/g dw). Total phenolic
   and flavonoid contents evaluation indicated that their amounts were
   ranged between 34.12-59.68 mg gallic acid (GA)/g dw for phenols and
   9.08-23.73 mg quercetin hydrate (QE)/g dw for flavonoids. Antimicrobial
   activity of extracts and essential oils was investigated by micro-well
   dilution assay. Minimum inhibitory (MIC) and minimum
   bactericidal/fungicidal concentrations (MBC/MFC) were defined. The
   methanol extract of inflorescence has shown to be the strongest in both,
   antibacterial (MICs= 4-8 mg/mL; MBCs= 9-13 mg/mL) and antifungal
   activity (MICs= 2-12 mg/mL; MFCs= 6-18 mg/mL). Essential oil from
   inflorescence and aerial parts of F. macedonica manifested stronger
   inhibition on growth of pathogenic bacteria and fungy compared to tested
   extracts and positive standards.",
journal = "Records of Natural Products",
title = "Composition, Antimicrobial and Antioxidant Properties of Endemic Species
 Ferulago macedonica Micevski \& E. Mayer",
number = "2",
volume = "9",
pages = "208-223",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2083"
}

Mileski, K. S., Džamić, A. M., Ćirić, A., Ristic, M. S., Grujic, S. M., Matevski, V. S.,& Marin, P. D.. (2015). Composition, Antimicrobial and Antioxidant Properties of Endemic Species
 Ferulago macedonica Micevski \& E. Mayer. in Records of Natural Products, 9(2), 208-223.
https://hdl.handle.net/21.15107/rcub_ibiss_2083

Mileski KS, Džamić AM, Ćirić A, Ristic MS, Grujic SM, Matevski VS, Marin PD. Composition, Antimicrobial and Antioxidant Properties of Endemic Species
 Ferulago macedonica Micevski \& E. Mayer. in Records of Natural Products. 2015;9(2):208-223.
https://hdl.handle.net/21.15107/rcub_ibiss_2083 .

Mileski, Ksenija S., Džamić, Ana M., Ćirić, Ana, Ristic, Mihailo S., Grujic, Slavica M., Matevski, Vlado S., Marin, Petar D., "Composition, Antimicrobial and Antioxidant Properties of Endemic Species
 Ferulago macedonica Micevski \& E. Mayer" in Records of Natural Products, 9, no. 2 (2015):208-223,
https://hdl.handle.net/21.15107/rcub_ibiss_2083 .