@conference{
author = "Perović, Milka and Ćirić, Jelena and Matović, Valentina and Srbovan, Maja and Koruga, Đuro and Kanazir, Selma and Ivković, Sanja",
year = "2022",
abstract = "The potential of fullerenes and fullerene’s water-soluble derivatives
to bind to amyloid-b has been well documented in vitro and
in silico. However, the anti-amyloid action of fullerenols in
in vivo treatments has not been fully examined. In the present study we assessed the effects of the hydroxylated fullerene-water
complex (3HFWC) on Alzheimer’s disease (AD) neuropathological
hallmarks in 5XFAD mice, a well-recognized AD animal
model. The 3-week-old 5XFAD mice were exposed to 3HFWC
water solution ad libitum for 3 months. The 3HFWC treatment
started in the presymptomatic phase of pathology and analyses
were focused on the effects on amyloid-b (Ab) accumulation, plaque
formation, gliosis, and synaptic plasticity in cortical and hippocampal
tissue. The 3HFWC treatment significantly decreased
the amyloid-b plaque load in specific parts of cerebral cortex, followed
by the unchanged levels of Ab. None of these changes
were detected in the hippocampus. At the same time, 3HFWC
treatment did not exacerbate the activation of glial cells, nor
altered the expression levels of synaptic proteins. The obtained
results point to the potential of 3HFWC, when applied in the
presymptomatic phase of AD, to interfere with Ab accumulation
and amyloid plaque formation without exacerbating the other
AD-related pathological processes.",
publisher = "Hoboken : John Wiley & Sons Ltd",
journal = "The Biochemistry Global Summit: 25th IUBMB Congress: 46th FEBS Congress: 15th PABMB Congress; 2022 Jul 9-14; Lisbon, Portugal",
title = "Composition comprising hydroxyl modified fullerene substances decrease plaque load in 5XFAD mouse model of Alzheimer's disease",
doi = "10.1002/2211-5463.13440",
pages = "130"
}
