TY  - JOUR
AU  - Stevanović, Darko
AU  - Trajković, Vladimir
AU  - Müller-Lühlhoff, Sabrina
AU  - Brandt, Elisabeth
AU  - Abplanalp, William
AU  - Bumke-Vogt, Christiane
AU  - Liehl, Beate
AU  - Wiedmer, Petra
AU  - Janjetović, Kristina
AU  - Starčević, Vesna
AU  - Pfeiffer, Andreas F.H.
AU  - Al-Hasani, Hadi
AU  - Tschöp, Matthias H.
AU  - Castañeda, Tamara R.
PY  - 2013
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6350
AB  - Signaling through the mammalian target of rapamycin complex 1 (mTORC1) and its effectors the S6-
kinases (S6K) in the hypothalamus is thought to be involved in nutrient sensing and control of food
intake. Given the anatomical proximity of this pathway to circuits for the hormone ghrelin, we investigated
the potential role of the mTORC1/S6K pathway in mediating the metabolic effects of ghrelin. We
found that ghrelin promoted phosphorylation of S6K1 in the mouse hypothalamic cell line N-41 and in
the rat hypothalamus after intracerebroventricular administration. Rapamycin, an inhibitor of mTORC1,
suppressed ghrelin-induced phosphorylation of hypothalamic S6K1 and increased food intake and insulin
in rats. Chronic peripheral administration of ghrelin induced a significant increase in body weight, fat
mass and food efficiency in wild-type and S6K2-knockout but not in S6K1-knockout mice. We therefore
propose that ghrelin-induced hyperphagia, adiposity and insulin secretion are controlled by a central nervous system involving the mTORC1/S6K1 pathway.
PB  - Elsevier
T2  - Molecular and Cellular Endocrinology
T1  - Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling
IS  - 1-2
VL  - 381
DO  - 10.1016/j.mce.2013.08.009
SP  - 280
EP  - 290
ER  - 

@article{
author = "Stevanović, Darko and Trajković, Vladimir and Müller-Lühlhoff, Sabrina and Brandt, Elisabeth and Abplanalp, William and Bumke-Vogt, Christiane and Liehl, Beate and Wiedmer, Petra and Janjetović, Kristina and Starčević, Vesna and Pfeiffer, Andreas F.H. and Al-Hasani, Hadi and Tschöp, Matthias H. and Castañeda, Tamara R.",
year = "2013",
abstract = "Signaling through the mammalian target of rapamycin complex 1 (mTORC1) and its effectors the S6-
kinases (S6K) in the hypothalamus is thought to be involved in nutrient sensing and control of food
intake. Given the anatomical proximity of this pathway to circuits for the hormone ghrelin, we investigated
the potential role of the mTORC1/S6K pathway in mediating the metabolic effects of ghrelin. We
found that ghrelin promoted phosphorylation of S6K1 in the mouse hypothalamic cell line N-41 and in
the rat hypothalamus after intracerebroventricular administration. Rapamycin, an inhibitor of mTORC1,
suppressed ghrelin-induced phosphorylation of hypothalamic S6K1 and increased food intake and insulin
in rats. Chronic peripheral administration of ghrelin induced a significant increase in body weight, fat
mass and food efficiency in wild-type and S6K2-knockout but not in S6K1-knockout mice. We therefore
propose that ghrelin-induced hyperphagia, adiposity and insulin secretion are controlled by a central nervous system involving the mTORC1/S6K1 pathway.",
publisher = "Elsevier",
journal = "Molecular and Cellular Endocrinology",
title = "Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling",
number = "1-2",
volume = "381",
doi = "10.1016/j.mce.2013.08.009",
pages = "280-290"
}

Stevanović, D., Trajković, V., Müller-Lühlhoff, S., Brandt, E., Abplanalp, W., Bumke-Vogt, C., Liehl, B., Wiedmer, P., Janjetović, K., Starčević, V., Pfeiffer, A. F.H., Al-Hasani, H., Tschöp, M. H.,& Castañeda, T. R.. (2013). Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling. in Molecular and Cellular Endocrinology
Elsevier., 381(1-2), 280-290.
https://doi.org/10.1016/j.mce.2013.08.009

Stevanović D, Trajković V, Müller-Lühlhoff S, Brandt E, Abplanalp W, Bumke-Vogt C, Liehl B, Wiedmer P, Janjetović K, Starčević V, Pfeiffer AF, Al-Hasani H, Tschöp MH, Castañeda TR. Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling. in Molecular and Cellular Endocrinology. 2013;381(1-2):280-290.
doi:10.1016/j.mce.2013.08.009 .

Stevanović, Darko, Trajković, Vladimir, Müller-Lühlhoff, Sabrina, Brandt, Elisabeth, Abplanalp, William, Bumke-Vogt, Christiane, Liehl, Beate, Wiedmer, Petra, Janjetović, Kristina, Starčević, Vesna, Pfeiffer, Andreas F.H., Al-Hasani, Hadi, Tschöp, Matthias H., Castañeda, Tamara R., "Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling" in Molecular and Cellular Endocrinology, 381, no. 1-2 (2013):280-290,
https://doi.org/10.1016/j.mce.2013.08.009 . .