TY  - JOUR
AU  - Popov Aleksandrov, Aleksandra
AU  - Belij-Rammerstorfer, Sandra
AU  - Mirkov, Ivana
AU  - Subota, Vesna
AU  - Kulaš, Jelena
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2018
UR  - https://www.tandfonline.com/doi/full/10.1080/15569527.2017.1328690
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2764
AB  - Purpose: The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy. Materials and methods: Rats received 3.5 mg/l of WF sodium in drinking water for 30 days and were thereafter skin-sensitized with 0.4% DNCB. Changes in the oxidative activity (myeloperoxidase/MPO, reduction of nitroblue tetrazolium/NBT and nitric oxide/NO production) as well as tumor necrosis factor (TNF) production by peripheral blood polymorphonuclear cells (PMN) were measured and compared with PMN from sensitized unexposed to WF rats. Results: WF intake enhanced some aspects of PMN activity (intracellular MPO activity and unstimulated NO production) as well as their responsiveness to exogenous stimulation (NBT reduction and TNF production from sensitized animals). However, WF also decreased PMN responsiveness of NO production to stimulation. WF affected NO and TNF production solely by PMN, as no effect on these activities of peripheral blood mononuclear cells was seen. Conclusion: Having in mind that polymorphonuclear leukocytes are the most abundant cell type in peripheral blood in humans, increase of basic aspects of PMN activity described in the present paper might be relevant for consideration of using WF as therapeutic modality in patients topically treated with DNCB.
T2  - Cutaneous and Ocular Toxicology
T1  - Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats
IS  - 1
VL  - 37
DO  - 10.1080/15569527.2017.1328690
SP  - 29
EP  - 35
ER  - 

@article{
author = "Popov Aleksandrov, Aleksandra and Belij-Rammerstorfer, Sandra and Mirkov, Ivana and Subota, Vesna and Kulaš, Jelena and Kataranovski, Dragan and Kataranovski, Milena",
year = "2018",
abstract = "Purpose: The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment of some skin dermatoses is based both on local and systemic effects. It is not known, however, whether it can be applied to patients receiving some other therapy associated with systemic immunomodulation. The aim of the present paper using a rat model was to examine whether oral warfarin (WF) intake, as shown by others and by us, had an immunomodulatory potential to interfere with effects of topical DNCB as systemic immunotherapy. Materials and methods: Rats received 3.5 mg/l of WF sodium in drinking water for 30 days and were thereafter skin-sensitized with 0.4% DNCB. Changes in the oxidative activity (myeloperoxidase/MPO, reduction of nitroblue tetrazolium/NBT and nitric oxide/NO production) as well as tumor necrosis factor (TNF) production by peripheral blood polymorphonuclear cells (PMN) were measured and compared with PMN from sensitized unexposed to WF rats. Results: WF intake enhanced some aspects of PMN activity (intracellular MPO activity and unstimulated NO production) as well as their responsiveness to exogenous stimulation (NBT reduction and TNF production from sensitized animals). However, WF also decreased PMN responsiveness of NO production to stimulation. WF affected NO and TNF production solely by PMN, as no effect on these activities of peripheral blood mononuclear cells was seen. Conclusion: Having in mind that polymorphonuclear leukocytes are the most abundant cell type in peripheral blood in humans, increase of basic aspects of PMN activity described in the present paper might be relevant for consideration of using WF as therapeutic modality in patients topically treated with DNCB.",
journal = "Cutaneous and Ocular Toxicology",
title = "Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats",
number = "1",
volume = "37",
doi = "10.1080/15569527.2017.1328690",
pages = "29-35"
}

Popov Aleksandrov, A., Belij-Rammerstorfer, S., Mirkov, I., Subota, V., Kulaš, J., Kataranovski, D.,& Kataranovski, M.. (2018). Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology, 37(1), 29-35.
https://doi.org/10.1080/15569527.2017.1328690

Popov Aleksandrov A, Belij-Rammerstorfer S, Mirkov I, Subota V, Kulaš J, Kataranovski D, Kataranovski M. Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats. in Cutaneous and Ocular Toxicology. 2018;37(1):29-35.
doi:10.1080/15569527.2017.1328690 .

Popov Aleksandrov, Aleksandra, Belij-Rammerstorfer, Sandra, Mirkov, Ivana, Subota, Vesna, Kulaš, Jelena, Kataranovski, Dragan, Kataranovski, Milena, "Oral warfarin affects some aspects of systemic immunomodulation with topical dinitrochlorobenzene (DNCB) in rats" in Cutaneous and Ocular Toxicology, 37, no. 1 (2018):29-35,
https://doi.org/10.1080/15569527.2017.1328690 . .

TY  - JOUR
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Ninkov, Marina
AU  - Mileusnić, Dina
AU  - Demenesku, Jelena
AU  - Zolotarevski, Lidija
AU  - Subota, Vesna
AU  - Stefik, Debora
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4813
AB  - Intestinal hemorrhage characterizes effectiveness of warfarin (WF) as rodenticide and is amongadverse effects of therapy in humans. Having in mind genetic variations in the effectiveness ofWF in wild rats and in the doses required for therapeutic effect, strain differences in the intestinaltoxicity of oral warfarin in rats were examined in this study. High WF dose (3.5 mg/l) led tomortality in Albino Oxford (AO) rats, with no lethality in Dark Agouti (DA) rats. Higher valuesof prothrombin time were noted at low WF dose (0.35 mg/l) in the former strain. Leukocyteinfiltration in intestine noted at this dose in both strains was associated with oxidative injury andmore pronounced anti-oxidative response in AO rats. Suppression of mesenteric lymph node cellproliferation and IFN-γ and IL-10 production in AO rats and lack of these effects in DA rats,represent different strategies to protect vulnerable intestine from harmful immune responses.
PB  - Amsterdam, Holland:Elsevier B.V.
T2  - Environmental Toxicology and Pharmacology
T1  - Strain differences in intestinal toxicity of warfarin in rats
VL  - 48
DO  - 10.1016/j.etap.2016.10.019
SP  - 175
EP  - 182
ER  - 

@article{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Ninkov, Marina and Mileusnić, Dina and Demenesku, Jelena and Zolotarevski, Lidija and Subota, Vesna and Stefik, Debora and Kataranovski, Dragan and Kataranovski, Milena",
year = "2016",
abstract = "Intestinal hemorrhage characterizes effectiveness of warfarin (WF) as rodenticide and is amongadverse effects of therapy in humans. Having in mind genetic variations in the effectiveness ofWF in wild rats and in the doses required for therapeutic effect, strain differences in the intestinaltoxicity of oral warfarin in rats were examined in this study. High WF dose (3.5 mg/l) led tomortality in Albino Oxford (AO) rats, with no lethality in Dark Agouti (DA) rats. Higher valuesof prothrombin time were noted at low WF dose (0.35 mg/l) in the former strain. Leukocyteinfiltration in intestine noted at this dose in both strains was associated with oxidative injury andmore pronounced anti-oxidative response in AO rats. Suppression of mesenteric lymph node cellproliferation and IFN-γ and IL-10 production in AO rats and lack of these effects in DA rats,represent different strategies to protect vulnerable intestine from harmful immune responses.",
publisher = "Amsterdam, Holland:Elsevier B.V.",
journal = "Environmental Toxicology and Pharmacology",
title = "Strain differences in intestinal toxicity of warfarin in rats",
volume = "48",
doi = "10.1016/j.etap.2016.10.019",
pages = "175-182"
}

Mirkov, I., Popov Aleksandrov, A., Ninkov, M., Mileusnić, D., Demenesku, J., Zolotarevski, L., Subota, V., Stefik, D., Kataranovski, D.,& Kataranovski, M.. (2016). Strain differences in intestinal toxicity of warfarin in rats. in Environmental Toxicology and Pharmacology
Amsterdam, Holland:Elsevier B.V.., 48, 175-182.
https://doi.org/10.1016/j.etap.2016.10.019

Mirkov I, Popov Aleksandrov A, Ninkov M, Mileusnić D, Demenesku J, Zolotarevski L, Subota V, Stefik D, Kataranovski D, Kataranovski M. Strain differences in intestinal toxicity of warfarin in rats. in Environmental Toxicology and Pharmacology. 2016;48:175-182.
doi:10.1016/j.etap.2016.10.019 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Ninkov, Marina, Mileusnić, Dina, Demenesku, Jelena, Zolotarevski, Lidija, Subota, Vesna, Stefik, Debora, Kataranovski, Dragan, Kataranovski, Milena, "Strain differences in intestinal toxicity of warfarin in rats" in Environmental Toxicology and Pharmacology, 48 (2016):175-182,
https://doi.org/10.1016/j.etap.2016.10.019 . .

TY  - JOUR
AU  - Subota, Vesna
AU  - Mirkov, Ivana
AU  - Demenesku, Jelena
AU  - Popov Aleksandrov, Aleksandra
AU  - Ninkov, Marina
AU  - Mileusnić, Dina
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4814
AB  - Occupational/accidental exposure data have showed hemorrhage as a result of transdermal exposure to
warfarin, however, other effects are not known. In the present study, the impact of epicutaneous application of 10 g or 100 g of warfarin (three times, once a day) on peripheral blood polymorphonuclear
(PMN) and mononuclear cells (PBMC) was examined in rats. Both doses resulted in prolongation of prothrombin time and changes in hematologic parameters. Increases in PMN intracellular myeloperoxidase
(MPO) activity were seen at higher warfarin dose and both doses resulted in higher percentages of granular CD11b+ cells. In contrast, a decrease in PMN TNF and IL-6 production (ELISA) and gene expression
(RT-PCR) was observed. Epicutaneous application of warfarin resulted in decreased numbers of PBMC,
higher numbers of mononuclear CD11b+ cells, but without effect on PMBC cytokine production. The data
obtained showed differential effects of transdermal exposure to warfarin depending on leukocyte type
and activity.
PB  - Amsterdam : Elsevier
T2  - Environmental Toxicology and Pharmacology
T1  - Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats
VL  - 41
DO  - 10.1016/j.etap.2015.12.006
SP  - 232
EP  - 240
ER  - 

@article{
author = "Subota, Vesna and Mirkov, Ivana and Demenesku, Jelena and Popov Aleksandrov, Aleksandra and Ninkov, Marina and Mileusnić, Dina and Kataranovski, Dragan and Kataranovski, Milena",
year = "2016",
abstract = "Occupational/accidental exposure data have showed hemorrhage as a result of transdermal exposure to
warfarin, however, other effects are not known. In the present study, the impact of epicutaneous application of 10 g or 100 g of warfarin (three times, once a day) on peripheral blood polymorphonuclear
(PMN) and mononuclear cells (PBMC) was examined in rats. Both doses resulted in prolongation of prothrombin time and changes in hematologic parameters. Increases in PMN intracellular myeloperoxidase
(MPO) activity were seen at higher warfarin dose and both doses resulted in higher percentages of granular CD11b+ cells. In contrast, a decrease in PMN TNF and IL-6 production (ELISA) and gene expression
(RT-PCR) was observed. Epicutaneous application of warfarin resulted in decreased numbers of PBMC,
higher numbers of mononuclear CD11b+ cells, but without effect on PMBC cytokine production. The data
obtained showed differential effects of transdermal exposure to warfarin depending on leukocyte type
and activity.",
publisher = "Amsterdam : Elsevier",
journal = "Environmental Toxicology and Pharmacology",
title = "Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats",
volume = "41",
doi = "10.1016/j.etap.2015.12.006",
pages = "232-240"
}

Subota, V., Mirkov, I., Demenesku, J., Popov Aleksandrov, A., Ninkov, M., Mileusnić, D., Kataranovski, D.,& Kataranovski, M.. (2016). Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats. in Environmental Toxicology and Pharmacology
Amsterdam : Elsevier., 41, 232-240.
https://doi.org/10.1016/j.etap.2015.12.006

Subota V, Mirkov I, Demenesku J, Popov Aleksandrov A, Ninkov M, Mileusnić D, Kataranovski D, Kataranovski M. Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats. in Environmental Toxicology and Pharmacology. 2016;41:232-240.
doi:10.1016/j.etap.2015.12.006 .

Subota, Vesna, Mirkov, Ivana, Demenesku, Jelena, Popov Aleksandrov, Aleksandra, Ninkov, Marina, Mileusnić, Dina, Kataranovski, Dragan, Kataranovski, Milena, "Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats" in Environmental Toxicology and Pharmacology, 41 (2016):232-240,
https://doi.org/10.1016/j.etap.2015.12.006 . .

TY  - CONF
AU  - Mirkov, Ivana
AU  - Popov Aleksandrov, Aleksandra
AU  - Demenesku, Jelena
AU  - Ninkov, Marina
AU  - Mileusnić, Dina
AU  - Zolotarevski, Lidija
AU  - Subota, Vesna
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4853
AB  - Warfarin is an anticoagulant that is widely used in the prevention and treatment of thromboembolic disorders in humans. Numerous side effects of oral therapy with this agent are known, which has led to the recommendation for transdermal administration of this agent. This study examined the effect of oral warfarin consumption (0.35 mg / l and 3.5 mg / l in drinking water, 30 days) on the intestinal immune system in rats, as well as the systemic effect (on peripheral blood leukocytes) of epicutaneous administration of this agent. µg or 100 µg, once a day, for three days).The anticoagulant effect, determined on the basis of the increase in prothrombin time, was observed after oral consumption of both doses, as well as after epicutaneous application. Orally administered warfarin leads to histologically evident damage to intestinal tissue and inflammation (cellular infiltration, myeloperoxidase activity, malodialdehyde content and superoxide dismutase and catalase activities), as well as increased concentrations of proinflammatory cytokines (IFN-γ, IL-17) in intestinal homogenate.In mesenteric lymph nodes, however, suppression of the immune response has been observed (decreased ability of cells to proliferate and produce IFN-γ and IL-17 in response to cannavalin A stimulation). Decreased production of IL-10 by mesenteric lymph node cells indicates the formation of a microenvironment that does not allow the activation of a potentially harmful immune response in this tissue. Epicutaneous administration of a higher dose of warfarin leads to an increase in the number of neutrophilic leukocytes and intracellular myeloperoxidase activity, as well as an increase in granular CD11b + cells. In contrast to this increase, a decrease in TNF and IL-6 production as well as mRNA levels for these cytokines was observed.After administration of a higher dose of warfarin, there is a decrease in the number of mononuclear cells with an increase in the presence of CD11b + in this population, but without an effect on cytokine production, indicating the differential effects of transdermal administration of warfarin. Taken together, the results indicate the need to monitor the (adverse) effects of warfarin therapy.
PB  - Belgrade: Immunological Society of Serbia
C3  - VII Naučni sastanak Društva imunologa Srbije, Belgrade, Serbia, 27-28 april 2016, Knjiga apstrakata
T1  - Immunomodulating effect of oral and transdermal varfarine therapy
T1  - Imunomodulatorni efekti oralne i transdermalne terapije varfarinom
SP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4853
ER  - 

@conference{
author = "Mirkov, Ivana and Popov Aleksandrov, Aleksandra and Demenesku, Jelena and Ninkov, Marina and Mileusnić, Dina and Zolotarevski, Lidija and Subota, Vesna and Kataranovski, Dragan and Kataranovski, Milena",
year = "2016",
abstract = "Warfarin is an anticoagulant that is widely used in the prevention and treatment of thromboembolic disorders in humans. Numerous side effects of oral therapy with this agent are known, which has led to the recommendation for transdermal administration of this agent. This study examined the effect of oral warfarin consumption (0.35 mg / l and 3.5 mg / l in drinking water, 30 days) on the intestinal immune system in rats, as well as the systemic effect (on peripheral blood leukocytes) of epicutaneous administration of this agent. µg or 100 µg, once a day, for three days).The anticoagulant effect, determined on the basis of the increase in prothrombin time, was observed after oral consumption of both doses, as well as after epicutaneous application. Orally administered warfarin leads to histologically evident damage to intestinal tissue and inflammation (cellular infiltration, myeloperoxidase activity, malodialdehyde content and superoxide dismutase and catalase activities), as well as increased concentrations of proinflammatory cytokines (IFN-γ, IL-17) in intestinal homogenate.In mesenteric lymph nodes, however, suppression of the immune response has been observed (decreased ability of cells to proliferate and produce IFN-γ and IL-17 in response to cannavalin A stimulation). Decreased production of IL-10 by mesenteric lymph node cells indicates the formation of a microenvironment that does not allow the activation of a potentially harmful immune response in this tissue. Epicutaneous administration of a higher dose of warfarin leads to an increase in the number of neutrophilic leukocytes and intracellular myeloperoxidase activity, as well as an increase in granular CD11b + cells. In contrast to this increase, a decrease in TNF and IL-6 production as well as mRNA levels for these cytokines was observed.After administration of a higher dose of warfarin, there is a decrease in the number of mononuclear cells with an increase in the presence of CD11b + in this population, but without an effect on cytokine production, indicating the differential effects of transdermal administration of warfarin. Taken together, the results indicate the need to monitor the (adverse) effects of warfarin therapy.",
publisher = "Belgrade: Immunological Society of Serbia",
journal = "VII Naučni sastanak Društva imunologa Srbije, Belgrade, Serbia, 27-28 april 2016, Knjiga apstrakata",
title = "Immunomodulating effect of oral and transdermal varfarine therapy, Imunomodulatorni efekti oralne i transdermalne terapije varfarinom",
pages = "33",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4853"
}

Mirkov, I., Popov Aleksandrov, A., Demenesku, J., Ninkov, M., Mileusnić, D., Zolotarevski, L., Subota, V., Kataranovski, D.,& Kataranovski, M.. (2016). Immunomodulating effect of oral and transdermal varfarine therapy. in VII Naučni sastanak Društva imunologa Srbije, Belgrade, Serbia, 27-28 april 2016, Knjiga apstrakata
Belgrade: Immunological Society of Serbia., 33.
https://hdl.handle.net/21.15107/rcub_ibiss_4853

Mirkov I, Popov Aleksandrov A, Demenesku J, Ninkov M, Mileusnić D, Zolotarevski L, Subota V, Kataranovski D, Kataranovski M. Immunomodulating effect of oral and transdermal varfarine therapy. in VII Naučni sastanak Društva imunologa Srbije, Belgrade, Serbia, 27-28 april 2016, Knjiga apstrakata. 2016;:33.
https://hdl.handle.net/21.15107/rcub_ibiss_4853 .

Mirkov, Ivana, Popov Aleksandrov, Aleksandra, Demenesku, Jelena, Ninkov, Marina, Mileusnić, Dina, Zolotarevski, Lidija, Subota, Vesna, Kataranovski, Dragan, Kataranovski, Milena, "Immunomodulating effect of oral and transdermal varfarine therapy" in VII Naučni sastanak Društva imunologa Srbije, Belgrade, Serbia, 27-28 april 2016, Knjiga apstrakata (2016):33,
https://hdl.handle.net/21.15107/rcub_ibiss_4853 .

TY  - CONF
AU  - Demenesku, Jelena
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Popov Aleksandrov, Aleksandra
AU  - Zolotarevski, Lidija
AU  - Subota, Vesna
AU  - Mileusnić, Dina
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/4808
AB  - Introduction: Conflicting data (suppression, augmentation, no effect) exist concerning cadmium (Cd) effects on immune system depending on activity and tissue examined. This study
investigates responses to acute Cd intoxication in three compartments (peripheral blood, spleen and lungs) in Dark Agouti (DA) and Albino Oxford (AO) rats, which are differently
susceptible to variety of stimuli.
Materials and Methods: Systemic (IL-6, TNF, acute phase proteins) and tissue responses [cell stress (metallothionein/MT gene expression), CD11b expression, and cytokine (IFN-γ,
IL-17, IL-10) production and mRNA expression] were measured following intraperitoneal (1 mg/kg) Cd administration.
Results: Cd induces systemic inflammatory response with similar intensity in both rat strains. Increase in Cd spleen content and MT expression evident in both strains (higher in DA
compared to AO rats) was followed by increase in neutrophil infiltration and CD11b expression (with same intensity). Although in both strains Cd caused decreased IFN-γ, unchanged
IL-17 and lower IL-10 responsiveness (compared to respective control), decrease of IFN-γ was more intense in DA compared to AO rats. In lungs of both strains increased Cd deposition
and MT expression (higher in AO) as well as neutrophil infiltration and CD11b expression (greater in DA) was observed. While decreased IFN-γ was noted in both strains, lower IL-17
and IL-10 (vs. controls) were evident in DA rats solely.
Conclusions: Acute Cd intoxication exerts strain-related effects (both inflammatory and immunosuppressive) depending on tissue and activity investigated, but the effects are more
pronounced in DA rats.
PB  - European Federation of Immunological Societies
C3  - 4th European Congress of Immunology, September 6-9, 2015, Vienna, Austria, p 353.
T1  - Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue
SP  - 353
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_4808
ER  - 

@conference{
author = "Demenesku, Jelena and Mirkov, Ivana and Ninkov, Marina and Popov Aleksandrov, Aleksandra and Zolotarevski, Lidija and Subota, Vesna and Mileusnić, Dina and Kataranovski, Dragan and Kataranovski, Milena",
year = "2015",
abstract = "Introduction: Conflicting data (suppression, augmentation, no effect) exist concerning cadmium (Cd) effects on immune system depending on activity and tissue examined. This study
investigates responses to acute Cd intoxication in three compartments (peripheral blood, spleen and lungs) in Dark Agouti (DA) and Albino Oxford (AO) rats, which are differently
susceptible to variety of stimuli.
Materials and Methods: Systemic (IL-6, TNF, acute phase proteins) and tissue responses [cell stress (metallothionein/MT gene expression), CD11b expression, and cytokine (IFN-γ,
IL-17, IL-10) production and mRNA expression] were measured following intraperitoneal (1 mg/kg) Cd administration.
Results: Cd induces systemic inflammatory response with similar intensity in both rat strains. Increase in Cd spleen content and MT expression evident in both strains (higher in DA
compared to AO rats) was followed by increase in neutrophil infiltration and CD11b expression (with same intensity). Although in both strains Cd caused decreased IFN-γ, unchanged
IL-17 and lower IL-10 responsiveness (compared to respective control), decrease of IFN-γ was more intense in DA compared to AO rats. In lungs of both strains increased Cd deposition
and MT expression (higher in AO) as well as neutrophil infiltration and CD11b expression (greater in DA) was observed. While decreased IFN-γ was noted in both strains, lower IL-17
and IL-10 (vs. controls) were evident in DA rats solely.
Conclusions: Acute Cd intoxication exerts strain-related effects (both inflammatory and immunosuppressive) depending on tissue and activity investigated, but the effects are more
pronounced in DA rats.",
publisher = "European Federation of Immunological Societies",
journal = "4th European Congress of Immunology, September 6-9, 2015, Vienna, Austria, p 353.",
title = "Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue",
pages = "353",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4808"
}

Demenesku, J., Mirkov, I., Ninkov, M., Popov Aleksandrov, A., Zolotarevski, L., Subota, V., Mileusnić, D., Kataranovski, D.,& Kataranovski, M.. (2015). Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue. in 4th European Congress of Immunology, September 6-9, 2015, Vienna, Austria, p 353.
European Federation of Immunological Societies., 353.
https://hdl.handle.net/21.15107/rcub_ibiss_4808

Demenesku J, Mirkov I, Ninkov M, Popov Aleksandrov A, Zolotarevski L, Subota V, Mileusnić D, Kataranovski D, Kataranovski M. Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue. in 4th European Congress of Immunology, September 6-9, 2015, Vienna, Austria, p 353.. 2015;:353.
https://hdl.handle.net/21.15107/rcub_ibiss_4808 .

Demenesku, Jelena, Mirkov, Ivana, Ninkov, Marina, Popov Aleksandrov, Aleksandra, Zolotarevski, Lidija, Subota, Vesna, Mileusnić, Dina, Kataranovski, Dragan, Kataranovski, Milena, "Strain differences in sterile inflammation and immune suppression induced by acute cadmium administration in rats depend on the affected activity and tissue" in 4th European Congress of Immunology, September 6-9, 2015, Vienna, Austria, p 353. (2015):353,
https://hdl.handle.net/21.15107/rcub_ibiss_4808 .

TY  - JOUR
AU  - Đokić, Jelena
AU  - Ninkov, Marina
AU  - Popov Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Subota, Vesna
AU  - Mihajlović, Luka
AU  - Stojadinović, Marija
AU  - Stanić-Vučinić, Dragana
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2013
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/566
AB  - Warfarin (3-(α-acetonylbenzyl)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-γ production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy.
AB  - Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.
T2  - Journal of the Serbian Chemical Society
T1  - Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova
T1  - Strain differences in the toxicity of the vitamin K antagonist warfarin in rats
IS  - 3
VL  - 78
SP  - 381
EP  - 394
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_566
ER  - 

@article{
author = "Đokić, Jelena and Ninkov, Marina and Popov Aleksandrov, Aleksandra and Mirkov, Ivana and Subota, Vesna and Mihajlović, Luka and Stojadinović, Marija and Stanić-Vučinić, Dragana and Kataranovski, Dragan and Kataranovski, Milena",
year = "2013, 2013",
abstract = "Warfarin (3-(α-acetonylbenzyl)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-γ production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy., Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.",
journal = "Journal of the Serbian Chemical Society",
title = "Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova, Strain differences in the toxicity of the vitamin K antagonist warfarin in rats",
number = "3",
volume = "78",
pages = "381-394",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_566"
}

Đokić, J., Ninkov, M., Popov Aleksandrov, A., Mirkov, I., Subota, V., Mihajlović, L., Stojadinović, M., Stanić-Vučinić, D., Kataranovski, D.,& Kataranovski, M.. (2013). Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova. in Journal of the Serbian Chemical Society, 78(3), 381-394.
https://hdl.handle.net/21.15107/rcub_ibiss_566

Đokić J, Ninkov M, Popov Aleksandrov A, Mirkov I, Subota V, Mihajlović L, Stojadinović M, Stanić-Vučinić D, Kataranovski D, Kataranovski M. Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova. in Journal of the Serbian Chemical Society. 2013;78(3):381-394.
https://hdl.handle.net/21.15107/rcub_ibiss_566 .

Đokić, Jelena, Ninkov, Marina, Popov Aleksandrov, Aleksandra, Mirkov, Ivana, Subota, Vesna, Mihajlović, Luka, Stojadinović, Marija, Stanić-Vučinić, Dragana, Kataranovski, Dragan, Kataranovski, Milena, "Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova" in Journal of the Serbian Chemical Society, 78, no. 3 (2013):381-394,
https://hdl.handle.net/21.15107/rcub_ibiss_566 .