TY  - JOUR
AU  - Mihajlović, Ljiljana E
AU  - Savić, Aleksandar R
AU  - Poljarević, Jelena M
AU  - Vucković, Ivan M
AU  - Mojić, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava
AU  - Miljković, Đorđe
AU  - Grgurić-Sipka, Sanja R
AU  - Sabo, Tibor J
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1195
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
IS  - null
VL  - 109
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1195
ER  - 

@article{
author = "Mihajlović, Ljiljana E and Savić, Aleksandar R and Poljarević, Jelena M and Vucković, Ivan M and Mojić, Marija and Bulatović, Mirna Z. and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava and Miljković, Đorđe and Grgurić-Sipka, Sanja R and Sabo, Tibor J",
year = "2012",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
number = "null",
volume = "109",
pages = "48",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1195"
}

Mihajlović, L. E., Savić, A. R., Poljarević, J. M., Vucković, I. M., Mojić, M., Bulatović, M. Z., Maksimović-Ivanić, D., Mijatović, S., Kaluđerović, G. N., Stošić-Grujičić, S., Miljković, Đ., Grgurić-Sipka, S. R.,& Sabo, T. J.. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry, 109(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1195

Mihajlović LE, Savić AR, Poljarević JM, Vucković IM, Mojić M, Bulatović MZ, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN, Stošić-Grujičić S, Miljković Đ, Grgurić-Sipka SR, Sabo TJ. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. in Journal of Inorganic Biochemistry. 2012;109(null):null-48.
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

Mihajlović, Ljiljana E, Savić, Aleksandar R, Poljarević, Jelena M, Vucković, Ivan M, Mojić, Marija, Bulatović, Mirna Z., Maksimović-Ivanić, Danijela, Mijatović, Sanja, Kaluđerović, Goran N., Stošić-Grujičić, Stanislava, Miljković, Đorđe, Grgurić-Sipka, Sanja R, Sabo, Tibor J, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" in Journal of Inorganic Biochemistry, 109, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1195 .

TY  - JOUR
AU  - Savković, Uroš
AU  - Vucković, Ivan M
AU  - Stojković, Biljana
PY  - 2012
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1165
AB  - Acanthoscelides obtectus (Say) (Coleoptera: Chrysomelidae: Bruchinae) is a widespread pest of stored products from Fabaceae family. The evolution of this species is associated with common bean domestication and the ability to invade other hosts in storages. To analyze the role of diverse nutrition in the ability of insects to shift to another host species we tested the effects of nutrition history on composition of cuticular hydrocarbons (CHCs), the compounds that have various ecological and reproductive functions in insects. The study was performed on A. obtectus laboratory populations which were bred for 51 generations either on common bean, Phaseolus vulgaris (L), or on chickpea, Cicer arietinum (L), a novel and less suitable species for larval development. To obtain conclusions about short-term nutritional effects, we tested whether exposure of seed weevils to alternative hosts for just one generation might influence CHC composition. Gas chromatography and gas chromatography-mass spectrometry analyses were performed and compounds' relative abundances were computed from the corresponding GC-FID peak areas. A total of 21 compounds were identified, among which 38% showed significant abundance differences between selection regimes and for 33% of compounds short-term developmental effects were revealed. All except three compounds showed significant differences between genders. We hypothesized that long-term changes in quantitative levels of specific CHC compounds were the results of diverse selection pressures on weevils' metabolic pathways induced by chemically divergent hosts. However, long-term adaptations to host species did not influence the ability of A. obtectus to quickly respond to chemical specificities of novel hosts (i.e., short-term effects were significant) which could be one of the major reasons for the great expansiveness of this species. Differences in relative CHCs abundances between sexes implied their roles in chemical communication and mate recognition systems. (C) 2012 Elsevier Ltd. All rights reserved.
T2  - Journal of Stored Products Research
T1  - The growth on different stored legume species affects the profiles of cuticular hydrocarbon (CHC) in Acanthoscelides obtectus (Say)
IS  - null
VL  - 50
EP  - 72
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1165
ER  - 

@article{
author = "Savković, Uroš and Vucković, Ivan M and Stojković, Biljana",
year = "2012",
abstract = "Acanthoscelides obtectus (Say) (Coleoptera: Chrysomelidae: Bruchinae) is a widespread pest of stored products from Fabaceae family. The evolution of this species is associated with common bean domestication and the ability to invade other hosts in storages. To analyze the role of diverse nutrition in the ability of insects to shift to another host species we tested the effects of nutrition history on composition of cuticular hydrocarbons (CHCs), the compounds that have various ecological and reproductive functions in insects. The study was performed on A. obtectus laboratory populations which were bred for 51 generations either on common bean, Phaseolus vulgaris (L), or on chickpea, Cicer arietinum (L), a novel and less suitable species for larval development. To obtain conclusions about short-term nutritional effects, we tested whether exposure of seed weevils to alternative hosts for just one generation might influence CHC composition. Gas chromatography and gas chromatography-mass spectrometry analyses were performed and compounds' relative abundances were computed from the corresponding GC-FID peak areas. A total of 21 compounds were identified, among which 38% showed significant abundance differences between selection regimes and for 33% of compounds short-term developmental effects were revealed. All except three compounds showed significant differences between genders. We hypothesized that long-term changes in quantitative levels of specific CHC compounds were the results of diverse selection pressures on weevils' metabolic pathways induced by chemically divergent hosts. However, long-term adaptations to host species did not influence the ability of A. obtectus to quickly respond to chemical specificities of novel hosts (i.e., short-term effects were significant) which could be one of the major reasons for the great expansiveness of this species. Differences in relative CHCs abundances between sexes implied their roles in chemical communication and mate recognition systems. (C) 2012 Elsevier Ltd. All rights reserved.",
journal = "Journal of Stored Products Research",
title = "The growth on different stored legume species affects the profiles of cuticular hydrocarbon (CHC) in Acanthoscelides obtectus (Say)",
number = "null",
volume = "50",
pages = "72",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1165"
}

Savković, U., Vucković, I. M.,& Stojković, B.. (2012). The growth on different stored legume species affects the profiles of cuticular hydrocarbon (CHC) in Acanthoscelides obtectus (Say). in Journal of Stored Products Research, 50(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1165

Savković U, Vucković IM, Stojković B. The growth on different stored legume species affects the profiles of cuticular hydrocarbon (CHC) in Acanthoscelides obtectus (Say). in Journal of Stored Products Research. 2012;50(null):null-72.
https://hdl.handle.net/21.15107/rcub_ibiss_1165 .

Savković, Uroš, Vucković, Ivan M, Stojković, Biljana, "The growth on different stored legume species affects the profiles of cuticular hydrocarbon (CHC) in Acanthoscelides obtectus (Say)" in Journal of Stored Products Research, 50, no. null (2012),
https://hdl.handle.net/21.15107/rcub_ibiss_1165 .

TY  - JOUR
AU  - Janacković, Peđa T
AU  - Soković, Marina
AU  - Vujisić, Ljubodrag V
AU  - Vajs, Vlatka E
AU  - Vucković, Ivan M
AU  - Krivosej, Zoran Đ
AU  - Marin, Petar D
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1275
AB  - The essential oil from aerial parts of Seseli globiferum Vis. obtained by hydrodistillation with Clevenger-type apparatus was analyzed by GC-MS. Twenty-eight compounds were identified, representing 99.4% of the total oil. The main components of the oil were sabinene (38.0%), alpha-pinene (21.2%) and beta-phellandrene (13.5%). The microbial growth inhibitory properties of the isolated essential oil were determined using the broth microdilution method against seven bacterial species: Salmonella typhimurium (ATCC 13311), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterobacter cloacae (clinical isolates), Bacillus cereus (clinical isolates), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Micrococcus flaw's (ATCC 10240) and three fungal species: Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Trichoderma viride (IAM 5061) and Penicillium funiculosum (ATCC 36839). The essential oil showed activity against bacteria P. aeruginosa, followed by M flavus, L. monocytigenes and E. coli, and all investigated fungal species.
T2  - Natural Product Communications
T1  - Composition and Antimicrobial Activity of Seseli globiferum Essential Oil
IS  - 8
VL  - 6
EP  - 1166
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1275
ER  - 

@article{
author = "Janacković, Peđa T and Soković, Marina and Vujisić, Ljubodrag V and Vajs, Vlatka E and Vucković, Ivan M and Krivosej, Zoran Đ and Marin, Petar D",
year = "2011",
abstract = "The essential oil from aerial parts of Seseli globiferum Vis. obtained by hydrodistillation with Clevenger-type apparatus was analyzed by GC-MS. Twenty-eight compounds were identified, representing 99.4% of the total oil. The main components of the oil were sabinene (38.0%), alpha-pinene (21.2%) and beta-phellandrene (13.5%). The microbial growth inhibitory properties of the isolated essential oil were determined using the broth microdilution method against seven bacterial species: Salmonella typhimurium (ATCC 13311), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterobacter cloacae (clinical isolates), Bacillus cereus (clinical isolates), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Micrococcus flaw's (ATCC 10240) and three fungal species: Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Trichoderma viride (IAM 5061) and Penicillium funiculosum (ATCC 36839). The essential oil showed activity against bacteria P. aeruginosa, followed by M flavus, L. monocytigenes and E. coli, and all investigated fungal species.",
journal = "Natural Product Communications",
title = "Composition and Antimicrobial Activity of Seseli globiferum Essential Oil",
number = "8",
volume = "6",
pages = "1166",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1275"
}

Janacković, P. T., Soković, M., Vujisić, L. V., Vajs, V. E., Vucković, I. M., Krivosej, Z. Đ.,& Marin, P. D.. (2011). Composition and Antimicrobial Activity of Seseli globiferum Essential Oil. in Natural Product Communications, 6(8).
https://hdl.handle.net/21.15107/rcub_ibiss_1275

Janacković PT, Soković M, Vujisić LV, Vajs VE, Vucković IM, Krivosej ZĐ, Marin PD. Composition and Antimicrobial Activity of Seseli globiferum Essential Oil. in Natural Product Communications. 2011;6(8):null-1166.
https://hdl.handle.net/21.15107/rcub_ibiss_1275 .

Janacković, Peđa T, Soković, Marina, Vujisić, Ljubodrag V, Vajs, Vlatka E, Vucković, Ivan M, Krivosej, Zoran Đ, Marin, Petar D, "Composition and Antimicrobial Activity of Seseli globiferum Essential Oil" in Natural Product Communications, 6, no. 8 (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1275 .