TY  - JOUR
AU  - Drulović, Jelena
AU  - Dujmović, Irena
AU  - Stojsavljević, Nebojša
AU  - Mesaroš, Šarlota
AU  - Anđelković, Slobodanka
AU  - Miljković, Đorđe
AU  - Perić, Vesna
AU  - Dragutinović, Gradimir
AU  - Marinković, Jelena
AU  - Lević, Zvonimir
AU  - Mostarica Stojković, Marija
PY  - 2001
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5995
AB  - The levels of uric acid (UA), a natural peroxynitrite scavenger, were measured in sera from 240 patients with multiple sclerosis (MS) and 104 sex- and age-matched control patients with other neurological diseases (OND). The mean serum UA concentration was lower in the MS than in the OND group, but the difference did not reach the level of statistical significance (P = 0.068). However, the mean serum UA level from patients with active MS (202.6 + 67.1 mumol/l) was significantly lower than that in inactive MS patients (226.5 + 78.6 mumol/l; P = 0.046) and OND controls (P = 0.007). We found a significant inverse correlation of serum UA concentration with female gender (P = 0.0001), disease activity (P = 0.012) and duration (P = 0.017), and a trend towards an inverse correlation with disability as assessed by EDSS score, which did not reach statistical significance (P = 0.067). Finally, multivariate linear regression analyses showed that UA concentration was independently correlated with gender (P = 0.0001), disease activity (P = 0.014) and duration of the disease (P = 0.043) in MS patients. These findings suggest that serum UA might serve as a possible marker of disease activity in MS. They also provide support to the potential beneficial therapeutic effect of radical-scavenging substances in MS.
PB  - Heidelberg: Springer
T2  - Journal of Neurology
T1  - Uric acid levels in sera from patients with multiple sclerosis
IS  - 2
VL  - 248
DO  - 10.1007/s004150170246
SP  - 121
EP  - 126
ER  - 

@article{
author = "Drulović, Jelena and Dujmović, Irena and Stojsavljević, Nebojša and Mesaroš, Šarlota and Anđelković, Slobodanka and Miljković, Đorđe and Perić, Vesna and Dragutinović, Gradimir and Marinković, Jelena and Lević, Zvonimir and Mostarica Stojković, Marija",
year = "2001",
abstract = "The levels of uric acid (UA), a natural peroxynitrite scavenger, were measured in sera from 240 patients with multiple sclerosis (MS) and 104 sex- and age-matched control patients with other neurological diseases (OND). The mean serum UA concentration was lower in the MS than in the OND group, but the difference did not reach the level of statistical significance (P = 0.068). However, the mean serum UA level from patients with active MS (202.6 + 67.1 mumol/l) was significantly lower than that in inactive MS patients (226.5 + 78.6 mumol/l; P = 0.046) and OND controls (P = 0.007). We found a significant inverse correlation of serum UA concentration with female gender (P = 0.0001), disease activity (P = 0.012) and duration (P = 0.017), and a trend towards an inverse correlation with disability as assessed by EDSS score, which did not reach statistical significance (P = 0.067). Finally, multivariate linear regression analyses showed that UA concentration was independently correlated with gender (P = 0.0001), disease activity (P = 0.014) and duration of the disease (P = 0.043) in MS patients. These findings suggest that serum UA might serve as a possible marker of disease activity in MS. They also provide support to the potential beneficial therapeutic effect of radical-scavenging substances in MS.",
publisher = "Heidelberg: Springer",
journal = "Journal of Neurology",
title = "Uric acid levels in sera from patients with multiple sclerosis",
number = "2",
volume = "248",
doi = "10.1007/s004150170246",
pages = "121-126"
}

Drulović, J., Dujmović, I., Stojsavljević, N., Mesaroš, Š., Anđelković, S., Miljković, Đ., Perić, V., Dragutinović, G., Marinković, J., Lević, Z.,& Mostarica Stojković, M.. (2001). Uric acid levels in sera from patients with multiple sclerosis. in Journal of Neurology
Heidelberg: Springer., 248(2), 121-126.
https://doi.org/10.1007/s004150170246

Drulović J, Dujmović I, Stojsavljević N, Mesaroš Š, Anđelković S, Miljković Đ, Perić V, Dragutinović G, Marinković J, Lević Z, Mostarica Stojković M. Uric acid levels in sera from patients with multiple sclerosis. in Journal of Neurology. 2001;248(2):121-126.
doi:10.1007/s004150170246 .

Drulović, Jelena, Dujmović, Irena, Stojsavljević, Nebojša, Mesaroš, Šarlota, Anđelković, Slobodanka, Miljković, Đorđe, Perić, Vesna, Dragutinović, Gradimir, Marinković, Jelena, Lević, Zvonimir, Mostarica Stojković, Marija, "Uric acid levels in sera from patients with multiple sclerosis" in Journal of Neurology, 248, no. 2 (2001):121-126,
https://doi.org/10.1007/s004150170246 . .