TY  - JOUR
AU  - Mihailović, Vladimir
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Mišić, Danijela
AU  - Stanković, Vesna
AU  - Katanić, Jelena
AU  - Mladenović, Milan
AU  - Solujić, Slavica
AU  - Matić, Sanja
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1043
AB  - This study is an attempt to evaluate the hepatoprotective activity of Gentiana asclepiadea L against carbon tetrachloride-induced liver injury in rats. Methanol extracts of aerial parts (GM) and roots (GAR) of G. asclepiadea at doses of 100, 200, and 400 mg/kg b.w. were orally administered to Wistar rats once daily for 7 days before they were treated with CCl4. The hepatoprotective activity of the extracts in this study was compared with the reference drug silymarin. In CCl4 treated animals, GM and GAR significantly decreased levels of serum transaminases, alkaline phosphatase and total bilirubin, and increased the level of total protein. Treatment with the extracts resulted in a significant increase in the levels of catalase, superoxide dismutase and reduced glutathione, accompanied with a marked reduction in the levels of malondialdehyde, as compared to CCl4 treated group. The histopathological studies confirmed protective effects of extracts against CCl4-induced liver injuries. No genotoxicity was observed in liver cells after GM treatment, while GAR showed only slight genotoxic effects by comet assay. Phytochemical analysis revealed the presence of sweroside, swertiamarin and gentiopicrin in high concentrations in both extracts. It could be concluded that the use of G. asclepiadea extracts in the treatment of chemical-induced hepatotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats
VL  - 52
DO  - 10.1016/j.fct.2012.10.034
SP  - 83
EP  - 90
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1043
ER  - 

@article{
author = "Mihailović, Vladimir and Mihailović, Mirjana and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Mišić, Danijela and Stanković, Vesna and Katanić, Jelena and Mladenović, Milan and Solujić, Slavica and Matić, Sanja",
year = "2013",
abstract = "This study is an attempt to evaluate the hepatoprotective activity of Gentiana asclepiadea L against carbon tetrachloride-induced liver injury in rats. Methanol extracts of aerial parts (GM) and roots (GAR) of G. asclepiadea at doses of 100, 200, and 400 mg/kg b.w. were orally administered to Wistar rats once daily for 7 days before they were treated with CCl4. The hepatoprotective activity of the extracts in this study was compared with the reference drug silymarin. In CCl4 treated animals, GM and GAR significantly decreased levels of serum transaminases, alkaline phosphatase and total bilirubin, and increased the level of total protein. Treatment with the extracts resulted in a significant increase in the levels of catalase, superoxide dismutase and reduced glutathione, accompanied with a marked reduction in the levels of malondialdehyde, as compared to CCl4 treated group. The histopathological studies confirmed protective effects of extracts against CCl4-induced liver injuries. No genotoxicity was observed in liver cells after GM treatment, while GAR showed only slight genotoxic effects by comet assay. Phytochemical analysis revealed the presence of sweroside, swertiamarin and gentiopicrin in high concentrations in both extracts. It could be concluded that the use of G. asclepiadea extracts in the treatment of chemical-induced hepatotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats",
volume = "52",
doi = "10.1016/j.fct.2012.10.034",
pages = "83-90",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1043"
}

Mihailović, V., Mihailović, M., Uskoković, A., Arambašić Jovanović, J., Mišić, D., Stanković, V., Katanić, J., Mladenović, M., Solujić, S.,& Matić, S.. (2013). Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. in Food and Chemical Toxicology
Elsevier., 52, 83-90.
https://doi.org/10.1016/j.fct.2012.10.034
https://hdl.handle.net/21.15107/rcub_ibiss_1043

Mihailović V, Mihailović M, Uskoković A, Arambašić Jovanović J, Mišić D, Stanković V, Katanić J, Mladenović M, Solujić S, Matić S. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. in Food and Chemical Toxicology. 2013;52:83-90.
doi:10.1016/j.fct.2012.10.034
https://hdl.handle.net/21.15107/rcub_ibiss_1043 .

Mihailović, Vladimir, Mihailović, Mirjana, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Mišić, Danijela, Stanković, Vesna, Katanić, Jelena, Mladenović, Milan, Solujić, Slavica, Matić, Sanja, "Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats" in Food and Chemical Toxicology, 52 (2013):83-90,
https://doi.org/10.1016/j.fct.2012.10.034 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1043 .

TY  - JOUR
AU  - Tucić, Nikola G
AU  - Šešlija, Darka M.
AU  - Stanković, Vesna D
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1753
AB  - We examined the influence of parental age on life history traits of their offspring in the lines of bean weevil that have evolved different rates of senescence. Measurements included preadult traits ( egg size, embryonic developmental time, total preadult developmental time, preadult viability) and adult traits ( body weight, total realized fecundity of females,first day of egg laying, early fecundity, late fecundity and longevity). The negative parental age effects were observed for all traits except for the early and total realized fecundity. We did not detect statistically significant line x parental age interactions for either preadult- or adult-survival, so offspring survival did not change with parental age after selection for early vs. late reproduction. It seems that selection acting on the quality of offspring produced by parents of different ages has not been responsible for the evolution of senescence in bean weevil.
T2  - Evolutionary Ecology
T1  - The short-term and long-term effects of parental age in the bean weevil (Acanthoscelides obtectus)
IS  - 2
VL  - 18
EP  - 201
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1753
ER  - 

@article{
author = "Tucić, Nikola G and Šešlija, Darka M. and Stanković, Vesna D",
year = "2004",
abstract = "We examined the influence of parental age on life history traits of their offspring in the lines of bean weevil that have evolved different rates of senescence. Measurements included preadult traits ( egg size, embryonic developmental time, total preadult developmental time, preadult viability) and adult traits ( body weight, total realized fecundity of females,first day of egg laying, early fecundity, late fecundity and longevity). The negative parental age effects were observed for all traits except for the early and total realized fecundity. We did not detect statistically significant line x parental age interactions for either preadult- or adult-survival, so offspring survival did not change with parental age after selection for early vs. late reproduction. It seems that selection acting on the quality of offspring produced by parents of different ages has not been responsible for the evolution of senescence in bean weevil.",
journal = "Evolutionary Ecology",
title = "The short-term and long-term effects of parental age in the bean weevil (Acanthoscelides obtectus)",
number = "2",
volume = "18",
pages = "201",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1753"
}

Tucić, N. G., Šešlija, D. M.,& Stanković, V. D.. (2004). The short-term and long-term effects of parental age in the bean weevil (Acanthoscelides obtectus). in Evolutionary Ecology, 18(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1753

Tucić NG, Šešlija DM, Stanković VD. The short-term and long-term effects of parental age in the bean weevil (Acanthoscelides obtectus). in Evolutionary Ecology. 2004;18(2):null-201.
https://hdl.handle.net/21.15107/rcub_ibiss_1753 .

Tucić, Nikola G, Šešlija, Darka M., Stanković, Vesna D, "The short-term and long-term effects of parental age in the bean weevil (Acanthoscelides obtectus)" in Evolutionary Ecology, 18, no. 2 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1753 .