TY  - JOUR
AU  - Katanić, Jelena
AU  - Matić, Sanja
AU  - Pferschy-Wenzig, Eva-Maria
AU  - Kretschmer, Nadine
AU  - Boroja, Tatjana
AU  - Mihailović, Vladimir
AU  - Stanković, Vesna
AU  - Stanković, Nevena
AU  - Mladenović, Milan
AU  - Stanić, Snežana
AU  - Mihailović, Mirjana
AU  - Bauer, Rudolf
PY  - 2017
UR  - https://www.sciencedirect.com/science/article/pii/S0278691516304343?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3178
AB  - Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.
T2  - Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association
T1  - Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
VL  - 99
DO  - 10.1016/j.fct.2016.11.018
SP  - 86
EP  - 102
ER  - 

@article{
author = "Katanić, Jelena and Matić, Sanja and Pferschy-Wenzig, Eva-Maria and Kretschmer, Nadine and Boroja, Tatjana and Mihailović, Vladimir and Stanković, Vesna and Stanković, Nevena and Mladenović, Milan and Stanić, Snežana and Mihailović, Mirjana and Bauer, Rudolf",
year = "2017",
abstract = "Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.",
journal = "Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association",
title = "Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.",
volume = "99",
doi = "10.1016/j.fct.2016.11.018",
pages = "86-102"
}

Katanić, J., Matić, S., Pferschy-Wenzig, E., Kretschmer, N., Boroja, T., Mihailović, V., Stanković, V., Stanković, N., Mladenović, M., Stanić, S., Mihailović, M.,& Bauer, R.. (2017). Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.. in Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association, 99, 86-102.
https://doi.org/10.1016/j.fct.2016.11.018

Katanić J, Matić S, Pferschy-Wenzig E, Kretschmer N, Boroja T, Mihailović V, Stanković V, Stanković N, Mladenović M, Stanić S, Mihailović M, Bauer R. Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.. in Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association. 2017;99:86-102.
doi:10.1016/j.fct.2016.11.018 .

Katanić, Jelena, Matić, Sanja, Pferschy-Wenzig, Eva-Maria, Kretschmer, Nadine, Boroja, Tatjana, Mihailović, Vladimir, Stanković, Vesna, Stanković, Nevena, Mladenović, Milan, Stanić, Snežana, Mihailović, Mirjana, Bauer, Rudolf, "Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis." in Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association, 99 (2017):86-102,
https://doi.org/10.1016/j.fct.2016.11.018 . .

TY  - GEN
AU  - Katanić, Jelena
AU  - Mihailović, Vladimir
AU  - Matić, Sanja
AU  - Stanković, Vesna
AU  - Stanković, Nevena
AU  - Boroja, Tatjana
AU  - Mladenović, Milan
AU  - Stanić, Snežana
AU  - Kreft, Samo
AU  - Mihailović, Mirjana
PY  - 2017
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1756464616303644
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2841
AB  - The authors regret that in Fig. 3 inadvertently was incorporated two photographs of the same tissue preparation of group VII (Fig. 3VII and X). They would like to inform that this wrong figure did not change the results of their study. The accurate representative photograph of kidney sections of experimental animals from group X (Fig. 3X in Fig. 3) is given below. The authors would like to apologize for any inconvenience caused.
T2  - Journal of Functional Foods
T1  - Corrigendum to “The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin” [J. Funct. Foods 18(A) (2015) 198–212]
VL  - 28
DO  - 10.1016/j.jff.2016.11.017
SP  - 326
EP  - 327
ER  - 

@misc{
author = "Katanić, Jelena and Mihailović, Vladimir and Matić, Sanja and Stanković, Vesna and Stanković, Nevena and Boroja, Tatjana and Mladenović, Milan and Stanić, Snežana and Kreft, Samo and Mihailović, Mirjana",
year = "2017",
abstract = "The authors regret that in Fig. 3 inadvertently was incorporated two photographs of the same tissue preparation of group VII (Fig. 3VII and X). They would like to inform that this wrong figure did not change the results of their study. The accurate representative photograph of kidney sections of experimental animals from group X (Fig. 3X in Fig. 3) is given below. The authors would like to apologize for any inconvenience caused.",
journal = "Journal of Functional Foods",
title = "Corrigendum to “The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin” [J. Funct. Foods 18(A) (2015) 198–212]",
volume = "28",
doi = "10.1016/j.jff.2016.11.017",
pages = "326-327"
}

Katanić, J., Mihailović, V., Matić, S., Stanković, V., Stanković, N., Boroja, T., Mladenović, M., Stanić, S., Kreft, S.,& Mihailović, M.. (2017). Corrigendum to “The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin” [J. Funct. Foods 18(A) (2015) 198–212]. in Journal of Functional Foods, 28, 326-327.
https://doi.org/10.1016/j.jff.2016.11.017

Katanić J, Mihailović V, Matić S, Stanković V, Stanković N, Boroja T, Mladenović M, Stanić S, Kreft S, Mihailović M. Corrigendum to “The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin” [J. Funct. Foods 18(A) (2015) 198–212]. in Journal of Functional Foods. 2017;28:326-327.
doi:10.1016/j.jff.2016.11.017 .

Katanić, Jelena, Mihailović, Vladimir, Matić, Sanja, Stanković, Vesna, Stanković, Nevena, Boroja, Tatjana, Mladenović, Milan, Stanić, Snežana, Kreft, Samo, Mihailović, Mirjana, "Corrigendum to “The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin” [J. Funct. Foods 18(A) (2015) 198–212]" in Journal of Functional Foods, 28 (2017):326-327,
https://doi.org/10.1016/j.jff.2016.11.017 . .

TY  - JOUR
AU  - Matić, Sanja
AU  - Stanić, Snežana
AU  - Mihailović, Mirjana
AU  - Bogojević, Desanka
PY  - 2016
UR  - http://www.sciencedirect.com/science/article/pii/S1319562X15001138
UR  - http://linkinghub.elsevier.com/retrieve/pii/S1319562X15001138
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3177
AB  - The Anacardiaceae Lindl. family comprises of many species which are used in nutrition and in traditional folk medicine for the treatment of several human diseases. Cotinus coggygria Scop. commonly known as “smoke tree”, is an commercial ornamental plant with high medicinal usages, belongs to the family Anacardiaceae. The present review provides a comprehensive report of empirical investigations on important pharmacological activities and phytochemical screening of essential oils and extracts. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Google Scholar, ScienceDirect, Web of Science, and Scopus. The plant has been extensively investigated in a broad range of studies to provide scientific evidence for folklore claims or to find new therapeutic uses. Numerous activities namely antioxidative, antibacterial, antifungal, antiviral, anticancer, antigenotoxic, hepatoprotective and anti-inflammatory have been demonstrated for all parts of these plants by in vivo and in vitro studies. Essential oils and extracts showed various pharmacological and biological properties which make them an effective remedy for various kinds of illnesses. Considering data from the literature, it could be demonstrated that C. coggygria possesses diverse bioactive properties and immense utilization in medicine, health care, cosmetics and as health supplements.
T2  - Saudi Journal of Biological Sciences
T1  - Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential
IS  - 4
VL  - 23
DO  - 10.1016/j.sjbs.2015.05.012
SP  - 452
EP  - 461
ER  - 

@article{
author = "Matić, Sanja and Stanić, Snežana and Mihailović, Mirjana and Bogojević, Desanka",
year = "2016",
abstract = "The Anacardiaceae Lindl. family comprises of many species which are used in nutrition and in traditional folk medicine for the treatment of several human diseases. Cotinus coggygria Scop. commonly known as “smoke tree”, is an commercial ornamental plant with high medicinal usages, belongs to the family Anacardiaceae. The present review provides a comprehensive report of empirical investigations on important pharmacological activities and phytochemical screening of essential oils and extracts. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Google Scholar, ScienceDirect, Web of Science, and Scopus. The plant has been extensively investigated in a broad range of studies to provide scientific evidence for folklore claims or to find new therapeutic uses. Numerous activities namely antioxidative, antibacterial, antifungal, antiviral, anticancer, antigenotoxic, hepatoprotective and anti-inflammatory have been demonstrated for all parts of these plants by in vivo and in vitro studies. Essential oils and extracts showed various pharmacological and biological properties which make them an effective remedy for various kinds of illnesses. Considering data from the literature, it could be demonstrated that C. coggygria possesses diverse bioactive properties and immense utilization in medicine, health care, cosmetics and as health supplements.",
journal = "Saudi Journal of Biological Sciences",
title = "Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential",
number = "4",
volume = "23",
doi = "10.1016/j.sjbs.2015.05.012",
pages = "452-461"
}

Matić, S., Stanić, S., Mihailović, M.,& Bogojević, D.. (2016). Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential. in Saudi Journal of Biological Sciences, 23(4), 452-461.
https://doi.org/10.1016/j.sjbs.2015.05.012

Matić S, Stanić S, Mihailović M, Bogojević D. Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential. in Saudi Journal of Biological Sciences. 2016;23(4):452-461.
doi:10.1016/j.sjbs.2015.05.012 .

Matić, Sanja, Stanić, Snežana, Mihailović, Mirjana, Bogojević, Desanka, "Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential" in Saudi Journal of Biological Sciences, 23, no. 4 (2016):452-461,
https://doi.org/10.1016/j.sjbs.2015.05.012 . .

TY  - JOUR
AU  - Mladenović, Milan
AU  - Stanković, Nevena
AU  - Matić, Sanja
AU  - Stanić, Snežana
AU  - Mihailović, Mirjana
AU  - Mihailović, Vladimir
AU  - Katanić, Jelena
AU  - Boroja, Tatjana
AU  - Vuković, Nenad
PY  - 2015
UR  - http://www.scopus.com/inward/record.url?eid=2-s2.0-84943457635&partnerID=tZOtx3y1
UR  - http://linkinghub.elsevier.com/retrieve/pii/S0006295215005511
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3175
AB  - Eight chroman-2,4-diones, namely 2a-h, previously investigated as anticoagulants, of which 2a and 2f as the most active, were evaluated as in vivo genotoxic agents in Wistar rat livers and kidneys using the comet assay. Compounds 2a, 2b, and 2f without genotoxic activity were applied prior to ethyl methanesulfonate (EMS) and diminished EMS-induced DNA damage according to the total score and percentage of reduction. EMS produce harmful O(6)-ethylguanine lesion which is incorporated in aberrant genotoxic GT and TG pairing after ATP-dependent DNA strand breaks have been catalyzed by rat Topoisomerase IIα (rTopIIα, EC 5.99.1.3). Therefore, the mechanism of 2a, 2b, and 2f antigenotoxic activity was investigated on the enzyme level using molecular docking and molecular dynamics simulations insamuch as it had been determined that compounds do not intercalate DNA but instead inhibit the ATPase activity. Calculations predicted that compounds inhibit ATP hydrolysis before the DNA-EMS cleavage is being catalyzed by rTopIIα, prevent EMS mutagenic and carcinogenic effects, and beside anticoagulant activity can even be applied in the cancer treatment to control the rate of anticancer alkylation drugs.
PB  - Elsevier
T2  - Biochemical Pharmacology
T1  - Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIα: A story behind the molecular modeling approach
IS  - 1
VL  - 98
DO  - 10.1016/j.bcp.2015.08.106
SP  - 243
EP  - 266
ER  - 

@article{
author = "Mladenović, Milan and Stanković, Nevena and Matić, Sanja and Stanić, Snežana and Mihailović, Mirjana and Mihailović, Vladimir and Katanić, Jelena and Boroja, Tatjana and Vuković, Nenad",
year = "2015",
abstract = "Eight chroman-2,4-diones, namely 2a-h, previously investigated as anticoagulants, of which 2a and 2f as the most active, were evaluated as in vivo genotoxic agents in Wistar rat livers and kidneys using the comet assay. Compounds 2a, 2b, and 2f without genotoxic activity were applied prior to ethyl methanesulfonate (EMS) and diminished EMS-induced DNA damage according to the total score and percentage of reduction. EMS produce harmful O(6)-ethylguanine lesion which is incorporated in aberrant genotoxic GT and TG pairing after ATP-dependent DNA strand breaks have been catalyzed by rat Topoisomerase IIα (rTopIIα, EC 5.99.1.3). Therefore, the mechanism of 2a, 2b, and 2f antigenotoxic activity was investigated on the enzyme level using molecular docking and molecular dynamics simulations insamuch as it had been determined that compounds do not intercalate DNA but instead inhibit the ATPase activity. Calculations predicted that compounds inhibit ATP hydrolysis before the DNA-EMS cleavage is being catalyzed by rTopIIα, prevent EMS mutagenic and carcinogenic effects, and beside anticoagulant activity can even be applied in the cancer treatment to control the rate of anticancer alkylation drugs.",
publisher = "Elsevier",
journal = "Biochemical Pharmacology",
title = "Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIα: A story behind the molecular modeling approach",
number = "1",
volume = "98",
doi = "10.1016/j.bcp.2015.08.106",
pages = "243-266"
}

Mladenović, M., Stanković, N., Matić, S., Stanić, S., Mihailović, M., Mihailović, V., Katanić, J., Boroja, T.,& Vuković, N.. (2015). Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIα: A story behind the molecular modeling approach. in Biochemical Pharmacology
Elsevier., 98(1), 243-266.
https://doi.org/10.1016/j.bcp.2015.08.106

Mladenović M, Stanković N, Matić S, Stanić S, Mihailović M, Mihailović V, Katanić J, Boroja T, Vuković N. Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIα: A story behind the molecular modeling approach. in Biochemical Pharmacology. 2015;98(1):243-266.
doi:10.1016/j.bcp.2015.08.106 .

Mladenović, Milan, Stanković, Nevena, Matić, Sanja, Stanić, Snežana, Mihailović, Mirjana, Mihailović, Vladimir, Katanić, Jelena, Boroja, Tatjana, Vuković, Nenad, "Newly discovered chroman-2,4-diones neutralize the in vivo DNA damage induced by alkylation through the inhibition of Topoisomerase IIα: A story behind the molecular modeling approach" in Biochemical Pharmacology, 98, no. 1 (2015):243-266,
https://doi.org/10.1016/j.bcp.2015.08.106 . .

TY  - JOUR
AU  - Matić, Sanja
AU  - Stanić, Snežana
AU  - Bogojević, Desanka
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Solujić, Slavica
AU  - Mladenović, Milan
AU  - Stanković, Nevena
AU  - Mihailović, Mirjana
PY  - 2013
UR  - http://www.sciencedirect.com/science/article/pii/S1383571813001836
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3188
AB  - The present study was undertaken to investigate the hepatoprotective effect of the methanol extract of Cotinus coggygria Scop. in rats exposed to the hepatotoxic compound pyrogallol. Assessed with the alkaline version of the comet assay, 1000 and 2000. mg/kg body weight (bw) of the extract showed a low level of genotoxicity, while 500. mg/kg bw of the extract showed no genotoxic potential. Quantitative HPLC analysis of phenolic acids and flavonoids in the methanol extract of C. coggygria showed that myricetin was a major component. To test the hepatoprotective effect, a non-genotoxic dose of the C. coggygria extract and an equivalent amount of synthetic myricetin, as present in the extract, were applied either 2 or 12. h prior to administration of 100. mg/kg bw of pyrogallol. The extract and myricetin promoted restoration of hepatic function by significantly reducing pyrogallol-induced elevation in the serum enzymes AST, ALT, ALP and in total bilirubin. As measured by the decrease in total score and tail moment, the DNA damage in liver was also reduced by the extract and by myricetin. Our results suggest that pro-surviving Akt activity and STAT3 protein expression play important roles in decreasing DNA damage and in mediating hepatic protection by the extract. These results suggest that myricetin, as a major component in the extract, is responsible for the antigenotoxic and hepatoprotective properties of the methanol extract of C. coggygria against pyrogallol-induced toxicity. © 2013 Elsevier B.V.
PB  - Elsevier
T2  - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
T2  - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
T1  - Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury
IS  - 2
VL  - 755
DO  - 10.1016/j.mrgentox.2013.03.011
SP  - 81
EP  - 89
ER  - 

@article{
author = "Matić, Sanja and Stanić, Snežana and Bogojević, Desanka and Vidaković, Melita and Grdović, Nevena and Dinić, Svetlana and Solujić, Slavica and Mladenović, Milan and Stanković, Nevena and Mihailović, Mirjana",
year = "2013",
abstract = "The present study was undertaken to investigate the hepatoprotective effect of the methanol extract of Cotinus coggygria Scop. in rats exposed to the hepatotoxic compound pyrogallol. Assessed with the alkaline version of the comet assay, 1000 and 2000. mg/kg body weight (bw) of the extract showed a low level of genotoxicity, while 500. mg/kg bw of the extract showed no genotoxic potential. Quantitative HPLC analysis of phenolic acids and flavonoids in the methanol extract of C. coggygria showed that myricetin was a major component. To test the hepatoprotective effect, a non-genotoxic dose of the C. coggygria extract and an equivalent amount of synthetic myricetin, as present in the extract, were applied either 2 or 12. h prior to administration of 100. mg/kg bw of pyrogallol. The extract and myricetin promoted restoration of hepatic function by significantly reducing pyrogallol-induced elevation in the serum enzymes AST, ALT, ALP and in total bilirubin. As measured by the decrease in total score and tail moment, the DNA damage in liver was also reduced by the extract and by myricetin. Our results suggest that pro-surviving Akt activity and STAT3 protein expression play important roles in decreasing DNA damage and in mediating hepatic protection by the extract. These results suggest that myricetin, as a major component in the extract, is responsible for the antigenotoxic and hepatoprotective properties of the methanol extract of C. coggygria against pyrogallol-induced toxicity. © 2013 Elsevier B.V.",
publisher = "Elsevier",
journal = "Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Mutation Research - Genetic Toxicology and Environmental Mutagenesis",
title = "Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury",
number = "2",
volume = "755",
doi = "10.1016/j.mrgentox.2013.03.011",
pages = "81-89"
}

Matić, S., Stanić, S., Bogojević, D., Vidaković, M., Grdović, N., Dinić, S., Solujić, S., Mladenović, M., Stanković, N.,& Mihailović, M.. (2013). Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury. in Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Elsevier., 755(2), 81-89.
https://doi.org/10.1016/j.mrgentox.2013.03.011

Matić S, Stanić S, Bogojević D, Vidaković M, Grdović N, Dinić S, Solujić S, Mladenović M, Stanković N, Mihailović M. Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury. in Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2013;755(2):81-89.
doi:10.1016/j.mrgentox.2013.03.011 .

Matić, Sanja, Stanić, Snežana, Bogojević, Desanka, Vidaković, Melita, Grdović, Nevena, Dinić, Svetlana, Solujić, Slavica, Mladenović, Milan, Stanković, Nevena, Mihailović, Mirjana, "Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury" in Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 755, no. 2 (2013):81-89,
https://doi.org/10.1016/j.mrgentox.2013.03.011 . .

TY  - JOUR
AU  - Stanić, Snežana
AU  - Matić, Sanja
AU  - Đelić, Gorica
AU  - Mihailović, Mirjana
AU  - Bogojević, Desanka
AU  - Solujić, Slavica
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3208
AB  - The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investigated using the Drosophila sex-linked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methanesulfonate EMS (0.75 ppm) induce recessive lethal mutations on X-chromosome on Drosophila melanogaster in all broods (I, II and III). Post-treatment with lower concentration of the methanol extract of Cotinus coggygria (2%) was effective in reducing genotoxicity ofmutagen.
PB  - Springer Nature
T2  - Russian Journal of Genetics
T1  - Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test.
IS  - 7
VL  - 47
DO  - 10.1134/S1022795411070167
SP  - 770
EP  - 774
ER  - 

@article{
author = "Stanić, Snežana and Matić, Sanja and Đelić, Gorica and Mihailović, Mirjana and Bogojević, Desanka and Solujić, Slavica",
year = "2011",
abstract = "The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investigated using the Drosophila sex-linked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methanesulfonate EMS (0.75 ppm) induce recessive lethal mutations on X-chromosome on Drosophila melanogaster in all broods (I, II and III). Post-treatment with lower concentration of the methanol extract of Cotinus coggygria (2%) was effective in reducing genotoxicity ofmutagen.",
publisher = "Springer Nature",
journal = "Russian Journal of Genetics",
title = "Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test.",
number = "7",
volume = "47",
doi = "10.1134/S1022795411070167",
pages = "770-774"
}

Stanić, S., Matić, S., Đelić, G., Mihailović, M., Bogojević, D.,& Solujić, S.. (2011). Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test.. in Russian Journal of Genetics
Springer Nature., 47(7), 770-774.
https://doi.org/10.1134/S1022795411070167

Stanić S, Matić S, Đelić G, Mihailović M, Bogojević D, Solujić S. Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test.. in Russian Journal of Genetics. 2011;47(7):770-774.
doi:10.1134/S1022795411070167 .

Stanić, Snežana, Matić, Sanja, Đelić, Gorica, Mihailović, Mirjana, Bogojević, Desanka, Solujić, Slavica, "Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test." in Russian Journal of Genetics, 47, no. 7 (2011):770-774,
https://doi.org/10.1134/S1022795411070167 . .

TY  - JOUR
AU  - Matić, Sanja
AU  - Stanić, Snežana
AU  - Bogojević, Desanka
AU  - Vidaković, Melita
AU  - Grdović, Nevena
AU  - Arambašić Jovanović, Jelena
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Poznanović, Goran
AU  - Solujić, Slavica
AU  - Mladenović, Milan
AU  - Marković, Jelena
AU  - Mihailović, Mirjana
PY  - 2011
UR  - http://www.nrcresearchpress.com/doi/10.1139/y11-043#.XBD8lM0o-Uk
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3204
AB  - To examine the protective potential of the Cotinus coggygria Scop. methanol extract, Wistar rats were treated with the hepatotoxic compound pyrogallol, which possesses a potent ability to generate free radicals and induce oxidative stress. The ability of the extract to counteract the oxidative stress was examined in rats that were injected with the extract intraperitoneally (500 mg·(kg body weight)(-1)) either 2 or 12 h before the pyrogallol treatment. The extract possesses a reducing activity in vitro and an ability to chelate the ferrous ion both in vivo and in vitro. Application of the extract prior to pyrogallol treatment led to a decrease in the levels of thiobarbituric acid-reactive substances, aspartate aminotransferase, and alanine aminotransferase, increased activities of antioxidant enzymes and attenuation of DNA damage, as well as increased Akt activity and inhibition of NF-κB protein expression. Treatment with the extract 12 h prior to pyrogallol administration was more effective in suppressing pyrogallol-induced oxidative damage than the 2 h pretreatment. Extract administration promoted an increase in acute phase reactants haptoglobin and α(2)-macroglobulin that was short of a full-fledged acute phase response. Administration of the extract considerably improved the markers of oxidative stress, thus revealing a potential hepatoprotective activity. Our results suggest that Akt activation, NF-κB inhibition, and induction of the acute phase play important roles in mediating hepatic protection by the extract. The greater effectiveness of the 12 h pretreatment with extract points to the important role that preconditioning assumes in improving resistance to subsequent exposure to oxidative stress.
PB  - NRC Research Press; Canadian Science Publishing; National Research Council of Canada
PB  - © 2011 by NRC Research Press
T2  - Canadian Journal of Physiology and Pharmacology
T1  - Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats
IS  - 6
VL  - 89
DO  - 10.1139/y11-043
SP  - 401
EP  - 411
ER  - 

@article{
author = "Matić, Sanja and Stanić, Snežana and Bogojević, Desanka and Vidaković, Melita and Grdović, Nevena and Arambašić Jovanović, Jelena and Dinić, Svetlana and Uskoković, Aleksandra and Poznanović, Goran and Solujić, Slavica and Mladenović, Milan and Marković, Jelena and Mihailović, Mirjana",
year = "2011",
abstract = "To examine the protective potential of the Cotinus coggygria Scop. methanol extract, Wistar rats were treated with the hepatotoxic compound pyrogallol, which possesses a potent ability to generate free radicals and induce oxidative stress. The ability of the extract to counteract the oxidative stress was examined in rats that were injected with the extract intraperitoneally (500 mg·(kg body weight)(-1)) either 2 or 12 h before the pyrogallol treatment. The extract possesses a reducing activity in vitro and an ability to chelate the ferrous ion both in vivo and in vitro. Application of the extract prior to pyrogallol treatment led to a decrease in the levels of thiobarbituric acid-reactive substances, aspartate aminotransferase, and alanine aminotransferase, increased activities of antioxidant enzymes and attenuation of DNA damage, as well as increased Akt activity and inhibition of NF-κB protein expression. Treatment with the extract 12 h prior to pyrogallol administration was more effective in suppressing pyrogallol-induced oxidative damage than the 2 h pretreatment. Extract administration promoted an increase in acute phase reactants haptoglobin and α(2)-macroglobulin that was short of a full-fledged acute phase response. Administration of the extract considerably improved the markers of oxidative stress, thus revealing a potential hepatoprotective activity. Our results suggest that Akt activation, NF-κB inhibition, and induction of the acute phase play important roles in mediating hepatic protection by the extract. The greater effectiveness of the 12 h pretreatment with extract points to the important role that preconditioning assumes in improving resistance to subsequent exposure to oxidative stress.",
publisher = "NRC Research Press; Canadian Science Publishing; National Research Council of Canada, © 2011 by NRC Research Press",
journal = "Canadian Journal of Physiology and Pharmacology",
title = "Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats",
number = "6",
volume = "89",
doi = "10.1139/y11-043",
pages = "401-411"
}

Matić, S., Stanić, S., Bogojević, D., Vidaković, M., Grdović, N., Arambašić Jovanović, J., Dinić, S., Uskoković, A., Poznanović, G., Solujić, S., Mladenović, M., Marković, J.,& Mihailović, M.. (2011). Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats. in Canadian Journal of Physiology and Pharmacology
NRC Research Press; Canadian Science Publishing; National Research Council of Canada., 89(6), 401-411.
https://doi.org/10.1139/y11-043

Matić S, Stanić S, Bogojević D, Vidaković M, Grdović N, Arambašić Jovanović J, Dinić S, Uskoković A, Poznanović G, Solujić S, Mladenović M, Marković J, Mihailović M. Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats. in Canadian Journal of Physiology and Pharmacology. 2011;89(6):401-411.
doi:10.1139/y11-043 .

Matić, Sanja, Stanić, Snežana, Bogojević, Desanka, Vidaković, Melita, Grdović, Nevena, Arambašić Jovanović, Jelena, Dinić, Svetlana, Uskoković, Aleksandra, Poznanović, Goran, Solujić, Slavica, Mladenović, Milan, Marković, Jelena, Mihailović, Mirjana, "Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats" in Canadian Journal of Physiology and Pharmacology, 89, no. 6 (2011):401-411,
https://doi.org/10.1139/y11-043 . .