TY  - JOUR
AU  - Ribeiro, Ana S.
AU  - Costa, Sofia M.
AU  - Ferreira, Diana P.
AU  - Calhelha, Ricardo C.
AU  - Barros, Lillian
AU  - Stojković, Dejan
AU  - Soković, Marina
AU  - Ferreira, Isabel C.F.R.
AU  - Fangueiro, Raul
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4095
AB  - The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications.
PB  - Elsevier B.V.
T2  - Reactive and Functional Polymers
T1  - Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications
VL  - 159
DO  - 10.1016/j.reactfunctpolym.2020.104808
SP  - 104808
ER  - 

@article{
author = "Ribeiro, Ana S. and Costa, Sofia M. and Ferreira, Diana P. and Calhelha, Ricardo C. and Barros, Lillian and Stojković, Dejan and Soković, Marina and Ferreira, Isabel C.F.R. and Fangueiro, Raul",
year = "2021",
abstract = "The combination of biodegradable fibers at nanoscale with plant-based extracts is attracting increasing attention to produce wound dressing systems. In this work, nanofibers based on chitosan (CS), poly(ethylene oxide) (PEO), cellulose nanocrystals (CNC) and acacia plant-based extract were developed by electrospinning. Firstly, the polymeric formulations and electrospinning parameters were optimized, resulting in nanofibers with average diameters of 80 nm. CNC were successfully introduced into the optimized CS/PEO blend and the membranes were characterized by FESEM, ATR-FTIR, TGA, XRD, WVTR and WCA. The CNC incorporation improved the nanofibers' physical integrity, morphology, diameters, water vapor transmission rate and thermal properties. After acacia introduction into the best CS/PEO/CNC system, the antibacterial effect was relatively maintained while the antifungal activity was enhanced for some fungi, demonstrating its great effect against a wide range of microorganisms, which is crucial to prevent or treat infections. All the developed systems exhibited absence of cytotoxicity in non-tumor cells, suggesting their biocompatibility. Finally, a continuous release of the acacia extract was observed for 24 h, showing its prolonged action, which contributes to the healing process while reduces the frequency of dressing's replacement. Overall, the developed nanofibers are very promising to act as localized drug delivery systems for wound care applications.",
publisher = "Elsevier B.V.",
journal = "Reactive and Functional Polymers",
title = "Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications",
volume = "159",
doi = "10.1016/j.reactfunctpolym.2020.104808",
pages = "104808"
}

Ribeiro, A. S., Costa, S. M., Ferreira, D. P., Calhelha, R. C., Barros, L., Stojković, D., Soković, M., Ferreira, I. C.F.R.,& Fangueiro, R.. (2021). Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. in Reactive and Functional Polymers
Elsevier B.V.., 159, 104808.
https://doi.org/10.1016/j.reactfunctpolym.2020.104808

Ribeiro AS, Costa SM, Ferreira DP, Calhelha RC, Barros L, Stojković D, Soković M, Ferreira IC, Fangueiro R. Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. in Reactive and Functional Polymers. 2021;159:104808.
doi:10.1016/j.reactfunctpolym.2020.104808 .

Ribeiro, Ana S., Costa, Sofia M., Ferreira, Diana P., Calhelha, Ricardo C., Barros, Lillian, Stojković, Dejan, Soković, Marina, Ferreira, Isabel C.F.R., Fangueiro, Raul, "Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications" in Reactive and Functional Polymers, 159 (2021):104808,
https://doi.org/10.1016/j.reactfunctpolym.2020.104808 . .