TY  - CONF
AU  - Miljić, Dragana
AU  - Pekić, Sandra
AU  - Doknić, Mirjana
AU  - Stojanović, Marko
AU  - Nikolić-Đurović, Marina
AU  - Medić-Stojanoska, Milica
AU  - Milošević, Verica
AU  - Šošić-Jurjević, Branka 
AU  - Ajdžanović, Vladimir
AU  - Jemuović, Zvezdana
AU  - Soldatović, Ivan
AU  - Popović, Vera
AU  - Petakov, Milan
PY  - 2018
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5967
AB  - Previous studies reported increased prevalence of metabolic syndrome (MS) and
mortality rates from cardiovascular causes in hypopituitary patients. Fatty liver
disease was added recently to this unfavorable cardio-metabolic phenotype. We
studied the prevalence of MS and non-alcoholic fatty liver disease (NAFLD) in
unselected cohort of 282 hypopituitary patients (146 male), mean age 49.2G15.1
years, on standard replacement therapy (76.4% received l-thyroxin, 76%
hydrocortisone, 9.8% gonadal steroids, 4.6% desmopressin, 1.8% growth
hormone). Surrogat marker of MS, lipid acummulation product (LAP) was
calculated using gender specific formulas including waist circumference and
triglyceride level. Marker of NAFLD, fatty liver index (FLI) was calculated using
formula including body weight, height, waist circumference, triglyceride and
gamma glutamyl transferase levels. Hepatic steatosis was assessed by
ultrasonography and liver function tests. In this cross-sectional study, prevalence
of MS was 57.1% (using IDF) and 48.6% (with ATP III criteria). MS was more
common in females than males (IDF 63.2% vs 51.4%, PZ0.044; ATP III 54.4%
vs 43.2%, PZ0.059) and significantly associated with unreplaced hypogonadism
in female patients (PZ0.003). Statistically significant associations (P!0.001)
were found for MS and age, obesity, adult onset of hypopituitarism and NAFLD.
Prevalence of NAFLD in the cohort was 20.6%, based on ultrasonographic
features of hepatic steatosis, while in addition to this 7.1% had elevated liver
enzymes. For NAFLD, statistically significant associations were found with MS
(P!0.001), etiology of non-functioning pituitary macroadenoma (PZ0.006) and
growth hormone deficiency (PZ0.026). Hypopitutary patients with NAFLD had
more severe features of MS with significantly higher body mass index, waist
circumference, cholesterol and triglycerides, LAP and FLI, but lower HDL
compared to no-NAFLD patients (P!0.001). ROC analysis confirmed that LAP
and FLI were reliable markers of hepatic steatosis and functional hepatic
impairment resulting from NAFLD. MS is common in hypopituitarism, featuring
NAFLD in one third of hypopituitary patients with MS. Hypopituitary NAFLD
patients present with more severe MS and higher LAP and FLI indexes compared
to no-NAFLD patients. LAP and FLI are reliable markers of hepatic steatosis and
functional hepatic impairment, resulting from NAFLD. Complex interactions of
multiple pituitary hormone deficiencies and balance in their replacement are very
important for metabolic phenotype, as well as age, gender, obesity, adult onset
and etiology of hypopituitarism.
PB  - bioscientifica
C3  - 20th European Congress of Endocrinology; 2018 May 19-22; Barcelona, Spain
T1  - Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?
DO  - 10.1530/endoabs.56.P821
ER  - 

@conference{
author = "Miljić, Dragana and Pekić, Sandra and Doknić, Mirjana and Stojanović, Marko and Nikolić-Đurović, Marina and Medić-Stojanoska, Milica and Milošević, Verica and Šošić-Jurjević, Branka  and Ajdžanović, Vladimir and Jemuović, Zvezdana and Soldatović, Ivan and Popović, Vera and Petakov, Milan",
year = "2018",
abstract = "Previous studies reported increased prevalence of metabolic syndrome (MS) and
mortality rates from cardiovascular causes in hypopituitary patients. Fatty liver
disease was added recently to this unfavorable cardio-metabolic phenotype. We
studied the prevalence of MS and non-alcoholic fatty liver disease (NAFLD) in
unselected cohort of 282 hypopituitary patients (146 male), mean age 49.2G15.1
years, on standard replacement therapy (76.4% received l-thyroxin, 76%
hydrocortisone, 9.8% gonadal steroids, 4.6% desmopressin, 1.8% growth
hormone). Surrogat marker of MS, lipid acummulation product (LAP) was
calculated using gender specific formulas including waist circumference and
triglyceride level. Marker of NAFLD, fatty liver index (FLI) was calculated using
formula including body weight, height, waist circumference, triglyceride and
gamma glutamyl transferase levels. Hepatic steatosis was assessed by
ultrasonography and liver function tests. In this cross-sectional study, prevalence
of MS was 57.1% (using IDF) and 48.6% (with ATP III criteria). MS was more
common in females than males (IDF 63.2% vs 51.4%, PZ0.044; ATP III 54.4%
vs 43.2%, PZ0.059) and significantly associated with unreplaced hypogonadism
in female patients (PZ0.003). Statistically significant associations (P!0.001)
were found for MS and age, obesity, adult onset of hypopituitarism and NAFLD.
Prevalence of NAFLD in the cohort was 20.6%, based on ultrasonographic
features of hepatic steatosis, while in addition to this 7.1% had elevated liver
enzymes. For NAFLD, statistically significant associations were found with MS
(P!0.001), etiology of non-functioning pituitary macroadenoma (PZ0.006) and
growth hormone deficiency (PZ0.026). Hypopitutary patients with NAFLD had
more severe features of MS with significantly higher body mass index, waist
circumference, cholesterol and triglycerides, LAP and FLI, but lower HDL
compared to no-NAFLD patients (P!0.001). ROC analysis confirmed that LAP
and FLI were reliable markers of hepatic steatosis and functional hepatic
impairment resulting from NAFLD. MS is common in hypopituitarism, featuring
NAFLD in one third of hypopituitary patients with MS. Hypopituitary NAFLD
patients present with more severe MS and higher LAP and FLI indexes compared
to no-NAFLD patients. LAP and FLI are reliable markers of hepatic steatosis and
functional hepatic impairment, resulting from NAFLD. Complex interactions of
multiple pituitary hormone deficiencies and balance in their replacement are very
important for metabolic phenotype, as well as age, gender, obesity, adult onset
and etiology of hypopituitarism.",
publisher = "bioscientifica",
journal = "20th European Congress of Endocrinology; 2018 May 19-22; Barcelona, Spain",
title = "Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?",
doi = "10.1530/endoabs.56.P821"
}

Miljić, D., Pekić, S., Doknić, M., Stojanović, M., Nikolić-Đurović, M., Medić-Stojanoska, M., Milošević, V., Šošić-Jurjević, B., Ajdžanović, V., Jemuović, Z., Soldatović, I., Popović, V.,& Petakov, M.. (2018). Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?. in 20th European Congress of Endocrinology; 2018 May 19-22; Barcelona, Spain
bioscientifica..
https://doi.org/10.1530/endoabs.56.P821

Miljić D, Pekić S, Doknić M, Stojanović M, Nikolić-Đurović M, Medić-Stojanoska M, Milošević V, Šošić-Jurjević B, Ajdžanović V, Jemuović Z, Soldatović I, Popović V, Petakov M. Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?. in 20th European Congress of Endocrinology; 2018 May 19-22; Barcelona, Spain. 2018;.
doi:10.1530/endoabs.56.P821 .

Miljić, Dragana, Pekić, Sandra, Doknić, Mirjana, Stojanović, Marko, Nikolić-Đurović, Marina, Medić-Stojanoska, Milica, Milošević, Verica, Šošić-Jurjević, Branka , Ajdžanović, Vladimir, Jemuović, Zvezdana, Soldatović, Ivan, Popović, Vera, Petakov, Milan, "Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?" in 20th European Congress of Endocrinology; 2018 May 19-22; Barcelona, Spain (2018),
https://doi.org/10.1530/endoabs.56.P821 . .

TY  - JOUR
AU  - Presetnik, Primož
AU  - Paunović, Milan
AU  - Karapandža, Branko
AU  - Đurović, Marina
AU  - Ivanović, Čeda
AU  - Ždralević, Maša
AU  - Benda, Petr
AU  - Budinski, Ivana
PY  - 2014
UR  - https://www.ceson.org/vespertilio/17/129_156_Presetnik.pdf
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6598
AB  - The first detailed review of the distribution of bats in Montenegro is presented. Altogether 28 species were confirmed to occur in the country: Rhinolophus ferrumequinum (55 records), R. hipposideros (54), R. euryale (12), R. blasii (5), Myotis myotis (7), M. blythii (37), M. nattereri (12), M. emarginatus (12), M. mystacinus (12), M. alcathoe (1), M. brandtii (2), M. daubentonii (3), M. capaccinii (32), Vespertilio murinus (4), Eptesicus serotinus (7), Hypsugo savii (18), Pipistrellus pipistrellus (22), P. pygmaeus (19), P. kuhlii (38), P. nathusii (6), Nyctalus noctula (13), N. leisleri (4), Plecotus auritus (2), P. macrobullaris (3), P. austriacus (4), Barbastella barbastellus (1), Miniopterus schreibersii (39), and Tadarida teniotis (18). For the first time, evidence of the presence of Myotis daubentonii and Barbastella barbastellus in the country is provided. Majority of the data comes from the past 15 years, and was collected through our own field research, and gathered from nine museum collections and 51 literature sources. The bat observations are concentrated mainly along the Adriatic Sea coast and to the lowland areas around the Skadar lake. However, records of bats are also available from medium altitudes as well as from the high mountain environment. Many species are represented by just a few sightings, and large parts of the country are without any records of even the most frequently observed species. Only 33% of the 10×10 km UTM squares covering Montenegro contain at least one bat record. There are several important summer cave roosts and a few known roosts in buildings, but generally, very little data are available on maternity roosts or hibernacula. We observed several threats to bat populations, from roost disturbance to roost destruction, and incidents of bat road traffic casualties were also recorded. In general, further research on a more extensive scale needs to be completed to get an adequate picture of the distribution and important habitats of individual bat species in Montenegro, and also with the aim of maintaining their favourable conservation status and monitoring their populations.
PB  - Czech Bat Conservation Society - Česká společnost pro ochranu netopýrů (ČESON)
T2  - Vespertilio
T1  - Distribution of bats (Chiroptera) in Montenegro
IS  - 17
SP  - 129
EP  - 156
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6598
ER  - 

@article{
author = "Presetnik, Primož and Paunović, Milan and Karapandža, Branko and Đurović, Marina and Ivanović, Čeda and Ždralević, Maša and Benda, Petr and Budinski, Ivana",
year = "2014",
abstract = "The first detailed review of the distribution of bats in Montenegro is presented. Altogether 28 species were confirmed to occur in the country: Rhinolophus ferrumequinum (55 records), R. hipposideros (54), R. euryale (12), R. blasii (5), Myotis myotis (7), M. blythii (37), M. nattereri (12), M. emarginatus (12), M. mystacinus (12), M. alcathoe (1), M. brandtii (2), M. daubentonii (3), M. capaccinii (32), Vespertilio murinus (4), Eptesicus serotinus (7), Hypsugo savii (18), Pipistrellus pipistrellus (22), P. pygmaeus (19), P. kuhlii (38), P. nathusii (6), Nyctalus noctula (13), N. leisleri (4), Plecotus auritus (2), P. macrobullaris (3), P. austriacus (4), Barbastella barbastellus (1), Miniopterus schreibersii (39), and Tadarida teniotis (18). For the first time, evidence of the presence of Myotis daubentonii and Barbastella barbastellus in the country is provided. Majority of the data comes from the past 15 years, and was collected through our own field research, and gathered from nine museum collections and 51 literature sources. The bat observations are concentrated mainly along the Adriatic Sea coast and to the lowland areas around the Skadar lake. However, records of bats are also available from medium altitudes as well as from the high mountain environment. Many species are represented by just a few sightings, and large parts of the country are without any records of even the most frequently observed species. Only 33% of the 10×10 km UTM squares covering Montenegro contain at least one bat record. There are several important summer cave roosts and a few known roosts in buildings, but generally, very little data are available on maternity roosts or hibernacula. We observed several threats to bat populations, from roost disturbance to roost destruction, and incidents of bat road traffic casualties were also recorded. In general, further research on a more extensive scale needs to be completed to get an adequate picture of the distribution and important habitats of individual bat species in Montenegro, and also with the aim of maintaining their favourable conservation status and monitoring their populations.",
publisher = "Czech Bat Conservation Society - Česká společnost pro ochranu netopýrů (ČESON)",
journal = "Vespertilio",
title = "Distribution of bats (Chiroptera) in Montenegro",
number = "17",
pages = "129-156",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6598"
}

Presetnik, P., Paunović, M., Karapandža, B., Đurović, M., Ivanović, Č., Ždralević, M., Benda, P.,& Budinski, I.. (2014). Distribution of bats (Chiroptera) in Montenegro. in Vespertilio
Czech Bat Conservation Society - Česká společnost pro ochranu netopýrů (ČESON).(17), 129-156.
https://hdl.handle.net/21.15107/rcub_ibiss_6598

Presetnik P, Paunović M, Karapandža B, Đurović M, Ivanović Č, Ždralević M, Benda P, Budinski I. Distribution of bats (Chiroptera) in Montenegro. in Vespertilio. 2014;(17):129-156.
https://hdl.handle.net/21.15107/rcub_ibiss_6598 .

Presetnik, Primož, Paunović, Milan, Karapandža, Branko, Đurović, Marina, Ivanović, Čeda, Ždralević, Maša, Benda, Petr, Budinski, Ivana, "Distribution of bats (Chiroptera) in Montenegro" in Vespertilio, no. 17 (2014):129-156,
https://hdl.handle.net/21.15107/rcub_ibiss_6598 .