TY  - JOUR
AU  - Petropoulos, Spyridon
AU  - Fernandes, Ângela
AU  - Pereira, Carla
AU  - Tzortzakis, Nikos
AU  - Vaz, Josiana
AU  - Soković, Marina
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0308814619305436?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3314
AB  - In the present study, the nutritional value, bioactive properties, and chemical composition of various cardoon (Cynara cardunculus L.) genotypes cultivated in central Greece were investigated. The results demonstrated that Cynara seeds are a good source of fat and protein, while they also contain considerable amounts of K, Mg, and Fe and low amount of Na. Sucrose, oxalic acid, and α-tocopherol were the only free sugar, organic acid, and tocopherol isoform respectively, found among the studied genotypes. The most abundant fatty acids were linoleic, oleic and palmitic acid, while PUFA was the most abundant fatty acid class. All the tested seeds contained only two phenolic compounds, namely 5-O-caffeoylquinic acid and 3,5-O-caffeoylquinic acid, while significant antioxidant activities and cytotoxicity against tumor cell lines and antimicrobial effects were also observed. In conclusion, cardoon seed extracts could be exploited in the food and pharmaceutical industries as alternative sources of natural compounds with bioactive properties.
T2  - Food Chemistry
T1  - Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds
VL  - 289
DO  - 10.1016/J.FOODCHEM.2019.03.066
SP  - 404
EP  - 412
ER  - 

@article{
author = "Petropoulos, Spyridon and Fernandes, Ângela and Pereira, Carla and Tzortzakis, Nikos and Vaz, Josiana and Soković, Marina and Barros, Lillian and Ferreira, Isabel C.F.R.",
year = "2019",
abstract = "In the present study, the nutritional value, bioactive properties, and chemical composition of various cardoon (Cynara cardunculus L.) genotypes cultivated in central Greece were investigated. The results demonstrated that Cynara seeds are a good source of fat and protein, while they also contain considerable amounts of K, Mg, and Fe and low amount of Na. Sucrose, oxalic acid, and α-tocopherol were the only free sugar, organic acid, and tocopherol isoform respectively, found among the studied genotypes. The most abundant fatty acids were linoleic, oleic and palmitic acid, while PUFA was the most abundant fatty acid class. All the tested seeds contained only two phenolic compounds, namely 5-O-caffeoylquinic acid and 3,5-O-caffeoylquinic acid, while significant antioxidant activities and cytotoxicity against tumor cell lines and antimicrobial effects were also observed. In conclusion, cardoon seed extracts could be exploited in the food and pharmaceutical industries as alternative sources of natural compounds with bioactive properties.",
journal = "Food Chemistry",
title = "Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds",
volume = "289",
doi = "10.1016/J.FOODCHEM.2019.03.066",
pages = "404-412"
}

Petropoulos, S., Fernandes, Â., Pereira, C., Tzortzakis, N., Vaz, J., Soković, M., Barros, L.,& Ferreira, I. C.F.R.. (2019). Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds. in Food Chemistry, 289, 404-412.
https://doi.org/10.1016/J.FOODCHEM.2019.03.066

Petropoulos S, Fernandes Â, Pereira C, Tzortzakis N, Vaz J, Soković M, Barros L, Ferreira IC. Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds. in Food Chemistry. 2019;289:404-412.
doi:10.1016/J.FOODCHEM.2019.03.066 .

Petropoulos, Spyridon, Fernandes, Ângela, Pereira, Carla, Tzortzakis, Nikos, Vaz, Josiana, Soković, Marina, Barros, Lillian, Ferreira, Isabel C.F.R., "Bioactivities, chemical composition and nutritional value of Cynara cardunculus L. seeds" in Food Chemistry, 289 (2019):404-412,
https://doi.org/10.1016/J.FOODCHEM.2019.03.066 . .

TY  - JOUR
AU  - Karkanis, Anestis C.
AU  - Fernandes, Ângela
AU  - Vaz, Josiana
AU  - Petropoulos, Spyridon
AU  - Georgiou, Eleftheria
AU  - Ćirić, Ana
AU  - Soković, Marina
AU  - Oludemi, Taofiq
AU  - Barros, Lillian
AU  - Ferreira, Isabel C. F. R.
PY  - 2019
UR  - http://xlink.rsc.org/?DOI=C8FO02601G
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3311
AB  - Sanguisorba minor Scop. is a perennial plant native to the Mediterranean region which exhibits several medicinal activities. In the present study, plant growth, chemical composition, and antitumor and antimicrobial properties of S. minor plants were evaluated under different growing conditions. In particular, plants were grown on different substrates, namely (A) peat, (B) peat : perlite (1 : 1) and (C) peat : perlite (2 : 1). The dry weight of the aerial parts and roots was higher for the peat treatment (A), whereas plant growth was severely affected in the peat : perlite (1 : 1) treatment (B). The major detected sugars were fructose and glucose, while the peat : perlite (2 : 1) treatment resulted in a significant increase of α-tocopherol, glucose and total sugars content, especially in the aerial parts. Oxalic acid and citric acid were the major organic acids detected, with a varied effect of growth substrate on organic acid profile. Growth substrate and plant part also had a significant effect on fatty acid composition, especially on linoleic acid and α-linolenic acid content which was higher in the peat : perlite (1 : 1) treatment in both aerial parts and roots. An impact on the composition of phenolic compounds was also observed, where the plants grown on peat : perlite (2 : 1) and peat : perlite (1 : 1) substrates had the highest content of individual and total phenolic compounds in their aerial parts and roots, respectively. Moreover, roots contained significantly higher amounts of phenolic compounds than the aerial parts. Moreover, plant extracts exhibited antiproliferative activity against four tumor cell lines (HeLa, HepG2, MCF-7 and NCI-H460) and a primary culture of porcine liver cells (PLP2), as well as significant antimicrobial properties. In conclusion, S. minor presented significant bioactive properties, while growth substrates affected the nutritional value, chemical composition, antitumor and antimicrobial properties of the species which could be probably attributed to the higher phenolic compound content and different compositions of phenolic compounds. Therefore, although the species is commonly found in the Mediterranean region, it is underexploited yet and its plant tissues could be a potential source of natural bioactive compounds with further use in pharmaceutical and medicinal applications.
T2  - Food & Function
T1  - Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions.
IS  - 3
VL  - 10
DO  - 10.1039/c8fo02601g
SP  - 1340
EP  - 1351
ER  - 

@article{
author = "Karkanis, Anestis C. and Fernandes, Ângela and Vaz, Josiana and Petropoulos, Spyridon and Georgiou, Eleftheria and Ćirić, Ana and Soković, Marina and Oludemi, Taofiq and Barros, Lillian and Ferreira, Isabel C. F. R.",
year = "2019",
abstract = "Sanguisorba minor Scop. is a perennial plant native to the Mediterranean region which exhibits several medicinal activities. In the present study, plant growth, chemical composition, and antitumor and antimicrobial properties of S. minor plants were evaluated under different growing conditions. In particular, plants were grown on different substrates, namely (A) peat, (B) peat : perlite (1 : 1) and (C) peat : perlite (2 : 1). The dry weight of the aerial parts and roots was higher for the peat treatment (A), whereas plant growth was severely affected in the peat : perlite (1 : 1) treatment (B). The major detected sugars were fructose and glucose, while the peat : perlite (2 : 1) treatment resulted in a significant increase of α-tocopherol, glucose and total sugars content, especially in the aerial parts. Oxalic acid and citric acid were the major organic acids detected, with a varied effect of growth substrate on organic acid profile. Growth substrate and plant part also had a significant effect on fatty acid composition, especially on linoleic acid and α-linolenic acid content which was higher in the peat : perlite (1 : 1) treatment in both aerial parts and roots. An impact on the composition of phenolic compounds was also observed, where the plants grown on peat : perlite (2 : 1) and peat : perlite (1 : 1) substrates had the highest content of individual and total phenolic compounds in their aerial parts and roots, respectively. Moreover, roots contained significantly higher amounts of phenolic compounds than the aerial parts. Moreover, plant extracts exhibited antiproliferative activity against four tumor cell lines (HeLa, HepG2, MCF-7 and NCI-H460) and a primary culture of porcine liver cells (PLP2), as well as significant antimicrobial properties. In conclusion, S. minor presented significant bioactive properties, while growth substrates affected the nutritional value, chemical composition, antitumor and antimicrobial properties of the species which could be probably attributed to the higher phenolic compound content and different compositions of phenolic compounds. Therefore, although the species is commonly found in the Mediterranean region, it is underexploited yet and its plant tissues could be a potential source of natural bioactive compounds with further use in pharmaceutical and medicinal applications.",
journal = "Food & Function",
title = "Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions.",
number = "3",
volume = "10",
doi = "10.1039/c8fo02601g",
pages = "1340-1351"
}

Karkanis, A. C., Fernandes, Â., Vaz, J., Petropoulos, S., Georgiou, E., Ćirić, A., Soković, M., Oludemi, T., Barros, L.,& Ferreira, I. C. F. R.. (2019). Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions.. in Food & Function, 10(3), 1340-1351.
https://doi.org/10.1039/c8fo02601g

Karkanis AC, Fernandes Â, Vaz J, Petropoulos S, Georgiou E, Ćirić A, Soković M, Oludemi T, Barros L, Ferreira ICFR. Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions.. in Food & Function. 2019;10(3):1340-1351.
doi:10.1039/c8fo02601g .

Karkanis, Anestis C., Fernandes, Ângela, Vaz, Josiana, Petropoulos, Spyridon, Georgiou, Eleftheria, Ćirić, Ana, Soković, Marina, Oludemi, Taofiq, Barros, Lillian, Ferreira, Isabel C. F. R., "Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions." in Food & Function, 10, no. 3 (2019):1340-1351,
https://doi.org/10.1039/c8fo02601g . .

TY  - JOUR
AU  - Senio, Sylwia
AU  - Pereira, Carla
AU  - Vaz, Josiana
AU  - Soković, Marina
AU  - Barros, Lillian
AU  - Ferreira, Isabel C.F.R.
PY  - 2018
UR  - https://www.sciencedirect.com/science/article/pii/S0926669018303650?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3050
AB  - Galium aparine L. is a very disseminated plant in temperate zones, commonly known as clivers or bedstraw, belonging to the Rubiaceae family and it is traditionally used for its medicinal applications. In this study, G. aparine hydromethanolic extracts and infusions were prepared from air-dried and freeze-dried samples in order to assess their phenolic profile, antioxidant, antimicrobial, and cytotoxic properties. All the studied extracts revealed a similar phenolic profile, but the hydromethanolic extract obtained from the freeze-dried sample presented the highest concentration of phenolic compounds, followed by the respective infusion and the air-dried sample hydromethanolic extract. The major compound detected in the extracts was 5-O-caffeoylquinic acid (from 145 to 163 mg/g extract). Regarding the bioactivity, in general, the extracts presenting higher phenolic concentrations also revealed enhanced bioactive properties. The EC50 values obtained in the antioxidant activity assays ranged from 13.5 to 884 μg/mL, with the freeze-dried sample hydromethanolic extract presenting the highest activity (13.5–555 μg/mL). Similar conclusions could be made in terms of antimicrobial properties, with this extract showing the lowest MIC (1.85–15 mg/mL), MBC (3.75–7.5 mg/mL), and MFC (3.75–20 mg/mL) values. None of the extracts revealed cytotoxicity. The results obtained in this study suggested that G. aparine extracts can be a good source of phenolic compounds with antioxidant and antimicrobial properties.
T2  - Industrial Crops and Products
T1  - Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.
VL  - 120
DO  - 10.1016/J.INDCROP.2018.04.054
SP  - 97
EP  - 103
ER  - 

@article{
author = "Senio, Sylwia and Pereira, Carla and Vaz, Josiana and Soković, Marina and Barros, Lillian and Ferreira, Isabel C.F.R.",
year = "2018",
abstract = "Galium aparine L. is a very disseminated plant in temperate zones, commonly known as clivers or bedstraw, belonging to the Rubiaceae family and it is traditionally used for its medicinal applications. In this study, G. aparine hydromethanolic extracts and infusions were prepared from air-dried and freeze-dried samples in order to assess their phenolic profile, antioxidant, antimicrobial, and cytotoxic properties. All the studied extracts revealed a similar phenolic profile, but the hydromethanolic extract obtained from the freeze-dried sample presented the highest concentration of phenolic compounds, followed by the respective infusion and the air-dried sample hydromethanolic extract. The major compound detected in the extracts was 5-O-caffeoylquinic acid (from 145 to 163 mg/g extract). Regarding the bioactivity, in general, the extracts presenting higher phenolic concentrations also revealed enhanced bioactive properties. The EC50 values obtained in the antioxidant activity assays ranged from 13.5 to 884 μg/mL, with the freeze-dried sample hydromethanolic extract presenting the highest activity (13.5–555 μg/mL). Similar conclusions could be made in terms of antimicrobial properties, with this extract showing the lowest MIC (1.85–15 mg/mL), MBC (3.75–7.5 mg/mL), and MFC (3.75–20 mg/mL) values. None of the extracts revealed cytotoxicity. The results obtained in this study suggested that G. aparine extracts can be a good source of phenolic compounds with antioxidant and antimicrobial properties.",
journal = "Industrial Crops and Products",
title = "Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.",
volume = "120",
doi = "10.1016/J.INDCROP.2018.04.054",
pages = "97-103"
}

Senio, S., Pereira, C., Vaz, J., Soković, M., Barros, L.,& Ferreira, I. C.F.R.. (2018). Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.. in Industrial Crops and Products, 120, 97-103.
https://doi.org/10.1016/J.INDCROP.2018.04.054

Senio S, Pereira C, Vaz J, Soković M, Barros L, Ferreira IC. Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.. in Industrial Crops and Products. 2018;120:97-103.
doi:10.1016/J.INDCROP.2018.04.054 .

Senio, Sylwia, Pereira, Carla, Vaz, Josiana, Soković, Marina, Barros, Lillian, Ferreira, Isabel C.F.R., "Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L." in Industrial Crops and Products, 120 (2018):97-103,
https://doi.org/10.1016/J.INDCROP.2018.04.054 . .