TY  - JOUR
AU  - Jelenković, Ankica V.
AU  - Jovanović, Marina D
AU  - Đurđević, Dragan
AU  - Stanimirović, Danica
AU  - Bokonjić, Dubravko R
AU  - Vasiljević, Ivana D
AU  - Mihajlović, Rosa R
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1426
AB  - Certain types of convulsions may lead to multiorgan dysfunction. We investigated whether the chemoconvulsant pentylenetetrazole (PTZ) could influence energy synthesis in the liver besides evoking convulsions in adult male Wistar rats. In 80% of the rats PTZ (100 mg/kg body weight, administered intraperitoneally - i.p.) evoked generalised clonic convulsions (GCCs) and in 60% of the rats generalised clonic-tonic convulsions (GCTCs) within 4 min after its administration. Cytochrome c oxidase activity was simultaneously reduced approximately three-fold compared to 0.9% NaCl-treated (control) rats (p < 0.01). Midazolam administered before PTZ was an excellent anti-convulsant especially against GCCs (p < 0.05). However, it did not protect against the decrease in cytochrome c oxidase activity induced by PTZ. In contrast to midazolam, pretreatment with L-arginine did not prevent PTZ-evoked convulsions. However, it offered some protection against the PTZ-mediated reduction in cytochrome c oxidase activity. Our results open new avenues of research that will focus on the mechanisms of action of PTZ, midazolam and L-arginine with particular reference to their direct and/or indirect effects on liver function.
T2  - Acta Veterinaria Brno
T1  - Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole
IS  - 3
VL  - 78
EP  - 490
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1426
ER  - 

@article{
author = "Jelenković, Ankica V. and Jovanović, Marina D and Đurđević, Dragan and Stanimirović, Danica and Bokonjić, Dubravko R and Vasiljević, Ivana D and Mihajlović, Rosa R",
year = "2009",
abstract = "Certain types of convulsions may lead to multiorgan dysfunction. We investigated whether the chemoconvulsant pentylenetetrazole (PTZ) could influence energy synthesis in the liver besides evoking convulsions in adult male Wistar rats. In 80% of the rats PTZ (100 mg/kg body weight, administered intraperitoneally - i.p.) evoked generalised clonic convulsions (GCCs) and in 60% of the rats generalised clonic-tonic convulsions (GCTCs) within 4 min after its administration. Cytochrome c oxidase activity was simultaneously reduced approximately three-fold compared to 0.9% NaCl-treated (control) rats (p < 0.01). Midazolam administered before PTZ was an excellent anti-convulsant especially against GCCs (p < 0.05). However, it did not protect against the decrease in cytochrome c oxidase activity induced by PTZ. In contrast to midazolam, pretreatment with L-arginine did not prevent PTZ-evoked convulsions. However, it offered some protection against the PTZ-mediated reduction in cytochrome c oxidase activity. Our results open new avenues of research that will focus on the mechanisms of action of PTZ, midazolam and L-arginine with particular reference to their direct and/or indirect effects on liver function.",
journal = "Acta Veterinaria Brno",
title = "Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole",
number = "3",
volume = "78",
pages = "490",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1426"
}

Jelenković, A. V., Jovanović, M. D., Đurđević, D., Stanimirović, D., Bokonjić, D. R., Vasiljević, I. D.,& Mihajlović, R. R.. (2009). Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole. in Acta Veterinaria Brno, 78(3).
https://hdl.handle.net/21.15107/rcub_ibiss_1426

Jelenković AV, Jovanović MD, Đurđević D, Stanimirović D, Bokonjić DR, Vasiljević ID, Mihajlović RR. Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole. in Acta Veterinaria Brno. 2009;78(3):null-490.
https://hdl.handle.net/21.15107/rcub_ibiss_1426 .

Jelenković, Ankica V., Jovanović, Marina D, Đurđević, Dragan, Stanimirović, Danica, Bokonjić, Dubravko R, Vasiljević, Ivana D, Mihajlović, Rosa R, "Influence of Midazolam and L-Arginine on Clinical Observations and Biochemical Changes in Rat Liver Induced by Pentylenetetrazole" in Acta Veterinaria Brno, 78, no. 3 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1426 .