TY  - JOUR
AU  - Stević, Tatjana
AU  - Stanković, Slaviša
AU  - Šavikin, Katarina
AU  - Gođevac, Dejan
AU  - Dimkić, Ivica
AU  - Soković, Marina
AU  - Berić, Tanja
PY  - 2014
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/412
AB  - In recent years great attention was paid to biological control, the application of natural products in order to protect crops and medicinal plants against contamination with phytopathogenic and saprophytic fungi. Essential oils have been evaluated as a potentially safe replacement for chemicals used for that purpose. In this regard, antifungal potential of six essential oils was examined coupled with determination of the complete qualitative and quantitative chemical composition by GC-FID and GC-MS analysis. While essential oils of rosemary, sage, Spanish sage and black pepper were exclusively composed of monoterpenes, vetiver essential oil was entirely composed of sesquiterpenes. In essential oil of cinnamon dominates (E)-cinnamaldehyde. Applying the in vitro microdilution method, it was found that all essential oils were active in inhibiting the growth of all tested 21 pre- and post-harvest phytopathogenic and saprophytic fungi. MIC and MFC ranged from 1.2 mg ml-1 up to 22.6 mg ml-1 according to the test oil. Rosemary oil showed the best antifungal potential, followed by black pepper and cinnamon oil. Sage and Spanish sage oils also exhibited significant antifungal potential. Vetiver oil demonstrated the lowest antifungal activity. Essential oils that showed considerable antifungal potential are good candidates for further examination of their use in preventing and/or protection of medicinal plants, their seeds and dried drugs against fungal infections, both in the field and in warehouses.
AB  - Poslednjih godina velika pažnja poklanja se biološkoj kontroli to jest primeni prirodnih produkata u zaštiti, kako poljoprivrednih kultura, tako i lekovitog bilja od kontaminacije fitopatogenim i saprofitnim gljivama. U tom smislu, ispitivan je antifungalni potencijal šest etarskih ulja uz određivanje kompletnog kvalitativnog i kvantitativnog hemijskog sastava primenom GC-FID i GC-MS analiza. Dok se korišćeni uzorci etarskih ulja ruzmarina, žalfije, španske žalfije i crnog bibera isključivo sastoje od monoterpena, u ulju vetivera potpuno dominiraju seskviterpeni. U etarskom ulju cimeta najzastupljenija komponneta je bila (E)- cinemaldehid. Primenom in vitro mikrodilucione metode, utvrđeno je da su sva ulja bila aktivna u inhibiciji rasta 21 testirane, pre- i post-žetvene, fitopatogene i saprofitne gljive, sa razlikama u efikasnosti. MIC i MFC vrednosti su varirale u opsegu od 1,2 mg ml-1 do 22,6 mg ml-1, u zavisnosti od ispitivanog ulja. Najbolja antifungalna aktivnost utvrđena je za ulje ruzmarina, nešto slabija za ulja crnog bibera i cimeta, dok je ulje vetivera ispoljilo najslabiju aktivnost. Etarska ulja obe vrste žalfija ispoljila su značajan antifungalni potencijal. Etarska ulja koja poseduju značajan antifungalni potencijal su dobri kandidati za nastavak istraživanja u pravcu njihove primene u prevenciji i zaštiti useva lekovitog bilja, kao i njihovih semena i osušenih biljnih droga od gljivičnih infekcija, i u polju i u skladištima.
T2  - Lekovite sirovine
T1  - Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja
T1  - Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants
IS  - 34
VL  - 34
SP  - 69
EP  - 80
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_412
ER  - 

@article{
author = "Stević, Tatjana and Stanković, Slaviša and Šavikin, Katarina and Gođevac, Dejan and Dimkić, Ivica and Soković, Marina and Berić, Tanja",
year = "2014, 2014",
abstract = "In recent years great attention was paid to biological control, the application of natural products in order to protect crops and medicinal plants against contamination with phytopathogenic and saprophytic fungi. Essential oils have been evaluated as a potentially safe replacement for chemicals used for that purpose. In this regard, antifungal potential of six essential oils was examined coupled with determination of the complete qualitative and quantitative chemical composition by GC-FID and GC-MS analysis. While essential oils of rosemary, sage, Spanish sage and black pepper were exclusively composed of monoterpenes, vetiver essential oil was entirely composed of sesquiterpenes. In essential oil of cinnamon dominates (E)-cinnamaldehyde. Applying the in vitro microdilution method, it was found that all essential oils were active in inhibiting the growth of all tested 21 pre- and post-harvest phytopathogenic and saprophytic fungi. MIC and MFC ranged from 1.2 mg ml-1 up to 22.6 mg ml-1 according to the test oil. Rosemary oil showed the best antifungal potential, followed by black pepper and cinnamon oil. Sage and Spanish sage oils also exhibited significant antifungal potential. Vetiver oil demonstrated the lowest antifungal activity. Essential oils that showed considerable antifungal potential are good candidates for further examination of their use in preventing and/or protection of medicinal plants, their seeds and dried drugs against fungal infections, both in the field and in warehouses., Poslednjih godina velika pažnja poklanja se biološkoj kontroli to jest primeni prirodnih produkata u zaštiti, kako poljoprivrednih kultura, tako i lekovitog bilja od kontaminacije fitopatogenim i saprofitnim gljivama. U tom smislu, ispitivan je antifungalni potencijal šest etarskih ulja uz određivanje kompletnog kvalitativnog i kvantitativnog hemijskog sastava primenom GC-FID i GC-MS analiza. Dok se korišćeni uzorci etarskih ulja ruzmarina, žalfije, španske žalfije i crnog bibera isključivo sastoje od monoterpena, u ulju vetivera potpuno dominiraju seskviterpeni. U etarskom ulju cimeta najzastupljenija komponneta je bila (E)- cinemaldehid. Primenom in vitro mikrodilucione metode, utvrđeno je da su sva ulja bila aktivna u inhibiciji rasta 21 testirane, pre- i post-žetvene, fitopatogene i saprofitne gljive, sa razlikama u efikasnosti. MIC i MFC vrednosti su varirale u opsegu od 1,2 mg ml-1 do 22,6 mg ml-1, u zavisnosti od ispitivanog ulja. Najbolja antifungalna aktivnost utvrđena je za ulje ruzmarina, nešto slabija za ulja crnog bibera i cimeta, dok je ulje vetivera ispoljilo najslabiju aktivnost. Etarska ulja obe vrste žalfija ispoljila su značajan antifungalni potencijal. Etarska ulja koja poseduju značajan antifungalni potencijal su dobri kandidati za nastavak istraživanja u pravcu njihove primene u prevenciji i zaštiti useva lekovitog bilja, kao i njihovih semena i osušenih biljnih droga od gljivičnih infekcija, i u polju i u skladištima.",
journal = "Lekovite sirovine",
title = "Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja, Chemical composition and inhibitory activity of selected essential oils against fungi isolated from medicinal plants",
number = "34",
volume = "34",
pages = "69-80",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_412"
}

Stević, T., Stanković, S., Šavikin, K., Gođevac, D., Dimkić, I., Soković, M.,& Berić, T.. (2014). Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja. in Lekovite sirovine, 34(34), 69-80.
https://hdl.handle.net/21.15107/rcub_ibiss_412

Stević T, Stanković S, Šavikin K, Gođevac D, Dimkić I, Soković M, Berić T. Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja. in Lekovite sirovine. 2014;34(34):69-80.
https://hdl.handle.net/21.15107/rcub_ibiss_412 .

Stević, Tatjana, Stanković, Slaviša, Šavikin, Katarina, Gođevac, Dejan, Dimkić, Ivica, Soković, Marina, Berić, Tanja, "Hemijski sastav i inhibitorna aktivnost odabranih etarskih ulja na gljive izolovane sa lekovitog bilja" in Lekovite sirovine, 34, no. 34 (2014):69-80,
https://hdl.handle.net/21.15107/rcub_ibiss_412 .

TY  - CONF
AU  - Stanković, S
AU  - Asanin, M
AU  - Vasiljević, Z
AU  - Majkić-Singh, N
AU  - Mihailović, Mirjana
AU  - Nikolajević, I
AU  - Ostojić, M
PY  - 2011
UR  - http://eurheartj.oxfordjournals.org/content/32/suppl_1
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3206
AB  - Background: The predictive value of myeloperoxidase (MPO) with respect to in-
hospital mortality in ST-segment elevation myocardial infarction (STEMI) treated
by primary percutaneous coronary intervention (PCI) is unknown. The aim of the
present study was to investigate MPO as a predictor of in-hospital mortality in
STEMI patients treated by primary PCI.
Methods: Study population consisted of 189 STEMI patients underwent primary
PCI. Plasma MPO level was measured 24h after symptom onset using chemilu-
minescent microparticle immunoassay (Abbott Diagnostics, Germany). The Re-
ceiver Operating Characteristic analysis was performed to identify the most useful
MPO cut-off level for the prediction of in-hospital mortality. The patients were di-
vided into two groups according to the cut-off MPO level.
Results: The incidence of in-hospital mortality was 5.8% (11/189 patients). It was
significantly higher in those with high MPO (≥840 pmol/L) (13.8%, 9/65 patients)
than in those with low MPO (<840 pmol/L) (1.6%, 2/124 patients) (p=0.001).
Patients with a high MPO had significantly more frequent anterior wall infarc-
tion (p<0.001), higher Killip class at admission (p=0.013), lower left ventricular
ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP)
(p=0.029) than patients with low MPO. Multiple logistic regression analysis re-
vealed that the independent predictors of in-hospital mortality were MPO (OR
3.88, 95%CI 1.13–13.34, p=0.031), BNP (OR 4.40, 95%CI 1.11–17.37, p=0.034),
lower LVEF (OR 0,88, 95%CI 0.80–0.97, p=0.009), estimated glomerular filtration
rate (OR 0,93, 95%CI 0.88–0.99, p=0.035), Killip class at admission (OR 10.76,
95%CI 1.23–94.01, p=0.032).
Conclusion: Plasma MPO level independently predicts in-hospital mortality in
STEMI patients treated by primary PCI.
PB  - European Society of Cardiology
C3  - ESC Congress 2011; 2011 Aug 37-31; Paris, France
T1  - Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
VL  - 32
DO  - 10.1093/eurheartj/ehr325
SP  - 1064
EP  - 1064
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3206
ER  - 

@conference{
author = "Stanković, S and Asanin, M and Vasiljević, Z and Majkić-Singh, N and Mihailović, Mirjana and Nikolajević, I and Ostojić, M",
year = "2011",
abstract = "Background: The predictive value of myeloperoxidase (MPO) with respect to in-
hospital mortality in ST-segment elevation myocardial infarction (STEMI) treated
by primary percutaneous coronary intervention (PCI) is unknown. The aim of the
present study was to investigate MPO as a predictor of in-hospital mortality in
STEMI patients treated by primary PCI.
Methods: Study population consisted of 189 STEMI patients underwent primary
PCI. Plasma MPO level was measured 24h after symptom onset using chemilu-
minescent microparticle immunoassay (Abbott Diagnostics, Germany). The Re-
ceiver Operating Characteristic analysis was performed to identify the most useful
MPO cut-off level for the prediction of in-hospital mortality. The patients were di-
vided into two groups according to the cut-off MPO level.
Results: The incidence of in-hospital mortality was 5.8% (11/189 patients). It was
significantly higher in those with high MPO (≥840 pmol/L) (13.8%, 9/65 patients)
than in those with low MPO (<840 pmol/L) (1.6%, 2/124 patients) (p=0.001).
Patients with a high MPO had significantly more frequent anterior wall infarc-
tion (p<0.001), higher Killip class at admission (p=0.013), lower left ventricular
ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP)
(p=0.029) than patients with low MPO. Multiple logistic regression analysis re-
vealed that the independent predictors of in-hospital mortality were MPO (OR
3.88, 95%CI 1.13–13.34, p=0.031), BNP (OR 4.40, 95%CI 1.11–17.37, p=0.034),
lower LVEF (OR 0,88, 95%CI 0.80–0.97, p=0.009), estimated glomerular filtration
rate (OR 0,93, 95%CI 0.88–0.99, p=0.035), Killip class at admission (OR 10.76,
95%CI 1.23–94.01, p=0.032).
Conclusion: Plasma MPO level independently predicts in-hospital mortality in
STEMI patients treated by primary PCI.",
publisher = "European Society of Cardiology",
journal = "ESC Congress 2011; 2011 Aug 37-31; Paris, France",
title = "Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention",
volume = "32",
doi = "10.1093/eurheartj/ehr325",
pages = "1064-1064",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3206"
}

Stanković, S., Asanin, M., Vasiljević, Z., Majkić-Singh, N., Mihailović, M., Nikolajević, I.,& Ostojić, M.. (2011). Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in ESC Congress 2011; 2011 Aug 37-31; Paris, France
European Society of Cardiology., 32, 1064-1064.
https://doi.org/10.1093/eurheartj/ehr325
https://hdl.handle.net/21.15107/rcub_ibiss_3206

Stanković S, Asanin M, Vasiljević Z, Majkić-Singh N, Mihailović M, Nikolajević I, Ostojić M. Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in ESC Congress 2011; 2011 Aug 37-31; Paris, France. 2011;32:1064-1064.
doi:10.1093/eurheartj/ehr325
https://hdl.handle.net/21.15107/rcub_ibiss_3206 .

Stanković, S, Asanin, M, Vasiljević, Z, Majkić-Singh, N, Mihailović, Mirjana, Nikolajević, I, Ostojić, M, "Prognostic significance of myeloperoxidase in prediction in-hospital mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention" in ESC Congress 2011; 2011 Aug 37-31; Paris, France, 32 (2011):1064-1064,
https://doi.org/10.1093/eurheartj/ehr325 .,
https://hdl.handle.net/21.15107/rcub_ibiss_3206 .