TY  - JOUR
AU  - Dujmović, Irena
AU  - Pekmezović, Tatjana D
AU  - Obrenović, Radmila Z
AU  - Nikolić, Aleksandra L.
AU  - Spasić, Mihajlo
AU  - Mostarica-Stojković, Marija B
AU  - Drulović, Jelena S
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1442
AB  - Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009; 47: 848-53.
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis
IS  - 7
VL  - 47
EP  - 853
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1442
ER  - 

@article{
author = "Dujmović, Irena and Pekmezović, Tatjana D and Obrenović, Radmila Z and Nikolić, Aleksandra L. and Spasić, Mihajlo and Mostarica-Stojković, Marija B and Drulović, Jelena S",
year = "2009",
abstract = "Background: Peroxynitrite was hypothesized to be involved in the pathogenesis of multiple sclerosis (MS) through its various neurotoxic effects. Uric acid (UA) was shown to be a strong peroxynitrite scavenger. Methods: We analyzed cerebrospinal fluid (CSF) and serum UA concentrations in 30 MS patients and 20 controls with non-inflammatory neurological diseases (NIND) and correlated these findings with demographic and clinical characteristics of MS patients. Disease activity was assessed by brain magnetic resonance imaging (MRI) and the CSF/serum albumin quotient as an indicator of the state of blood-brain-barrier (BBB). Results: Serum UA concentrations were found to be significantly lower in MS patients compared with controls (p=0.019). CSF UA concentrations were lower in MS patients as compared to controls, as well as in patients with active MS (clinical and/or MRI activity) in comparison to patients with inactive MS or controls, but these differences were not statistically significant. Significant correlation was found between CSF and serum UA concentrations (p=0.016) in MS patients, but not in controls; and between CSF UA concentrations and the CSF/serum albumin quotient in MS patients (p=0.043), but not in controls. Conclusions: Our results support the significance of UA in the pathogenesis of MS. Decreased serum UA concentrations in MS patients might be due to both intrinsically reduced antioxidant capacity and increased UA consumption in MS. CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS). Clin Chem Lab Med 2009; 47: 848-53.",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis",
number = "7",
volume = "47",
pages = "853",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1442"
}

Dujmović, I., Pekmezović, T. D., Obrenović, R. Z., Nikolić, A. L., Spasić, M., Mostarica-Stojković, M. B.,& Drulović, J. S.. (2009). Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis. in Clinical Chemistry and Laboratory Medicine, 47(7).
https://hdl.handle.net/21.15107/rcub_ibiss_1442

Dujmović I, Pekmezović TD, Obrenović RZ, Nikolić AL, Spasić M, Mostarica-Stojković MB, Drulović JS. Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis. in Clinical Chemistry and Laboratory Medicine. 2009;47(7):null-853.
https://hdl.handle.net/21.15107/rcub_ibiss_1442 .

Dujmović, Irena, Pekmezović, Tatjana D, Obrenović, Radmila Z, Nikolić, Aleksandra L., Spasić, Mihajlo, Mostarica-Stojković, Marija B, Drulović, Jelena S, "Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis" in Clinical Chemistry and Laboratory Medicine, 47, no. 7 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1442 .

TY  - JOUR
AU  - Drulović, Jelena
AU  - Popadić, Dušan
AU  - Mesaroš, Šarlota
AU  - Dujmović, Irena
AU  - Stojanović, Ivana D.
AU  - Miljković, Djordje
AU  - Stojsavljević, Nebojša
AU  - Pravica, Vera
AU  - Pekmezović, Tatjana
AU  - Bogdanović, Gradimir
AU  - Jarebinski, Mirjana
AU  - Mostarica Stojković, Marija
PY  - 2003
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5924
AB  - Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high TNFalpha production. We investigated the TNFalpha -308 polymorphism in 143 unrelated Serbian patients with MS and 123 ethnically matched, healthy individuals using the allele-specific restriction fragment length polymorphism polymerase chain reaction technique. The frequency of the TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients. The result suggests that in the Serbian population polymorphism at position -308 of TNFalpha or at an adjacent locus might have a role in MS susceptibility.
PB  - Basel: Krager AG
T2  - European Neurology
T1  - Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis
IS  - 1
VL  - 50
DO  - 10.1159/000070855
SP  - 25
EP  - 29
ER  - 

@article{
author = "Drulović, Jelena and Popadić, Dušan and Mesaroš, Šarlota and Dujmović, Irena and Stojanović, Ivana D. and Miljković, Djordje and Stojsavljević, Nebojša and Pravica, Vera and Pekmezović, Tatjana and Bogdanović, Gradimir and Jarebinski, Mirjana and Mostarica Stojković, Marija",
year = "2003",
abstract = "Tumor necrosis factor (TNF) alpha has been considered the prototypic cytopathogenic cytokine in multiple sclerosis (MS), but recently this cytokine has been shown to possess significant anti-inflammatory and neuroprotective effects in demyelinating diseases. It has been reported that the TNFalpha -308 polymorphism influences levels of TNFalpha production, and that the rare allele, TNF2, is associated with high TNFalpha production. We investigated the TNFalpha -308 polymorphism in 143 unrelated Serbian patients with MS and 123 ethnically matched, healthy individuals using the allele-specific restriction fragment length polymorphism polymerase chain reaction technique. The frequency of the TNF2 allele was significantly decreased in MS patients (14%) in comparison with controls (24%; p = 0.044). The TNF2 allele had no influence on disease behavior, since it was not associated with the course and severity of MS in this group of patients. The result suggests that in the Serbian population polymorphism at position -308 of TNFalpha or at an adjacent locus might have a role in MS susceptibility.",
publisher = "Basel: Krager AG",
journal = "European Neurology",
title = "Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis",
number = "1",
volume = "50",
doi = "10.1159/000070855",
pages = "25-29"
}

Drulović, J., Popadić, D., Mesaroš, Š., Dujmović, I., Stojanović, I. D., Miljković, D., Stojsavljević, N., Pravica, V., Pekmezović, T., Bogdanović, G., Jarebinski, M.,& Mostarica Stojković, M.. (2003). Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis. in European Neurology
Basel: Krager AG., 50(1), 25-29.
https://doi.org/10.1159/000070855

Drulović J, Popadić D, Mesaroš Š, Dujmović I, Stojanović ID, Miljković D, Stojsavljević N, Pravica V, Pekmezović T, Bogdanović G, Jarebinski M, Mostarica Stojković M. Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis. in European Neurology. 2003;50(1):25-29.
doi:10.1159/000070855 .

Drulović, Jelena, Popadić, Dušan, Mesaroš, Šarlota, Dujmović, Irena, Stojanović, Ivana D., Miljković, Djordje, Stojsavljević, Nebojša, Pravica, Vera, Pekmezović, Tatjana, Bogdanović, Gradimir, Jarebinski, Mirjana, Mostarica Stojković, Marija, "Decreased Frequency of the Tumor Necrosis Factor α –308 Allele in Serbian Patients with Multiple Sclerosis" in European Neurology, 50, no. 1 (2003):25-29,
https://doi.org/10.1159/000070855 . .