TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Grdović, Nevena
AU  - Dinić, Svetlana
AU  - Uskoković, Aleksandra
AU  - Vidaković, Melita
AU  - Grigorov, Ilijana
AU  - Bogojević, Desanka
AU  - Ivanović Matić, Svetlana
AU  - Petrović, Miodrag
AU  - Labus-Blagojević, Svetlana
AU  - Martinović, Vesna
AU  - Arambašić Jovanović, Jelena
AU  - Poznanović, Goran
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1342
AB  - Background and Purpose CYP1A is one of the most sensitive biomarkers in fish of exposure to polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) These compounds induce a dose-dependent transcriptional induction of the CYP1A gene that results in increased protein concentrations The aim of this study was the detection of changes in CYP1A protein levels as a result of the exposure of fish to PAHs and PCBs at the mouth of the river Bojana in the spring Materials and Methods The PAH and PCB contents in seawater and sediment were determined by gas chromatography CYP1A induction was examined in the hepatopancreas of Red mullet (Mullus barbatus), European hake (Merluccius merluccius) and Tub gurnard (Trigla lucerna) by immunoblot analysis Results and Conclusions Chemical analyses of seawater and sediment revealed the presence of several PAHs and PCBs CYP1A was detected in the hepatic microsomal fraction in all examined fish species as an adaptive response to the presence of pollutants The reported changes at the molecular level represent an early-warning signal that reflected the biological response of fish to elevated toxin concentrations in the environment
PB  - Zagreb: Hrvatsko prirodoslovno društvo
T2  - Periodicum Biologorum
T1  - CYP1A expression in the hepatopancreas of Mullus barbatus, Merluccius merluccius and Trigla lucerna at the mouth of the river Bojana
IS  - 2
VL  - 112
SP  - 167
EP  - 171
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1342
ER  - 

@article{
author = "Mihailović, Mirjana and Grdović, Nevena and Dinić, Svetlana and Uskoković, Aleksandra and Vidaković, Melita and Grigorov, Ilijana and Bogojević, Desanka and Ivanović Matić, Svetlana and Petrović, Miodrag and Labus-Blagojević, Svetlana and Martinović, Vesna and Arambašić Jovanović, Jelena and Poznanović, Goran",
year = "2010",
abstract = "Background and Purpose CYP1A is one of the most sensitive biomarkers in fish of exposure to polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) These compounds induce a dose-dependent transcriptional induction of the CYP1A gene that results in increased protein concentrations The aim of this study was the detection of changes in CYP1A protein levels as a result of the exposure of fish to PAHs and PCBs at the mouth of the river Bojana in the spring Materials and Methods The PAH and PCB contents in seawater and sediment were determined by gas chromatography CYP1A induction was examined in the hepatopancreas of Red mullet (Mullus barbatus), European hake (Merluccius merluccius) and Tub gurnard (Trigla lucerna) by immunoblot analysis Results and Conclusions Chemical analyses of seawater and sediment revealed the presence of several PAHs and PCBs CYP1A was detected in the hepatic microsomal fraction in all examined fish species as an adaptive response to the presence of pollutants The reported changes at the molecular level represent an early-warning signal that reflected the biological response of fish to elevated toxin concentrations in the environment",
publisher = "Zagreb: Hrvatsko prirodoslovno društvo",
journal = "Periodicum Biologorum",
title = "CYP1A expression in the hepatopancreas of Mullus barbatus, Merluccius merluccius and Trigla lucerna at the mouth of the river Bojana",
number = "2",
volume = "112",
pages = "167-171",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1342"
}

Mihailović, M., Grdović, N., Dinić, S., Uskoković, A., Vidaković, M., Grigorov, I., Bogojević, D., Ivanović Matić, S., Petrović, M., Labus-Blagojević, S., Martinović, V., Arambašić Jovanović, J.,& Poznanović, G.. (2010). CYP1A expression in the hepatopancreas of Mullus barbatus, Merluccius merluccius and Trigla lucerna at the mouth of the river Bojana. in Periodicum Biologorum
Zagreb: Hrvatsko prirodoslovno društvo., 112(2), 167-171.
https://hdl.handle.net/21.15107/rcub_ibiss_1342

Mihailović M, Grdović N, Dinić S, Uskoković A, Vidaković M, Grigorov I, Bogojević D, Ivanović Matić S, Petrović M, Labus-Blagojević S, Martinović V, Arambašić Jovanović J, Poznanović G. CYP1A expression in the hepatopancreas of Mullus barbatus, Merluccius merluccius and Trigla lucerna at the mouth of the river Bojana. in Periodicum Biologorum. 2010;112(2):167-171.
https://hdl.handle.net/21.15107/rcub_ibiss_1342 .

Mihailović, Mirjana, Grdović, Nevena, Dinić, Svetlana, Uskoković, Aleksandra, Vidaković, Melita, Grigorov, Ilijana, Bogojević, Desanka, Ivanović Matić, Svetlana, Petrović, Miodrag, Labus-Blagojević, Svetlana, Martinović, Vesna, Arambašić Jovanović, Jelena, Poznanović, Goran, "CYP1A expression in the hepatopancreas of Mullus barbatus, Merluccius merluccius and Trigla lucerna at the mouth of the river Bojana" in Periodicum Biologorum, 112, no. 2 (2010):167-171,
https://hdl.handle.net/21.15107/rcub_ibiss_1342 .

TY  - JOUR
AU  - Mihailović, Mirjana
AU  - Dobrić, Silva Lj
AU  - Poznanović, Goran
AU  - Petrović, Miodrag V
AU  - Uskoković, Aleksandra
AU  - Arambašić Jovanović, Jelena
AU  - Bogojević, Desanka
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1449
AB  - The importance of alpha(2)-macroglobulin (alpha(2)M) in natural radioprotection was studied by examining its radioprotective effectiveness in rat models of exogenously and endogenously, preexposure-increased alpha(2)M. Radioprotective efficacy was ascertained by the postirradiation survival rate, the restoration of body weight, and the leukocyte count, which were monitored during a 4-week follow-up period. The results were compared with the effects of a pretreatment with the synthetic radioprotective agent amifostine (Ami), which provides 100% protection in rats whole-body-irradiated by x-rays given in a dose of 6.7 Gy (LD(50/30)). Raising the plasma concentration of alpha(2)M 15-fold in male rats by a single intraperitoneal injection of purified protein provided 100% survival of irradiated animals. Female rats on the 19th day of pregnancy with endogenously elevated levels of alpha(2)M displayed improved survival (80%) compared with untreated rats (50% survival). After alpha(2)M administration, the pregnant, irradiated rats exhibited 100% survival. In both males and pregnant females, alpha(2)M administration promoted body weight and leukocyte postirradiation recovery as in Ami-pretreated rats. These findings, together with our observation that Ami administration induced a 45-fold increase in alpha(2)M in the circulation, led us to conclude that alpha(2)M has an essential role in both natural and amifostine-mediated radioprotection in the rat.
PB  - Wolters Kluwer Health, Inc.
T2  - Shock
T1  - The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat
IS  - 6
VL  - 31
DO  - 10.1097/SHK.0b013e31818bb625
SP  - 607
EP  - 614
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1449
ER  - 

@article{
author = "Mihailović, Mirjana and Dobrić, Silva Lj and Poznanović, Goran and Petrović, Miodrag V and Uskoković, Aleksandra and Arambašić Jovanović, Jelena and Bogojević, Desanka",
year = "2009",
abstract = "The importance of alpha(2)-macroglobulin (alpha(2)M) in natural radioprotection was studied by examining its radioprotective effectiveness in rat models of exogenously and endogenously, preexposure-increased alpha(2)M. Radioprotective efficacy was ascertained by the postirradiation survival rate, the restoration of body weight, and the leukocyte count, which were monitored during a 4-week follow-up period. The results were compared with the effects of a pretreatment with the synthetic radioprotective agent amifostine (Ami), which provides 100% protection in rats whole-body-irradiated by x-rays given in a dose of 6.7 Gy (LD(50/30)). Raising the plasma concentration of alpha(2)M 15-fold in male rats by a single intraperitoneal injection of purified protein provided 100% survival of irradiated animals. Female rats on the 19th day of pregnancy with endogenously elevated levels of alpha(2)M displayed improved survival (80%) compared with untreated rats (50% survival). After alpha(2)M administration, the pregnant, irradiated rats exhibited 100% survival. In both males and pregnant females, alpha(2)M administration promoted body weight and leukocyte postirradiation recovery as in Ami-pretreated rats. These findings, together with our observation that Ami administration induced a 45-fold increase in alpha(2)M in the circulation, led us to conclude that alpha(2)M has an essential role in both natural and amifostine-mediated radioprotection in the rat.",
publisher = "Wolters Kluwer Health, Inc.",
journal = "Shock",
title = "The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat",
number = "6",
volume = "31",
doi = "10.1097/SHK.0b013e31818bb625",
pages = "607-614",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1449"
}

Mihailović, M., Dobrić, S. L., Poznanović, G., Petrović, M. V., Uskoković, A., Arambašić Jovanović, J.,& Bogojević, D.. (2009). The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat. in Shock
Wolters Kluwer Health, Inc.., 31(6), 607-614.
https://doi.org/10.1097/SHK.0b013e31818bb625
https://hdl.handle.net/21.15107/rcub_ibiss_1449

Mihailović M, Dobrić SL, Poznanović G, Petrović MV, Uskoković A, Arambašić Jovanović J, Bogojević D. The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat. in Shock. 2009;31(6):607-614.
doi:10.1097/SHK.0b013e31818bb625
https://hdl.handle.net/21.15107/rcub_ibiss_1449 .

Mihailović, Mirjana, Dobrić, Silva Lj, Poznanović, Goran, Petrović, Miodrag V, Uskoković, Aleksandra, Arambašić Jovanović, Jelena, Bogojević, Desanka, "The Acute-Phase Protein Alpha(2)-Macroglobulin Plays An Important Role in Radioprotection in the Rat" in Shock, 31, no. 6 (2009):607-614,
https://doi.org/10.1097/SHK.0b013e31818bb625 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1449 .

TY  - CONF
AU  - Vidaković, Melita
AU  - Gluch, Angela
AU  - Mihailović, Mirjana
AU  - Uskoković, Aleksandra
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Arambašić Jovanović, Jelena
AU  - Petrović, Miodrag V
AU  - Martinović, Vesna
AU  - Poznanović, Goran
AU  - Bode, Jurgen
PY  - 2008
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5541
PB  - Luxembourg: Fondation de Recherche Cancer et Sang
C3  - Apoptosis world 2008, From mechanisms to applications; 2008 Jan 23-26; Luxemburg, Luxemburg
T1  - DNA damage with methansulfonate induces up regulatin of PARP-1 gene transcription and non-apoptotic death in higer dose-range
SP  - 496
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5541
ER  - 

@conference{
author = "Vidaković, Melita and Gluch, Angela and Mihailović, Mirjana and Uskoković, Aleksandra and Dinić, Svetlana and Grdović, Nevena and Arambašić Jovanović, Jelena and Petrović, Miodrag V and Martinović, Vesna and Poznanović, Goran and Bode, Jurgen",
year = "2008",
publisher = "Luxembourg: Fondation de Recherche Cancer et Sang",
journal = "Apoptosis world 2008, From mechanisms to applications; 2008 Jan 23-26; Luxemburg, Luxemburg",
title = "DNA damage with methansulfonate induces up regulatin of PARP-1 gene transcription and non-apoptotic death in higer dose-range",
pages = "496",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5541"
}

Vidaković, M., Gluch, A., Mihailović, M., Uskoković, A., Dinić, S., Grdović, N., Arambašić Jovanović, J., Petrović, M. V., Martinović, V., Poznanović, G.,& Bode, J.. (2008). DNA damage with methansulfonate induces up regulatin of PARP-1 gene transcription and non-apoptotic death in higer dose-range. in Apoptosis world 2008, From mechanisms to applications; 2008 Jan 23-26; Luxemburg, Luxemburg
Luxembourg: Fondation de Recherche Cancer et Sang., 496.
https://hdl.handle.net/21.15107/rcub_ibiss_5541

Vidaković M, Gluch A, Mihailović M, Uskoković A, Dinić S, Grdović N, Arambašić Jovanović J, Petrović MV, Martinović V, Poznanović G, Bode J. DNA damage with methansulfonate induces up regulatin of PARP-1 gene transcription and non-apoptotic death in higer dose-range. in Apoptosis world 2008, From mechanisms to applications; 2008 Jan 23-26; Luxemburg, Luxemburg. 2008;:496.
https://hdl.handle.net/21.15107/rcub_ibiss_5541 .

Vidaković, Melita, Gluch, Angela, Mihailović, Mirjana, Uskoković, Aleksandra, Dinić, Svetlana, Grdović, Nevena, Arambašić Jovanović, Jelena, Petrović, Miodrag V, Martinović, Vesna, Poznanović, Goran, Bode, Jurgen, "DNA damage with methansulfonate induces up regulatin of PARP-1 gene transcription and non-apoptotic death in higer dose-range" in Apoptosis world 2008, From mechanisms to applications; 2008 Jan 23-26; Luxemburg, Luxemburg (2008):496,
https://hdl.handle.net/21.15107/rcub_ibiss_5541 .

TY  - JOUR
AU  - Bogojević, Desanka
AU  - Grigorov, Ilijana
AU  - Vidaković, Melita
AU  - Ivanović Matić, Svetlana
AU  - Labus-Blagojević, Svetlana D
AU  - Mihailović, Mirjana
AU  - Martinović, Vesna
AU  - Uskoković, Aleksandra
AU  - Petrović, Miodrag V
AU  - Dinić, Svetlana
AU  - Grdović, Nevena
AU  - Poznanović, Goran
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1630
PB  - Springer Nature
T2  - Bulletin of Environmental Contamination and Toxicology
T1  - CYP1 a expression in Mullus barbatus and Merluccius merluccius from the Adriatic Sea in Serbia and Montenegro
IS  - 4
VL  - 77
DO  - 10.1007/s00128-006-1100-1
SP  - 559
EP  - 565
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1630
ER  - 

@article{
author = "Bogojević, Desanka and Grigorov, Ilijana and Vidaković, Melita and Ivanović Matić, Svetlana and Labus-Blagojević, Svetlana D and Mihailović, Mirjana and Martinović, Vesna and Uskoković, Aleksandra and Petrović, Miodrag V and Dinić, Svetlana and Grdović, Nevena and Poznanović, Goran",
year = "2006",
publisher = "Springer Nature",
journal = "Bulletin of Environmental Contamination and Toxicology",
title = "CYP1 a expression in Mullus barbatus and Merluccius merluccius from the Adriatic Sea in Serbia and Montenegro",
number = "4",
volume = "77",
doi = "10.1007/s00128-006-1100-1",
pages = "559-565",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1630"
}

Bogojević, D., Grigorov, I., Vidaković, M., Ivanović Matić, S., Labus-Blagojević, S. D., Mihailović, M., Martinović, V., Uskoković, A., Petrović, M. V., Dinić, S., Grdović, N.,& Poznanović, G.. (2006). CYP1 a expression in Mullus barbatus and Merluccius merluccius from the Adriatic Sea in Serbia and Montenegro. in Bulletin of Environmental Contamination and Toxicology
Springer Nature., 77(4), 559-565.
https://doi.org/10.1007/s00128-006-1100-1
https://hdl.handle.net/21.15107/rcub_ibiss_1630

Bogojević D, Grigorov I, Vidaković M, Ivanović Matić S, Labus-Blagojević SD, Mihailović M, Martinović V, Uskoković A, Petrović MV, Dinić S, Grdović N, Poznanović G. CYP1 a expression in Mullus barbatus and Merluccius merluccius from the Adriatic Sea in Serbia and Montenegro. in Bulletin of Environmental Contamination and Toxicology. 2006;77(4):559-565.
doi:10.1007/s00128-006-1100-1
https://hdl.handle.net/21.15107/rcub_ibiss_1630 .

Bogojević, Desanka, Grigorov, Ilijana, Vidaković, Melita, Ivanović Matić, Svetlana, Labus-Blagojević, Svetlana D, Mihailović, Mirjana, Martinović, Vesna, Uskoković, Aleksandra, Petrović, Miodrag V, Dinić, Svetlana, Grdović, Nevena, Poznanović, Goran, "CYP1 a expression in Mullus barbatus and Merluccius merluccius from the Adriatic Sea in Serbia and Montenegro" in Bulletin of Environmental Contamination and Toxicology, 77, no. 4 (2006):559-565,
https://doi.org/10.1007/s00128-006-1100-1 .,
https://hdl.handle.net/21.15107/rcub_ibiss_1630 .

TY  - JOUR
AU  - Milosavljević, Tanja S
AU  - Lazić, Tanja
AU  - Uskoković, Aleksandra
AU  - Petrović, Miodrag V
AU  - Grigorov, Ilijana
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1765
AB  - CCAAT/enhancer binding proteins (C/EBP) alpha, -beta and -delta play an important role in mediating I interleukin-6 (IL-6) dependent expression of acute-phase protein (APP) genes in liver during acute-phase (AP) response. Based on the presence of type IL-6 responsive element (IL-6 RE) in the rat haptoglobin (Hp) gene promoter we assumed that some C/EBPalpha, -beta and/or -delta isoforms could mediate the expression of this gene during turpentine-induced AP response. By Western immunoblot and Northern blot assays, we found that turpentine treatment of rats led to a coordinate induction of C/EBPbeta and -delta as well as repression of C/EBPalpha isoforms pool levels in rat liver nuclear extracts (NEs) which was preceded by an adequate alteration of their mRNAs expression in liver. Consequently, results of DNA affinity chromatography revealed that affinity of certain C/EBPalpha isoforms to bind the type I IL-6 RE within the rat Hp gene promoter decreased whereas affinities of certain C/EBPbeta isoforms and C/EBPdelta were increased and induced, respectively. Our data suggest that turpentine-induced alterations of C/EBPalpha, -beta and -delta pool levels and DNA-binding activities can be regarded as an integral part of activation of the Hp gene expression in the course of AP response.
T2  - General Physiology and Biophysics
T1  - Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBP alpha, -beta and -delta proteins
IS  - 2
VL  - 22
EP  - 190
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1765
ER  - 

@article{
author = "Milosavljević, Tanja S and Lazić, Tanja and Uskoković, Aleksandra and Petrović, Miodrag V and Grigorov, Ilijana",
year = "2003",
abstract = "CCAAT/enhancer binding proteins (C/EBP) alpha, -beta and -delta play an important role in mediating I interleukin-6 (IL-6) dependent expression of acute-phase protein (APP) genes in liver during acute-phase (AP) response. Based on the presence of type IL-6 responsive element (IL-6 RE) in the rat haptoglobin (Hp) gene promoter we assumed that some C/EBPalpha, -beta and/or -delta isoforms could mediate the expression of this gene during turpentine-induced AP response. By Western immunoblot and Northern blot assays, we found that turpentine treatment of rats led to a coordinate induction of C/EBPbeta and -delta as well as repression of C/EBPalpha isoforms pool levels in rat liver nuclear extracts (NEs) which was preceded by an adequate alteration of their mRNAs expression in liver. Consequently, results of DNA affinity chromatography revealed that affinity of certain C/EBPalpha isoforms to bind the type I IL-6 RE within the rat Hp gene promoter decreased whereas affinities of certain C/EBPbeta isoforms and C/EBPdelta were increased and induced, respectively. Our data suggest that turpentine-induced alterations of C/EBPalpha, -beta and -delta pool levels and DNA-binding activities can be regarded as an integral part of activation of the Hp gene expression in the course of AP response.",
journal = "General Physiology and Biophysics",
title = "Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBP alpha, -beta and -delta proteins",
number = "2",
volume = "22",
pages = "190",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1765"
}

Milosavljević, T. S., Lazić, T., Uskoković, A., Petrović, M. V.,& Grigorov, I.. (2003). Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBP alpha, -beta and -delta proteins. in General Physiology and Biophysics, 22(2).
https://hdl.handle.net/21.15107/rcub_ibiss_1765

Milosavljević TS, Lazić T, Uskoković A, Petrović MV, Grigorov I. Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBP alpha, -beta and -delta proteins. in General Physiology and Biophysics. 2003;22(2):null-190.
https://hdl.handle.net/21.15107/rcub_ibiss_1765 .

Milosavljević, Tanja S, Lazić, Tanja, Uskoković, Aleksandra, Petrović, Miodrag V, Grigorov, Ilijana, "Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBP alpha, -beta and -delta proteins" in General Physiology and Biophysics, 22, no. 2 (2003),
https://hdl.handle.net/21.15107/rcub_ibiss_1765 .

TY  - JOUR
AU  - Milosavljević, Tanja S
AU  - Petrović, Miodrag V
AU  - Cvetković, Ivana
AU  - Grigorov, Ilijana
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1789
AB  - Turpentine-induced acute-phase (AP) response in rats is followed by transcriptional activation Of the (alpha(2)- macroglobulin (MG) gene mediated by cytokine interleukin-6 (IL-6) and glucocorticoids. Based on nucleotide sequence analysis of the alpha(2)-MG gene promoter regions responsive to IL-6, we postulated that binding of members of the liver-enriched CCAAT-enhancer-binding proteins (C/EBP) family of transcription factors to the type I IL-6 responsive element (IL-6RE) may participate in the transcriptional activation of this gene during AP response. Results of Western immunoblot and Northern-blot assays revealed coordinate changes in the pool levels of C/EBPalpha, -beta, and -delta protein isoforms and their genes expression in liver in response to turpentine. By means of an in vitro phosphorylation assay, South-Western blot, and selective proteolysis we have also found that only abilities of 35-kD C/EBPbeta and 27-kD C/EBPdelta to bind to the alpha(2)-MG gene promoter were affected by phosphorylation. Based on these data we concluded that transcriptional induction of the rat alpha(2)-MG gene during AP response correlates with both increased synthesis and phosphorylation- induced binding of 35-kD C/EBPbeta and 27-kD C/EBPdelta.
T2  - Biochemistry-Moscow
T1  - DNA binding activity of C/EBP beta and C/EBP delta for the rat alpha(2)-macroglobulin gene promoter is regulated in an acute-phase dependent manner
IS  - 8
VL  - 67
EP  - 926
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1789
ER  - 

@article{
author = "Milosavljević, Tanja S and Petrović, Miodrag V and Cvetković, Ivana and Grigorov, Ilijana",
year = "2002",
abstract = "Turpentine-induced acute-phase (AP) response in rats is followed by transcriptional activation Of the (alpha(2)- macroglobulin (MG) gene mediated by cytokine interleukin-6 (IL-6) and glucocorticoids. Based on nucleotide sequence analysis of the alpha(2)-MG gene promoter regions responsive to IL-6, we postulated that binding of members of the liver-enriched CCAAT-enhancer-binding proteins (C/EBP) family of transcription factors to the type I IL-6 responsive element (IL-6RE) may participate in the transcriptional activation of this gene during AP response. Results of Western immunoblot and Northern-blot assays revealed coordinate changes in the pool levels of C/EBPalpha, -beta, and -delta protein isoforms and their genes expression in liver in response to turpentine. By means of an in vitro phosphorylation assay, South-Western blot, and selective proteolysis we have also found that only abilities of 35-kD C/EBPbeta and 27-kD C/EBPdelta to bind to the alpha(2)-MG gene promoter were affected by phosphorylation. Based on these data we concluded that transcriptional induction of the rat alpha(2)-MG gene during AP response correlates with both increased synthesis and phosphorylation- induced binding of 35-kD C/EBPbeta and 27-kD C/EBPdelta.",
journal = "Biochemistry-Moscow",
title = "DNA binding activity of C/EBP beta and C/EBP delta for the rat alpha(2)-macroglobulin gene promoter is regulated in an acute-phase dependent manner",
number = "8",
volume = "67",
pages = "926",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1789"
}

Milosavljević, T. S., Petrović, M. V., Cvetković, I.,& Grigorov, I.. (2002). DNA binding activity of C/EBP beta and C/EBP delta for the rat alpha(2)-macroglobulin gene promoter is regulated in an acute-phase dependent manner. in Biochemistry-Moscow, 67(8).
https://hdl.handle.net/21.15107/rcub_ibiss_1789

Milosavljević TS, Petrović MV, Cvetković I, Grigorov I. DNA binding activity of C/EBP beta and C/EBP delta for the rat alpha(2)-macroglobulin gene promoter is regulated in an acute-phase dependent manner. in Biochemistry-Moscow. 2002;67(8):null-926.
https://hdl.handle.net/21.15107/rcub_ibiss_1789 .

Milosavljević, Tanja S, Petrović, Miodrag V, Cvetković, Ivana, Grigorov, Ilijana, "DNA binding activity of C/EBP beta and C/EBP delta for the rat alpha(2)-macroglobulin gene promoter is regulated in an acute-phase dependent manner" in Biochemistry-Moscow, 67, no. 8 (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1789 .