TY  - JOUR
AU  - Drljača, Jovana
AU  - Vejnović, Ana-Marija
AU  - Miljković, Dejan
AU  - Popović, Milan
AU  - Rakić, Dušica
AU  - Sekulić, Slobodan
AU  - Čapo, Ivan
AU  - Petković, Branka
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4473
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3655
AB  - The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.
T2  - Archives of Biological Sciences
T1  - Changes in mouse thymus after exposure to tube-restraint stress
IS  - 1
VL  - 72
DO  - 10.2298/abs190716060d
SP  - 5
EP  - 11
ER  - 

@article{
author = "Drljača, Jovana and Vejnović, Ana-Marija and Miljković, Dejan and Popović, Milan and Rakić, Dušica and Sekulić, Slobodan and Čapo, Ivan and Petković, Branka",
year = "2020",
abstract = "The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.",
journal = "Archives of Biological Sciences",
title = "Changes in mouse thymus after exposure to tube-restraint stress",
number = "1",
volume = "72",
doi = "10.2298/abs190716060d",
pages = "5-11"
}

Drljača, J., Vejnović, A., Miljković, D., Popović, M., Rakić, D., Sekulić, S., Čapo, I.,& Petković, B.. (2020). Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences, 72(1), 5-11.
https://doi.org/10.2298/abs190716060d

Drljača J, Vejnović A, Miljković D, Popović M, Rakić D, Sekulić S, Čapo I, Petković B. Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences. 2020;72(1):5-11.
doi:10.2298/abs190716060d .

Drljača, Jovana, Vejnović, Ana-Marija, Miljković, Dejan, Popović, Milan, Rakić, Dušica, Sekulić, Slobodan, Čapo, Ivan, Petković, Branka, "Changes in mouse thymus after exposure to tube-restraint stress" in Archives of Biological Sciences, 72, no. 1 (2020):5-11,
https://doi.org/10.2298/abs190716060d . .