TY  - JOUR
AU  - Kasapović, Jelena D
AU  - Pejić, Snezana A
AU  - Stojiljković, Vesna R
AU  - Todorović, Ana U
AU  - Radosević-Jelić, Ljiljana M
AU  - Saičić, Zorica
AU  - Pajović, Snezana B
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1335
AB  - Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p<0.05) and decreased AO enzyme activities (CuZnSOD: p<0.01, GPx: p<0.05, GR: p<0.01) and GSH level (p<0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p<0.05), while it increased after the radiotherapy of breast cancer (p<0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H(2)O(2) detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide
IS  - 16-17
VL  - 43
EP  - 1293
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1335
ER  - 

@article{
author = "Kasapović, Jelena D and Pejić, Snezana A and Stojiljković, Vesna R and Todorović, Ana U and Radosević-Jelić, Ljiljana M and Saičić, Zorica and Pajović, Snezana B",
year = "2010",
abstract = "Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p<0.05) and decreased AO enzyme activities (CuZnSOD: p<0.01, GPx: p<0.05, GR: p<0.01) and GSH level (p<0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p<0.05), while it increased after the radiotherapy of breast cancer (p<0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H(2)O(2) detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide",
number = "16-17",
volume = "43",
pages = "1293",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1335"
}

Kasapović, J. D., Pejić, S. A., Stojiljković, V. R., Todorović, A. U., Radosević-Jelić, L. M., Saičić, Z.,& Pajović, S. B.. (2010). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry, 43(16-17).
https://hdl.handle.net/21.15107/rcub_ibiss_1335

Kasapović JD, Pejić SA, Stojiljković VR, Todorović AU, Radosević-Jelić LM, Saičić Z, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry. 2010;43(16-17):null-1293.
https://hdl.handle.net/21.15107/rcub_ibiss_1335 .

Kasapović, Jelena D, Pejić, Snezana A, Stojiljković, Vesna R, Todorović, Ana U, Radosević-Jelić, Ljiljana M, Saičić, Zorica, Pajović, Snezana B, "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide" in Clinical Biochemistry, 43, no. 16-17 (2010),
https://hdl.handle.net/21.15107/rcub_ibiss_1335 .

TY  - JOUR
AU  - Stojiljković, Vesna R
AU  - Todorović, Ana U
AU  - Pejić, Snezana A
AU  - Kasapović, Jelena D
AU  - Saičić, Zorica
AU  - Radlović, Nedeljko P
AU  - Pajović, Snezana B
PY  - 2009
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1429
AB  - Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease
IS  - 13-14
VL  - 42
EP  - 1437
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1429
ER  - 

@article{
author = "Stojiljković, Vesna R and Todorović, Ana U and Pejić, Snezana A and Kasapović, Jelena D and Saičić, Zorica and Radlović, Nedeljko P and Pajović, Snezana B",
year = "2009",
abstract = "Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease",
number = "13-14",
volume = "42",
pages = "1437",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1429"
}

Stojiljković, V. R., Todorović, A. U., Pejić, S. A., Kasapović, J. D., Saičić, Z., Radlović, N. P.,& Pajović, S. B.. (2009). Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry, 42(13-14).
https://hdl.handle.net/21.15107/rcub_ibiss_1429

Stojiljković VR, Todorović AU, Pejić SA, Kasapović JD, Saičić Z, Radlović NP, Pajović SB. Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry. 2009;42(13-14):null-1437.
https://hdl.handle.net/21.15107/rcub_ibiss_1429 .

Stojiljković, Vesna R, Todorović, Ana U, Pejić, Snezana A, Kasapović, Jelena D, Saičić, Zorica, Radlović, Nedeljko P, Pajović, Snezana B, "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease" in Clinical Biochemistry, 42, no. 13-14 (2009),
https://hdl.handle.net/21.15107/rcub_ibiss_1429 .