TY  - JOUR
AU  - Stojković, Dejan
AU  - Glamočlija, Jasmina
AU  - Zivković, Jelena
AU  - Soković, Marina
AU  - Ferreira, Isabel CFR
AU  - Janković, Teodora
AU  - Maksimović, Zoran A
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1017
AB  - This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay against six strains of Gram-positive and Gram-negative bacteria. Listeria monocytogenes was the most sensitive of the tested bacterial species. Antibacterial preserving properties of protocatechuic acid were also evaluated after its incorporation in cream cheese, using L. monocytogenes as commonly cheese contaminant. The compound successfully inhibited L monocytogenes development in cream cheese, at room temperature and in refrigerator (25 degrees C and 4 degrees C, respectively), after 3 days of inoculation. Sensory evaluation was carried out in order to validate the mentioned food system. A possible mode of action of the tested compound towards bacterial cells was assessed and appears to be direct lysis of pathogenic cytoplasmic membrane. Prediction of pharmacokinetic properties was also performed using computational analyzes. The obtained results can serve as an important platform for the development of effective natural preservatives. (C) 2013 Elsevier Ltd. All rights reserved.
T2  - Food and Chemical Toxicology
T1  - Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system
IS  - null
VL  - 55
SP  - 39
EP  - 213
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1017
ER  - 

@article{
author = "Stojković, Dejan and Glamočlija, Jasmina and Zivković, Jelena and Soković, Marina and Ferreira, Isabel CFR and Janković, Teodora and Maksimović, Zoran A",
year = "2013",
abstract = "This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay against six strains of Gram-positive and Gram-negative bacteria. Listeria monocytogenes was the most sensitive of the tested bacterial species. Antibacterial preserving properties of protocatechuic acid were also evaluated after its incorporation in cream cheese, using L. monocytogenes as commonly cheese contaminant. The compound successfully inhibited L monocytogenes development in cream cheese, at room temperature and in refrigerator (25 degrees C and 4 degrees C, respectively), after 3 days of inoculation. Sensory evaluation was carried out in order to validate the mentioned food system. A possible mode of action of the tested compound towards bacterial cells was assessed and appears to be direct lysis of pathogenic cytoplasmic membrane. Prediction of pharmacokinetic properties was also performed using computational analyzes. The obtained results can serve as an important platform for the development of effective natural preservatives. (C) 2013 Elsevier Ltd. All rights reserved.",
journal = "Food and Chemical Toxicology",
title = "Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system",
number = "null",
volume = "55",
pages = "39-213",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1017"
}

Stojković, D., Glamočlija, J., Zivković, J., Soković, M., Ferreira, I. C., Janković, T.,& Maksimović, Z. A.. (2013). Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. in Food and Chemical Toxicology, 55(null), 39-213.
https://hdl.handle.net/21.15107/rcub_ibiss_1017

Stojković D, Glamočlija J, Zivković J, Soković M, Ferreira IC, Janković T, Maksimović ZA. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. in Food and Chemical Toxicology. 2013;55(null):39-213.
https://hdl.handle.net/21.15107/rcub_ibiss_1017 .

Stojković, Dejan, Glamočlija, Jasmina, Zivković, Jelena, Soković, Marina, Ferreira, Isabel CFR, Janković, Teodora, Maksimović, Zoran A, "Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system" in Food and Chemical Toxicology, 55, no. null (2013):39-213,
https://hdl.handle.net/21.15107/rcub_ibiss_1017 .

TY  - JOUR
AU  - Stojković, Dejan
AU  - Davidović, Slobodan
AU  - Zivković, Jelena
AU  - Glamočlija, Jasmina
AU  - Ćirić, Ana
AU  - Stevanović, Milena
AU  - Ferreira, Isabel CFR
AU  - Soković, Marina
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/939
AB  - Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.
T2  - Frontiers in Life Science
T1  - Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid
IS  - 3-4
VL  - 7
SP  - 1405
EP  - 223
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_939
ER  - 

@article{
author = "Stojković, Dejan and Davidović, Slobodan and Zivković, Jelena and Glamočlija, Jasmina and Ćirić, Ana and Stevanović, Milena and Ferreira, Isabel CFR and Soković, Marina",
year = "2013",
abstract = "Morchella esculenta (L.) Pers. methanolic extracts, obtained from fruiting bodies growing wild in Serbia and Portugal, were screened for their antimutagenic properties and compared to protocatechuic acid, previously identified in both species. Salmonella typhimurium TA100 reversion assay was used for the antimutagenic properties. Methanolic extracts expressed important antimutagenic potency towards S. typhimurium, which was documented by index of antimutagenicity (I). A sample from Serbia expressed slightly higher antimutagenic properties with an inhibition rate of 58.7%. A sample from Portugal gave an inhibition rate of 51.7%. Protocatechuic acid had an inhibition rate I of his(+) revertants of 72.4%. Cell viability in the presence of extracts was also documented. M. esculenta samples from Serbia and Portugal possessed novel biological potential for the studied species, as well as its phenolic compound - protocatechuic acid, identified in both samples. Genotoxic effect, regarding mitotic index and chromosomal aberration score, was also assessed by using the Allium cepa L. assay. Protocatechuic acid showed the most significant decrease in mitotic index, as well as decrease in chromosomal aberration score.",
journal = "Frontiers in Life Science",
title = "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid",
number = "3-4",
volume = "7",
pages = "1405-223",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_939"
}

Stojković, D., Davidović, S., Zivković, J., Glamočlija, J., Ćirić, A., Stevanović, M., Ferreira, I. C.,& Soković, M.. (2013). Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science, 7(3-4), 1405-223.
https://hdl.handle.net/21.15107/rcub_ibiss_939

Stojković D, Davidović S, Zivković J, Glamočlija J, Ćirić A, Stevanović M, Ferreira IC, Soković M. Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid. in Frontiers in Life Science. 2013;7(3-4):1405-223.
https://hdl.handle.net/21.15107/rcub_ibiss_939 .

Stojković, Dejan, Davidović, Slobodan, Zivković, Jelena, Glamočlija, Jasmina, Ćirić, Ana, Stevanović, Milena, Ferreira, Isabel CFR, Soković, Marina, "Comparative evaluation of antimutagenic and antimitotic effects of Morchella esculenta extracts and protocatechuic acid" in Frontiers in Life Science, 7, no. 3-4 (2013):1405-223,
https://hdl.handle.net/21.15107/rcub_ibiss_939 .

TY  - JOUR
AU  - Popović, Visnja
AU  - Zivković, Jelena
AU  - Davidović, Slobodan B
AU  - Stevanović, Milena J
AU  - Stojković, Dejan
PY  - 2013
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/950
AB  - Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.
T2  - Current Topics in Medicinal Chemistry
T1  - Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
IS  - 21
VL  - 13
SP  - 69
EP  - 2806
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_950
ER  - 

@article{
author = "Popović, Visnja and Zivković, Jelena and Davidović, Slobodan B and Stevanović, Milena J and Stojković, Dejan",
year = "2013",
abstract = "Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, beta-glucans, alpha-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously.",
journal = "Current Topics in Medicinal Chemistry",
title = "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action",
number = "21",
volume = "13",
pages = "69-2806",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_950"
}

Popović, V., Zivković, J., Davidović, S. B., Stevanović, M. J.,& Stojković, D.. (2013). Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry, 13(21), 69-2806.
https://hdl.handle.net/21.15107/rcub_ibiss_950

Popović V, Zivković J, Davidović SB, Stevanović MJ, Stojković D. Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action. in Current Topics in Medicinal Chemistry. 2013;13(21):69-2806.
https://hdl.handle.net/21.15107/rcub_ibiss_950 .

Popović, Visnja, Zivković, Jelena, Davidović, Slobodan B, Stevanović, Milena J, Stojković, Dejan, "Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action" in Current Topics in Medicinal Chemistry, 13, no. 21 (2013):69-2806,
https://hdl.handle.net/21.15107/rcub_ibiss_950 .