TY  - JOUR
AU  - Maletić, Snezana D
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Ognjanović, Branka I
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Spasić, Mihajlo
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1757
AB  - The effects of the sodium nitroprusside (SNP), a nitric oxide (NO) donor clinically used in the treatment of hypertensive emergencies on the energy production of rat reticulocytes were investigated. Rat reticulocyte-rich red blood cell suspensions were aerobically incubated without (control) or in the presence of different concentrations of SNP (0.1, 0.25, 0.5, 1.0 mM). SNP decreased total and coupled, but increased uncoupled oxygen consumption. This was accompanied by the stimulation of glycolysis, as measured by increased glucose consumption and lactate accumulation. Levels of all glycolytic intermediates indicate stimulation of hexokinase-phosphofructo kinase (HK-PFK), glyceraldehyde 3-phosphate dehydrogenase (GAPD) and pyruvate kinase (PK) activities in the presence of SNP. Due to the decrease of coupled oxygen consumption in the presence of SNP, ATP production via oxidative phosphorylation was significantly diminished. Simultaneous increase of glycolytic ATP production was not enough to provide constant ATP production. In addition, SNP significantly decreased ATP level, which was accompanied with increased ADP and AMP levels. However, the level of total adenine nucleotides was significantly lower, which was the consequence of increased catabolism of adenine nucleotides (increased hypoxanthine level). ATP/ADP ratio and adenylate energy charge level were significantly decreased. In conclusion, SNP induced inhibition of oxidative phosphorylation, stimulation of glycolysis, but depletion of total energy production in rat reticulocytes. These alterations were accompanied with instability of energy status.
T2  - Physiological Research
T1  - Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes
IS  - 4
VL  - 53
EP  - 447
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1757
ER  - 

@article{
author = "Maletić, Snezana D and Dragićević-Đoković, Ljiljana M. and Ognjanović, Branka I and Žikić, Radoslav V. and Stajn, Andras S and Spasić, Mihajlo",
year = "2004",
abstract = "The effects of the sodium nitroprusside (SNP), a nitric oxide (NO) donor clinically used in the treatment of hypertensive emergencies on the energy production of rat reticulocytes were investigated. Rat reticulocyte-rich red blood cell suspensions were aerobically incubated without (control) or in the presence of different concentrations of SNP (0.1, 0.25, 0.5, 1.0 mM). SNP decreased total and coupled, but increased uncoupled oxygen consumption. This was accompanied by the stimulation of glycolysis, as measured by increased glucose consumption and lactate accumulation. Levels of all glycolytic intermediates indicate stimulation of hexokinase-phosphofructo kinase (HK-PFK), glyceraldehyde 3-phosphate dehydrogenase (GAPD) and pyruvate kinase (PK) activities in the presence of SNP. Due to the decrease of coupled oxygen consumption in the presence of SNP, ATP production via oxidative phosphorylation was significantly diminished. Simultaneous increase of glycolytic ATP production was not enough to provide constant ATP production. In addition, SNP significantly decreased ATP level, which was accompanied with increased ADP and AMP levels. However, the level of total adenine nucleotides was significantly lower, which was the consequence of increased catabolism of adenine nucleotides (increased hypoxanthine level). ATP/ADP ratio and adenylate energy charge level were significantly decreased. In conclusion, SNP induced inhibition of oxidative phosphorylation, stimulation of glycolysis, but depletion of total energy production in rat reticulocytes. These alterations were accompanied with instability of energy status.",
journal = "Physiological Research",
title = "Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes",
number = "4",
volume = "53",
pages = "447",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1757"
}

Maletić, S. D., Dragićević-Đoković, L. M., Ognjanović, B. I., Žikić, R. V., Stajn, A. S.,& Spasić, M.. (2004). Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes. in Physiological Research, 53(4).
https://hdl.handle.net/21.15107/rcub_ibiss_1757

Maletić SD, Dragićević-Đoković LM, Ognjanović BI, Žikić RV, Stajn AS, Spasić M. Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes. in Physiological Research. 2004;53(4):null-447.
https://hdl.handle.net/21.15107/rcub_ibiss_1757 .

Maletić, Snezana D, Dragićević-Đoković, Ljiljana M., Ognjanović, Branka I, Žikić, Radoslav V., Stajn, Andras S, Spasić, Mihajlo, "Effects of exogenous donor of nitric oxide - Sodium nitroprusside on energy production of rat reticulocytes" in Physiological Research, 53, no. 4 (2004),
https://hdl.handle.net/21.15107/rcub_ibiss_1757 .

TY  - JOUR
AU  - Ognjanović, Branka I
AU  - Pavlović, Slađan
AU  - Maletić, Snezana D
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Radojičić, Ratko M.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2003
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1783
AB  - The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E+Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system.
T2  - Physiological Research
T1  - Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium
IS  - 5
VL  - 52
EP  - 570
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1783
ER  - 

@article{
author = "Ognjanović, Branka I and Pavlović, Slađan and Maletić, Snezana D and Žikić, Radoslav V. and Stajn, Andras S and Radojičić, Ratko M. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2003",
abstract = "The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E+Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system.",
journal = "Physiological Research",
title = "Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium",
number = "5",
volume = "52",
pages = "570",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1783"
}

Ognjanović, B. I., Pavlović, S., Maletić, S. D., Žikić, R. V., Stajn, A. S., Radojičić, R. M., Saičić, Z.,& Petrović, V. M.. (2003). Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. in Physiological Research, 52(5).
https://hdl.handle.net/21.15107/rcub_ibiss_1783

Ognjanović BI, Pavlović S, Maletić SD, Žikić RV, Stajn AS, Radojičić RM, Saičić Z, Petrović VM. Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. in Physiological Research. 2003;52(5):null-570.
https://hdl.handle.net/21.15107/rcub_ibiss_1783 .

Ognjanović, Branka I, Pavlović, Slađan, Maletić, Snezana D, Žikić, Radoslav V., Stajn, Andras S, Radojičić, Ratko M., Saičić, Zorica, Petrović, Vojislav M., "Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium" in Physiological Research, 52, no. 5 (2003),
https://hdl.handle.net/21.15107/rcub_ibiss_1783 .

TY  - CONF
AU  - Ognjanović, Branka I
AU  - Pavlović, Slađan
AU  - Maletić, Snezana D
AU  - Žikić, Radoslav V.
AU  - Stajn, Andras S
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1805
C3  - Free Radical Biology and Medicine
T1  - The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium
IS  - null
VL  - 33
EP  - S104
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1805
ER  - 

@conference{
author = "Ognjanović, Branka I and Pavlović, Slađan and Maletić, Snezana D and Žikić, Radoslav V. and Stajn, Andras S and Saičić, Zorica and Petrović, Vojislav M.",
year = "2002",
journal = "Free Radical Biology and Medicine",
title = "The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium",
number = "null",
volume = "33",
pages = "S104",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1805"
}

Ognjanović, B. I., Pavlović, S., Maletić, S. D., Žikić, R. V., Stajn, A. S., Saičić, Z.,& Petrović, V. M.. (2002). The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Free Radical Biology and Medicine, 33(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1805

Ognjanović BI, Pavlović S, Maletić SD, Žikić RV, Stajn AS, Saičić Z, Petrović VM. The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium. in Free Radical Biology and Medicine. 2002;33(null):null-S104.
https://hdl.handle.net/21.15107/rcub_ibiss_1805 .

Ognjanović, Branka I, Pavlović, Slađan, Maletić, Snezana D, Žikić, Radoslav V., Stajn, Andras S, Saičić, Zorica, Petrović, Vojislav M., "The effect of coenzyme Q(10) on antioxidant defense system in the blood of rats acutely exposed to cadmium" in Free Radical Biology and Medicine, 33, no. null (2002),
https://hdl.handle.net/21.15107/rcub_ibiss_1805 .