TY  - CONF
AU  - Šavikin, Katarina P.
AU  - Krstić Milošević, Dijana
AU  - Menković, Nebojša R.
AU  - Beara, Ivana N.
AU  - Mrkonjić, Zorica O.
AU  - Pljevljakušić, Dejan S.
PY  - 2017
UR  - http://www.naturalproduct.us/
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2756
AB  - The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.
C3  - Natural Product Communications
T1  - Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity
IS  - 2
VL  - 12
DO  - 10.1177/1934578x1701200204
SP  - 159
EP  - 162
ER  - 

@conference{
author = "Šavikin, Katarina P. and Krstić Milošević, Dijana and Menković, Nebojša R. and Beara, Ivana N. and Mrkonjić, Zorica O. and Pljevljakušić, Dejan S.",
year = "2017",
abstract = "The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.",
journal = "Natural Product Communications",
title = "Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity",
number = "2",
volume = "12",
doi = "10.1177/1934578x1701200204",
pages = "159-162"
}

Šavikin, K. P., Krstić Milošević, D., Menković, N. R., Beara, I. N., Mrkonjić, Z. O.,& Pljevljakušić, D. S.. (2017). Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. in Natural Product Communications, 12(2), 159-162.
https://doi.org/10.1177/1934578x1701200204

Šavikin KP, Krstić Milošević D, Menković NR, Beara IN, Mrkonjić ZO, Pljevljakušić DS. Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. in Natural Product Communications. 2017;12(2):159-162.
doi:10.1177/1934578x1701200204 .

Šavikin, Katarina P., Krstić Milošević, Dijana, Menković, Nebojša R., Beara, Ivana N., Mrkonjić, Zorica O., Pljevljakušić, Dejan S., "Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity" in Natural Product Communications, 12, no. 2 (2017):159-162,
https://doi.org/10.1177/1934578x1701200204 . .