TY  - CONF
AU  - Perović-Blagojević, Iva
AU  - Marković, Milica
AU  - Jelić, Svetlana
AU  - Eror, Tatjana
AU  - Ajdžanović, Vladimir
AU  - Milošević, Verica
AU  - Majkić-Singh, Nada
PY  - 2013
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6276
AB  - Background: Polycystic ovary syndrome (PCOS) is one of the pathological conditions associated with inflammation and oxidative stress. Ferritin was considered as one of the inflammatory reactants or markers of oxidative status. The question remains whether elevated serum ferritin levels representing iron overload in patients with PCOS are the cause or consequence of insulin resistance existing in these subjects. The aim of this study was to test the hypothesis that serum ferritin, like the leptin levels in young women with polycystic ovary syndrome depend on the nutritional status.
Methods: Study included 54 female patients, in the age of 18 to 40 years, with proven PCOS (among whom 32 lean, with body mass index-BMI<25 kg/m2 and 22 overweight or obese, with BMl>25 kg/m2) and 46 healthy control female patients, in the age of 20 to 36 years (among whom 29 lean and 17 overweight or obese). PCOS was diagnosed based on well-known clinic, biochemical and ultrasonographic criteria. Ferritin was measured by immunochemiluminescence method, while leptin was measured in blood samples by sandwich enzyme­linked immunosorbent assay (ELISA).
Results: In all the subjects included in this investigation there was a strong positive correlation between leptin and ferritin levels (r=0.429, P<0.001), as well as between leptin and BMI (r=0.930, P<0.001) and ferritin and BMI (r=0.467, P<0.001). However, while leptin levels differed significantly between lean and overweight healthy control (P<0.001) and PCOS (P<0.001) subjects, this could not be demonstrated for ferritin. Ferritin levels did not differ significantly neither between lean and overweight healthy control, nor between lean and overweight PCOS subjects. At the same time, ferritin levels were significantly higher in lean subjects with PCOS than in lean healthy control subjects (p=0.025), as well as in overweight patients with PCOS than in overweight healthy control subjects (P=0.018).
Conclusions: Results of this investigation have suggested that while leptin levels depend almost solely on nutritional status, ferritin levels were determined by some additional factors in young women with PCOS. Role of inflammation, oxidative stress and/or insulin resistance in this context has to be determined in future investigations.
PB  - Società ltaliana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC)
C3  - Abstracts Volume: 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab): 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC); 2013 May 19-23; Milan, Italy
T1  - Does ferritin and leptin level in young women with polycystic ovary syndrome depend on the nutritional status?
EP  - S319
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6276
ER  - 

@conference{
author = "Perović-Blagojević, Iva and Marković, Milica and Jelić, Svetlana and Eror, Tatjana and Ajdžanović, Vladimir and Milošević, Verica and Majkić-Singh, Nada",
year = "2013",
abstract = "Background: Polycystic ovary syndrome (PCOS) is one of the pathological conditions associated with inflammation and oxidative stress. Ferritin was considered as one of the inflammatory reactants or markers of oxidative status. The question remains whether elevated serum ferritin levels representing iron overload in patients with PCOS are the cause or consequence of insulin resistance existing in these subjects. The aim of this study was to test the hypothesis that serum ferritin, like the leptin levels in young women with polycystic ovary syndrome depend on the nutritional status.
Methods: Study included 54 female patients, in the age of 18 to 40 years, with proven PCOS (among whom 32 lean, with body mass index-BMI<25 kg/m2 and 22 overweight or obese, with BMl>25 kg/m2) and 46 healthy control female patients, in the age of 20 to 36 years (among whom 29 lean and 17 overweight or obese). PCOS was diagnosed based on well-known clinic, biochemical and ultrasonographic criteria. Ferritin was measured by immunochemiluminescence method, while leptin was measured in blood samples by sandwich enzyme­linked immunosorbent assay (ELISA).
Results: In all the subjects included in this investigation there was a strong positive correlation between leptin and ferritin levels (r=0.429, P<0.001), as well as between leptin and BMI (r=0.930, P<0.001) and ferritin and BMI (r=0.467, P<0.001). However, while leptin levels differed significantly between lean and overweight healthy control (P<0.001) and PCOS (P<0.001) subjects, this could not be demonstrated for ferritin. Ferritin levels did not differ significantly neither between lean and overweight healthy control, nor between lean and overweight PCOS subjects. At the same time, ferritin levels were significantly higher in lean subjects with PCOS than in lean healthy control subjects (p=0.025), as well as in overweight patients with PCOS than in overweight healthy control subjects (P=0.018).
Conclusions: Results of this investigation have suggested that while leptin levels depend almost solely on nutritional status, ferritin levels were determined by some additional factors in young women with PCOS. Role of inflammation, oxidative stress and/or insulin resistance in this context has to be determined in future investigations.",
publisher = "Società ltaliana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC)",
journal = "Abstracts Volume: 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab): 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC); 2013 May 19-23; Milan, Italy",
title = "Does ferritin and leptin level in young women with polycystic ovary syndrome depend on the nutritional status?",
pages = "S319",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6276"
}

Perović-Blagojević, I., Marković, M., Jelić, S., Eror, T., Ajdžanović, V., Milošević, V.,& Majkić-Singh, N.. (2013). Does ferritin and leptin level in young women with polycystic ovary syndrome depend on the nutritional status?. in Abstracts Volume: 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab): 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC); 2013 May 19-23; Milan, Italy
Società ltaliana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC)..
https://hdl.handle.net/21.15107/rcub_ibiss_6276

Perović-Blagojević I, Marković M, Jelić S, Eror T, Ajdžanović V, Milošević V, Majkić-Singh N. Does ferritin and leptin level in young women with polycystic ovary syndrome depend on the nutritional status?. in Abstracts Volume: 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab): 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC); 2013 May 19-23; Milan, Italy. 2013;:null-S319.
https://hdl.handle.net/21.15107/rcub_ibiss_6276 .

Perović-Blagojević, Iva, Marković, Milica, Jelić, Svetlana, Eror, Tatjana, Ajdžanović, Vladimir, Milošević, Verica, Majkić-Singh, Nada, "Does ferritin and leptin level in young women with polycystic ovary syndrome depend on the nutritional status?" in Abstracts Volume: 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine (EuroMedLab): 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC); 2013 May 19-23; Milan, Italy (2013),
https://hdl.handle.net/21.15107/rcub_ibiss_6276 .

TY  - CONF
AU  - Terzić, Milica
AU  - Ignjatović, Svetlana D
AU  - Dajak, Marijana M
AU  - Marković, D
AU  - Ajdžanović, Vladimir
AU  - Milošević, Verica
AU  - Majkić-Singh, Nada T
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1294
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Perioperative Cortisol Release in Patients Who Underwent Carotid Endaarterektomy. the Impact of Anesthetic Modality
IS  - null
VL  - 49
EP  - S284
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_1294
ER  - 

@conference{
author = "Terzić, Milica and Ignjatović, Svetlana D and Dajak, Marijana M and Marković, D and Ajdžanović, Vladimir and Milošević, Verica and Majkić-Singh, Nada T",
year = "2011",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Perioperative Cortisol Release in Patients Who Underwent Carotid Endaarterektomy. the Impact of Anesthetic Modality",
number = "null",
volume = "49",
pages = "S284",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_1294"
}

Terzić, M., Ignjatović, S. D., Dajak, M. M., Marković, D., Ajdžanović, V., Milošević, V.,& Majkić-Singh, N. T.. (2011). Perioperative Cortisol Release in Patients Who Underwent Carotid Endaarterektomy. the Impact of Anesthetic Modality. in Clinical Chemistry and Laboratory Medicine, 49(null).
https://hdl.handle.net/21.15107/rcub_ibiss_1294

Terzić M, Ignjatović SD, Dajak MM, Marković D, Ajdžanović V, Milošević V, Majkić-Singh NT. Perioperative Cortisol Release in Patients Who Underwent Carotid Endaarterektomy. the Impact of Anesthetic Modality. in Clinical Chemistry and Laboratory Medicine. 2011;49(null):null-S284.
https://hdl.handle.net/21.15107/rcub_ibiss_1294 .

Terzić, Milica, Ignjatović, Svetlana D, Dajak, Marijana M, Marković, D, Ajdžanović, Vladimir, Milošević, Verica, Majkić-Singh, Nada T, "Perioperative Cortisol Release in Patients Who Underwent Carotid Endaarterektomy. the Impact of Anesthetic Modality" in Clinical Chemistry and Laboratory Medicine, 49, no. null (2011),
https://hdl.handle.net/21.15107/rcub_ibiss_1294 .