TY  - JOUR
AU  - Nikolić, Biljana
AU  - Vasilijević, Bojana
AU  - Ćirić, Ana
AU  - Mitić-Ćulafić, Dragana
AU  - Cvetković, Stefana
AU  - Džamić, Ana
AU  - Knežević-Vukčević, Jelena
PY  - 2019
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641900005N
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/3760
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3401
AB  - Previously chemically characterized Juniperus communis essential oil (EO) and post-distillation waste (PDW) were tested for cytotoxicity and antimicrobial activity against food contaminants. Microdilution assay showed that PDW induced moderate antifungal (minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, ranging between 0.118-0.900 mg mL-1), and an antibacterial effect against Listeria monocytogenes (MIC and minimum bactericidal concentration (MBC) were 0.39 and 0.74 mg mL-1, respectively). Combinations of EO/PDW with selected antibiotics induced synergistic antilisterial activity in the checkerboard assay. The MTT assay determined that cytotoxicity against colon cancer cells was high for the EO but negligible for PDW (IC50 values were 0.087-0.106 and 1.450-6.840 mg mL-1, respectively). The selectivity indices indicated high selectivity of PDW against tested fungi and L. monocytogenes. In the adhesion-inhibition assay, PDW reduced in vitro adhesion of L. monocytogenes to colon cells (29-62% of inhibition). In conclusion, PDW exhibited an antimicrobial effect against important food spoilage and poisoning fungi and L. monocytogenes, and also reduced in vitro adhesion of L. monocytogenes to colon cells. The results indicate that J. communis PDW could be considered as natural preservative against food spoilage and poisonous fungi, and as an adjuvant to conventional therapy of listeriosis
T2  - Archives of Biological Sciences
T1  - Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants
IS  - 2
VL  - 71
DO  - 10.2298/ABS181217005N
SP  - 235
EP  - 244
ER  - 

@article{
author = "Nikolić, Biljana and Vasilijević, Bojana and Ćirić, Ana and Mitić-Ćulafić, Dragana and Cvetković, Stefana and Džamić, Ana and Knežević-Vukčević, Jelena",
year = "2019",
abstract = "Previously chemically characterized Juniperus communis essential oil (EO) and post-distillation waste (PDW) were tested for cytotoxicity and antimicrobial activity against food contaminants. Microdilution assay showed that PDW induced moderate antifungal (minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values, ranging between 0.118-0.900 mg mL-1), and an antibacterial effect against Listeria monocytogenes (MIC and minimum bactericidal concentration (MBC) were 0.39 and 0.74 mg mL-1, respectively). Combinations of EO/PDW with selected antibiotics induced synergistic antilisterial activity in the checkerboard assay. The MTT assay determined that cytotoxicity against colon cancer cells was high for the EO but negligible for PDW (IC50 values were 0.087-0.106 and 1.450-6.840 mg mL-1, respectively). The selectivity indices indicated high selectivity of PDW against tested fungi and L. monocytogenes. In the adhesion-inhibition assay, PDW reduced in vitro adhesion of L. monocytogenes to colon cells (29-62% of inhibition). In conclusion, PDW exhibited an antimicrobial effect against important food spoilage and poisoning fungi and L. monocytogenes, and also reduced in vitro adhesion of L. monocytogenes to colon cells. The results indicate that J. communis PDW could be considered as natural preservative against food spoilage and poisonous fungi, and as an adjuvant to conventional therapy of listeriosis",
journal = "Archives of Biological Sciences",
title = "Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants",
number = "2",
volume = "71",
doi = "10.2298/ABS181217005N",
pages = "235-244"
}

Nikolić, B., Vasilijević, B., Ćirić, A., Mitić-Ćulafić, D., Cvetković, S., Džamić, A.,& Knežević-Vukčević, J.. (2019). Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants. in Archives of Biological Sciences, 71(2), 235-244.
https://doi.org/10.2298/ABS181217005N

Nikolić B, Vasilijević B, Ćirić A, Mitić-Ćulafić D, Cvetković S, Džamić A, Knežević-Vukčević J. Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants. in Archives of Biological Sciences. 2019;71(2):235-244.
doi:10.2298/ABS181217005N .

Nikolić, Biljana, Vasilijević, Bojana, Ćirić, Ana, Mitić-Ćulafić, Dragana, Cvetković, Stefana, Džamić, Ana, Knežević-Vukčević, Jelena, "Bioactivity of Juniperus communis essential oil and post-distillation waste: Assessment of selective toxicity against food contaminants" in Archives of Biological Sciences, 71, no. 2 (2019):235-244,
https://doi.org/10.2298/ABS181217005N . .