TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Maletić, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Pavlović, Slađan
AU  - Saičić, Zorica
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/100
AB  - The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system (AOS), lipid peroxide (LP) concentration and hematological parameters, and the possible protective role of coenzyme Q10 (CoQ10) was studied. Male Wistar albino rats 3 months old were treated with cadmium as CdCl2 (0,4mg Cd/kg b.m., i.p., 24h before the sacrificing) or with coenzyme Q10 + Cd (20mg CoQ10/kg b.m., i.m., 48h + 0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The hematological parameters: red blood cells count (RBCs), hemoglobin (Hb) concentration and hematocrite (Ht) value were significantly decreased in the blood of Cd treated rats. Intoxication with Cd was also followed by significantly increased of LP concentration. We also observed increased concentrations of non-enzymatic components of antioxidant defense system (AOS): reduced glutathione (GSH), vitamin C (Vit C) and vitamin E (Vit E). Pretreatment with CoQ10 exhibited a protective role on the toxic effects of Cd on the hematological values, LP concentration as well as on endogeneous antioxidant components.
AB  - Cilj ovog rada je bio da se ispita uticaj kadmijuma (Cd) na antioksidacioni zaštitni sistem (AOS), koncentraciju lipidnih peroksida (LP) i hematološke parametre u krvi, kao i zaštitna uloga koenzima Q10 (CoQ10). Mužjaci pacova Wistar albino, stari tri meseca, akutno su tretirani kadmijumom (0,4mg Cd/kg t.m., i.p., 24h pre žrtvovanja) i koenzimom Q10 + Cd (20mg CoQ10/kg t.m., i.m., 48h + 0,4mg Cd/kg t.m., 24h pre žrtvovanja). Hematološki parametri: broj eritrocita (RBCs), koncentracija hemoglobina (Hb) i hematološka vrednost (Ht) su značajno smanjeni u krvi pacova posle tretmana kadmijumom. Cd značajno povećava i koncentraciju LP, kao i koncentracije neenzimskih komponenti AOS-a: redukovani glutation (GSH), vitamin C (Vit C) i vitamin E (Vit E). Eksperimenti sa pacovima koji su izazvanu anemiju i oksidaciona oštećenja (smanjuje koncentraciju LP), kao i značajno umanjuje toksične efekte Cd na komponente AOS-a.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu
T1  - Antioxidant effect of coenzyme Q10 in blood from cadmium-exposed rats
IS  - 1-3
VL  - 40
SP  - 81
EP  - 88
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_100
ER  - 

@article{
author = "Ognjanović, Branka I. and Maletić, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Pavlović, Slađan and Saičić, Zorica",
year = "2004",
abstract = "The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system (AOS), lipid peroxide (LP) concentration and hematological parameters, and the possible protective role of coenzyme Q10 (CoQ10) was studied. Male Wistar albino rats 3 months old were treated with cadmium as CdCl2 (0,4mg Cd/kg b.m., i.p., 24h before the sacrificing) or with coenzyme Q10 + Cd (20mg CoQ10/kg b.m., i.m., 48h + 0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The hematological parameters: red blood cells count (RBCs), hemoglobin (Hb) concentration and hematocrite (Ht) value were significantly decreased in the blood of Cd treated rats. Intoxication with Cd was also followed by significantly increased of LP concentration. We also observed increased concentrations of non-enzymatic components of antioxidant defense system (AOS): reduced glutathione (GSH), vitamin C (Vit C) and vitamin E (Vit E). Pretreatment with CoQ10 exhibited a protective role on the toxic effects of Cd on the hematological values, LP concentration as well as on endogeneous antioxidant components., Cilj ovog rada je bio da se ispita uticaj kadmijuma (Cd) na antioksidacioni zaštitni sistem (AOS), koncentraciju lipidnih peroksida (LP) i hematološke parametre u krvi, kao i zaštitna uloga koenzima Q10 (CoQ10). Mužjaci pacova Wistar albino, stari tri meseca, akutno su tretirani kadmijumom (0,4mg Cd/kg t.m., i.p., 24h pre žrtvovanja) i koenzimom Q10 + Cd (20mg CoQ10/kg t.m., i.m., 48h + 0,4mg Cd/kg t.m., 24h pre žrtvovanja). Hematološki parametri: broj eritrocita (RBCs), koncentracija hemoglobina (Hb) i hematološka vrednost (Ht) su značajno smanjeni u krvi pacova posle tretmana kadmijumom. Cd značajno povećava i koncentraciju LP, kao i koncentracije neenzimskih komponenti AOS-a: redukovani glutation (GSH), vitamin C (Vit C) i vitamin E (Vit E). Eksperimenti sa pacovima koji su izazvanu anemiju i oksidaciona oštećenja (smanjuje koncentraciju LP), kao i značajno umanjuje toksične efekte Cd na komponente AOS-a.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu, Antioxidant effect of coenzyme Q10 in blood from cadmium-exposed rats",
number = "1-3",
volume = "40",
pages = "81-88",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_100"
}

Ognjanović, B. I., Maletić, S. D., Žikić, R. V., Štajn, A. Š., Pavlović, S.,& Saičić, Z.. (2004). Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 40(1-3), 81-88.
https://hdl.handle.net/21.15107/rcub_ibiss_100

Ognjanović BI, Maletić SD, Žikić RV, Štajn AŠ, Pavlović S, Saičić Z. Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2004;40(1-3):81-88.
https://hdl.handle.net/21.15107/rcub_ibiss_100 .

Ognjanović, Branka I., Maletić, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Pavlović, Slađan, Saičić, Zorica, "Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 40, no. 1-3 (2004):81-88,
https://hdl.handle.net/21.15107/rcub_ibiss_100 .

TY  - JOUR
AU  - Maletić, Snežana D.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2004
PY  - 2004
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/89
AB  - Sodium nitroprusside (SNP) is an established drug, clinically used in the treatment of hypertensive emergencies. The aim of this study is further elucidation of the molecular mechanism of the SNP action, particularly its metabolism in rat erythrocytes and reticulocytes. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SNP (0.1,0.25,0.5,1.0 and 1.5 mM). The concentrations of reactive nitrogen species (RNS) and reactive oxygen species (ROS) were determined after incubation. In rat erythrocytes, SNP did not alter nitrite level (NO+ ion indicator), while significantly increased concentrations of hydroxylamine (NO- ion indicator), S-nitrosothiols (SNO) and 3-nitrotyrosine (peroxynitrite indicator). Concentration of superoxide anion (O2-) decreased in the presence of low doses of SNP only, while level of hydrogen peroxide (H2O2) increased in dose-dependent manner in rat erythrocytes. On the other hand, SNP significantly increased nitrite, hydroxylamine and 3-nitrotyrosine concentrations in rat reticulocytes. In addition, low doses of SNP induced decrease of O2- level. Concentration of H2O2 did not alter in rat reticulocytes. On the basis of these data, we can conclude: SNP spontaneously liberated nitric oxide as NO- ion in rat erythrocytes and reticulocytes. In addition, applied experimental doses of SNP induced strong nitrosative and oxidative stress in these cells.
AB  - Natrijum nitroprusid (SNP) je lek koji se klinički koristi u tretmanu hipertenzija. Cilj ovog rada je da se objasne molekularni mehanizmi delovanja SNPa, sa posebnim akcentom na metabolizam ovog leka u eritrocitima i retikulocitima pacova. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima su aerobno inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SNPa (0.1, 0.25, 0.5, 1.0 i 1.5 mM). Koncentracije reaktivnih vrsta azota (RNS) i kiseonika (ROS) su određivane nakon inkubacije. U eritrocitima pacova, SNP ne menja koncentraciju nitrita (indikator NO+ jona), dok značajno povećava koncentracije hidroksilamina (indicator NO- jona), S-nitrozotiola (SNO) and 3-nitrotirozina (indikator peroksinitrita). Koncentracija superoksid anjon radikala (O2-) je smanjena samo u prisustvu niskih doza SNP, dok je nivo vodonik peroksida (H2O2) povećan na dozno-zavisan način u eritrocitima pacova. S druge strane, SNP značajno povećava koncentracije nitrita, hidroksilamina i 3-nitrotirozina u retikulocitima pacova. Niske doze SNPa indukuju smanjenje O2- nivoa. Koncentracije H2O2 nisu promenjenje u retikulocitima pacova. Na osnovu iznetih podataka, možemo zaključiti: SNP spontano oslobađa azot monoksid kao NO" jon u eritrocitima i retikulocitima pacova. Primenjene eksperimentalne doze SNPa indukuju snažan nitrozacioni i oksidacioni stres u ovim ćelijama.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Metabolizam natrijum nitroprusida (SNP) u crvenim krvnim ćelijama pacova
T1  - Metabolism of sodium nitroprusside (SNP) in rat red blood cells
IS  - 1-3
VL  - 40
SP  - 37
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_89
ER  - 

@article{
author = "Maletić, Snežana D. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica and Spasić, Mihajlo",
year = "2004, 2004",
abstract = "Sodium nitroprusside (SNP) is an established drug, clinically used in the treatment of hypertensive emergencies. The aim of this study is further elucidation of the molecular mechanism of the SNP action, particularly its metabolism in rat erythrocytes and reticulocytes. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SNP (0.1,0.25,0.5,1.0 and 1.5 mM). The concentrations of reactive nitrogen species (RNS) and reactive oxygen species (ROS) were determined after incubation. In rat erythrocytes, SNP did not alter nitrite level (NO+ ion indicator), while significantly increased concentrations of hydroxylamine (NO- ion indicator), S-nitrosothiols (SNO) and 3-nitrotyrosine (peroxynitrite indicator). Concentration of superoxide anion (O2-) decreased in the presence of low doses of SNP only, while level of hydrogen peroxide (H2O2) increased in dose-dependent manner in rat erythrocytes. On the other hand, SNP significantly increased nitrite, hydroxylamine and 3-nitrotyrosine concentrations in rat reticulocytes. In addition, low doses of SNP induced decrease of O2- level. Concentration of H2O2 did not alter in rat reticulocytes. On the basis of these data, we can conclude: SNP spontaneously liberated nitric oxide as NO- ion in rat erythrocytes and reticulocytes. In addition, applied experimental doses of SNP induced strong nitrosative and oxidative stress in these cells., Natrijum nitroprusid (SNP) je lek koji se klinički koristi u tretmanu hipertenzija. Cilj ovog rada je da se objasne molekularni mehanizmi delovanja SNPa, sa posebnim akcentom na metabolizam ovog leka u eritrocitima i retikulocitima pacova. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima su aerobno inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SNPa (0.1, 0.25, 0.5, 1.0 i 1.5 mM). Koncentracije reaktivnih vrsta azota (RNS) i kiseonika (ROS) su određivane nakon inkubacije. U eritrocitima pacova, SNP ne menja koncentraciju nitrita (indikator NO+ jona), dok značajno povećava koncentracije hidroksilamina (indicator NO- jona), S-nitrozotiola (SNO) and 3-nitrotirozina (indikator peroksinitrita). Koncentracija superoksid anjon radikala (O2-) je smanjena samo u prisustvu niskih doza SNP, dok je nivo vodonik peroksida (H2O2) povećan na dozno-zavisan način u eritrocitima pacova. S druge strane, SNP značajno povećava koncentracije nitrita, hidroksilamina i 3-nitrotirozina u retikulocitima pacova. Niske doze SNPa indukuju smanjenje O2- nivoa. Koncentracije H2O2 nisu promenjenje u retikulocitima pacova. Na osnovu iznetih podataka, možemo zaključiti: SNP spontano oslobađa azot monoksid kao NO" jon u eritrocitima i retikulocitima pacova. Primenjene eksperimentalne doze SNPa indukuju snažan nitrozacioni i oksidacioni stres u ovim ćelijama.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Metabolizam natrijum nitroprusida (SNP) u crvenim krvnim ćelijama pacova, Metabolism of sodium nitroprusside (SNP) in rat red blood cells",
number = "1-3",
volume = "40",
pages = "37-42",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_89"
}

Maletić, S. D., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Saičić, Z.,& Spasić, M.. (2004). Metabolizam natrijum nitroprusida (SNP) u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 40(1-3), 37-42.
https://hdl.handle.net/21.15107/rcub_ibiss_89

Maletić SD, Ognjanović BI, Štajn AŠ, Žikić RV, Saičić Z, Spasić M. Metabolizam natrijum nitroprusida (SNP) u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2004;40(1-3):37-42.
https://hdl.handle.net/21.15107/rcub_ibiss_89 .

Maletić, Snežana D., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, Spasić, Mihajlo, "Metabolizam natrijum nitroprusida (SNP) u crvenim krvnim ćelijama pacova" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 40, no. 1-3 (2004):37-42,
https://hdl.handle.net/21.15107/rcub_ibiss_89 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Maletić, Snežana
AU  - Radojičić, Ratko
AU  - Petrović, Vojislav M.
PY  - 2002
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5936
AB  - Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.
PB  - International Coenzyme Q10 Association
C3  - Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
T1  - The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats
SP  - 167
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5936
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Maletić, Snežana and Radojičić, Ratko and Petrović, Vojislav M.",
year = "2002",
abstract = "Cadmium (Cd) is an important pollutant of environment which accwnulates in the liver and the kidneys, as well as in other tissues. Cd induces oxidative damage causing many metabolic, histological and pathological changes, such as nephrotoxicity, cardiotoxicity, increased lipid peroxidation (LP) and alteration of the antioxidant defense system (AOS). Recent studies have shown that coenzyme Q10 (CoQ10) and vitamin E (Vit E) are the powerful liposoluble antioxidants, which inhibit lipid peroxidation and thus prevent free radical med.iated oxidative injuries. It is well known that CoQ10 and Vit E may act synergistically as antioxidants. The aim of this study was to investigate a possible protective influence of CoQ10 and Vit E in Cd induced oxidative stress in the rat hearts.",
publisher = "International Coenzyme Q10 Association",
journal = "Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom",
title = "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats",
pages = "167-169",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5936"
}

Ognjanović, B., Pavlović, S., Žikić, R. V., Štajn, A. Š., Saičić, Z., Maletić, S., Radojičić, R.,& Petrović, V. M.. (2002). The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom
International Coenzyme Q10 Association., 167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936

Ognjanović B, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z, Maletić S, Radojičić R, Petrović VM. The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats. in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom. 2002;:167-169.
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

Ognjanović, Branka, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Maletić, Snežana, Radojičić, Ratko, Petrović, Vojislav M., "The protective role of coenzyme Q10 and vitamin E on antioxidant defense system in the heart of cadmium treated rats" in Programm and Abstracts: Third Conference of the International Coenzyme Q10 Association; 2002 Nov 22-24; London, United Kingdom (2002):167-169,
https://hdl.handle.net/21.15107/rcub_ibiss_5936 .

TY  - JOUR
AU  - Vukajlović, Miroslava
AU  - Štajn, Andraš Š.
AU  - Milošević, Nataša
AU  - Maletić, Snežana D.
AU  - Ognjanović, Branka I.
AU  - Žikić, Radoslav
AU  - Radojičić, Ratko M.
AU  - Spasić, Mihajlo
PY  - 2002
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/557
AB  - The aim of this study is elucidation of the molecular mechanism of the 3-morpholino-sydnonimine-hydrochloride (SIN-1) action, particularly its metabolism in rat erythrocytes and reticulocytes. SIN-1 is active metabolite of molsidomine, an established vasodilator drug, clinically used in the treatment of coronary artery disease. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SIN-1 (0.1, 0.25, 0.5, 1,0 and 1.5 mM). The concentrations of reactive nitrogen species (RNS), reactive oxygen species (ROS) and parameters that indicate oxidative damage of red blood cells were determined after incubation. In rat erythrocytes SIN-1 in high doses increased concentrations of nitrite (NO+ ion indicator), hydroxylamine (NO- ion indicator) and 3-nitrotyrosine (peroxynitrite indicator). Concentration of superoxide anion radical (O2) increased in the presence of SIN-1 on dose-dependent way (except in the presence of higher applied dose), while level of hydrogen peroxide (H2O2) did not alter. In rat reticulocytes SIN-1 significantly increased 3-nitrotyrosine concentrations only. In addition, low doses of SIN-1 induced decrease of O2.- level, while concentration of H2O2 increased dose-dependently. These data indicate that SIN-1-induced nitrosative and oxidative stress in rat red blood cells. The strong oxidative damage of erythrocytes and reticulocytes (increased level of methemoglobin, Heinz bodies and lipid peroxides concentrations) are appeared as consequence of SIN-1-induced oxidative stress.
AB  - Cilj ovog rada je da se objasne molekularni mehanizmi delovanja 3-morfolino-sidnonimin-hidrohlorida (SIN-1) sa posebnim akcentom na metabolizam ovog leka u eritrocitima i retikulocitima pacova. SIN-1 je aktivni metabolit molsidomina, leka koji se klinički koristi u terapiji bolesti koronarnih arterija. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima su aerobno inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SIN-1 (0.1, 0.25, 0.5, 1.0 i 1.5 mM). Koncentracije reaktivnih vrsta azota (RNS) i reaktivnih vrsta kiseonika (ROS), kao i koncentracije parametara koji ukazuju na oksidaciona oštećenja crvenih krvnih ćelija, određivane su nakon inkubacije. U eritrocitima pacova, SIN-1 samo u visokim dozama povećava koncentracije nitrita (indikator NO+ jona) hidroksilamina (indicator NO- jona) i 3-nitrotirozina (indikator peroksinitrita). Koncentracija superoksid anjon radikala (O2.-) je povećana na dozno-zavisan način (osim u prisustvu maksimalne primenjene doze SIN-1) dok se nivo vodonik peroksida (H2O2) ne menja. U retikulocitima pacova SIN-1 značajno povećava samo koncentraciju 3-nitrotirozina. Niske doze SIN-1 indukuju smanjenje O2.- nivoa, dok koncentracije H2O2 rastu na dozno-zavisan način. Na osnovu iznetih podataka, možemo zaključiti da SIN-1 indukuje nitrozacioni i oksidacioni stres u crvenim krvnim ćelijama pacova. Ovakvo stanje je posledično praćeno snažnim oksidacionim oštećenjem eritrocita i retikulocita (povećanjem koncentracija methemoglobina, Heinz-ovih telašaca i lipidnih peroksida).
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Metabolizam SIN-1 (donor peroksinitrita) u crvenim krvnim ćelijama pacova
T1  - Metabolism of SIN-1: Peroxynitrite donor in rat red blood cells
IS  - 3
VL  - 38
SP  - 85
EP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_557
ER  - 

@article{
author = "Vukajlović, Miroslava and Štajn, Andraš Š. and Milošević, Nataša and Maletić, Snežana D. and Ognjanović, Branka I. and Žikić, Radoslav and Radojičić, Ratko M. and Spasić, Mihajlo",
year = "2002, 2002",
abstract = "The aim of this study is elucidation of the molecular mechanism of the 3-morpholino-sydnonimine-hydrochloride (SIN-1) action, particularly its metabolism in rat erythrocytes and reticulocytes. SIN-1 is active metabolite of molsidomine, an established vasodilator drug, clinically used in the treatment of coronary artery disease. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SIN-1 (0.1, 0.25, 0.5, 1,0 and 1.5 mM). The concentrations of reactive nitrogen species (RNS), reactive oxygen species (ROS) and parameters that indicate oxidative damage of red blood cells were determined after incubation. In rat erythrocytes SIN-1 in high doses increased concentrations of nitrite (NO+ ion indicator), hydroxylamine (NO- ion indicator) and 3-nitrotyrosine (peroxynitrite indicator). Concentration of superoxide anion radical (O2) increased in the presence of SIN-1 on dose-dependent way (except in the presence of higher applied dose), while level of hydrogen peroxide (H2O2) did not alter. In rat reticulocytes SIN-1 significantly increased 3-nitrotyrosine concentrations only. In addition, low doses of SIN-1 induced decrease of O2.- level, while concentration of H2O2 increased dose-dependently. These data indicate that SIN-1-induced nitrosative and oxidative stress in rat red blood cells. The strong oxidative damage of erythrocytes and reticulocytes (increased level of methemoglobin, Heinz bodies and lipid peroxides concentrations) are appeared as consequence of SIN-1-induced oxidative stress., Cilj ovog rada je da se objasne molekularni mehanizmi delovanja 3-morfolino-sidnonimin-hidrohlorida (SIN-1) sa posebnim akcentom na metabolizam ovog leka u eritrocitima i retikulocitima pacova. SIN-1 je aktivni metabolit molsidomina, leka koji se klinički koristi u terapiji bolesti koronarnih arterija. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima su aerobno inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SIN-1 (0.1, 0.25, 0.5, 1.0 i 1.5 mM). Koncentracije reaktivnih vrsta azota (RNS) i reaktivnih vrsta kiseonika (ROS), kao i koncentracije parametara koji ukazuju na oksidaciona oštećenja crvenih krvnih ćelija, određivane su nakon inkubacije. U eritrocitima pacova, SIN-1 samo u visokim dozama povećava koncentracije nitrita (indikator NO+ jona) hidroksilamina (indicator NO- jona) i 3-nitrotirozina (indikator peroksinitrita). Koncentracija superoksid anjon radikala (O2.-) je povećana na dozno-zavisan način (osim u prisustvu maksimalne primenjene doze SIN-1) dok se nivo vodonik peroksida (H2O2) ne menja. U retikulocitima pacova SIN-1 značajno povećava samo koncentraciju 3-nitrotirozina. Niske doze SIN-1 indukuju smanjenje O2.- nivoa, dok koncentracije H2O2 rastu na dozno-zavisan način. Na osnovu iznetih podataka, možemo zaključiti da SIN-1 indukuje nitrozacioni i oksidacioni stres u crvenim krvnim ćelijama pacova. Ovakvo stanje je posledično praćeno snažnim oksidacionim oštećenjem eritrocita i retikulocita (povećanjem koncentracija methemoglobina, Heinz-ovih telašaca i lipidnih peroksida).",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Metabolizam SIN-1 (donor peroksinitrita) u crvenim krvnim ćelijama pacova, Metabolism of SIN-1: Peroxynitrite donor in rat red blood cells",
number = "3",
volume = "38",
pages = "85-92",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_557"
}

Vukajlović, M., Štajn, A. Š., Milošević, N., Maletić, S. D., Ognjanović, B. I., Žikić, R., Radojičić, R. M.,& Spasić, M.. (2002). Metabolizam SIN-1 (donor peroksinitrita) u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38(3), 85-92.
https://hdl.handle.net/21.15107/rcub_ibiss_557

Vukajlović M, Štajn AŠ, Milošević N, Maletić SD, Ognjanović BI, Žikić R, Radojičić RM, Spasić M. Metabolizam SIN-1 (donor peroksinitrita) u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2002;38(3):85-92.
https://hdl.handle.net/21.15107/rcub_ibiss_557 .

Vukajlović, Miroslava, Štajn, Andraš Š., Milošević, Nataša, Maletić, Snežana D., Ognjanović, Branka I., Žikić, Radoslav, Radojičić, Ratko M., Spasić, Mihajlo, "Metabolizam SIN-1 (donor peroksinitrita) u crvenim krvnim ćelijama pacova" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38, no. 3 (2002):85-92,
https://hdl.handle.net/21.15107/rcub_ibiss_557 .

TY  - JOUR
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I.
AU  - Maletić, Snežana D.
AU  - Marković, Mirjana D.
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Radojičić, Ratko M.
AU  - Saičić, Zorica
PY  - 2002
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/85
AB  - The influence of acute hypoxia on glucose, pyruvate, lipid peroxide (LP) reduced glutathione (GSH) concentrations and lactate level in the whole blood of carp (Cyprinus carpio L) under aquarium conditions were studied. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), the concentrations of ATP and ADP and ATP/ADP ratio in the red blood cells (RBCs) were analyzed. Glutathione-S-transferase (GST) activity was determined in the plasma. Our experiments showed that short-term and long-term hypoxia causes significant changes of all examined haema-tological parameters. Increased concentration of LP and increased SOD CAT and GST activities, as well as a decreased GSH-Px activity showed that under hypoxic conditions oxidative stress and RBCs damage were produced.
AB  - Uticaj akutne hipoksije na koncentraciju glukoze, piruvata, lipidnih peroksida (LP), redukovanog glutationa (GSH) i na nivo laktata u krvi šarana (Cyprinu carpio L) je analiziran u akvarijumskim uslovima. U crvenim krvnim zrncima (RBCs) je analizirana aktivnost enzima superoksid-peroksidaze (GSH-Px) kao i koncentracije ATP, ADP i odnos ATP/ADP. U plazmi je analizirana aktivnost glutation S-transferaze (GST). U našim eksperimentima je utvrđeno da kratkotrajna progresivna hipoksija izaziva značajne promene svih ispitivanih hematoloških parametara. Povećanje koncentracije LP i povećanje aktivnosti enzima SOD, CAT i GST uz istovremeno smanjenje aktivnosti GSH-Px potvrđuju nastanak oksidacionog stresa i oštećenje RBCs pod hipoksičnim uslovima.
T2  - Archives of Biological Sciences
T1  - Efekti akutne hipoksije na energetski status i antioksidacioni zaštitni sistem u krvi šarana - Cyprinus carpio L.
T1  - Effects of acute hypoxia on the energy status and antioxidant defense system in the blood of carp - Cyprinvs carpio L.
IS  - 1-2
VL  - 54
SP  - 11
EP  - 18
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_85
ER  - 

@article{
author = "Žikić, Radoslav V. and Štajn, Andraš Š. and Pavlović, Slađan and Ognjanović, Branka I. and Maletić, Snežana D. and Marković, Mirjana D. and Dragićević-Đoković, Ljiljana M. and Radojičić, Ratko M. and Saičić, Zorica",
year = "2002, 2002",
abstract = "The influence of acute hypoxia on glucose, pyruvate, lipid peroxide (LP) reduced glutathione (GSH) concentrations and lactate level in the whole blood of carp (Cyprinus carpio L) under aquarium conditions were studied. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), the concentrations of ATP and ADP and ATP/ADP ratio in the red blood cells (RBCs) were analyzed. Glutathione-S-transferase (GST) activity was determined in the plasma. Our experiments showed that short-term and long-term hypoxia causes significant changes of all examined haema-tological parameters. Increased concentration of LP and increased SOD CAT and GST activities, as well as a decreased GSH-Px activity showed that under hypoxic conditions oxidative stress and RBCs damage were produced., Uticaj akutne hipoksije na koncentraciju glukoze, piruvata, lipidnih peroksida (LP), redukovanog glutationa (GSH) i na nivo laktata u krvi šarana (Cyprinu carpio L) je analiziran u akvarijumskim uslovima. U crvenim krvnim zrncima (RBCs) je analizirana aktivnost enzima superoksid-peroksidaze (GSH-Px) kao i koncentracije ATP, ADP i odnos ATP/ADP. U plazmi je analizirana aktivnost glutation S-transferaze (GST). U našim eksperimentima je utvrđeno da kratkotrajna progresivna hipoksija izaziva značajne promene svih ispitivanih hematoloških parametara. Povećanje koncentracije LP i povećanje aktivnosti enzima SOD, CAT i GST uz istovremeno smanjenje aktivnosti GSH-Px potvrđuju nastanak oksidacionog stresa i oštećenje RBCs pod hipoksičnim uslovima.",
journal = "Archives of Biological Sciences",
title = "Efekti akutne hipoksije na energetski status i antioksidacioni zaštitni sistem u krvi šarana - Cyprinus carpio L., Effects of acute hypoxia on the energy status and antioxidant defense system in the blood of carp - Cyprinvs carpio L.",
number = "1-2",
volume = "54",
pages = "11-18",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_85"
}

Žikić, R. V., Štajn, A. Š., Pavlović, S., Ognjanović, B. I., Maletić, S. D., Marković, M. D., Dragićević-Đoković, L. M., Radojičić, R. M.,& Saičić, Z.. (2002). Efekti akutne hipoksije na energetski status i antioksidacioni zaštitni sistem u krvi šarana - Cyprinus carpio L.. in Archives of Biological Sciences, 54(1-2), 11-18.
https://hdl.handle.net/21.15107/rcub_ibiss_85

Žikić RV, Štajn AŠ, Pavlović S, Ognjanović BI, Maletić SD, Marković MD, Dragićević-Đoković LM, Radojičić RM, Saičić Z. Efekti akutne hipoksije na energetski status i antioksidacioni zaštitni sistem u krvi šarana - Cyprinus carpio L.. in Archives of Biological Sciences. 2002;54(1-2):11-18.
https://hdl.handle.net/21.15107/rcub_ibiss_85 .

Žikić, Radoslav V., Štajn, Andraš Š., Pavlović, Slađan, Ognjanović, Branka I., Maletić, Snežana D., Marković, Mirjana D., Dragićević-Đoković, Ljiljana M., Radojičić, Ratko M., Saičić, Zorica, "Efekti akutne hipoksije na energetski status i antioksidacioni zaštitni sistem u krvi šarana - Cyprinus carpio L." in Archives of Biological Sciences, 54, no. 1-2 (2002):11-18,
https://hdl.handle.net/21.15107/rcub_ibiss_85 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Maletić, Snežana D.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Radojičić, Ratko M.
AU  - Saičić, Zorica
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/23
AB  - The present study investigated the possible protective role of olive oil on antioxidative defense components in liver of cadmium (Cd) intoxicated animals. Male, Wistar albino 3 months old rats were injected with a single dose of: 1) CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24h), 2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and 3) olive oil + Cd (in above mentioned amounts). Treatment with Cd increased lipid peroxidation (LP) in blood and activities of alanine and aspartate transaminase (ALT and AST) in plasma. Concentrations of non enzymatic components of antioxidative defense system (AOS): vitamin C (Vit C) and vitamin E (Vit E) were significantly decreased in liver tissue of Cd treated rats. Pretreatment with olive oil reversed Cd induced alterations in LP content and transaminases activities, as well as on endogenous antioxidive defense components.
AB  - U ovom radu ispitivana je moguća zaštitna uloga maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova intoksiciranim kadmijumom (Cd). Mužjaci pacova Wistar albino, starosti tri meseca akutno su tretirani sa: 1) CdCl (0.4 mg Cd/kg t.m., i.p., 24h pre žrtvovanja), 2) maslinovim uljem (0.4 ml maslinovog ulja/kg t.m., i.m., 48h pre žrtvovanja) i 3) maslinovim uljem + Cd (u navedenim količinama). Posle tretmana kadmijumom značajno se povećava koncentracija lipidnih peroksida (LP) u krvi, kao i aktivnost alanin i aspartat transaminaza (ALT i AST) u plazmi. Koncentracije neenzimskih komponenti antioksidacionog zaštitnog sistema (AOS): vitamin C (Vit C) i vitamin E (Vit E) su značajno smanjene u jetri kod pacova tretiranih kadmijumom. Eksperimenti sa pacovima koji su u pred tretmanu dobijali maslinovo ulje pokazuju da maslinovo ulje sprečava ili ublažava kadmijumom izazvane promene u koncentraciji LP, aktivnosti, kao i koncentraciji endogenih antioksidacionih zaštitnih komponenti.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom
T1  - Effect of olive oil on antioxidative defense components in liver of cadmium intoxicated rats
IS  - 3
VL  - 38
SP  - 101
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_23
ER  - 

@article{
author = "Ognjanović, Branka I. and Maletić, Snežana D. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Radojičić, Ratko M. and Saičić, Zorica",
year = "2002",
abstract = "The present study investigated the possible protective role of olive oil on antioxidative defense components in liver of cadmium (Cd) intoxicated animals. Male, Wistar albino 3 months old rats were injected with a single dose of: 1) CdCl2 (0.4 mg Cd/kg i.p. and sacrificed after 24h), 2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and 3) olive oil + Cd (in above mentioned amounts). Treatment with Cd increased lipid peroxidation (LP) in blood and activities of alanine and aspartate transaminase (ALT and AST) in plasma. Concentrations of non enzymatic components of antioxidative defense system (AOS): vitamin C (Vit C) and vitamin E (Vit E) were significantly decreased in liver tissue of Cd treated rats. Pretreatment with olive oil reversed Cd induced alterations in LP content and transaminases activities, as well as on endogenous antioxidive defense components., U ovom radu ispitivana je moguća zaštitna uloga maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova intoksiciranim kadmijumom (Cd). Mužjaci pacova Wistar albino, starosti tri meseca akutno su tretirani sa: 1) CdCl (0.4 mg Cd/kg t.m., i.p., 24h pre žrtvovanja), 2) maslinovim uljem (0.4 ml maslinovog ulja/kg t.m., i.m., 48h pre žrtvovanja) i 3) maslinovim uljem + Cd (u navedenim količinama). Posle tretmana kadmijumom značajno se povećava koncentracija lipidnih peroksida (LP) u krvi, kao i aktivnost alanin i aspartat transaminaza (ALT i AST) u plazmi. Koncentracije neenzimskih komponenti antioksidacionog zaštitnog sistema (AOS): vitamin C (Vit C) i vitamin E (Vit E) su značajno smanjene u jetri kod pacova tretiranih kadmijumom. Eksperimenti sa pacovima koji su u pred tretmanu dobijali maslinovo ulje pokazuju da maslinovo ulje sprečava ili ublažava kadmijumom izazvane promene u koncentraciji LP, aktivnosti, kao i koncentraciji endogenih antioksidacionih zaštitnih komponenti.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom, Effect of olive oil on antioxidative defense components in liver of cadmium intoxicated rats",
number = "3",
volume = "38",
pages = "101-110",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_23"
}

Ognjanović, B. I., Maletić, S. D., Pavlović, S., Žikić, R. V., Štajn, A. Š., Radojičić, R. M.,& Saičić, Z.. (2002). Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38(3), 101-110.
https://hdl.handle.net/21.15107/rcub_ibiss_23

Ognjanović BI, Maletić SD, Pavlović S, Žikić RV, Štajn AŠ, Radojičić RM, Saičić Z. Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2002;38(3):101-110.
https://hdl.handle.net/21.15107/rcub_ibiss_23 .

Ognjanović, Branka I., Maletić, Snežana D., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Radojičić, Ratko M., Saičić, Zorica, "Efekat maslinovog ulja na antioksidacione zaštitne komponente u jetri pacova posle intoksikacije kadmijumom" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38, no. 3 (2002):101-110,
https://hdl.handle.net/21.15107/rcub_ibiss_23 .

TY  - JOUR
AU  - Milošević, Nataša
AU  - Vukajlović, Miroslava
AU  - Maletić, Snežana D.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2002
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/12
AB  - The main objective of this research is to establish the effect of 3-morpholino-sydnonimine-hydrochloride (SIN-1) on antioxidative defense system (AOS) in rat red blood cells. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SIN-1 (0.1, 0.25, 0.5, 1.0 and 1.5 mM). The concentrations of non-enzymatic components and activities of enzymatic component of AOS were determined after incubation. In rat erythrocytes SIN-1 did not alter vitamin C (Vit C), while induced increase of vitamin E (Vit E) concentrations. Unaltered concentration of reduced glutathione (GSH) following by decrease of oxidized glutathione (GSSG) resulted in decrease of reduction potential of this redox couple (decrease of GSSG/2GSH ratio). These data indicate that GSH redox couple is included in defense of rat erythrocytes from oxidative damage. Activities of all AOS enzyme did not altered in the presence of SIN-1 in rat erythrocytes. In reticulocytes a high doses of SIN-1 induced a decrease of Vit C and increase of Vit E concentrations, indicating defense role of antioxidative vitamins. Level of GSH redox couple is not changed. SIN-1 inhibited activity of manganese containing superoxide dismutase (Mn SOD) which was followed by stimulation of copper zinc containing superoxide dismutase (CuZn SOD) activity. SIN-1 did not alter activities of other AOS enzyme in rat reticulocytes.
AB  - Cilj ovog istraživanja bio je da se objasni efekat 3-morfolino-sidnonimin-hidrohlorida (SIN-1) na antioksidacioni zaštitni sistem (AOS) u crvenim krvnim ćelijama pacova. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima aerobno su inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SIN-1 (0.1, 0.25, 0.5 1.0 i 1.5 mM). Koncentracije neenzimskih komponenti AOS i aktivnost enzima AOS određivane su nakon inkubacije crvenih krvnih ćelija. U eritrocitima pacova SIN-1 ne menja Vit C, dok povećava koncentraciju Vit E. Nepromenjena koncentracija redukovanog glutationa (GSH) praćena je smanjenjem nivoa oksidovanog glutaliona (GSSG) rezultujući smanjenjem redukcionog potencijala ovog redoks para (smanjenje GSSG/2GSH odnosa). Ovi podaci pokazuju da je GSH redoks par uključen u odbranu eritrocita od oksidacionih oštećenja. Aktivnost svih enzima AOS-a nisu bile promenjene u prisustvu SIN-1 u eritrocitima pacova. U retikulocitima pacova SIN-1 u visokim dozama izaziva smanjenje Vit C i povećanje Vit E koncentracije što ukazuje na zaštitnu ulogu antioksidacionih vitamina. Nivo GSH redoks para nije promenjen. SIN-1 inhibirá aktivnost Mn SOD što je praćeno stimulacijom aktivnosti CuZn SOD. SIN-1 ne menja aktivnost ostalih enzima AOS-a u retikulocitima pacova.
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Efekti SIN-1 na antioksidacioni zaštitni sistem u crvenim krvnim ćelijama pacova
T1  - Effect of SIN-1 on antioxidative defence system in red blood cells of rats
IS  - 3
VL  - 38
SP  - 93
EP  - 100
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_12
ER  - 

@article{
author = "Milošević, Nataša and Vukajlović, Miroslava and Maletić, Snežana D. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2002",
abstract = "The main objective of this research is to establish the effect of 3-morpholino-sydnonimine-hydrochloride (SIN-1) on antioxidative defense system (AOS) in rat red blood cells. Rats erythrocyte and reticulocyte-rich suspensions were aerobically incubated without (control) or in the presence of SIN-1 (0.1, 0.25, 0.5, 1.0 and 1.5 mM). The concentrations of non-enzymatic components and activities of enzymatic component of AOS were determined after incubation. In rat erythrocytes SIN-1 did not alter vitamin C (Vit C), while induced increase of vitamin E (Vit E) concentrations. Unaltered concentration of reduced glutathione (GSH) following by decrease of oxidized glutathione (GSSG) resulted in decrease of reduction potential of this redox couple (decrease of GSSG/2GSH ratio). These data indicate that GSH redox couple is included in defense of rat erythrocytes from oxidative damage. Activities of all AOS enzyme did not altered in the presence of SIN-1 in rat erythrocytes. In reticulocytes a high doses of SIN-1 induced a decrease of Vit C and increase of Vit E concentrations, indicating defense role of antioxidative vitamins. Level of GSH redox couple is not changed. SIN-1 inhibited activity of manganese containing superoxide dismutase (Mn SOD) which was followed by stimulation of copper zinc containing superoxide dismutase (CuZn SOD) activity. SIN-1 did not alter activities of other AOS enzyme in rat reticulocytes., Cilj ovog istraživanja bio je da se objasni efekat 3-morfolino-sidnonimin-hidrohlorida (SIN-1) na antioksidacioni zaštitni sistem (AOS) u crvenim krvnim ćelijama pacova. Suspenzije eritrocita i crvenih krvnih ćelija bogate retikulocitima aerobno su inkubirane bez (kontrola) ili u prisustvu različitih koncentracija SIN-1 (0.1, 0.25, 0.5 1.0 i 1.5 mM). Koncentracije neenzimskih komponenti AOS i aktivnost enzima AOS određivane su nakon inkubacije crvenih krvnih ćelija. U eritrocitima pacova SIN-1 ne menja Vit C, dok povećava koncentraciju Vit E. Nepromenjena koncentracija redukovanog glutationa (GSH) praćena je smanjenjem nivoa oksidovanog glutaliona (GSSG) rezultujući smanjenjem redukcionog potencijala ovog redoks para (smanjenje GSSG/2GSH odnosa). Ovi podaci pokazuju da je GSH redoks par uključen u odbranu eritrocita od oksidacionih oštećenja. Aktivnost svih enzima AOS-a nisu bile promenjene u prisustvu SIN-1 u eritrocitima pacova. U retikulocitima pacova SIN-1 u visokim dozama izaziva smanjenje Vit C i povećanje Vit E koncentracije što ukazuje na zaštitnu ulogu antioksidacionih vitamina. Nivo GSH redoks para nije promenjen. SIN-1 inhibirá aktivnost Mn SOD što je praćeno stimulacijom aktivnosti CuZn SOD. SIN-1 ne menja aktivnost ostalih enzima AOS-a u retikulocitima pacova.",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Efekti SIN-1 na antioksidacioni zaštitni sistem u crvenim krvnim ćelijama pacova, Effect of SIN-1 on antioxidative defence system in red blood cells of rats",
number = "3",
volume = "38",
pages = "93-100",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_12"
}

Milošević, N., Vukajlović, M., Maletić, S. D., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2002). Efekti SIN-1 na antioksidacioni zaštitni sistem u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38(3), 93-100.
https://hdl.handle.net/21.15107/rcub_ibiss_12

Milošević N, Vukajlović M, Maletić SD, Ognjanović BI, Štajn AŠ, Žikić RV, Saičić Z. Efekti SIN-1 na antioksidacioni zaštitni sistem u crvenim krvnim ćelijama pacova. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2002;38(3):93-100.
https://hdl.handle.net/21.15107/rcub_ibiss_12 .

Milošević, Nataša, Vukajlović, Miroslava, Maletić, Snežana D., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Efekti SIN-1 na antioksidacioni zaštitni sistem u crvenim krvnim ćelijama pacova" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 38, no. 3 (2002):93-100,
https://hdl.handle.net/21.15107/rcub_ibiss_12 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Pavlović, Slađan
AU  - Maletić, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2001
PY  - 2001
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/487
AB  - Male Wistar albino rats, 3 months old, were acutely treated with cadmium (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and with vitamin E + Cd (20 IU Vit E/kg b.m., i.m., 48h + 0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The haematological values: red blood cells (RBC) count, haematocrite (Htc) value, haemoglobin (Hb) and lipid peroxide (LP) concentrations were determined. The status of antioxidant defense system (AOS): copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione-S-transferase (GST) activities and reduced glutathione (GSH), ascorbic acid (AsA) and vitamin E (Vit E) concentrations were also determined in the blood of rats. RBC count, Htc value and Hb concentration were significantly decreased in the blood of rats acute treated by Cd. Vit E prevents anaemia caused by Cd. Acute administration of Cd significantly increased LP concentration, while Vit E reversed this changes. All examined components of AOS in the blood were significantly increased in Cd-treated rats. Pretreatment of rats with Vit E abolished the toxic effects of Cd on AOS.
T2  - Kragujevac Journal of Science
T1  - Protective role of vitamin E on antioxidant defense system and lipid peroxide concentration in the blood of rats acutely exposed to cadmium
IS  - 23
VL  - null
SP  - 115
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_487
ER  - 

@article{
author = "Ognjanović, Branka I. and Pavlović, Slađan and Maletić, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2001, 2001",
abstract = "Male Wistar albino rats, 3 months old, were acutely treated with cadmium (0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing) and with vitamin E + Cd (20 IU Vit E/kg b.m., i.m., 48h + 0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The haematological values: red blood cells (RBC) count, haematocrite (Htc) value, haemoglobin (Hb) and lipid peroxide (LP) concentrations were determined. The status of antioxidant defense system (AOS): copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione-S-transferase (GST) activities and reduced glutathione (GSH), ascorbic acid (AsA) and vitamin E (Vit E) concentrations were also determined in the blood of rats. RBC count, Htc value and Hb concentration were significantly decreased in the blood of rats acute treated by Cd. Vit E prevents anaemia caused by Cd. Acute administration of Cd significantly increased LP concentration, while Vit E reversed this changes. All examined components of AOS in the blood were significantly increased in Cd-treated rats. Pretreatment of rats with Vit E abolished the toxic effects of Cd on AOS.",
journal = "Kragujevac Journal of Science",
title = "Protective role of vitamin E on antioxidant defense system and lipid peroxide concentration in the blood of rats acutely exposed to cadmium",
number = "23",
volume = "null",
pages = "115-126",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_487"
}

Ognjanović, B. I., Pavlović, S., Maletić, S. D., Žikić, R. V., Štajn, A. Š., Saičić, Z.,& Petrović, V. M.. (2001). Protective role of vitamin E on antioxidant defense system and lipid peroxide concentration in the blood of rats acutely exposed to cadmium. in Kragujevac Journal of Science, null(23), 115-126.
https://hdl.handle.net/21.15107/rcub_ibiss_487

Ognjanović BI, Pavlović S, Maletić SD, Žikić RV, Štajn AŠ, Saičić Z, Petrović VM. Protective role of vitamin E on antioxidant defense system and lipid peroxide concentration in the blood of rats acutely exposed to cadmium. in Kragujevac Journal of Science. 2001;null(23):115-126.
https://hdl.handle.net/21.15107/rcub_ibiss_487 .

Ognjanović, Branka I., Pavlović, Slađan, Maletić, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Petrović, Vojislav M., "Protective role of vitamin E on antioxidant defense system and lipid peroxide concentration in the blood of rats acutely exposed to cadmium" in Kragujevac Journal of Science, null, no. 23 (2001):115-126,
https://hdl.handle.net/21.15107/rcub_ibiss_487 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5934
AB  - Cadmium (Cd) is a heavy metal commonly used  in ecotoxicological studies. Cd induces oxidative damage in erythrocytes, causes loss of  membrane function by enhancing lipid peroxidation and by alteration of the antioxidant defense  system  in  erythrocytes. On  the  other  hand,  recent  studies have shown   that   coenzyme   Q10   and   vitamin   E   are   the    powerful   liposoluble antiox idants,  which  inhibit   lipid   peroxidation   and   thus  prevent   free radical mediated oxidant injuries. The aim of thi s study was to i nve stigate a possible  protective  role  of  coenzyme  Q10   (CoQ 10)   and  vitamin  E  (Vit  E)  in cadmium  induced  oxidative stress  in the blood of  rats.
PB  - International Coenzyme Q10 Association
C3  - Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
T1  - Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats
SP  - 151
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5934
ER  - 

@conference{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000",
abstract = "Cadmium (Cd) is a heavy metal commonly used  in ecotoxicological studies. Cd induces oxidative damage in erythrocytes, causes loss of  membrane function by enhancing lipid peroxidation and by alteration of the antioxidant defense  system  in  erythrocytes. On  the  other  hand,  recent  studies have shown   that   coenzyme   Q10   and   vitamin   E   are   the    powerful   liposoluble antiox idants,  which  inhibit   lipid   peroxidation   and   thus  prevent   free radical mediated oxidant injuries. The aim of thi s study was to i nve stigate a possible  protective  role  of  coenzyme  Q10   (CoQ 10)   and  vitamin  E  (Vit  E)  in cadmium  induced  oxidative stress  in the blood of  rats.",
publisher = "International Coenzyme Q10 Association",
journal = "Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany",
title = "Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats",
pages = "151-153",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5934"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š., Saičić, Z.,& Petrović, V. M.. (2000). Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany
International Coenzyme Q10 Association., 151-153.
https://hdl.handle.net/21.15107/rcub_ibiss_5934

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z, Petrović VM. Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats. in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany. 2000;:151-153.
https://hdl.handle.net/21.15107/rcub_ibiss_5934 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Petrović, Vojislav M., "Protective role of coenzyme Q10 and vitamin e in cadmium induced oxidative Stress in the blood of rats" in Programme and Abstracts: Second Conference of the International Coenzyme Q10 Association; 2000 Dec 1-3; Frankfurt, Germany (2000):151-153,
https://hdl.handle.net/21.15107/rcub_ibiss_5934 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Maletić, Snežana D.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 2000
PY  - 2000
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/483
UR  - https://www.pmf.kg.ac.rs/KJS/en/images/volumes/vol22/kjs22bognjanovic93.pdf
AB  - Male Wistar albino 3 months old rats were acutely treated with cadmium (Cd, 0.4 mg/kg b.m., i.p., 24h before the sacrificing), with olive oil (0.4 mL/kg b.m., i.m., 48h before the sacrificing) and Cd+olive oil (in above mentioned amounts). The activities of alanin aminotransaminase (ALT) and aspartat aminotransaminase (AST) in the plasma, as well as hematological values: red blood cells (RBC) count, hematocrite (Ht) value, hemoglobin (Hb) and glucose concentrations were determined in the control and experimental groups of animals. The activities of ALT and AST in the plasma were significantly increased (p<0.005) only in animals treated with cadmium, while in other experimental groups no differences in comparison to controls were found. Our results show a significant alteration of hematological values. The RBC count (p<0.005), as well as Ht value and Hb concentration (p<0.01) were significantly decreased in respect to the control animals. Blood glucose concentration was significantly increased (p<0.005) in rats treated with Cd when compared with control rats. However, pretreatment of rats with olive oil diminished the negative effects of cadmium and shows that olive oil prevents or mitigates anemia caused by cadmium. .
PB  - Kragujevac: Faculty of Science
T2  - Kragujevac Journal of Science
T1  - The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium
VL  - 22
SP  - 93
EP  - 99
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_483
ER  - 

@article{
author = "Ognjanović, Branka I. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Maletić, Snežana D. and Saičić, Zorica and Petrović, Vojislav M.",
year = "2000, 2000",
abstract = "Male Wistar albino 3 months old rats were acutely treated with cadmium (Cd, 0.4 mg/kg b.m., i.p., 24h before the sacrificing), with olive oil (0.4 mL/kg b.m., i.m., 48h before the sacrificing) and Cd+olive oil (in above mentioned amounts). The activities of alanin aminotransaminase (ALT) and aspartat aminotransaminase (AST) in the plasma, as well as hematological values: red blood cells (RBC) count, hematocrite (Ht) value, hemoglobin (Hb) and glucose concentrations were determined in the control and experimental groups of animals. The activities of ALT and AST in the plasma were significantly increased (p<0.005) only in animals treated with cadmium, while in other experimental groups no differences in comparison to controls were found. Our results show a significant alteration of hematological values. The RBC count (p<0.005), as well as Ht value and Hb concentration (p<0.01) were significantly decreased in respect to the control animals. Blood glucose concentration was significantly increased (p<0.005) in rats treated with Cd when compared with control rats. However, pretreatment of rats with olive oil diminished the negative effects of cadmium and shows that olive oil prevents or mitigates anemia caused by cadmium. .",
publisher = "Kragujevac: Faculty of Science",
journal = "Kragujevac Journal of Science",
title = "The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium",
volume = "22",
pages = "93-99",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_483"
}

Ognjanović, B. I., Pavlović, S., Žikić, R. V., Štajn, A. Š., Maletić, S. D., Saičić, Z.,& Petrović, V. M.. (2000). The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium. in Kragujevac Journal of Science
Kragujevac: Faculty of Science., 22, 93-99.
https://hdl.handle.net/21.15107/rcub_ibiss_483

Ognjanović BI, Pavlović S, Žikić RV, Štajn AŠ, Maletić SD, Saičić Z, Petrović VM. The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium. in Kragujevac Journal of Science. 2000;22:93-99.
https://hdl.handle.net/21.15107/rcub_ibiss_483 .

Ognjanović, Branka I., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Maletić, Snežana D., Saičić, Zorica, Petrović, Vojislav M., "The effect of olive oil on the plasma transaminase activities and blood hematological values of rats acutely exposed to cadmium" in Kragujevac Journal of Science, 22 (2000):93-99,
https://hdl.handle.net/21.15107/rcub_ibiss_483 .

TY  - JOUR
AU  - Ognjanović, Branka
AU  - Pavlović, Slađan
AU  - Maletić, Snežana
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Petrović, Vojislav M.
PY  - 1999
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5903
AB  - Adult male Wistar albino 3 months old rats were treated by acute administration of (1) cadmium (0.4 mg Cd/kg b.m., i.p., 24" before the sacrificing), (2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and (3) olive oil + Cd (in above mentioned amounts). Haematological values (haematocrit - Htc, haemoglobin concentration - Hb and red blood cells count - RBC) and metabolic parameters (activity of transaminases - ALT and AST, as well as the concentration of glucose) were determined in control and experimental groups of animals. Our results show significant alterations of haematological values. Haematocrit values and haemoglobin concentrations were decreased (p<O.OI) as well as the number of red blood cells (p<0.005) after acute, intraperitoneal (i.p.) administration of cadmium. Experiments with rats receiving olive oil in pretreatment show that olive oil prevents or mitigates anemia caused by cadmium.
The activities of enzymes ALT and AST in plasma were significantly increased only in animals treated with cadmium (p<0.005), where as in other experimental groups the were no differences in comparison to control values. Concentration of blood glucose was significantly increased in rats treated with cadmium (p<0.005) in comparison to control values. However, the pretreatment of rats with olive oil, the negative effects of cadmium were significantly diminished.
PB  - Unija bioloških naučnih društava Jugoslavije
T2  - Iugoslavica Physiologica Pharmacologica Acta
T1  - Effect of olive oil on the haematological and metabolic values in blood and plasma of rats after acute cadmium intoxication
IS  - 3
VL  - 35
SP  - 129
EP  - 138
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5903
ER  - 

@article{
author = "Ognjanović, Branka and Pavlović, Slađan and Maletić, Snežana and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica and Petrović, Vojislav M.",
year = "1999",
abstract = "Adult male Wistar albino 3 months old rats were treated by acute administration of (1) cadmium (0.4 mg Cd/kg b.m., i.p., 24" before the sacrificing), (2) olive oil (0.4 ml olive oil/kg b.m., i.m., 48h before the sacrificing) and (3) olive oil + Cd (in above mentioned amounts). Haematological values (haematocrit - Htc, haemoglobin concentration - Hb and red blood cells count - RBC) and metabolic parameters (activity of transaminases - ALT and AST, as well as the concentration of glucose) were determined in control and experimental groups of animals. Our results show significant alterations of haematological values. Haematocrit values and haemoglobin concentrations were decreased (p<O.OI) as well as the number of red blood cells (p<0.005) after acute, intraperitoneal (i.p.) administration of cadmium. Experiments with rats receiving olive oil in pretreatment show that olive oil prevents or mitigates anemia caused by cadmium.
The activities of enzymes ALT and AST in plasma were significantly increased only in animals treated with cadmium (p<0.005), where as in other experimental groups the were no differences in comparison to control values. Concentration of blood glucose was significantly increased in rats treated with cadmium (p<0.005) in comparison to control values. However, the pretreatment of rats with olive oil, the negative effects of cadmium were significantly diminished.",
publisher = "Unija bioloških naučnih društava Jugoslavije",
journal = "Iugoslavica Physiologica Pharmacologica Acta",
title = "Effect of olive oil on the haematological and metabolic values in blood and plasma of rats after acute cadmium intoxication",
number = "3",
volume = "35",
pages = "129-138",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5903"
}

Ognjanović, B., Pavlović, S., Maletić, S., Žikić, R. V., Štajn, A. Š., Saičić, Z.,& Petrović, V. M.. (1999). Effect of olive oil on the haematological and metabolic values in blood and plasma of rats after acute cadmium intoxication. in Iugoslavica Physiologica Pharmacologica Acta
Unija bioloških naučnih društava Jugoslavije., 35(3), 129-138.
https://hdl.handle.net/21.15107/rcub_ibiss_5903

Ognjanović B, Pavlović S, Maletić S, Žikić RV, Štajn AŠ, Saičić Z, Petrović VM. Effect of olive oil on the haematological and metabolic values in blood and plasma of rats after acute cadmium intoxication. in Iugoslavica Physiologica Pharmacologica Acta. 1999;35(3):129-138.
https://hdl.handle.net/21.15107/rcub_ibiss_5903 .

Ognjanović, Branka, Pavlović, Slađan, Maletić, Snežana, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, Petrović, Vojislav M., "Effect of olive oil on the haematological and metabolic values in blood and plasma of rats after acute cadmium intoxication" in Iugoslavica Physiologica Pharmacologica Acta, 35, no. 3 (1999):129-138,
https://hdl.handle.net/21.15107/rcub_ibiss_5903 .

TY  - JOUR
AU  - Maletić, Snežana D.
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Banić, Ivana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Kostić, Milosav M.
PY  - 1997
UR  - https://www.pmf.kg.ac.rs/KJS/en/index.php?page=26&Itemid=4
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5897
AB  - Exogenous hydrogen peroxide (H2O2) in concentrations of 2 and 5 mmol/l, but not 0.2 mmol/l and 1 mmol/l, induces significant changes of energy metabolism in retictiloeytes of rats. It induces reduction of total and coupled oxygen consumption accompanied by stimulation of glycolysis and increased degradation of adenine nucleotides. Due to inhibition of mitochondrial oxidative phosphorylation appears a significant decline of ATP production. However, simultaneous stimulation of glycolysis (Pasteur effect) is not sufficient to prevent the decline of ATP concentration. The loss of ATP is not compensated with an expected increase of ADP and AMP concentrations, but with an increase of hypoxanthine concentrations. Despite reduced overall ATP	production and ATP concentrations, average energy turnover was not significantly changed. Activity of oxidative pentose phosphate shunt, metabolic pathway serving primarily antioxidative function in reticulocytes, was also unchanged under the influence of H2O2.
PB  - Kragujevac: University of Kragujevac, Faculty of Science
T2  - Collection of Scientific Papers of the Faculty of Science Kragujevac
T1  - The effects of hydrogen-peroxide on rat reticulocyte energy metabolism
VL  - 19
SP  - 109
EP  - 117
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5897
ER  - 

@article{
author = "Maletić, Snežana D. and Dragićević-Đoković, Ljiljana M. and Banić, Ivana and Pavlović, Slađan and Žikić, Radoslav V. and Kostić, Milosav M.",
year = "1997",
abstract = "Exogenous hydrogen peroxide (H2O2) in concentrations of 2 and 5 mmol/l, but not 0.2 mmol/l and 1 mmol/l, induces significant changes of energy metabolism in retictiloeytes of rats. It induces reduction of total and coupled oxygen consumption accompanied by stimulation of glycolysis and increased degradation of adenine nucleotides. Due to inhibition of mitochondrial oxidative phosphorylation appears a significant decline of ATP production. However, simultaneous stimulation of glycolysis (Pasteur effect) is not sufficient to prevent the decline of ATP concentration. The loss of ATP is not compensated with an expected increase of ADP and AMP concentrations, but with an increase of hypoxanthine concentrations. Despite reduced overall ATP	production and ATP concentrations, average energy turnover was not significantly changed. Activity of oxidative pentose phosphate shunt, metabolic pathway serving primarily antioxidative function in reticulocytes, was also unchanged under the influence of H2O2.",
publisher = "Kragujevac: University of Kragujevac, Faculty of Science",
journal = "Collection of Scientific Papers of the Faculty of Science Kragujevac",
title = "The effects of hydrogen-peroxide on rat reticulocyte energy metabolism",
volume = "19",
pages = "109-117",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5897"
}

Maletić, S. D., Dragićević-Đoković, L. M., Banić, I., Pavlović, S., Žikić, R. V.,& Kostić, M. M.. (1997). The effects of hydrogen-peroxide on rat reticulocyte energy metabolism. in Collection of Scientific Papers of the Faculty of Science Kragujevac
Kragujevac: University of Kragujevac, Faculty of Science., 19, 109-117.
https://hdl.handle.net/21.15107/rcub_ibiss_5897

Maletić SD, Dragićević-Đoković LM, Banić I, Pavlović S, Žikić RV, Kostić MM. The effects of hydrogen-peroxide on rat reticulocyte energy metabolism. in Collection of Scientific Papers of the Faculty of Science Kragujevac. 1997;19:109-117.
https://hdl.handle.net/21.15107/rcub_ibiss_5897 .

Maletić, Snežana D., Dragićević-Đoković, Ljiljana M., Banić, Ivana, Pavlović, Slađan, Žikić, Radoslav V., Kostić, Milosav M., "The effects of hydrogen-peroxide on rat reticulocyte energy metabolism" in Collection of Scientific Papers of the Faculty of Science Kragujevac, 19 (1997):109-117,
https://hdl.handle.net/21.15107/rcub_ibiss_5897 .