TY  - JOUR
AU  - Tratrat, Christophe
AU  - Haroun, Michelyne
AU  - Paparisva, Aliki
AU  - Geronikaki, Athina
AU  - Camoutsis, Charalabos
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Soković, Marina
AU  - Fotakis, Charalmpos
AU  - Zoumpoulakis, Panagiotis
AU  - Bhunia, Shome
AU  - Saxena, Anil
PY  - 2018
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4306
AB  - As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.
PB  - Elsevier B.V. on behalf of King Saud University
T2  - Arabian Journal of Chemistry
T1  - Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity
IS  - 4
VL  - 11
DO  - 10.1016/j.arabjc.2016.06.007
SP  - 573
EP  - 590
ER  - 

@article{
author = "Tratrat, Christophe and Haroun, Michelyne and Paparisva, Aliki and Geronikaki, Athina and Camoutsis, Charalabos and Ćirić, Ana and Glamočlija, Jasmina and Soković, Marina and Fotakis, Charalmpos and Zoumpoulakis, Panagiotis and Bhunia, Shome and Saxena, Anil",
year = "2018",
abstract = "As a part of our ongoing studies in developing new derivatives as antimicrobial agents we
describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6
(5H)ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and
antifungal activity. All compounds have shown antibacterial properties with compounds 1–9 showing
the lowest activity, followed by compounds 10–14 while compounds 15–25 the highest antibacterial
activity. Specific compounds appeared to be more active than ampicillin in most studied
strains and in some cases more active than streptomycin. Antifungal activity in most cases also
was better than that of reference drugs ketoconazole and bifonazole. Elucidating the relation of molecular properties to antimicrobial activity as well as generation of pharmacophore model for
antifungal activity of two fungal species Aspergillus fumigatus and Candida albicans were performed.",
publisher = "Elsevier B.V. on behalf of King Saud University",
journal = "Arabian Journal of Chemistry",
title = "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity",
number = "4",
volume = "11",
doi = "10.1016/j.arabjc.2016.06.007",
pages = "573-590"
}

Tratrat, C., Haroun, M., Paparisva, A., Geronikaki, A., Camoutsis, C., Ćirić, A., Glamočlija, J., Soković, M., Fotakis, C., Zoumpoulakis, P., Bhunia, S.,& Saxena, A.. (2018). Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry
Elsevier B.V. on behalf of King Saud University., 11(4), 573-590.
https://doi.org/10.1016/j.arabjc.2016.06.007

Tratrat C, Haroun M, Paparisva A, Geronikaki A, Camoutsis C, Ćirić A, Glamočlija J, Soković M, Fotakis C, Zoumpoulakis P, Bhunia S, Saxena A. Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity. in Arabian Journal of Chemistry. 2018;11(4):573-590.
doi:10.1016/j.arabjc.2016.06.007 .

Tratrat, Christophe, Haroun, Michelyne, Paparisva, Aliki, Geronikaki, Athina, Camoutsis, Charalabos, Ćirić, Ana, Glamočlija, Jasmina, Soković, Marina, Fotakis, Charalmpos, Zoumpoulakis, Panagiotis, Bhunia, Shome, Saxena, Anil, "Design, synthesis and biological evaluation of new substituted 5-benzylideno-2-adamantylthiazol[3,2- b][1,2,4]triazol-6(5H)ones. Pharmacophore models for antifungal activity" in Arabian Journal of Chemistry, 11, no. 4 (2018):573-590,
https://doi.org/10.1016/j.arabjc.2016.06.007 . .