TY  - JOUR
AU  - García-Pérez, Pascual
AU  - Ayuso, Manuel
AU  - Lozano-Milo, Eva
AU  - Pereira, Carla
AU  - Dias, Maria Inês
AU  - Ivanov, Marija
AU  - Calhelha, Ricardo C.
AU  - Soković, Marina
AU  - Ferreira, Isabel C.F.R.
AU  - Barros, Lillian
AU  - Gallego, Pedro P.
PY  - 2021
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4207
AB  - Bryophyllum constitutes a subgenus within the genus Kalanchoe that contains several plant species used in traditional medicine worldwide for the treatment of several diseases. However, little is known about the phytoconstituents of Bryophyllum spp. and previous reports have pointed at their low in Planta concentrations of bioactive compounds. In this work, we take advantage of plant in vitro culture for the study of the phenolic compounds found in the aerial parts of Bryophyllum spp. and their associated bioactivities. Our results show that the induction of nutritional stress leads to an improved accumulation of phenolic compounds, mainly flavonols and anthocyanins, represented by myricetin and malvidin glycosides, respectively. This effect is mainly found for B. × houghtonii, whose hydroethanolic extracts promoted the highest antioxidant, cytotoxic and anti-inflammatory activities. In the case of cytotoxic activity, Bryophyllum extracts showed an enhanced activity against the MCF-7 human breast carcinoma cell line. Meanwhile, extracts from B. daigremontianum promoted a wide range of effectiveness against different bacterial and fungal strains. This study is committed to shed light about the phytochemical potential associated to this unexplored subgenus, with the aim of considering Bryophyllum spp. as a valuable source of bioactive compounds for their exploitation in food, cosmetic and pharmaceutical industries.
PB  - Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants
VL  - 162
DO  - 10.1016/j.indcrop.2021.113241
SP  - 113241
ER  - 

@article{
author = "García-Pérez, Pascual and Ayuso, Manuel and Lozano-Milo, Eva and Pereira, Carla and Dias, Maria Inês and Ivanov, Marija and Calhelha, Ricardo C. and Soković, Marina and Ferreira, Isabel C.F.R. and Barros, Lillian and Gallego, Pedro P.",
year = "2021",
abstract = "Bryophyllum constitutes a subgenus within the genus Kalanchoe that contains several plant species used in traditional medicine worldwide for the treatment of several diseases. However, little is known about the phytoconstituents of Bryophyllum spp. and previous reports have pointed at their low in Planta concentrations of bioactive compounds. In this work, we take advantage of plant in vitro culture for the study of the phenolic compounds found in the aerial parts of Bryophyllum spp. and their associated bioactivities. Our results show that the induction of nutritional stress leads to an improved accumulation of phenolic compounds, mainly flavonols and anthocyanins, represented by myricetin and malvidin glycosides, respectively. This effect is mainly found for B. × houghtonii, whose hydroethanolic extracts promoted the highest antioxidant, cytotoxic and anti-inflammatory activities. In the case of cytotoxic activity, Bryophyllum extracts showed an enhanced activity against the MCF-7 human breast carcinoma cell line. Meanwhile, extracts from B. daigremontianum promoted a wide range of effectiveness against different bacterial and fungal strains. This study is committed to shed light about the phytochemical potential associated to this unexplored subgenus, with the aim of considering Bryophyllum spp. as a valuable source of bioactive compounds for their exploitation in food, cosmetic and pharmaceutical industries.",
publisher = "Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants",
volume = "162",
doi = "10.1016/j.indcrop.2021.113241",
pages = "113241"
}

García-Pérez, P., Ayuso, M., Lozano-Milo, E., Pereira, C., Dias, M. I., Ivanov, M., Calhelha, R. C., Soković, M., Ferreira, I. C.F.R., Barros, L.,& Gallego, P. P.. (2021). Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants. in Industrial Crops and Products
Elsevier B.V.., 162, 113241.
https://doi.org/10.1016/j.indcrop.2021.113241

García-Pérez P, Ayuso M, Lozano-Milo E, Pereira C, Dias MI, Ivanov M, Calhelha RC, Soković M, Ferreira IC, Barros L, Gallego PP. Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants. in Industrial Crops and Products. 2021;162:113241.
doi:10.1016/j.indcrop.2021.113241 .

García-Pérez, Pascual, Ayuso, Manuel, Lozano-Milo, Eva, Pereira, Carla, Dias, Maria Inês, Ivanov, Marija, Calhelha, Ricardo C., Soković, Marina, Ferreira, Isabel C.F.R., Barros, Lillian, Gallego, Pedro P., "Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants" in Industrial Crops and Products, 162 (2021):113241,
https://doi.org/10.1016/j.indcrop.2021.113241 . .