TY  - JOUR
AU  - Carregosa, Diogo
AU  - Mota, Sara
AU  - Ferreira, Sofia
AU  - Alves-Dias, Beatriz
AU  - Lončarević-Vasiljković, Nataša
AU  - Crespo, Carolina Lage
AU  - Menezes, Regina
AU  - Teodoro, Rita
AU  - Santos, Cláudia Nunes dos
PY  - 2021
UR  - https://www.mdpi.com/2072-6643/13/9/2940
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8464690
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4475
AB  - The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.
T2  - Nutrients
T1  - Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms.
IS  - 9
VL  - 13
DO  - 10.3390/nu13092940
SP  - 2940
ER  - 

@article{
author = "Carregosa, Diogo and Mota, Sara and Ferreira, Sofia and Alves-Dias, Beatriz and Lončarević-Vasiljković, Nataša and Crespo, Carolina Lage and Menezes, Regina and Teodoro, Rita and Santos, Cláudia Nunes dos",
year = "2021",
abstract = "The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.",
journal = "Nutrients",
title = "Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms.",
number = "9",
volume = "13",
doi = "10.3390/nu13092940",
pages = "2940"
}

Carregosa, D., Mota, S., Ferreira, S., Alves-Dias, B., Lončarević-Vasiljković, N., Crespo, C. L., Menezes, R., Teodoro, R.,& Santos, C. N. d.. (2021). Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms.. in Nutrients, 13(9), 2940.
https://doi.org/10.3390/nu13092940

Carregosa D, Mota S, Ferreira S, Alves-Dias B, Lončarević-Vasiljković N, Crespo CL, Menezes R, Teodoro R, Santos CND. Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms.. in Nutrients. 2021;13(9):2940.
doi:10.3390/nu13092940 .

Carregosa, Diogo, Mota, Sara, Ferreira, Sofia, Alves-Dias, Beatriz, Lončarević-Vasiljković, Nataša, Crespo, Carolina Lage, Menezes, Regina, Teodoro, Rita, Santos, Cláudia Nunes dos, "Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms." in Nutrients, 13, no. 9 (2021):2940,
https://doi.org/10.3390/nu13092940 . .