TY  - JOUR
AU  - Paunović, Milica G.
AU  - Ognjanović, Branka I.
AU  - Matić, Miloš M.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2016
UR  - http://www.degruyter.com/view/j/aiht.2016.67.issue-4/aiht-2016-67-2795/aiht-2016-67-2795.xml
UR  - https://www.scopus.com/record/display.uri?eid=2-s2.0-85008698288&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=BCBFF82A73D51FA0ED62BC41FE5E598
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2510
AB  - Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg
T2  - Archives of Industrial Hygiene and Toxicology
T1  - Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats
IS  - 4
VL  - 67
DO  - 10.1515/aiht-2016-67-2795
SP  - 304
EP  - 310
ER  - 

@article{
author = "Paunović, Milica G. and Ognjanović, Branka I. and Matić, Miloš M. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2016",
abstract = "Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg",
journal = "Archives of Industrial Hygiene and Toxicology",
title = "Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats",
number = "4",
volume = "67",
doi = "10.1515/aiht-2016-67-2795",
pages = "304-310"
}

Paunović, M. G., Ognjanović, B. I., Matić, M. M., Štajn, A. Š.,& Saičić, Z.. (2016). Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats. in Archives of Industrial Hygiene and Toxicology, 67(4), 304-310.
https://doi.org/10.1515/aiht-2016-67-2795

Paunović MG, Ognjanović BI, Matić MM, Štajn AŠ, Saičić Z. Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats. in Archives of Industrial Hygiene and Toxicology. 2016;67(4):304-310.
doi:10.1515/aiht-2016-67-2795 .

Paunović, Milica G., Ognjanović, Branka I., Matić, Miloš M., Štajn, Andraš Š., Saičić, Zorica, "Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats" in Archives of Industrial Hygiene and Toxicology, 67, no. 4 (2016):304-310,
https://doi.org/10.1515/aiht-2016-67-2795 . .

TY  - JOUR
AU  - Matić, Miloš M.
AU  - Milošević, Marija D.
AU  - Paunović, Milica G.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2016
UR  - http://www.pmf.kg.ac.rs/KJS/images/volumes/vol38/kjs38maticmilosevic135.pdf
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2616
AB  - Paracetamol (acetaminophen) is widely used as an ov er-the-counter analgesic and antipyretic drug. The aim of this stu dy was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β -glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative s tress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (R BCs count, Hb concentration, Ht value and WBCs count), suggesting that the paraceta mol induced haematotoxicity. Paracetamol reduced serum total protein (TP), album in and globulin, while increased alanine aminotransferase (ALT), aspartate aminotran sferase (AST) and lactate dehydrogenase (LDH) activities compared to the cont rol. The results indicate that paracetamol is led to significant decrease in the c oncentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministra tion of vitamin C and β -glucan with paracetamol reversed these changes of haematol ogical and biochemical parameters and diminished the toxic effects of paracetamol. Th e obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β -glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effec ts and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministrat ion with vitamin C and β -glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.
T2  - Kragujevac Journal of Science
T1  - Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan
VL  - 38
SP  - 135
EP  - 146
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_2616
ER  - 

@article{
author = "Matić, Miloš M. and Milošević, Marija D. and Paunović, Milica G. and Ognjanović, Branka I. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2016",
abstract = "Paracetamol (acetaminophen) is widely used as an ov er-the-counter analgesic and antipyretic drug. The aim of this stu dy was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β -glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative s tress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (R BCs count, Hb concentration, Ht value and WBCs count), suggesting that the paraceta mol induced haematotoxicity. Paracetamol reduced serum total protein (TP), album in and globulin, while increased alanine aminotransferase (ALT), aspartate aminotran sferase (AST) and lactate dehydrogenase (LDH) activities compared to the cont rol. The results indicate that paracetamol is led to significant decrease in the c oncentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministra tion of vitamin C and β -glucan with paracetamol reversed these changes of haematol ogical and biochemical parameters and diminished the toxic effects of paracetamol. Th e obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β -glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effec ts and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministrat ion with vitamin C and β -glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.",
journal = "Kragujevac Journal of Science",
title = "Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan",
volume = "38",
pages = "135-146",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_2616"
}

Matić, M. M., Milošević, M. D., Paunović, M. G., Ognjanović, B. I., Štajn, A. Š.,& Saičić, Z.. (2016). Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. in Kragujevac Journal of Science, 38, 135-146.
https://hdl.handle.net/21.15107/rcub_ibiss_2616

Matić MM, Milošević MD, Paunović MG, Ognjanović BI, Štajn AŠ, Saičić Z. Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. in Kragujevac Journal of Science. 2016;38:135-146.
https://hdl.handle.net/21.15107/rcub_ibiss_2616 .

Matić, Miloš M., Milošević, Marija D., Paunović, Milica G., Ognjanović, Branka I., Štajn, Andraš Š., Saičić, Zorica, "Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan" in Kragujevac Journal of Science, 38 (2016):135-146,
https://hdl.handle.net/21.15107/rcub_ibiss_2616 .

TY  - JOUR
AU  - Prokić, Marko
AU  - Paunović, Milica G.
AU  - Matić, Miloš M.
AU  - Đorđević, Nataša Z.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2015
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2054
AB  - Aspartame (ASP) is one of the most widely used nonnutritive sweeteners.
   This study investigates the chronic effects of ASP on hematological and
   biochemical parameters, and its effects on the oxidative/antioxidative
   status in the red blood cells of Wistar albino rats. Rats were provided
   with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased
   food and fluid intake was observed in the ASP-treated rats. Total body
   mass was significantly decreased in the ASP-treated rats. Treatment with
   ASP caused an increase in the concentrations of glucose, cholesterol,
   LDL-cholesterol, and in the activities of alanine aminotransferase
   (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH),
   as well as a decrease in the levels of HDL-cholesterol in the serum. A
   significant decline in the number of white blood cells (WBC) was
   observed after ASP uptake. Based on the results we conclude that ASP
   induces oxidative stress, observed as an alteration of the glutathione
   redox status, which leads to increased concentrations of nitric oxide
   (NO) and lipid peroxides (LPO) in the red blood cells. Changes in
   biochemical parameters, lipid metabolism, as well as changes in the
   levels of oxidative stress markers and the appearance of signs of liver
   damage indicate that chronic use of ASP can lead to the development of
   hyperglycemia, hypercholesterolemia and associated diseases.
T2  - Archives of Biological Sciences
T1  - Effect of aspartame on biochemical and oxidative stress parameters in rat blood
IS  - 2
VL  - 67
DO  - 10.2298/ABS141009016P
SP  - 535
EP  - 545
ER  - 

@article{
author = "Prokić, Marko and Paunović, Milica G. and Matić, Miloš M. and Đorđević, Nataša Z. and Ognjanović, Branka I. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2015",
abstract = "Aspartame (ASP) is one of the most widely used nonnutritive sweeteners.
   This study investigates the chronic effects of ASP on hematological and
   biochemical parameters, and its effects on the oxidative/antioxidative
   status in the red blood cells of Wistar albino rats. Rats were provided
   with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased
   food and fluid intake was observed in the ASP-treated rats. Total body
   mass was significantly decreased in the ASP-treated rats. Treatment with
   ASP caused an increase in the concentrations of glucose, cholesterol,
   LDL-cholesterol, and in the activities of alanine aminotransferase
   (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH),
   as well as a decrease in the levels of HDL-cholesterol in the serum. A
   significant decline in the number of white blood cells (WBC) was
   observed after ASP uptake. Based on the results we conclude that ASP
   induces oxidative stress, observed as an alteration of the glutathione
   redox status, which leads to increased concentrations of nitric oxide
   (NO) and lipid peroxides (LPO) in the red blood cells. Changes in
   biochemical parameters, lipid metabolism, as well as changes in the
   levels of oxidative stress markers and the appearance of signs of liver
   damage indicate that chronic use of ASP can lead to the development of
   hyperglycemia, hypercholesterolemia and associated diseases.",
journal = "Archives of Biological Sciences",
title = "Effect of aspartame on biochemical and oxidative stress parameters in rat blood",
number = "2",
volume = "67",
doi = "10.2298/ABS141009016P",
pages = "535-545"
}

Prokić, M., Paunović, M. G., Matić, M. M., Đorđević, N. Z., Ognjanović, B. I., Štajn, A. Š.,& Saičić, Z.. (2015). Effect of aspartame on biochemical and oxidative stress parameters in rat blood. in Archives of Biological Sciences, 67(2), 535-545.
https://doi.org/10.2298/ABS141009016P

Prokić M, Paunović MG, Matić MM, Đorđević NZ, Ognjanović BI, Štajn AŠ, Saičić Z. Effect of aspartame on biochemical and oxidative stress parameters in rat blood. in Archives of Biological Sciences. 2015;67(2):535-545.
doi:10.2298/ABS141009016P .

Prokić, Marko, Paunović, Milica G., Matić, Miloš M., Đorđević, Nataša Z., Ognjanović, Branka I., Štajn, Andraš Š., Saičić, Zorica, "Effect of aspartame on biochemical and oxidative stress parameters in rat blood" in Archives of Biological Sciences, 67, no. 2 (2015):535-545,
https://doi.org/10.2298/ABS141009016P . .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Đorđević, Nataša Z.
AU  - Ćurčić, Milena G.
AU  - Štajn, Andraš Š.
AU  - Spasić, Mihajlo
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2151
AB  - The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by
   liberated nitric oxide (NO) and formed reactive nitrogen species, which
   induces oxidative stress during biotransformation in red blood cells
   (RBCs). The aim of this study was to evaluate effects of GTN on
   antioxidative defense system (AOS) in rat erythrocytes (without) and
   reticulocytes (with functional mitochondria). Rat erythrocyte and
   reticulocyte-rich RBC suspensions were aerobically incubated (2 h, 37
   degrees C) without (control) or in the presence of different
   concentrations of GTN (0.1-1.5 mM). After incubation, concentrations of
   non-enzymatic components of AOS, activities of antioxidative enzymes and
   oxidative pentose phosphate (OPP) pathway activity were followed in RBC
   suspensions. In rat reticulocytes, GTN decreased the activity of
   mitochondrial MnSOD and increased the activity of CuZnSOD. In rat RBCs,
   GTN induced increase of Vit E concentration (at high doses), but
   decreased glutathione content and activities of all
   glutathione-dependent antioxidative enzymes; the OPP pathway activity
   significantly increased. GTN biotransformation and induction of
   oxidative stress were followed by general disbalance of antioxidative
   capacities in both kinds of RBCs. We suggest that oxidative stress,
   MnSOD inhibition and depletion of glutathione pool in response to GTN
   treatment lead to decreased bioavailability of NO after GTN
   biotransformation in rat reticulocytes.
T2  - General Physiology and Biophysics
T1  - Biotransformation and nitroglycerin-induced effects on antioxidative
 defense system in rat erythrocytes and reticulocytes
IS  - 4
VL  - 33
DO  - 10.4149/gpb_2014018
SP  - 393
EP  - 401
ER  - 

@article{
author = "Marković, Snežana D. and Đorđević, Nataša Z. and Ćurčić, Milena G. and Štajn, Andraš Š. and Spasić, Mihajlo",
year = "2014",
abstract = "The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by
   liberated nitric oxide (NO) and formed reactive nitrogen species, which
   induces oxidative stress during biotransformation in red blood cells
   (RBCs). The aim of this study was to evaluate effects of GTN on
   antioxidative defense system (AOS) in rat erythrocytes (without) and
   reticulocytes (with functional mitochondria). Rat erythrocyte and
   reticulocyte-rich RBC suspensions were aerobically incubated (2 h, 37
   degrees C) without (control) or in the presence of different
   concentrations of GTN (0.1-1.5 mM). After incubation, concentrations of
   non-enzymatic components of AOS, activities of antioxidative enzymes and
   oxidative pentose phosphate (OPP) pathway activity were followed in RBC
   suspensions. In rat reticulocytes, GTN decreased the activity of
   mitochondrial MnSOD and increased the activity of CuZnSOD. In rat RBCs,
   GTN induced increase of Vit E concentration (at high doses), but
   decreased glutathione content and activities of all
   glutathione-dependent antioxidative enzymes; the OPP pathway activity
   significantly increased. GTN biotransformation and induction of
   oxidative stress were followed by general disbalance of antioxidative
   capacities in both kinds of RBCs. We suggest that oxidative stress,
   MnSOD inhibition and depletion of glutathione pool in response to GTN
   treatment lead to decreased bioavailability of NO after GTN
   biotransformation in rat reticulocytes.",
journal = "General Physiology and Biophysics",
title = "Biotransformation and nitroglycerin-induced effects on antioxidative
 defense system in rat erythrocytes and reticulocytes",
number = "4",
volume = "33",
doi = "10.4149/gpb_2014018",
pages = "393-401"
}

Marković, S. D., Đorđević, N. Z., Ćurčić, M. G., Štajn, A. Š.,& Spasić, M.. (2014). Biotransformation and nitroglycerin-induced effects on antioxidative
 defense system in rat erythrocytes and reticulocytes. in General Physiology and Biophysics, 33(4), 393-401.
https://doi.org/10.4149/gpb_2014018

Marković SD, Đorđević NZ, Ćurčić MG, Štajn AŠ, Spasić M. Biotransformation and nitroglycerin-induced effects on antioxidative
 defense system in rat erythrocytes and reticulocytes. in General Physiology and Biophysics. 2014;33(4):393-401.
doi:10.4149/gpb_2014018 .

Marković, Snežana D., Đorđević, Nataša Z., Ćurčić, Milena G., Štajn, Andraš Š., Spasić, Mihajlo, "Biotransformation and nitroglycerin-induced effects on antioxidative
 defense system in rat erythrocytes and reticulocytes" in General Physiology and Biophysics, 33, no. 4 (2014):393-401,
https://doi.org/10.4149/gpb_2014018 . .

TY  - JOUR
AU  - Prokić, Marko
AU  - Paunovic, Milica G.
AU  - Matic, Milos M.
AU  - Djordjevic, Natasa Z.
AU  - Ognjanovic, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2113
AB  - Since aspartame (L-aspartyl-L-phenylalanine methyl ester, ASP) is one of
   the most widely used artificial sweeteners, the aim of the present study
   was to investigate its effects on serum glucose and lipid levels as well
   as its effects on oxidative/antioxidative status in erythrocytes of
   rats. The experiment included two groups of animals: the control group
   was administered with water only, while the experimental group was
   orally administered with ASP (40 mg/kg b.w.) daily, for a period of six
   weeks. When compared with the control group, the group administrated
   with ASP indicated higher values of serum glucose, cholesterol and
   triglycerides. Significantly increased concentrations of superoxide
   anion (O-2(center dot-)), hydrogen peroxide (H2O2), peroxynitrite
   (ONOO-) and lipid peroxides (LPO) were recorded in the erythrocytes of
   ASP treated group in comparison to the control group. In the course of
   chronic ASP administration, the following was observed: the
   concentration of reduced glutathione (GSH) and the activity of catalase
   (CAT) increased. Thus, these findings suggest that long-term consumption
   of ASP leads to hyperglycemia and hyperlipidemia, as well as to
   oxidative stress in erythrocytes.
T2  - Journal of Biosciences
T1  - Prooxidative effects of aspartame on antioxidant defense status in
 erythrocytes of rats
IS  - 5
VL  - 39
DO  - 10.1007/s12038-014-9487-z
SP  - 859
EP  - 866
ER  - 

@article{
author = "Prokić, Marko and Paunovic, Milica G. and Matic, Milos M. and Djordjevic, Natasa Z. and Ognjanovic, Branka I. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2014",
abstract = "Since aspartame (L-aspartyl-L-phenylalanine methyl ester, ASP) is one of
   the most widely used artificial sweeteners, the aim of the present study
   was to investigate its effects on serum glucose and lipid levels as well
   as its effects on oxidative/antioxidative status in erythrocytes of
   rats. The experiment included two groups of animals: the control group
   was administered with water only, while the experimental group was
   orally administered with ASP (40 mg/kg b.w.) daily, for a period of six
   weeks. When compared with the control group, the group administrated
   with ASP indicated higher values of serum glucose, cholesterol and
   triglycerides. Significantly increased concentrations of superoxide
   anion (O-2(center dot-)), hydrogen peroxide (H2O2), peroxynitrite
   (ONOO-) and lipid peroxides (LPO) were recorded in the erythrocytes of
   ASP treated group in comparison to the control group. In the course of
   chronic ASP administration, the following was observed: the
   concentration of reduced glutathione (GSH) and the activity of catalase
   (CAT) increased. Thus, these findings suggest that long-term consumption
   of ASP leads to hyperglycemia and hyperlipidemia, as well as to
   oxidative stress in erythrocytes.",
journal = "Journal of Biosciences",
title = "Prooxidative effects of aspartame on antioxidant defense status in
 erythrocytes of rats",
number = "5",
volume = "39",
doi = "10.1007/s12038-014-9487-z",
pages = "859-866"
}

Prokić, M., Paunovic, M. G., Matic, M. M., Djordjevic, N. Z., Ognjanovic, B. I., Štajn, A. Š.,& Saičić, Z.. (2014). Prooxidative effects of aspartame on antioxidant defense status in
 erythrocytes of rats. in Journal of Biosciences, 39(5), 859-866.
https://doi.org/10.1007/s12038-014-9487-z

Prokić M, Paunovic MG, Matic MM, Djordjevic NZ, Ognjanovic BI, Štajn AŠ, Saičić Z. Prooxidative effects of aspartame on antioxidant defense status in
 erythrocytes of rats. in Journal of Biosciences. 2014;39(5):859-866.
doi:10.1007/s12038-014-9487-z .

Prokić, Marko, Paunovic, Milica G., Matic, Milos M., Djordjevic, Natasa Z., Ognjanovic, Branka I., Štajn, Andraš Š., Saičić, Zorica, "Prooxidative effects of aspartame on antioxidant defense status in
 erythrocytes of rats" in Journal of Biosciences, 39, no. 5 (2014):859-866,
https://doi.org/10.1007/s12038-014-9487-z . .

TY  - JOUR
AU  - Mladenovic, Jelena
AU  - Ognjanovic, Branka
AU  - Đorđević, Natasa
AU  - Matic, Milos
AU  - Knezevic, Veroljub
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2235
AB  - The aim of this study was to investigate the protective effects of
   oestradiol (E2, 4 mg kg(-1) b.w.i.p.) against cadmium-induced (Cd, 2 mg
   kg(-1) b.w. i.p.) blood changes in rats. Cadmium induced a significant
   decline in haemoglobin, haematocrit, and total erythrocyte, lymphocyte,
   and thrombocyte count, whereas total leukocytes and granulocytes
   increased. A significant increase was also observed in serum
   cholesterol, triglycerides, glucose, AST, and ALT activities, whereas
   total protein and albumin levels dropped significantly. Administration
   of E2 in combination with Cd alleviated most of these adverse effects.
   In terms of oxidative stress, Cd significantly increased oxygen-free
   radicals (O-2-and H2O2) in neutrophils and lipid peroxidation in
   erythrocytes, whereas E2 treatment reversed these changes to control
   values. Acute Cd poisoning significantly lowered antioxidant enzyme (SOD
   and CAT) activity and the level of non-enzymatic antioxidants (GSH and
   vitamin E), while increasing in GSSG. Treatments with E2 reversed
   Cd-induced effects on the antioxidant defences and significantly lowered
   Cd-induced oxidative damage in erythrocytes. This study suggests that
   exogenous E2 effectively restores redox balance in rat erythrocytes and
   counters adverse haematological and biochemical effects of Cd poisoning.
   It also improves the antioxidant capacity of erythrocytes, acting in
   synergy with endogenous antioxidants.
T2  - Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Protective effects of oestradiol against cadmium-induced changes in
 blood parameters and oxidative damage in rats
IS  - 1
VL  - 65
DO  - 10.2478/10004-1254-65-2014-2405
SP  - 37
EP  - 46
ER  - 

@article{
author = "Mladenovic, Jelena and Ognjanovic, Branka and Đorđević, Natasa and Matic, Milos and Knezevic, Veroljub and Štajn, Andraš Š. and Saičić, Zorica",
year = "2014",
abstract = "The aim of this study was to investigate the protective effects of
   oestradiol (E2, 4 mg kg(-1) b.w.i.p.) against cadmium-induced (Cd, 2 mg
   kg(-1) b.w. i.p.) blood changes in rats. Cadmium induced a significant
   decline in haemoglobin, haematocrit, and total erythrocyte, lymphocyte,
   and thrombocyte count, whereas total leukocytes and granulocytes
   increased. A significant increase was also observed in serum
   cholesterol, triglycerides, glucose, AST, and ALT activities, whereas
   total protein and albumin levels dropped significantly. Administration
   of E2 in combination with Cd alleviated most of these adverse effects.
   In terms of oxidative stress, Cd significantly increased oxygen-free
   radicals (O-2-and H2O2) in neutrophils and lipid peroxidation in
   erythrocytes, whereas E2 treatment reversed these changes to control
   values. Acute Cd poisoning significantly lowered antioxidant enzyme (SOD
   and CAT) activity and the level of non-enzymatic antioxidants (GSH and
   vitamin E), while increasing in GSSG. Treatments with E2 reversed
   Cd-induced effects on the antioxidant defences and significantly lowered
   Cd-induced oxidative damage in erythrocytes. This study suggests that
   exogenous E2 effectively restores redox balance in rat erythrocytes and
   counters adverse haematological and biochemical effects of Cd poisoning.
   It also improves the antioxidant capacity of erythrocytes, acting in
   synergy with endogenous antioxidants.",
journal = "Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Protective effects of oestradiol against cadmium-induced changes in
 blood parameters and oxidative damage in rats",
number = "1",
volume = "65",
doi = "10.2478/10004-1254-65-2014-2405",
pages = "37-46"
}

Mladenovic, J., Ognjanovic, B., Đorđević, N., Matic, M., Knezevic, V., Štajn, A. Š.,& Saičić, Z.. (2014). Protective effects of oestradiol against cadmium-induced changes in
 blood parameters and oxidative damage in rats. in Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology, 65(1), 37-46.
https://doi.org/10.2478/10004-1254-65-2014-2405

Mladenovic J, Ognjanovic B, Đorđević N, Matic M, Knezevic V, Štajn AŠ, Saičić Z. Protective effects of oestradiol against cadmium-induced changes in
 blood parameters and oxidative damage in rats. in Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology. 2014;65(1):37-46.
doi:10.2478/10004-1254-65-2014-2405 .

Mladenovic, Jelena, Ognjanovic, Branka, Đorđević, Natasa, Matic, Milos, Knezevic, Veroljub, Štajn, Andraš Š., Saičić, Zorica, "Protective effects of oestradiol against cadmium-induced changes in
 blood parameters and oxidative damage in rats" in Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology, 65, no. 1 (2014):37-46,
https://doi.org/10.2478/10004-1254-65-2014-2405 . .

TY  - JOUR
AU  - Mladenovic, Jelena M.
AU  - Paunovic, Milica G.
AU  - Matic, Milos M.
AU  - Knezevic, Veroljub S.
AU  - Ognjanovic, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2014
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2259
AB  - The effects of subchronic exposure to copper (Cu) on lipid peroxidation,
   hemato-biochemical parameters, and the possible protective role of
   flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar
   albino rats were treated with Cu (560 mg/L, p.o. as CuCl2 center dot
   2H(2)O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each,
   i.p., every third day during the last 3 weeks) alone or in combination.
   Cu increased the concentration of lipid peroxides, decreased the number
   of erythrocytes, hemoglobin and hematocrit values and increased the
   activities of aspartate aminotransferase, alanine aminotransferase and
   lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin
   with Cu lowered the process of lipid peroxidation and restored examined
   hemato-biochemical parameters to control values. Our results indicate
   that Cu induced oxidative damage in erythrocytes, which led to anemia,
   while Quercetin and (-)-Epicatechin showed a protective effect on the
   hemato-biochemical processes in the blood of rats.
T2  - Archives of Biological Sciences
T1  - COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
 PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS
IS  - 3
VL  - 66
DO  - 10.2298/ABS1403271M
SP  - 1271
EP  - 1279
ER  - 

@article{
author = "Mladenovic, Jelena M. and Paunovic, Milica G. and Matic, Milos M. and Knezevic, Veroljub S. and Ognjanovic, Branka I. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2014",
abstract = "The effects of subchronic exposure to copper (Cu) on lipid peroxidation,
   hemato-biochemical parameters, and the possible protective role of
   flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar
   albino rats were treated with Cu (560 mg/L, p.o. as CuCl2 center dot
   2H(2)O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each,
   i.p., every third day during the last 3 weeks) alone or in combination.
   Cu increased the concentration of lipid peroxides, decreased the number
   of erythrocytes, hemoglobin and hematocrit values and increased the
   activities of aspartate aminotransferase, alanine aminotransferase and
   lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin
   with Cu lowered the process of lipid peroxidation and restored examined
   hemato-biochemical parameters to control values. Our results indicate
   that Cu induced oxidative damage in erythrocytes, which led to anemia,
   while Quercetin and (-)-Epicatechin showed a protective effect on the
   hemato-biochemical processes in the blood of rats.",
journal = "Archives of Biological Sciences",
title = "COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
 PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS",
number = "3",
volume = "66",
doi = "10.2298/ABS1403271M",
pages = "1271-1279"
}

Mladenovic, J. M., Paunovic, M. G., Matic, M. M., Knezevic, V. S., Ognjanovic, B. I., Štajn, A. Š.,& Saičić, Z.. (2014). COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
 PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS. in Archives of Biological Sciences, 66(3), 1271-1279.
https://doi.org/10.2298/ABS1403271M

Mladenovic JM, Paunovic MG, Matic MM, Knezevic VS, Ognjanovic BI, Štajn AŠ, Saičić Z. COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
 PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS. in Archives of Biological Sciences. 2014;66(3):1271-1279.
doi:10.2298/ABS1403271M .

Mladenovic, Jelena M., Paunovic, Milica G., Matic, Milos M., Knezevic, Veroljub S., Ognjanovic, Branka I., Štajn, Andraš Š., Saičić, Zorica, "COPPER-INDUCED CHANGES OF LIPID PEROXIDATION AND HEMATO-BIOCHEMICAL
 PARAMETERS IN RAT BLOOD: PROTECTIVE ROLE OF FLAVONOIDS" in Archives of Biological Sciences, 66, no. 3 (2014):1271-1279,
https://doi.org/10.2298/ABS1403271M . .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Đačić, Dragana S.
AU  - Cvetković, Danijela M.
AU  - Obradović, Ana D.
AU  - Žižić, Jovana B.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
AU  - Spasić, Mihajlo
PY  - 2010
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/491
AB  - Ascorbic acid (Vit C) is a reducing agent that efficiently quenches potentially damaging free radicals. The aim of this study was to investigate effects of high acute dose of Vit C on redox and antioxidative status in blood of rats. Our study included two groups of Wistar albino rats: I - untreated group (control); II - group treated with Vit C (500 mg/kg bw, i.p.). In all cases animals were sacrificed after three days of treatment and blood samples were taken at the day of sacrifice. Concentration of Heinz bodies (HB) was determined in whole blood, while the concentration of reactive oxygen and nitrogen species (ROS and RNS), as well as, parameters of antioxidative defense system were followed in plasma and red blood cells (RBC). Our results showed that Vit C treatment induced higher levels of peroxynitrites and lipid peroxidation in plasma. In RBC, Vit C induced higher level of HB, GSSG/2 GSH ratio and glutathione peroxidase activity, while decreased glutathione reductase activity. In conclusion, acute high doses of Vit C act as prooxidant and induced oxidative stress that resulted in lipid peroxidation in plasma and hemoglobin oxidation in RBC. .
T2  - Kragujevac Journal of Science
T1  - Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats
IS  - 32
VL  - null
SP  - 109
EP  - 116
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_491
ER  - 

@article{
author = "Marković, Snežana D. and Đačić, Dragana S. and Cvetković, Danijela M. and Obradović, Ana D. and Žižić, Jovana B. and Ognjanović, Branka I. and Štajn, Andraš Š. and Saičić, Zorica and Spasić, Mihajlo",
year = "2010, 2010",
abstract = "Ascorbic acid (Vit C) is a reducing agent that efficiently quenches potentially damaging free radicals. The aim of this study was to investigate effects of high acute dose of Vit C on redox and antioxidative status in blood of rats. Our study included two groups of Wistar albino rats: I - untreated group (control); II - group treated with Vit C (500 mg/kg bw, i.p.). In all cases animals were sacrificed after three days of treatment and blood samples were taken at the day of sacrifice. Concentration of Heinz bodies (HB) was determined in whole blood, while the concentration of reactive oxygen and nitrogen species (ROS and RNS), as well as, parameters of antioxidative defense system were followed in plasma and red blood cells (RBC). Our results showed that Vit C treatment induced higher levels of peroxynitrites and lipid peroxidation in plasma. In RBC, Vit C induced higher level of HB, GSSG/2 GSH ratio and glutathione peroxidase activity, while decreased glutathione reductase activity. In conclusion, acute high doses of Vit C act as prooxidant and induced oxidative stress that resulted in lipid peroxidation in plasma and hemoglobin oxidation in RBC. .",
journal = "Kragujevac Journal of Science",
title = "Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats",
number = "32",
volume = "null",
pages = "109-116",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_491"
}

Marković, S. D., Đačić, D. S., Cvetković, D. M., Obradović, A. D., Žižić, J. B., Ognjanović, B. I., Štajn, A. Š., Saičić, Z.,& Spasić, M.. (2010). Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats. in Kragujevac Journal of Science, null(32), 109-116.
https://hdl.handle.net/21.15107/rcub_ibiss_491

Marković SD, Đačić DS, Cvetković DM, Obradović AD, Žižić JB, Ognjanović BI, Štajn AŠ, Saičić Z, Spasić M. Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats. in Kragujevac Journal of Science. 2010;null(32):109-116.
https://hdl.handle.net/21.15107/rcub_ibiss_491 .

Marković, Snežana D., Đačić, Dragana S., Cvetković, Danijela M., Obradović, Ana D., Žižić, Jovana B., Ognjanović, Branka I., Štajn, Andraš Š., Saičić, Zorica, Spasić, Mihajlo, "Effects of acute treatment of vitamin C on redox and antioxidative metabolism in plasma and red blood cells of rats" in Kragujevac Journal of Science, null, no. 32 (2010):109-116,
https://hdl.handle.net/21.15107/rcub_ibiss_491 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Milovanović, Jasmina G.
AU  - Đorđević, Nataša Z.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2008
PY  - 2008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/490
AB  - Fish are the most important organisms in the biomonitoring of aquatic ecosystems. A number of pollutants may cause the oxidative stress in the organism of fish. The monitoring of parameters of oxidative stress in tissues of fish is a good biomarker in the assessment of the condition of environment. Catch of commercially important species of fish, hake (Merluccius merluccius L.) was carried out in front of sea-port Bar (South Adriatic) at the end of May 2005. The parameters of oxidative stress: concentrations of lipid peroxides (LP) and reduced glutathione (GSH) were determined in liver and white muscle. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) as well as the concentrations of nitrites, nitrates and detergents in the water of investigated locality were determined. The obtained results showed the tissue specificity that was the consequence of different metabolic and antioxidative activities. In the liver of hake, the increased concentration of LP was found in comparison to the white muscle, whereas in white muscle the increased concentration of GSH was recorded in comparison to the liver. These results suggest that the intensity of oxidative stress was higher in the liver in comparison to the white muscle, which is the consequence of increased presence of pollutants in water of the investigated locality. .
T2  - Kragujevac Journal of Science
T1  - Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea
IS  - 30
VL  - null
SP  - 137
EP  - 144
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_490
ER  - 

@article{
author = "Ognjanović, Branka I. and Milovanović, Jasmina G. and Đorđević, Nataša Z. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2008, 2008",
abstract = "Fish are the most important organisms in the biomonitoring of aquatic ecosystems. A number of pollutants may cause the oxidative stress in the organism of fish. The monitoring of parameters of oxidative stress in tissues of fish is a good biomarker in the assessment of the condition of environment. Catch of commercially important species of fish, hake (Merluccius merluccius L.) was carried out in front of sea-port Bar (South Adriatic) at the end of May 2005. The parameters of oxidative stress: concentrations of lipid peroxides (LP) and reduced glutathione (GSH) were determined in liver and white muscle. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) as well as the concentrations of nitrites, nitrates and detergents in the water of investigated locality were determined. The obtained results showed the tissue specificity that was the consequence of different metabolic and antioxidative activities. In the liver of hake, the increased concentration of LP was found in comparison to the white muscle, whereas in white muscle the increased concentration of GSH was recorded in comparison to the liver. These results suggest that the intensity of oxidative stress was higher in the liver in comparison to the white muscle, which is the consequence of increased presence of pollutants in water of the investigated locality. .",
journal = "Kragujevac Journal of Science",
title = "Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea",
number = "30",
volume = "null",
pages = "137-144",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_490"
}

Ognjanović, B. I., Milovanović, J. G., Đorđević, N. Z., Marković, S. D., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2008). Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea. in Kragujevac Journal of Science, null(30), 137-144.
https://hdl.handle.net/21.15107/rcub_ibiss_490

Ognjanović BI, Milovanović JG, Đorđević NZ, Marković SD, Žikić RV, Štajn AŠ, Saičić Z. Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea. in Kragujevac Journal of Science. 2008;null(30):137-144.
https://hdl.handle.net/21.15107/rcub_ibiss_490 .

Ognjanović, Branka I., Milovanović, Jasmina G., Đorđević, Nataša Z., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Parameters of oxidative stress in liver and white muscle of hake (Merluccius merluccius L.) from the Adriatic Sea" in Kragujevac Journal of Science, null, no. 30 (2008):137-144,
https://hdl.handle.net/21.15107/rcub_ibiss_490 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Đorđević, Nataša
AU  - Pavlović, Slađan
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5999
AB  - The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea
SP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5999
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Đorđević, Nataša and Pavlović, Slađan and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2007",
abstract = "The environment is continuously loaded with foreign organic chemicals (xenobiotics) released by urban communities and industries. Many classes of environmental contaminants (or their metabolites) are know to enhance the intracellular formation of reactive oxygen species (ROS) causing oxidative damage to biological systems. Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment.
Specimens two marine fishes of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) were collected May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress: activity of antioxidative enzymes (superoxide dismutase­ SOD and catalase-CAT) and concentration of lipid peroxidation-LP and glutathione-GSH were determined in the liver of hake and red mullet.
Obtained results showed that activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to changes ofphysical­ chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet. This increased ROS production and subsequent oxidati e damage has been associated with pollutant mediated mechanism of toxicity in liver of investigated fishes.
According to the analyses of our results the investigated parameters of oxidative stress (concentration of LP and GSH, as well as activity of antioxidative enzymes SOD and CAT) in liver of hake and red mullet demonstrate     significant     and     reliable     biomarkers     m  monitoring,environmental  pollution.",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea",
pages = "69",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5999"
}

Ognjanović, B., Marković, S., Đorđević, N., Pavlović, S., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2007). Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999

Ognjanović B, Marković S, Đorđević N, Pavlović S, Štajn AŠ, Žikić RV, Saičić Z. Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:69.
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

Ognjanović, Branka, Marković, Snežana, Đorđević, Nataša, Pavlović, Slađan, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Oxidative stress parameters in the liver of hake (Merluccius merluccius L.) and red mullet (Mullus barbatus L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):69,
https://hdl.handle.net/21.15107/rcub_ibiss_5999 .

TY  - CONF
AU  - Đorđević, Nataša
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5998
AB  - Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni
PB  - Novi Sad: Faculty of Sciences, Department of Biology and Ecology
C3  - Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
T1  - Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea
SP  - 55
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5998
ER  - 

@conference{
author = "Đorđević, Nataša and Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Recent investigations in biomonitoring include the monitoring of biochemical and physiological parameters to evaluate the condition of environment. Parameters of oxidative stress are significant biomarkers of environmental pollution of the sea. Specimens of marine fish - hake (Merluccius merluccius) was collected from the localities of Platamuni and Valdanos (Sauth Adriatic) in winter   and   spring   during   2003   year.   Concentrations   of antioxidant compounds such as Vitamin E (Vit E) and Vitamin C (Vit C) as well as, lipid peroxidation (LP) were determined in the liver and white muscle of the hake. Physical chemical parameters of water of investigated  localities  were also determined: salinity, temperature, oxygen saturation and concentrations of nitrites, nitrates and detergent in both seasons.
The obtained results showed higher concentrations of LP, Vit E and Vit C in liver of hake in comparison to white muscle. Concentrations of LP and Vit C were increased, while the concentrations of Vit E were decreased in winter period in comparison to spring. Concentrations of LP were increased while the concentrations of Vit E were decreased in both investigated tissues of hake from the waters of locality Valdanos in respect to Platamuni. These changes of parameters of oxidative stress are, in part, the consequence of changes of temperature as well as, concentrations of nitrites, nitrates and detergents in water of investigated localities and in particular season.
In conclusion, the concentrations of parameter of oxidative stress in investigated tissues of hake represent a good marker in the biomonitoring of environmental pollution. The intensity of oxidative stress was increased in the liver of hake in comparison to white muscle, in winter period ill respect to spring and in waters of Valdanos in comparison to Platamuni",
publisher = "Novi Sad: Faculty of Sciences, Department of Biology and Ecology",
journal = "Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia",
title = "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea",
pages = "55",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5998"
}

Đorđević, N., Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia
Novi Sad: Faculty of Sciences, Department of Biology and Ecology., 55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998

Đorđević N, Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea. in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia. 2007;:55.
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

Đorđević, Nataša, Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Concentration of antioxidant compounds and lipid peroxidation in some tissues of hake (Merluccius merluccius L.) from the Adriatic sea" in Collection of abstracts: 1st International Congress on Biology in Serbia: Kobis 2007; 2007 Oct 25-28; Palić, Serbia (2007):55,
https://hdl.handle.net/21.15107/rcub_ibiss_5998 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2007
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5971
AB  - Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
T1  - Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.
SP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5971
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2007",
abstract = "Cadmium (Cd) is  an  ubiquitous,  nonessential  element  that  has  recentl y  raised concerns due to its accumulation in the environment. The toxicity of Cd as an industrial  pollutant  a  food  contaminant and  as  one  of  the  major  components   in  cigarette smoke has been well established. A number of nutrient s have been shown to interact with Cd and alter its cellular effects. Several protective agents, including conzyme Q10 (CoQ10) and vitamin E (Vit E) play an important role in detoxification of  endogenous  and  exogenous  compounds.  Our  study  investigated  the possible protective  effects  of  coenzyme Q10  (CoQ 10)  and  vitamin   E  (Vit  E)  alone  or  in cornbrnation against cadmium (Cd) induced alterations of antioxidant defense system  in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4 mg Cd/kg  i.p.),  CoQ10 (20  mg CoQ 1 0/kg  i. m.) and  Vit E (20  lU  Vit  E/kg, i. m.), a lone or in combination. Acute  intoxication  of  rats with Cd  were followed  by significantly  increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD  was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations . Treatment with CoQ10+Vit E reversed  Cd-induced  alterations  in Vit C and  Vit  E concentrations. Our study suggests that the prooxidative effect of Cd is respon si ble for  alterations in prooxidant-ant ioxidant balance in the heart. The obtained results support the assumption   that   CoQ10  and Vit E functions   cooperatively with endogenous antioxidants and diminished some toxic effects of Cd in rat hearts .",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia",
title = "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.",
pages = "112",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5971"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2007). Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia
Belgrade: Serbian Physiology Society., 112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart.. in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia. 2007;:112.
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Antioxidant effect of coenzyme Q10 and vitamin E in Cadmium induced alterations of antioxidant defense system in the rat heart." in Abstract book: A Scientific Conference with International Participation: Nutrition, Treatment and Cardiovascular Risk Management; 2007 May 24-27; Novi Sad, Serbia (2007):112,
https://hdl.handle.net/21.15107/rcub_ibiss_5971 .

TY  - CONF
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5969
AB  - Cadmium (Cd) is a commonly occurring environmental contaminant which after being intake into the organism accumulates mostly in the liver and kidneys. Recent studies on mammals have shown that Cd stimulates formation of superoxide anion radicals, hydrogen peroxide and hydroxyl radicals. As a consequence, enhanced lipid peroxidation, DNA damage, altered calcium and sulfhydryl homeostasis, as well as marked disturbances of antioxidant defense system occur.
Coenzyme Q10 (CoQ10) in its reduced form (CoQ10H2) is a powerful antioxidant. As an antioxidant it is exploited either directly upon superoxide or indirectly on lipid radicals. CoQ10 may prevent both the initiation and propagation of lipid peroxidation, protects DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stress induced by various toxic agents. 
	The activities of Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GR and phase II biotransformation enzyme-GST, as well as Vit C and Vit E concentrations were analyzed in the liver, heart and kidneys of male, two months old Wistar albino rats treated with Cd (200 mg CdCl2 x H2O, in drinking water during 30 days), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and in control animals (C). 
	 This study suggested that Cd influences antioxidative defense enzyme activities in the liver, heart and kidneys of rats in various ways, especially depending on its metabolic activity. CoQ10 only partially (and tissue-specific) reversed Cd-induced changes on these enzymes. At the same time, CoQ10 exerts very strong beneficial effects on Vit C and Vit E by elevating its concentrations and thus induced an increase in antioxidative defense potential in investigated tissues of rats treated with Cd.
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia
T1  - Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.
SP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5969
ER  - 

@conference{
author = "Pavlović, Slađan and Ognjanović, Branka and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2006",
abstract = "Cadmium (Cd) is a commonly occurring environmental contaminant which after being intake into the organism accumulates mostly in the liver and kidneys. Recent studies on mammals have shown that Cd stimulates formation of superoxide anion radicals, hydrogen peroxide and hydroxyl radicals. As a consequence, enhanced lipid peroxidation, DNA damage, altered calcium and sulfhydryl homeostasis, as well as marked disturbances of antioxidant defense system occur.
Coenzyme Q10 (CoQ10) in its reduced form (CoQ10H2) is a powerful antioxidant. As an antioxidant it is exploited either directly upon superoxide or indirectly on lipid radicals. CoQ10 may prevent both the initiation and propagation of lipid peroxidation, protects DNA from oxidation causing by lipid peroxidation and protects organism from oxidative stress induced by various toxic agents. 
	The activities of Total SOD, Mn SOD, CuZn SOD, CAT, GSH-Px, GR and phase II biotransformation enzyme-GST, as well as Vit C and Vit E concentrations were analyzed in the liver, heart and kidneys of male, two months old Wistar albino rats treated with Cd (200 mg CdCl2 x H2O, in drinking water during 30 days), CoQ10 (20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (200 mg CdCl2 x H2O, in drinking water during 30 days + 20 mg/kg CoQ10 dissolved in olive oil, i.m., every fifth day) and in control animals (C). 
	 This study suggested that Cd influences antioxidative defense enzyme activities in the liver, heart and kidneys of rats in various ways, especially depending on its metabolic activity. CoQ10 only partially (and tissue-specific) reversed Cd-induced changes on these enzymes. At the same time, CoQ10 exerts very strong beneficial effects on Vit C and Vit E by elevating its concentrations and thus induced an increase in antioxidative defense potential in investigated tissues of rats treated with Cd.",
publisher = "Belgrade: Serbian Physiology Society",
journal = "Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia",
title = "Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.",
pages = "33",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5969"
}

Pavlović, S., Ognjanović, B., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2006). Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.. in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia
Belgrade: Serbian Physiology Society., 33.
https://hdl.handle.net/21.15107/rcub_ibiss_5969

Pavlović S, Ognjanović B, Štajn AŠ, Žikić RV, Saičić Z. Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats.. in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia. 2006;:33.
https://hdl.handle.net/21.15107/rcub_ibiss_5969 .

Pavlović, Slađan, Ognjanović, Branka, Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Effect of cadmium on antioxidant defense system: changes after co-treatment with coenzyme Q10 in some tissues of rats." in Abstract book: The 2nd Multidisciplinary Scientific Meeting with International participation: Oxidative Stress and the Mechanisms of Protection; 2006 Nov 2-3; Kragujevac, Serbia (2006):33,
https://hdl.handle.net/21.15107/rcub_ibiss_5969 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Filipović, Jasmina
AU  - Nikolić, Dubravka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5966
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea
SP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5966
ER  - 

@conference{
author = "Ognjanović, Branka and Filipović, Jasmina and Nikolić, Dubravka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica",
year = "2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems.Parameters of oxidative stress in fish tissues represent significant biomarkers in theassessment of the status of environment. Specimens of hake (Merluccius merluccius L.) andsea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality infront of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration oflipid peroxidase – LP and reduced glutathione – GSH) were determined in the liver and whitemuscle of hake and sea bream. Physical-chemical parameters (salinity, concentration ofdissolved oxygen and temperature) were determined in water of the investigated locality.Obtained results showed that the concentration of LP was higher in liver of hake and seabream in comparison to white muscle. However, significantly higher concentration of GSHwas found in white muscle of hake and sea bream in comparison to liver. These changes ofoxidative stress parameters point to tissue specificity, which is the consequence of differentmetabolic and antioxidative activity. Inter-specific differences were also established. Higherconcentrations of LP and GSH in liver of hake and in white muscle of sea bream wererecorded, due to changes of physical-chemical parameters of environment. The intensity ofoxidative stress in liver of hake and sea bream was higher in comparison to muscle.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea",
pages = "91",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5966"
}

Ognjanović, B., Filipović, J., Nikolić, D., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z.. (2006). Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966

Ognjanović B, Filipović J, Nikolić D, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić Z. Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:91.
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

Ognjanović, Branka, Filipović, Jasmina, Nikolić, Dubravka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica, "Lipid peroxidation and glutathione content in tissues of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic sea" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):91,
https://hdl.handle.net/21.15107/rcub_ibiss_5966 .

TY  - CONF
AU  - Ognjanović, Branka
AU  - Marković, Snežana
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Saičić, Zorica S.
PY  - 2006
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5964
AB  - Specimens of the carps (Cyprinus carpio L.) were adapted to the oxygen concentration of 6.5mg/L water (100%) as control (C) group. The first (H1) and second (H2) experimental groupswere exposed to progressive reduction of O2 to 4.2 mg/L (55%) during 115 hours and 2.3 mg/L(30%) during 230 hours, respectively. Acute hypoxia decreased glucose (H1) and pyruvate (H1and H2) concentrations in the blood of carps, while lactate level was significantly increased(H2). Concentration of red blood cells (RBCs) ATP was decreased in both (H1 and H2)groups of fish. Concomitant increase of ADP concentration was observed in (H2) group offish. The decrease of ATP/ADP ratio in (H2) group was also found. In carps of (H1) group,the activities of superoxide dismutase (SOD) and catalase (CAT) in RBCs were increasedwhereas glutathione-S-transferase (GST) activity in the plasma was increased in both groupsof fish. Glutathione peroxidase (GSH-Px) activity and the concentration of reducedglutathione (GSH) were decreased in the same conditions. Increased concentration of lipidperoxides (LP) in the blood of (H1 and H2) groups of animals in relation to the controls wasalso found. In conclusion, acute hypoxia induced a significant alteration of antioxidantenzyme activities and lipid peroxide concentration in the blood of carps (Cyprinus carpio L.)under influence of progressive reduction of oxygen concentration. All specified changes aredependent from duration of hypoxic conditions. The presented results suggest that during the evolution carps developed a well defined metabolic regulation and antioxidant defense systemfor the protection from acute hypoxia.
PB  - Podgorica: Centre for Biodiversity of Montenegro
C3  - The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
T1  - Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia
SP  - 90
EP  - 91
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5964
ER  - 

@conference{
author = "Ognjanović, Branka and Marković, Snežana and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Saičić, Zorica S.",
year = "2006",
abstract = "Specimens of the carps (Cyprinus carpio L.) were adapted to the oxygen concentration of 6.5mg/L water (100%) as control (C) group. The first (H1) and second (H2) experimental groupswere exposed to progressive reduction of O2 to 4.2 mg/L (55%) during 115 hours and 2.3 mg/L(30%) during 230 hours, respectively. Acute hypoxia decreased glucose (H1) and pyruvate (H1and H2) concentrations in the blood of carps, while lactate level was significantly increased(H2). Concentration of red blood cells (RBCs) ATP was decreased in both (H1 and H2)groups of fish. Concomitant increase of ADP concentration was observed in (H2) group offish. The decrease of ATP/ADP ratio in (H2) group was also found. In carps of (H1) group,the activities of superoxide dismutase (SOD) and catalase (CAT) in RBCs were increasedwhereas glutathione-S-transferase (GST) activity in the plasma was increased in both groupsof fish. Glutathione peroxidase (GSH-Px) activity and the concentration of reducedglutathione (GSH) were decreased in the same conditions. Increased concentration of lipidperoxides (LP) in the blood of (H1 and H2) groups of animals in relation to the controls wasalso found. In conclusion, acute hypoxia induced a significant alteration of antioxidantenzyme activities and lipid peroxide concentration in the blood of carps (Cyprinus carpio L.)under influence of progressive reduction of oxygen concentration. All specified changes aredependent from duration of hypoxic conditions. The presented results suggest that during the evolution carps developed a well defined metabolic regulation and antioxidant defense systemfor the protection from acute hypoxia.",
publisher = "Podgorica: Centre for Biodiversity of Montenegro",
journal = "The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro",
title = "Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia",
pages = "90-91",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5964"
}

Ognjanović, B., Marković, S., Pavlović, S., Žikić, R. V., Štajn, A. Š.,& Saičić, Z. S.. (2006). Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro
Podgorica: Centre for Biodiversity of Montenegro., 90-91.
https://hdl.handle.net/21.15107/rcub_ibiss_5964

Ognjanović B, Marković S, Pavlović S, Žikić RV, Štajn AŠ, Saičić ZS. Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia. in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro. 2006;:90-91.
https://hdl.handle.net/21.15107/rcub_ibiss_5964 .

Ognjanović, Branka, Marković, Snežana, Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Saičić, Zorica S., "Alterations of energy metabolism and (anti)oxidant status in red blood cells of carps (Cyprinus carpio L.) exposed to acute hypoxia" in The Book of Abstracts and Programme: II International Symposium of Ecologists of Montenegro ISEM2; 2006 Sep 20-24; Kotor, Montenegro (2006):90-91,
https://hdl.handle.net/21.15107/rcub_ibiss_5964 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/133
AB  - Cadmium (Cd) has been recognized as being among the most toxic environmental and industrial pollutants, one that is pres­ ent in soils, sediments, air, and water (S to e pp 1 er, 1991) . After penetrating into the organism, mostly through the respir­ atory and gastrointestinal tracts, Cd accumulates in the liver and kidneys, as well as in other tissues and organs, causing many metabolic, histological, and pathological changes, such as neph­ rotoxicity, cardiotoxicity, increased lipid peroxidation and hem­ orrhagic lesions of seminal tubules. In tissues, Cd also binds to proteins of low molecular mass, producing metallothioneins by the induction of metallothionein mRNA synthesis (G e o r g e et al., 1996). Cadmium depletes glutathione and protein-bound sulfhydryl groups, resulting in enhanced production of reactive oxygen species (ROS). These ROS result in increased lipid per­ oxidation, enhanced excretion of urinary lipid metabolites, modulation of intracellular oxidized states, DNA damage, membrane damage, altered gene expression, and apoptosis (Kim et al., 2003).
T2  - Archives of Biological Sciences
T1  - Effect of coenzyme Q10 on ascorbic acid, vitamin E, and coenzyme Q concentrations in testes of rats chronically exposed to cadmium
IS  - 3
VL  - 58
DO  - 10.2298/ABS0603001P
SP  - 19P
EP  - 20P
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_133
ER  - 

@article{
author = "Pavlović, Slađan and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Cadmium (Cd) has been recognized as being among the most toxic environmental and industrial pollutants, one that is pres­ ent in soils, sediments, air, and water (S to e pp 1 er, 1991) . After penetrating into the organism, mostly through the respir­ atory and gastrointestinal tracts, Cd accumulates in the liver and kidneys, as well as in other tissues and organs, causing many metabolic, histological, and pathological changes, such as neph­ rotoxicity, cardiotoxicity, increased lipid peroxidation and hem­ orrhagic lesions of seminal tubules. In tissues, Cd also binds to proteins of low molecular mass, producing metallothioneins by the induction of metallothionein mRNA synthesis (G e o r g e et al., 1996). Cadmium depletes glutathione and protein-bound sulfhydryl groups, resulting in enhanced production of reactive oxygen species (ROS). These ROS result in increased lipid per­ oxidation, enhanced excretion of urinary lipid metabolites, modulation of intracellular oxidized states, DNA damage, membrane damage, altered gene expression, and apoptosis (Kim et al., 2003).",
journal = "Archives of Biological Sciences",
title = "Effect of coenzyme Q10 on ascorbic acid, vitamin E, and coenzyme Q concentrations in testes of rats chronically exposed to cadmium",
number = "3",
volume = "58",
doi = "10.2298/ABS0603001P",
pages = "19P-20P",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_133"
}

Pavlović, S., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V.,& Saičić, Z.. (2006). Effect of coenzyme Q10 on ascorbic acid, vitamin E, and coenzyme Q concentrations in testes of rats chronically exposed to cadmium. in Archives of Biological Sciences, 58(3), 19P-20P.
https://doi.org/10.2298/ABS0603001P
https://hdl.handle.net/21.15107/rcub_ibiss_133

Pavlović S, Ognjanović BI, Štajn AŠ, Žikić RV, Saičić Z. Effect of coenzyme Q10 on ascorbic acid, vitamin E, and coenzyme Q concentrations in testes of rats chronically exposed to cadmium. in Archives of Biological Sciences. 2006;58(3):19P-20P.
doi:10.2298/ABS0603001P
https://hdl.handle.net/21.15107/rcub_ibiss_133 .

Pavlović, Slađan, Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Saičić, Zorica, "Effect of coenzyme Q10 on ascorbic acid, vitamin E, and coenzyme Q concentrations in testes of rats chronically exposed to cadmium" in Archives of Biological Sciences, 58, no. 3 (2006):19P-20P,
https://doi.org/10.2298/ABS0603001P .,
https://hdl.handle.net/21.15107/rcub_ibiss_133 .

TY  - JOUR
AU  - Radovanović, Tijana
AU  - Pavlović, Slađan
AU  - Borković Mitić, Slavica
AU  - Milošević, Slaviša M.
AU  - Kosanović, Katica
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/300
AB  - In our experiments, we studied superoxide dismutase (SOD) and catalase (CAT) activities in the hepatopancreas, the gills and the abdominal muscle of Noble crayfish (Astacus astacus), Stone crayfish (Austropotamobius torrentium) and Spynicheek crayfish (Orconectes limosus) from the South Morava River, Krajkovačka River and Serbian part of the Danube respectively. The specific SOD activity in the hepatopancreas of the A. astacus was significantly higher in respect to other two species (p<0.005) as well as in the hepatopancreas of A. torrentium then in O. limosus (p<0.02). The same trend was obtained for the total SOD activity in the hepatopancreas, which was significantly decreased in O. limosus compared to two other investigated species (p<0.005). The specific CAT activity in the muscle of the Austropotamobius torrentium was significantly higher in respect to Astacus astacus (p<0.005) and Orconectes limosus (p<0.005). Specific CAT activity was considerably higher in the Astacus astacus then in Orconectes limosus (p<0.02). The same trend was detected in the case of the total CAT activity in the muscle but, total CAT activity was significantly decrease in Orconectes limosus, compare to Astacus astacus (p<0.01). The obtained results show strong tissue and species specificities, indicating different metabolic activities and various environmental influences.
AB  - U našim eksperimentima određivali smo aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u hepatopankreasu, škrgama i abdominalnom mišiću rečnog raka (Astacus astacus L) sa lokaliteta Južna Morava, raka kamenjara (Austropotamobius torrentium Schrank) sa lokaliteta Krajkovačka reka i američkog raka (Orconectes limosus Raf) sa lokaliteta Dunav. Specifična aktivnost SOD u hepatopankreasu rečnog raka bila je značajno veća u hepatopankreasu u poređenju sa druge dve vrste (p<0.005), kao i u hepatopankreasu Austropotamobius torrentium u odnosu na Orconectes limosus (p<0.02). Isti trend je zabeležen za ukupnu SOD aktivnost u hepatopankreasu Orconectes limosus koja je bila značajno manja u odnosu na druge dve ispitivane vrste (p<0.005). Specifična aktivnost CAT u mišiću Austropotamobius torrentium bila je značajno veća nego kod vrsta Astacus astacus i Orconectes limosus (p<0.005). Specifična aktivnost CAT bila je značajno veća kod Astacus astacus u odnosu na Orconectes limosus (p<0.02). Isti trend je zabeležen u slučaju ukupne aktivnosti CAT u mišiću, pri čemu je ukupna aktivnosti CAT bila značajno manja kod Orconectes limosus u poređenju sa Astacus astacus (p<0.01). Dobijeni rezultati pokazuju veliku tkivnu i species-specifičnost i ukazuju na postojanje razlika u metaboličkoj aktivnosti, kao i na različite uslove spoljašnje sredine.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u nekim tkivima tri vrste slatkovodnih rakova
T1  - Superoxide dismutase (SOD) and catalase (CAT) activities in some tissues of three freshwater crayfish species
IS  - 3
VL  - 42
SP  - 193
EP  - 201
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_300
ER  - 

@article{
author = "Radovanović, Tijana and Pavlović, Slađan and Borković Mitić, Slavica and Milošević, Slaviša M. and Kosanović, Katica and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "In our experiments, we studied superoxide dismutase (SOD) and catalase (CAT) activities in the hepatopancreas, the gills and the abdominal muscle of Noble crayfish (Astacus astacus), Stone crayfish (Austropotamobius torrentium) and Spynicheek crayfish (Orconectes limosus) from the South Morava River, Krajkovačka River and Serbian part of the Danube respectively. The specific SOD activity in the hepatopancreas of the A. astacus was significantly higher in respect to other two species (p<0.005) as well as in the hepatopancreas of A. torrentium then in O. limosus (p<0.02). The same trend was obtained for the total SOD activity in the hepatopancreas, which was significantly decreased in O. limosus compared to two other investigated species (p<0.005). The specific CAT activity in the muscle of the Austropotamobius torrentium was significantly higher in respect to Astacus astacus (p<0.005) and Orconectes limosus (p<0.005). Specific CAT activity was considerably higher in the Astacus astacus then in Orconectes limosus (p<0.02). The same trend was detected in the case of the total CAT activity in the muscle but, total CAT activity was significantly decrease in Orconectes limosus, compare to Astacus astacus (p<0.01). The obtained results show strong tissue and species specificities, indicating different metabolic activities and various environmental influences., U našim eksperimentima određivali smo aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u hepatopankreasu, škrgama i abdominalnom mišiću rečnog raka (Astacus astacus L) sa lokaliteta Južna Morava, raka kamenjara (Austropotamobius torrentium Schrank) sa lokaliteta Krajkovačka reka i američkog raka (Orconectes limosus Raf) sa lokaliteta Dunav. Specifična aktivnost SOD u hepatopankreasu rečnog raka bila je značajno veća u hepatopankreasu u poređenju sa druge dve vrste (p<0.005), kao i u hepatopankreasu Austropotamobius torrentium u odnosu na Orconectes limosus (p<0.02). Isti trend je zabeležen za ukupnu SOD aktivnost u hepatopankreasu Orconectes limosus koja je bila značajno manja u odnosu na druge dve ispitivane vrste (p<0.005). Specifična aktivnost CAT u mišiću Austropotamobius torrentium bila je značajno veća nego kod vrsta Astacus astacus i Orconectes limosus (p<0.005). Specifična aktivnost CAT bila je značajno veća kod Astacus astacus u odnosu na Orconectes limosus (p<0.02). Isti trend je zabeležen u slučaju ukupne aktivnosti CAT u mišiću, pri čemu je ukupna aktivnosti CAT bila značajno manja kod Orconectes limosus u poređenju sa Astacus astacus (p<0.01). Dobijeni rezultati pokazuju veliku tkivnu i species-specifičnost i ukazuju na postojanje razlika u metaboličkoj aktivnosti, kao i na različite uslove spoljašnje sredine.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u nekim tkivima tri vrste slatkovodnih rakova, Superoxide dismutase (SOD) and catalase (CAT) activities in some tissues of three freshwater crayfish species",
number = "3",
volume = "42",
pages = "193-201",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_300"
}

Radovanović, T., Pavlović, S., Borković Mitić, S., Milošević, S. M., Kosanović, K., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2006). Aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u nekim tkivima tri vrste slatkovodnih rakova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 193-201.
https://hdl.handle.net/21.15107/rcub_ibiss_300

Radovanović T, Pavlović S, Borković Mitić S, Milošević SM, Kosanović K, Štajn AŠ, Petrović VM, Saičić Z. Aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u nekim tkivima tri vrste slatkovodnih rakova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):193-201.
https://hdl.handle.net/21.15107/rcub_ibiss_300 .

Radovanović, Tijana, Pavlović, Slađan, Borković Mitić, Slavica, Milošević, Slaviša M., Kosanović, Katica, Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) u nekim tkivima tri vrste slatkovodnih rakova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):193-201,
https://hdl.handle.net/21.15107/rcub_ibiss_300 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Filipović, Jasmina Ž.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/256
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration of lipid peroxidase - LP and reduced glutathione - GSH) were determined in the liver and white muscle of hake and sea bream. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) were determined in water of the investigated locality. Obtained results showed that the concentration of LP was higher in liver of hake and sea bream in comparison to white muscle. However, significantly higher concentration of GSH was found in white muscle of hake and sea bream in comparison to liver. These changes of oxidative stress parameters point to tissue specificity, which is the consequence of different metabolic and antioxidative activity. Inter-specific differences were also established. Higher concentrations of LP and GSH in liver of hake and in white muscle of sea bream were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake and sea bream was higher in comparison to muscle.
AB  - Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) sa lokaliteta ispred luke Bar (Južni Jadran). Parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovani glutationa - GSH) su određivani u tkivima jetre i belog mišića oslića i arbuna. U vodi ispitivanog lokaliteta određivani su i fizičko-hemijski parametri (salinitet, koncentracija rastvorenog kiseonika i temperatura). Dobijeni rezultati su pokazali da je koncentracija LP veća u jetri oslića i arbuna u odnosu na belo mišićno tkivo. Međutim, zabeležena je znatno veća koncentracija GSH u belom mišiću i oslića i arbuna u odnosu na jetru. Ovakve promene parametara oksidacionog stresa ukazuju na tkivnu specifičnost, kao posledica različite metaboličke i antioksidacione aktivnosti. Ustanovljene su i interspecijske razlike, zabeležena je veća koncentracija LP i GSH u jetri oslića, kao i u belom mišiću arbuna, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića i arbuna je bio viši u odnosu na mišiće.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora
T1  - Lipid peroxidation and glutathione content in the liver and white muscle of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic Sea
IS  - 2
VL  - 42
SP  - 129
EP  - 139
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_256
ER  - 

@article{
author = "Ognjanović, Branka I. and Filipović, Jasmina Ž. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) were collected at the end of May 2005 from the locality in front of sea-port Bar (South Adriatic Sea). Parameters of oxidative stress (concentration of lipid peroxidase - LP and reduced glutathione - GSH) were determined in the liver and white muscle of hake and sea bream. Physical-chemical parameters (salinity, concentration of dissolved oxygen and temperature) were determined in water of the investigated locality. Obtained results showed that the concentration of LP was higher in liver of hake and sea bream in comparison to white muscle. However, significantly higher concentration of GSH was found in white muscle of hake and sea bream in comparison to liver. These changes of oxidative stress parameters point to tissue specificity, which is the consequence of different metabolic and antioxidative activity. Inter-specific differences were also established. Higher concentrations of LP and GSH in liver of hake and in white muscle of sea bream were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake and sea bream was higher in comparison to muscle., Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) sa lokaliteta ispred luke Bar (Južni Jadran). Parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovani glutationa - GSH) su određivani u tkivima jetre i belog mišića oslića i arbuna. U vodi ispitivanog lokaliteta određivani su i fizičko-hemijski parametri (salinitet, koncentracija rastvorenog kiseonika i temperatura). Dobijeni rezultati su pokazali da je koncentracija LP veća u jetri oslića i arbuna u odnosu na belo mišićno tkivo. Međutim, zabeležena je znatno veća koncentracija GSH u belom mišiću i oslića i arbuna u odnosu na jetru. Ovakve promene parametara oksidacionog stresa ukazuju na tkivnu specifičnost, kao posledica različite metaboličke i antioksidacione aktivnosti. Ustanovljene su i interspecijske razlike, zabeležena je veća koncentracija LP i GSH u jetri oslića, kao i u belom mišiću arbuna, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića i arbuna je bio viši u odnosu na mišiće.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora, Lipid peroxidation and glutathione content in the liver and white muscle of hake (Merluccius merluccius L.) and sea bream (Pagellus erythrinus L.) from the Adriatic Sea",
number = "2",
volume = "42",
pages = "129-139",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_256"
}

Ognjanović, B. I., Filipović, J. Ž., Marković, S. D., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2006). Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(2), 129-139.
https://hdl.handle.net/21.15107/rcub_ibiss_256

Ognjanović BI, Filipović JŽ, Marković SD, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(2):129-139.
https://hdl.handle.net/21.15107/rcub_ibiss_256 .

Ognjanović, Branka I., Filipović, Jasmina Ž., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Koncentracije lipidnih peroksida i glutationa u jetri i belom mišiću oslića (Merluccius merluccius L.) i arbuna (Pagellus erythrinus L.) iz Jadranskog mora" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 2 (2006):129-139,
https://hdl.handle.net/21.15107/rcub_ibiss_256 .

TY  - JOUR
AU  - Ognjanović, Branka I.
AU  - Marković, Snežana D.
AU  - Pavlović, Slađan
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Ziemnicki, Kazimir
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/367
AB  - The effects of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and the possible protective effects of selenium (Se, 7 μg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against Cd toxicity.
AB  - U ovom radu ispitivan je efekat kadmijuma (Cd, 15 mg/kg/danu) na antioksidacioni zaštitni sistem i moguća zaštitna uloga selena (Se, 7 μg/kg/danu). Posle hroničnog tretmana Cd značajno se povećavaju aktivnosti bakar, cink superoksid dismutaze (CuZn SOD), katalaze (CAT) i glutation peroksidaze (GSH-Px) u crvenim krvnim ćelijama (RBC), kao i aktivnost glutation S-transferaze (GST) i koncentracije vitamina E (Vit E) u plazmi. Selen značajno povećava aktivnosti enzima GSH-Px i GST, kao i koncentracije vitamina C i E. Mehanizam kojim selen smanjuje toksičnost Cd kod pacova odnosi se na zaštitu antioksidacionog sistema u krvi, posebno formiranje ne-toksičnih kadmium-selenita. Akumulacija Cd u RBC takođe je značajno smanjena posle ko-tretmana selenom. Dobijeni rezultati pokazuju da Cd ispoljava toksične efekte na antioksidacioni zaštitni sistem u krvi pacova i da Se pokazuje zaštitni efekat protiv toksičnosti Cd.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom
T1  - Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium
IS  - 3
VL  - 42
SP  - 247
EP  - 256
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_367
ER  - 

@article{
author = "Ognjanović, Branka I. and Marković, Snežana D. and Pavlović, Slađan and Žikić, Radoslav V. and Štajn, Andraš Š. and Ziemnicki, Kazimir and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "The effects of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and the possible protective effects of selenium (Se, 7 μg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against Cd toxicity., U ovom radu ispitivan je efekat kadmijuma (Cd, 15 mg/kg/danu) na antioksidacioni zaštitni sistem i moguća zaštitna uloga selena (Se, 7 μg/kg/danu). Posle hroničnog tretmana Cd značajno se povećavaju aktivnosti bakar, cink superoksid dismutaze (CuZn SOD), katalaze (CAT) i glutation peroksidaze (GSH-Px) u crvenim krvnim ćelijama (RBC), kao i aktivnost glutation S-transferaze (GST) i koncentracije vitamina E (Vit E) u plazmi. Selen značajno povećava aktivnosti enzima GSH-Px i GST, kao i koncentracije vitamina C i E. Mehanizam kojim selen smanjuje toksičnost Cd kod pacova odnosi se na zaštitu antioksidacionog sistema u krvi, posebno formiranje ne-toksičnih kadmium-selenita. Akumulacija Cd u RBC takođe je značajno smanjena posle ko-tretmana selenom. Dobijeni rezultati pokazuju da Cd ispoljava toksične efekte na antioksidacioni zaštitni sistem u krvi pacova i da Se pokazuje zaštitni efekat protiv toksičnosti Cd.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom, Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium",
number = "3",
volume = "42",
pages = "247-256",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_367"
}

Ognjanović, B. I., Marković, S. D., Pavlović, S., Žikić, R. V., Štajn, A. Š., Ziemnicki, K., Petrović, V. M.,& Saičić, Z.. (2006). Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 247-256.
https://hdl.handle.net/21.15107/rcub_ibiss_367

Ognjanović BI, Marković SD, Pavlović S, Žikić RV, Štajn AŠ, Ziemnicki K, Petrović VM, Saičić Z. Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):247-256.
https://hdl.handle.net/21.15107/rcub_ibiss_367 .

Ognjanović, Branka I., Marković, Snežana D., Pavlović, Slađan, Žikić, Radoslav V., Štajn, Andraš Š., Ziemnicki, Kazimir, Petrović, Vojislav M., Saičić, Zorica, "Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):247-256,
https://hdl.handle.net/21.15107/rcub_ibiss_367 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Radojičić, Ratko M.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/278
AB  - The aim of our study was to investigate the copper and zinc containing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in red blood cells (RBCs), as well as phase II biotransformation enzyme glutathione-S-transferase (GST) activity in the plasma of male, two months old Wistar albino rats. The rats were divided into two experimental groups: control animals and animals treated with olive oil (100 μL of virgin olive oil, i.m., every fifth day during 30 days). The obtained results show that olive oil induced a significant decrease of CuZn SOD, CAT and GSH-Px activities in RBCs (p<0.05) and significant increase of GST activity in the plasma (p<0.05) in relation to the control animals. The results show that olive oil influences the activity of investigated enzymes in the blood of rats and in that way improves the overall antioxidative defense.
AB  - Cilj našeg rada bio je da se odrede aktivnosti bakar cink sadržavajuće superoksid-dismutaze (CuZn SOD), katalaze (CAT) i glutation-peroksidaze (GSH-Px) u eritrocitima, kao i enzima faze II biotransformacije glutation-S-transferaze (GST) u plazmi mužjaka dva meseca starih Wistar albino pacova tretiranih maslinovim uljem. Pacovi su podeljeni u dve grupe i to kontrolna i grupa tretirana maslinovim uljem (100 μL of maslinovog ulja, i.m., svaki peti dan tokom 30 dana). Rezultati pokazuju da maslinovo ulje izaziva značajno smanjenje aktivnosti CuZn SOD, CAT i GSH-Px (p<0.05) u eritrocitima, kao i povećanje aktivnosti GST u plazmi pacova (p<0.05) u odnosu na kontrolu. Dobijeni rezultati pokazuju da maslinovo ulje utiče na aktivnost ispitivanih enzima u smislu poboljšanja antioksidacione zaštite.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Aktivnost enzima zaštite od oksidacionih oštećenja u krvi pacova tretiranih maslinovim uljem
T1  - The activities of antioxidative defense enzymes in the blood of rats treated with olive oil
IS  - 3
VL  - 42
SP  - 177
EP  - 183
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_278
ER  - 

@article{
author = "Pavlović, Slađan and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Radojičić, Ratko M. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "The aim of our study was to investigate the copper and zinc containing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in red blood cells (RBCs), as well as phase II biotransformation enzyme glutathione-S-transferase (GST) activity in the plasma of male, two months old Wistar albino rats. The rats were divided into two experimental groups: control animals and animals treated with olive oil (100 μL of virgin olive oil, i.m., every fifth day during 30 days). The obtained results show that olive oil induced a significant decrease of CuZn SOD, CAT and GSH-Px activities in RBCs (p<0.05) and significant increase of GST activity in the plasma (p<0.05) in relation to the control animals. The results show that olive oil influences the activity of investigated enzymes in the blood of rats and in that way improves the overall antioxidative defense., Cilj našeg rada bio je da se odrede aktivnosti bakar cink sadržavajuće superoksid-dismutaze (CuZn SOD), katalaze (CAT) i glutation-peroksidaze (GSH-Px) u eritrocitima, kao i enzima faze II biotransformacije glutation-S-transferaze (GST) u plazmi mužjaka dva meseca starih Wistar albino pacova tretiranih maslinovim uljem. Pacovi su podeljeni u dve grupe i to kontrolna i grupa tretirana maslinovim uljem (100 μL of maslinovog ulja, i.m., svaki peti dan tokom 30 dana). Rezultati pokazuju da maslinovo ulje izaziva značajno smanjenje aktivnosti CuZn SOD, CAT i GSH-Px (p<0.05) u eritrocitima, kao i povećanje aktivnosti GST u plazmi pacova (p<0.05) u odnosu na kontrolu. Dobijeni rezultati pokazuju da maslinovo ulje utiče na aktivnost ispitivanih enzima u smislu poboljšanja antioksidacione zaštite.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Aktivnost enzima zaštite od oksidacionih oštećenja u krvi pacova tretiranih maslinovim uljem, The activities of antioxidative defense enzymes in the blood of rats treated with olive oil",
number = "3",
volume = "42",
pages = "177-183",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_278"
}

Pavlović, S., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Radojičić, R. M., Petrović, V. M.,& Saičić, Z.. (2006). Aktivnost enzima zaštite od oksidacionih oštećenja u krvi pacova tretiranih maslinovim uljem. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 177-183.
https://hdl.handle.net/21.15107/rcub_ibiss_278

Pavlović S, Ognjanović BI, Štajn AŠ, Žikić RV, Radojičić RM, Petrović VM, Saičić Z. Aktivnost enzima zaštite od oksidacionih oštećenja u krvi pacova tretiranih maslinovim uljem. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):177-183.
https://hdl.handle.net/21.15107/rcub_ibiss_278 .

Pavlović, Slađan, Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Radojičić, Ratko M., Petrović, Vojislav M., Saičić, Zorica, "Aktivnost enzima zaštite od oksidacionih oštećenja u krvi pacova tretiranih maslinovim uljem" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):177-183,
https://hdl.handle.net/21.15107/rcub_ibiss_278 .

TY  - JOUR
AU  - Filipović, Jasmina Ž.
AU  - Nikolić, Dubravka M.
AU  - Ognjanović, Branka I.
AU  - Marković, Snežana D.
AU  - Žikić, Radoslav V.
AU  - Štajn, Andraš Š.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/378
AB  - Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L) and red mullet (Mullus barbatus L) were collected from the locality in front of sea-port Bar (South Adriatic Sea) at the end of May 2005. Activity of the enzymes of the antioxidative system (superoxide dismutase - SOD and catalase - CAT) and parameters of oxidative stress (lipid peroxidation - LP and reduced glutathione - GSH content) were determined in the liver of hake and red mullet. Obtained results showed that the activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet.
AB  - Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L) i trlje (Mullus barbatus L) sa lokaliteta ispred luke Bar (Južni Jadran). Aktivnost enzima antioksidacionog sistema (superoksid dismutaze - SOD i katalaze - CAT) i parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovanog glutationa - GSH) su određivani u jetri oslića i trlje. Dobijeni rezultati su pokazali da su aktivnosti SOD i CAT značajno manje u jetri oslića nego kod trlje. Zabeležena je veća koncentracija LP i GSH u jetri oslića, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića je bio viši u odnosu na trlju.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora
T1  - Activity of the enzymes of the antioxidative system, glutathione and lipid peroxidation content in the liver of two fish species from the Adriatic sea
IS  - 3
VL  - 42
SP  - 257
EP  - 262
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_378
ER  - 

@article{
author = "Filipović, Jasmina Ž. and Nikolić, Dubravka M. and Ognjanović, Branka I. and Marković, Snežana D. and Žikić, Radoslav V. and Štajn, Andraš Š. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Fish are the most important organisms used in biomonitoring of aquatic ecosystems. Parameters of oxidative stress in fish tissues represent significant biomarkers in the assessment of the status of environment. Specimens of hake (Merluccius merluccius L) and red mullet (Mullus barbatus L) were collected from the locality in front of sea-port Bar (South Adriatic Sea) at the end of May 2005. Activity of the enzymes of the antioxidative system (superoxide dismutase - SOD and catalase - CAT) and parameters of oxidative stress (lipid peroxidation - LP and reduced glutathione - GSH content) were determined in the liver of hake and red mullet. Obtained results showed that the activities of SOD and CAT were significantly lower in the liver of hake than in red mullet. Higher concentrations of LP and GSH in liver of hake were recorded, due to the changes of physical-chemical parameters of environment. The intensity of oxidative stress in liver of hake was higher in comparison to red mullet., Ribe predstavljaju najznačajnije organizme koji se koriste u biomonitoringu vodenih ekosistema. Parametri oksidacionog stresa u tkivima riba predstavljaju značajne biomarkere u proceni stanja životne sredine. Krajem maja 2005. godine uzorkovane su jedinke oslića (Merluccius merluccius L) i trlje (Mullus barbatus L) sa lokaliteta ispred luke Bar (Južni Jadran). Aktivnost enzima antioksidacionog sistema (superoksid dismutaze - SOD i katalaze - CAT) i parametri oksidacionog stresa (koncentracija lipidnih peroksida - LP i redukovanog glutationa - GSH) su određivani u jetri oslića i trlje. Dobijeni rezultati su pokazali da su aktivnosti SOD i CAT značajno manje u jetri oslića nego kod trlje. Zabeležena je veća koncentracija LP i GSH u jetri oslića, kao posledica promena fizičko-hemijskih parametara sredine i prisustva polutanata. Intenzitet oksidacionog stresa u jetri oslića je bio viši u odnosu na trlju.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora, Activity of the enzymes of the antioxidative system, glutathione and lipid peroxidation content in the liver of two fish species from the Adriatic sea",
number = "3",
volume = "42",
pages = "257-262",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_378"
}

Filipović, J. Ž., Nikolić, D. M., Ognjanović, B. I., Marković, S. D., Žikić, R. V., Štajn, A. Š., Petrović, V. M.,& Saičić, Z.. (2006). Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 257-262.
https://hdl.handle.net/21.15107/rcub_ibiss_378

Filipović JŽ, Nikolić DM, Ognjanović BI, Marković SD, Žikić RV, Štajn AŠ, Petrović VM, Saičić Z. Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):257-262.
https://hdl.handle.net/21.15107/rcub_ibiss_378 .

Filipović, Jasmina Ž., Nikolić, Dubravka M., Ognjanović, Branka I., Marković, Snežana D., Žikić, Radoslav V., Štajn, Andraš Š., Petrović, Vojislav M., Saičić, Zorica, "Aktivnost enzima antioksidacione zaštite, koncentracija glutationa i lipidnih peroksida u jetri dve vrste riba iz Jadranskog mora" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):257-262,
https://hdl.handle.net/21.15107/rcub_ibiss_378 .

TY  - JOUR
AU  - Marković, Snežana D.
AU  - Dragićević-Đoković, Ljiljana M.
AU  - Đorđević, Nataša Z.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
AU  - Babić, Goran M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/222
AB  - Preeclampsia represents a pregnancy specific syndrome characterized by elevated arterial blood pressure and proteinuria. The aim of this study was to evaluate whole blood and erythrocytes energy status in healthy and preeclamptic women. Our study involved 18 healthy (control) and 19 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection and erythrocytes extraction, the next parameters were followed: concentrations of lactate and adenine nucleotides (ATP, ADP and AMP). Results showed increased concentrations of lactate and ATP in whole blood of preeclamptic, vs. control pregnant women. All parameters of energy status were also elevated in erythrocites of preeclamptic women (elevation of ADP level was significant). This study suggests that preeclamsia was followed by an elevation of all parameters of energy status in whole blood and in erythrocytes, as a result of increased rate of glycolysis. .
AB  - Preeklampsija predstavlja za trudnoću specifičan sindrom koji se karakteriše povišenim krvnim pritiskom i proteinurijom. Cilj istraživanja je određivanje energetskog statusa pune krvi i eritrocita zdravih i trudnica sa preeklampsijom. Ispitivanjem je bilo obuhvaćeno 18 zdravih i 19 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. Nakon uzimanja krvi i ekstrakcije eritrocita praćeni su sledeći parametri: koncentracije laktata i adenin nukleotida (ATP, ADP i AMP). Rezultati su pokazali povećanje koncentracija laktata i ATP u punoj krvi trudnica sa preeklampsijom u odnosu na kontrolne trudnice. U eritrocitima, svi parametri energetskog statusa su bili povećani u preeklampsiji (povećanje ADP nivoa je bilo značajno). Ova studija pokazuje da je preeklampsija praćena povećanjem svih parametara energetskog statusa u punoj krvi i eritrocitima, kao posledica stimulisanog intenziteta procesa glikolize. .
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Energetski status u krvi i eritrocitima trudnica sa preeklampsijom
T1  - Energy status of whole blood and erythrocytes in preeclampsia
IS  - 1
VL  - 42
SP  - 51
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_222
ER  - 

@article{
author = "Marković, Snežana D. and Dragićević-Đoković, Ljiljana M. and Đorđević, Nataša Z. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M. and Babić, Goran M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Preeclampsia represents a pregnancy specific syndrome characterized by elevated arterial blood pressure and proteinuria. The aim of this study was to evaluate whole blood and erythrocytes energy status in healthy and preeclamptic women. Our study involved 18 healthy (control) and 19 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection and erythrocytes extraction, the next parameters were followed: concentrations of lactate and adenine nucleotides (ATP, ADP and AMP). Results showed increased concentrations of lactate and ATP in whole blood of preeclamptic, vs. control pregnant women. All parameters of energy status were also elevated in erythrocites of preeclamptic women (elevation of ADP level was significant). This study suggests that preeclamsia was followed by an elevation of all parameters of energy status in whole blood and in erythrocytes, as a result of increased rate of glycolysis. ., Preeklampsija predstavlja za trudnoću specifičan sindrom koji se karakteriše povišenim krvnim pritiskom i proteinurijom. Cilj istraživanja je određivanje energetskog statusa pune krvi i eritrocita zdravih i trudnica sa preeklampsijom. Ispitivanjem je bilo obuhvaćeno 18 zdravih i 19 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. Nakon uzimanja krvi i ekstrakcije eritrocita praćeni su sledeći parametri: koncentracije laktata i adenin nukleotida (ATP, ADP i AMP). Rezultati su pokazali povećanje koncentracija laktata i ATP u punoj krvi trudnica sa preeklampsijom u odnosu na kontrolne trudnice. U eritrocitima, svi parametri energetskog statusa su bili povećani u preeklampsiji (povećanje ADP nivoa je bilo značajno). Ova studija pokazuje da je preeklampsija praćena povećanjem svih parametara energetskog statusa u punoj krvi i eritrocitima, kao posledica stimulisanog intenziteta procesa glikolize. .",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Energetski status u krvi i eritrocitima trudnica sa preeklampsijom, Energy status of whole blood and erythrocytes in preeclampsia",
number = "1",
volume = "42",
pages = "51-56",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_222"
}

Marković, S. D., Dragićević-Đoković, L. M., Đorđević, N. Z., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Petrović, V. M., Babić, G. M.,& Saičić, Z.. (2006). Energetski status u krvi i eritrocitima trudnica sa preeklampsijom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(1), 51-56.
https://hdl.handle.net/21.15107/rcub_ibiss_222

Marković SD, Dragićević-Đoković LM, Đorđević NZ, Ognjanović BI, Štajn AŠ, Žikić RV, Petrović VM, Babić GM, Saičić Z. Energetski status u krvi i eritrocitima trudnica sa preeklampsijom. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(1):51-56.
https://hdl.handle.net/21.15107/rcub_ibiss_222 .

Marković, Snežana D., Dragićević-Đoković, Ljiljana M., Đorđević, Nataša Z., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., Babić, Goran M., Saičić, Zorica, "Energetski status u krvi i eritrocitima trudnica sa preeklampsijom" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 1 (2006):51-56,
https://hdl.handle.net/21.15107/rcub_ibiss_222 .

TY  - JOUR
AU  - Đorđević, Nataša Z.
AU  - Babić, Goran M.
AU  - Marković, Snežana D.
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Petrović, Vojislav M.
AU  - Saičić, Zorica
PY  - 2006
PY  - 2006
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/345
AB  - Preeclampsia represents a pregnancy specific syndrome with high rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by elevated arterial blood pressure and proteinuria. Several recent studies have reported that there is a disbalance of oxidant/antioxidant system in women with preeclampsia, and this factor might contribute to the pathogenesis of the disease. Our study involved 22 healthy (control) and 20 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection, the next parameters were followed in erythrocytes: concentration of lipid peroxides (TBARS) non-enzymatic components (reduced glutathione - GSH, oxidized glutathione GSSG) and activities of enzymatic components of AOS (glutathione peroxidase GSH-Px, glutathione reductase - GR and glutathione-S-transferase - GST). Results of this study showed that concentration of TBARS and activity of GST were significantly higher, while activity of GR was significantly lower in erythrocytes of preeclamptic, vs. healthy women. Concentrations of GSH, GSSG and activity GSH-Px did not change significantly. Increased concentration of TBARS and activity of GST, as well as disorder in GSH and GSH-dependent enzymes status were indicators of oxidative stress in erythrocytes of preeclamptic women.
AB  - Preeklampsija je sindrom specifičan za trudnoću sa visokim stepenom morbiditeta i mortaliteta fetusa i majke. Klinički se manifestuje posle 20. nedelje gestacije. Kod majke sindrom se manifestuje povišenim krvnim pritiskom i proteinurijom. Brojne savremene studije pokazuju da je disbalans oksidacionog i antioksidacionog sistema značajan faktor u patogenezi preeklampsije. Istraživanjem je obuhvaćeno 22 zdrave i 20 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. U eritrocitima su praćeni sledeći parametri: koncentracija lipidnih peroksida (TBARS), neenzimskih komponenti (redukovani glutation - GSH, oksidovani glutation - GSSG) i aktivnost enzimskih komponenti AOS (glutation-peroksidaza, GSH-Px, glutation-reduktaza, GR i glutation-S-transferaza, GST). Rezultati ove studije pokazuju da je koncentracija TBARS i aktivnost GST značajno povećana, dok je aktivnost GR značajno smanjena u eritrocitima trudnica sa preeklampsijom u odnosu na zdrave trudnice. Koncentracije GSH i GSSG, kao i aktivnost GSH-Px nisu značajno promenjene. Povećanje koncentracije TBARS i aktivnosti GST, kao i poremećaj u GSH i GSH-zavisnom enzimskom statusu su indikatori oksidacionog stresa u eritrocitima trudnica sa preeklampsijom.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Antioksidacioni zaštitni sistem eritrocita u preeklampsiji
T1  - Antioxidative defense system of erythrocytes in preeclampsia
IS  - 3
VL  - 42
SP  - 227
EP  - 232
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_345
ER  - 

@article{
author = "Đorđević, Nataša Z. and Babić, Goran M. and Marković, Snežana D. and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Petrović, Vojislav M. and Saičić, Zorica",
year = "2006, 2006",
abstract = "Preeclampsia represents a pregnancy specific syndrome with high rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by elevated arterial blood pressure and proteinuria. Several recent studies have reported that there is a disbalance of oxidant/antioxidant system in women with preeclampsia, and this factor might contribute to the pathogenesis of the disease. Our study involved 22 healthy (control) and 20 preeclamptic women. Diagnosis of preeclampsia was done according to the recommendation of International Society for the Study of Hypertension in Pregnancy. After blood collection, the next parameters were followed in erythrocytes: concentration of lipid peroxides (TBARS) non-enzymatic components (reduced glutathione - GSH, oxidized glutathione GSSG) and activities of enzymatic components of AOS (glutathione peroxidase GSH-Px, glutathione reductase - GR and glutathione-S-transferase - GST). Results of this study showed that concentration of TBARS and activity of GST were significantly higher, while activity of GR was significantly lower in erythrocytes of preeclamptic, vs. healthy women. Concentrations of GSH, GSSG and activity GSH-Px did not change significantly. Increased concentration of TBARS and activity of GST, as well as disorder in GSH and GSH-dependent enzymes status were indicators of oxidative stress in erythrocytes of preeclamptic women., Preeklampsija je sindrom specifičan za trudnoću sa visokim stepenom morbiditeta i mortaliteta fetusa i majke. Klinički se manifestuje posle 20. nedelje gestacije. Kod majke sindrom se manifestuje povišenim krvnim pritiskom i proteinurijom. Brojne savremene studije pokazuju da je disbalans oksidacionog i antioksidacionog sistema značajan faktor u patogenezi preeklampsije. Istraživanjem je obuhvaćeno 22 zdrave i 20 trudnica sa preeklampsijom. Dijagnoza preeklampsije je postavljena prema preporukama International Society for the Study of Hypertension in Pregnancy. U eritrocitima su praćeni sledeći parametri: koncentracija lipidnih peroksida (TBARS), neenzimskih komponenti (redukovani glutation - GSH, oksidovani glutation - GSSG) i aktivnost enzimskih komponenti AOS (glutation-peroksidaza, GSH-Px, glutation-reduktaza, GR i glutation-S-transferaza, GST). Rezultati ove studije pokazuju da je koncentracija TBARS i aktivnost GST značajno povećana, dok je aktivnost GR značajno smanjena u eritrocitima trudnica sa preeklampsijom u odnosu na zdrave trudnice. Koncentracije GSH i GSSG, kao i aktivnost GSH-Px nisu značajno promenjene. Povećanje koncentracije TBARS i aktivnosti GST, kao i poremećaj u GSH i GSH-zavisnom enzimskom statusu su indikatori oksidacionog stresa u eritrocitima trudnica sa preeklampsijom.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Antioksidacioni zaštitni sistem eritrocita u preeklampsiji, Antioxidative defense system of erythrocytes in preeclampsia",
number = "3",
volume = "42",
pages = "227-232",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_345"
}

Đorđević, N. Z., Babić, G. M., Marković, S. D., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Petrović, V. M.,& Saičić, Z.. (2006). Antioksidacioni zaštitni sistem eritrocita u preeklampsiji. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 227-232.
https://hdl.handle.net/21.15107/rcub_ibiss_345

Đorđević NZ, Babić GM, Marković SD, Ognjanović BI, Štajn AŠ, Žikić RV, Petrović VM, Saičić Z. Antioksidacioni zaštitni sistem eritrocita u preeklampsiji. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):227-232.
https://hdl.handle.net/21.15107/rcub_ibiss_345 .

Đorđević, Nataša Z., Babić, Goran M., Marković, Snežana D., Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Petrović, Vojislav M., Saičić, Zorica, "Antioksidacioni zaštitni sistem eritrocita u preeklampsiji" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):227-232,
https://hdl.handle.net/21.15107/rcub_ibiss_345 .

TY  - JOUR
AU  - Pavlović, Slađan
AU  - Ognjanović, Branka I.
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Radojičić, Ratko M.
AU  - Spasić, Mihajlo
AU  - Saičić, Zorica
PY  - 2005
PY  - 2005
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/39
AB  - The effect of cadmium (Cd), coenzyme Q10 (CoQ10) and Cd+CoQ10 on the activities of superoxide dismutases (total SOD), manganese containing superoxide dismutase (Mn SOD) and copper-zinc containing superoxide dismutase (Cu,Zn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-Stransferase (GST), glutathione reductase (GR) and concentrations of ascorbic acid (AsA) and vitamin E (Vit E) in the heart of male Wistar albino rats were studied in comparison to the controls and cadmium treated animals. Cd induces a significant increase of total SOD, Cu, Zn SOD and GSH-Px activities, as well as AsA and Vit E concentrations, but leads to a significant decrease of CAT and GR activities. CoQ10 induces a significant increase of total SOD, Mn SOD, Cu, Zn SOD and GSH-Px activities, as well as AsA and Vit E concentrations. In the same group of animals the activities of CAT, GST and GR were significantly decreased. By concomitant treatment of rats with Cd+CoQ10 the activities of total SOD, Mn SOD and GSH-Px, as well as concentrations of AsA and Vit E were markedly increased. In the same group of animals the activities of Cu, Zn SOD, CAT and GR were significantly decreased. In respect to the Cd treated rats in Cd+CoQ10 partially are reversed changes (Cu,Zn SOD) of antioxidant defense system in the heart.
AB  - Ispitivan je uticaj kadmijuma (Cd), koenzima Q10 (CoQ10) i Cd+ CoQ10 na aktivnost ukupne superoksid dismutaze (Uk SOD), mangan sadržavajuće superoksid dismutaze (Mn SOD), bakar cink sadržavajuće superoksid dismutaze (Cu,Zn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px), glutation-Stransferaze (GST) i glutation reduktaze (GR), kao i na koncentracije askorbinske kiseline (AsA) i vitamina E (Vit E) u srcu mužjaka Wistar albino pacova u poređenju sa kontrolnom grupom i grupom tretiranom sa kadmijumom. Cd u srcu indukuje značajno povećanje aktivnosti Uk SOD, Cu,Zn SOD i GSH-Px, kao i koncentracija AsA Vit E uz značajno smanjenje aktivnosti CAT i GR. CoQ10 izaziva značajno povećanje aktivnosti Uk SOD, Mn SOD, Cu,Zn SOD i GSH-Px, kao i koncentracija AsA i Vit E. U istoj grupi životinja aktivnosti CAT, GST i GR su značajno smanjene. Istovremeni tretman sa Cd+CoQ10 dovodi do značajnog povećanja aktivnosti Uk SOD, Mn SOD i GSH-Px, kao i koncentracija AsA i Vit E. U istoj grupi životinja aktivnosti Cu,Zn SOD, CAT i GR su značajno smanjene. U poređenju sa pacovima tretiranim sa kadmijumom kod Cd+CoQ10 grupe dobijen je delimični zaštitni efekat (Cu,Zn SOD) na antioksidacioni zaštitni sistem u srcu pacova.
T2  - Jugoslovenska medicinska biohemija
T1  - Moguća zaštitna uloga koenzima Q10 na sistem zaštite od oksidacionih oštećenja u srcu pacova tretiranih kadmijumom
T1  - A possible protective role of coenzyme Q10 on antioxidant defense system in the heart of rats treated with cadmium
IS  - 2
VL  - 24
DO  - 10.2298/JMH0502121P
SP  - 121
EP  - 127
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_39
ER  - 

@article{
author = "Pavlović, Slađan and Ognjanović, Branka I. and Štajn, Andraš Š. and Žikić, Radoslav V. and Radojičić, Ratko M. and Spasić, Mihajlo and Saičić, Zorica",
year = "2005, 2005",
abstract = "The effect of cadmium (Cd), coenzyme Q10 (CoQ10) and Cd+CoQ10 on the activities of superoxide dismutases (total SOD), manganese containing superoxide dismutase (Mn SOD) and copper-zinc containing superoxide dismutase (Cu,Zn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-Stransferase (GST), glutathione reductase (GR) and concentrations of ascorbic acid (AsA) and vitamin E (Vit E) in the heart of male Wistar albino rats were studied in comparison to the controls and cadmium treated animals. Cd induces a significant increase of total SOD, Cu, Zn SOD and GSH-Px activities, as well as AsA and Vit E concentrations, but leads to a significant decrease of CAT and GR activities. CoQ10 induces a significant increase of total SOD, Mn SOD, Cu, Zn SOD and GSH-Px activities, as well as AsA and Vit E concentrations. In the same group of animals the activities of CAT, GST and GR were significantly decreased. By concomitant treatment of rats with Cd+CoQ10 the activities of total SOD, Mn SOD and GSH-Px, as well as concentrations of AsA and Vit E were markedly increased. In the same group of animals the activities of Cu, Zn SOD, CAT and GR were significantly decreased. In respect to the Cd treated rats in Cd+CoQ10 partially are reversed changes (Cu,Zn SOD) of antioxidant defense system in the heart., Ispitivan je uticaj kadmijuma (Cd), koenzima Q10 (CoQ10) i Cd+ CoQ10 na aktivnost ukupne superoksid dismutaze (Uk SOD), mangan sadržavajuće superoksid dismutaze (Mn SOD), bakar cink sadržavajuće superoksid dismutaze (Cu,Zn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px), glutation-Stransferaze (GST) i glutation reduktaze (GR), kao i na koncentracije askorbinske kiseline (AsA) i vitamina E (Vit E) u srcu mužjaka Wistar albino pacova u poređenju sa kontrolnom grupom i grupom tretiranom sa kadmijumom. Cd u srcu indukuje značajno povećanje aktivnosti Uk SOD, Cu,Zn SOD i GSH-Px, kao i koncentracija AsA Vit E uz značajno smanjenje aktivnosti CAT i GR. CoQ10 izaziva značajno povećanje aktivnosti Uk SOD, Mn SOD, Cu,Zn SOD i GSH-Px, kao i koncentracija AsA i Vit E. U istoj grupi životinja aktivnosti CAT, GST i GR su značajno smanjene. Istovremeni tretman sa Cd+CoQ10 dovodi do značajnog povećanja aktivnosti Uk SOD, Mn SOD i GSH-Px, kao i koncentracija AsA i Vit E. U istoj grupi životinja aktivnosti Cu,Zn SOD, CAT i GR su značajno smanjene. U poređenju sa pacovima tretiranim sa kadmijumom kod Cd+CoQ10 grupe dobijen je delimični zaštitni efekat (Cu,Zn SOD) na antioksidacioni zaštitni sistem u srcu pacova.",
journal = "Jugoslovenska medicinska biohemija",
title = "Moguća zaštitna uloga koenzima Q10 na sistem zaštite od oksidacionih oštećenja u srcu pacova tretiranih kadmijumom, A possible protective role of coenzyme Q10 on antioxidant defense system in the heart of rats treated with cadmium",
number = "2",
volume = "24",
doi = "10.2298/JMH0502121P",
pages = "121-127",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_39"
}

Pavlović, S., Ognjanović, B. I., Štajn, A. Š., Žikić, R. V., Radojičić, R. M., Spasić, M.,& Saičić, Z.. (2005). Moguća zaštitna uloga koenzima Q10 na sistem zaštite od oksidacionih oštećenja u srcu pacova tretiranih kadmijumom. in Jugoslovenska medicinska biohemija, 24(2), 121-127.
https://doi.org/10.2298/JMH0502121P
https://hdl.handle.net/21.15107/rcub_ibiss_39

Pavlović S, Ognjanović BI, Štajn AŠ, Žikić RV, Radojičić RM, Spasić M, Saičić Z. Moguća zaštitna uloga koenzima Q10 na sistem zaštite od oksidacionih oštećenja u srcu pacova tretiranih kadmijumom. in Jugoslovenska medicinska biohemija. 2005;24(2):121-127.
doi:10.2298/JMH0502121P
https://hdl.handle.net/21.15107/rcub_ibiss_39 .

Pavlović, Slađan, Ognjanović, Branka I., Štajn, Andraš Š., Žikić, Radoslav V., Radojičić, Ratko M., Spasić, Mihajlo, Saičić, Zorica, "Moguća zaštitna uloga koenzima Q10 na sistem zaštite od oksidacionih oštećenja u srcu pacova tretiranih kadmijumom" in Jugoslovenska medicinska biohemija, 24, no. 2 (2005):121-127,
https://doi.org/10.2298/JMH0502121P .,
https://hdl.handle.net/21.15107/rcub_ibiss_39 .

TY  - CONF
AU  - Borković-Mitić, Slavica
AU  - Milošević, Slaviša
AU  - Radovanović, Tijana
AU  - Pavlović, Slađan
AU  - Štajn, Andraš Š.
AU  - Žikić, Radoslav V.
AU  - Maksimović-Kosanović, Katica
AU  - Saičić, Zorica
PY  - 2005
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5951
AB  - In our experiment we studied the antioxidant enzyme activities (superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase-GSH-Px, glutathione reductase-GR, and glutathione-S-transferase-GST} in hepatopancreas, gills and abdominal muscle of spinycheek crayfish (Orconectes limosus) from the Serbian part of Danube River. The speciments were collected with deep nets and tissue samples were prepared for analisys by standard methods. All enzyme activities were  measured spectrophotometrically and expressed as specific (U/mg proteins) and total (U/g net mass). The results show strong tissue specifity of investigated enzymes. Specific and total SOD activity in hepatopancreas was lower than in gills  and muscle. At the same time, total SOD activity in gills was significantly lower in respect to muscle. The specific and total activity of CAT was significantly higher in hepatopancreas than in gills and muscle, as well as in gills in respect to the muscle. Same trend was obtained for specific and total activity of GSH-Px. In gills of spinycheek crayfish·, specific activity of GR was significantly higher than in hepatopancreas and muscle, as well as in gills in respect to the muscle. Total GR activity was also significantly higher in gills comparing to hepatopancreas and muscle. The specific and total activity of GST was significantly increased in hepatopancreas than in gills and muscle. At the same time, the activity of GST was higher in gills than in muscle. The obtained results show a strong tissue specifity of antioxidant defense enzymes in investigated tissues of spinycheek crayfish which is accompanied with its different metabolic activity.
PB  - Društvo fiziologa Republike Srbije
PB  - Belgrade: Serbian Physiology Society
C3  - Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
T1  - Activities of antioxidant defense enzyme in some tissues of spinycheek crayfish (Orconectes limosus Rafinesque) from Serbian part of Danube river
SP  - 219
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5951
ER  - 

@conference{
author = "Borković-Mitić, Slavica and Milošević, Slaviša and Radovanović, Tijana and Pavlović, Slađan and Štajn, Andraš Š. and Žikić, Radoslav V. and Maksimović-Kosanović, Katica and Saičić, Zorica",
year = "2005",
abstract = "In our experiment we studied the antioxidant enzyme activities (superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase-GSH-Px, glutathione reductase-GR, and glutathione-S-transferase-GST} in hepatopancreas, gills and abdominal muscle of spinycheek crayfish (Orconectes limosus) from the Serbian part of Danube River. The speciments were collected with deep nets and tissue samples were prepared for analisys by standard methods. All enzyme activities were  measured spectrophotometrically and expressed as specific (U/mg proteins) and total (U/g net mass). The results show strong tissue specifity of investigated enzymes. Specific and total SOD activity in hepatopancreas was lower than in gills  and muscle. At the same time, total SOD activity in gills was significantly lower in respect to muscle. The specific and total activity of CAT was significantly higher in hepatopancreas than in gills and muscle, as well as in gills in respect to the muscle. Same trend was obtained for specific and total activity of GSH-Px. In gills of spinycheek crayfish·, specific activity of GR was significantly higher than in hepatopancreas and muscle, as well as in gills in respect to the muscle. Total GR activity was also significantly higher in gills comparing to hepatopancreas and muscle. The specific and total activity of GST was significantly increased in hepatopancreas than in gills and muscle. At the same time, the activity of GST was higher in gills than in muscle. The obtained results show a strong tissue specifity of antioxidant defense enzymes in investigated tissues of spinycheek crayfish which is accompanied with its different metabolic activity.",
publisher = "Društvo fiziologa Republike Srbije, Belgrade: Serbian Physiology Society",
journal = "Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia",
title = "Activities of antioxidant defense enzyme in some tissues of spinycheek crayfish (Orconectes limosus Rafinesque) from Serbian part of Danube river",
pages = "219",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5951"
}

Borković-Mitić, S., Milošević, S., Radovanović, T., Pavlović, S., Štajn, A. Š., Žikić, R. V., Maksimović-Kosanović, K.,& Saičić, Z.. (2005). Activities of antioxidant defense enzyme in some tissues of spinycheek crayfish (Orconectes limosus Rafinesque) from Serbian part of Danube river. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia
Društvo fiziologa Republike Srbije., 219.
https://hdl.handle.net/21.15107/rcub_ibiss_5951

Borković-Mitić S, Milošević S, Radovanović T, Pavlović S, Štajn AŠ, Žikić RV, Maksimović-Kosanović K, Saičić Z. Activities of antioxidant defense enzyme in some tissues of spinycheek crayfish (Orconectes limosus Rafinesque) from Serbian part of Danube river. in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia. 2005;:219.
https://hdl.handle.net/21.15107/rcub_ibiss_5951 .

Borković-Mitić, Slavica, Milošević, Slaviša, Radovanović, Tijana, Pavlović, Slađan, Štajn, Andraš Š., Žikić, Radoslav V., Maksimović-Kosanović, Katica, Saičić, Zorica, "Activities of antioxidant defense enzyme in some tissues of spinycheek crayfish (Orconectes limosus Rafinesque) from Serbian part of Danube river" in Abstract Book: The first congress of physiological sciences of Serbia and Montenegro with international participation: Molecular, Cellular and Integrative Basis of Health, Disease and Therapy; 2005 Nov 9-12; Belgrade, Serbia (2005):219,
https://hdl.handle.net/21.15107/rcub_ibiss_5951 .