@conference{
author = "Ćirić, Ana and Džamić, Ana and Žarković, Lazar and Nikolić, Biljana and Kostić, Marina and Adakalić, Mirjana and Lazović, Biljana and Perović, Tatjana",
year = "2021",
abstract = "Jujube (Zizifus jujuba Mill., Rhamnaceae) is a warm climate plant. The fruit has high energy and nutritional
value, contains a lot of sugar, dietary fiber, vitamin C, minerals, phenolic compounds. Therefore, this plant
is a valuable source of phytochemicals, bioactives, vitamins etc. which makes it to be effective in curing or
prevention from various diseases. The present work investigate quantification of total phenols and
flavonoids, antioxidant and antimicrobial potential of different extracts Z. jujuba, originating from different
localities of Montenegro (Podgorica, Ulcinj, and Bar). Four different dry extracts were extracted from dried
fruits, by ultrasound assisted extraction using various solvents (methanol, water, dichloromethane and n butanol). Quantification of total phenols and flavonoids was done by spectrophotometric methods. The
results showed that these extracts are rich in phenolic compounds, but do not contain a high percentage of
flavonoids. The antioxidant activity of the extracts was performed by DPPH and ABTS method. The best
antioxidant potential in the DPPH test was shown for n-butanol extracts, while in the ABTS test methanol,
dichloromethane and aqueous extracts were shown to be significantly better antioxidants. The antimicrobial
effect of Z. jujuba extracts was tested on seven bacterial species, belonging to human infectious agents and
food contaminants and four clinical isolates of dermatomycetes, by microdilution method. Based on the
results, all extracts possessed antibacterial/antifungal activity against tested bacteria and fungi. The extracts
showed very high antimicrobial potential, with the aqueous extract being slightly weaker compared to the
other three ones. In addition to small differences in the effect of the extracts, resistant Escherichia coli (R)
proved to be the most resistant bacteria, with MIC of 0.19 mg/mL and a MBC of 0.38 mg/mL. Tested
extracts possessed similar activates against dermatomycetes, but n-butanol extracts had the best potential
(MIC and MFC values was in the ranges of 0.045-0.38 and 0.09-0.75 mg/mL, respectively). Also, there is
no difference in antifungal potential according to the origin of the extracts. The extracts from all three
localities show approximately the same antifungal effect. Microsporum canis proved to be the most sensitive
fungus, whose growth was inhibited at very low concentrations (MIC 0.09-0.19 mg/mL and MFC 0.19-0.38
mg/mL).
The obtained results show that fruit of Z. jujuba and its extracts represent a potential source of new
compounds with antioxidant and antimicrobial activity. It is an appropriate candidate for treatment of
microbial infections and for therapeutic application.",
publisher = "Bragança, Portugal: Instituto Politécnico de Bragança (IPB)",
journal = "1st Natural products application: Health, Cosmetic and Food: book of abstracts",
title = "In vitro assay of bioactive potential of Ziziphus jujuba Mill. extracts",
pages = "102",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_4375"
}
