TY  - JOUR
AU  - Stojković, Dejan
AU  - Ivanov, Marija
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Van Griensven, L.
AU  - Ferreira, I.C.F.R.
AU  - Soković, Marina
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0254629917314205?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3245
AB  - As a continuation of our search for biologically active mushroom species the present study investigates in vitro antidiabetic properties of six edible and medicinal mushroom species: Agaricus blazei Murrill, Coprinus comatus (O.F. Müll.) Pers., Cordyceps militaris (L.) Fr., Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. & M.A. Curtis. In vitro assays on α-amylase and α-glucosidase enzymes inhibition were performed with methanolic extracts of the selected mushrooms. Furthermore, we calculated the necessary daily intake of mushroom extracts and dry mushroom powders based on the equivalent doses of therapeutic drug acarbose given to diabetic patients per day. Our comparative study on enzymes inhibition showed that the most promising potential is ascribed to Inonotus obliquus extract, while no inhibition of α-amylase was recorded with Morchella conica and Cordyceps militaris methanolic extract at the tested concentration. This comparative study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase and α-glucosidase with methanolic extracts; which makes the investigated species more promising for the diabetes type-2 treatment by an additional and different mechanism of action.
T2  - South African Journal of Botany
T1  - An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes
VL  - 120
DO  - 10.1016/J.SAJB.2018.01.007
SP  - 100
EP  - 103
ER  - 

@article{
author = "Stojković, Dejan and Ivanov, Marija and Ćirić, Ana and Glamočlija, Jasmina and Van Griensven, L. and Ferreira, I.C.F.R. and Soković, Marina",
year = "2019",
abstract = "As a continuation of our search for biologically active mushroom species the present study investigates in vitro antidiabetic properties of six edible and medicinal mushroom species: Agaricus blazei Murrill, Coprinus comatus (O.F. Müll.) Pers., Cordyceps militaris (L.) Fr., Inonotus obliquus (Ach. ex Pers.) Pilát, Morchella conica Pers. and Phellinus linteus Berk. & M.A. Curtis. In vitro assays on α-amylase and α-glucosidase enzymes inhibition were performed with methanolic extracts of the selected mushrooms. Furthermore, we calculated the necessary daily intake of mushroom extracts and dry mushroom powders based on the equivalent doses of therapeutic drug acarbose given to diabetic patients per day. Our comparative study on enzymes inhibition showed that the most promising potential is ascribed to Inonotus obliquus extract, while no inhibition of α-amylase was recorded with Morchella conica and Cordyceps militaris methanolic extract at the tested concentration. This comparative study is the first highlighting in vitro antidiabetic potential by inhibition of α-amylase and α-glucosidase with methanolic extracts; which makes the investigated species more promising for the diabetes type-2 treatment by an additional and different mechanism of action.",
journal = "South African Journal of Botany",
title = "An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes",
volume = "120",
doi = "10.1016/J.SAJB.2018.01.007",
pages = "100-103"
}

Stojković, D., Ivanov, M., Ćirić, A., Glamočlija, J., Van Griensven, L., Ferreira, I.C.F.R.,& Soković, M.. (2019). An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes. in South African Journal of Botany, 120, 100-103.
https://doi.org/10.1016/J.SAJB.2018.01.007

Stojković D, Ivanov M, Ćirić A, Glamočlija J, Van Griensven L, Ferreira I, Soković M. An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes. in South African Journal of Botany. 2019;120:100-103.
doi:10.1016/J.SAJB.2018.01.007 .

Stojković, Dejan, Ivanov, Marija, Ćirić, Ana, Glamočlija, Jasmina, Van Griensven, L., Ferreira, I.C.F.R., Soković, Marina, "An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes" in South African Journal of Botany, 120 (2019):100-103,
https://doi.org/10.1016/J.SAJB.2018.01.007 . .