TY  - JOUR
AU  - Gozzi, Marta
AU  - Schwarze, Benedikt
AU  - Sárosi, Menyhárt-Botond
AU  - Lönnecke, Peter
AU  - Drača, Dijana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Hey-Hawkins, Evamarie
PY  - 2017
UR  - http://xlink.rsc.org/?DOI=C7DT02027A
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2858
AB  - Three [(η6-arene)RuC2B9H11] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-C6H4 (4)) were synthesised according to modified literature procedures and fully characterised. 2-4 were found to be moderately active against two types of tumour cell lines (HCT116 and MCF7), with IC50 values in the low micromolar range. However, viability of normal, healthy cells (MRC-5 cell line, MLEC and mouse macrophages) was not affected by treatment with 2-4, indicating high selectivity of the metallacarborane complexes towards tumour cell lines, compared to the unselective antitumour agent cisplatin and other potential RuII drugs. Moreover, flow cytometric analysis suggested that 4 induces cell death via a caspase-dependent apoptotic mechanism. DFT calculations of the frontier molecular orbitals showed that the HOMO-LUMO gap in 2-4 is smaller than in the corresponding cyclopentadienyl complexes 2-Cp-4-Cp (e.g. 5.47 (2) vs. 6.31 eV (2-Cp)). In order to assess the stability of 2-4, particularly the ruthenium-dicarbollide bond, energy decomposition analysis (EDA) of 2-4, together with the respective cyclopentadienyl analogues 2-Cp-4-Cp, was performed. EDA suggests that the ruthenium(ii)-dicarbollide bond in the three complexes is mostly ionic and far stronger than the ruthenium(ii)-arene bond.
T2  - Dalton Transactions
T1  - Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines
IS  - 36
VL  - 46
DO  - 10.1039/C7DT02027A
SP  - 12067
EP  - 12080
ER  - 

@article{
author = "Gozzi, Marta and Schwarze, Benedikt and Sárosi, Menyhárt-Botond and Lönnecke, Peter and Drača, Dijana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Hey-Hawkins, Evamarie",
year = "2017",
abstract = "Three [(η6-arene)RuC2B9H11] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-C6H4 (4)) were synthesised according to modified literature procedures and fully characterised. 2-4 were found to be moderately active against two types of tumour cell lines (HCT116 and MCF7), with IC50 values in the low micromolar range. However, viability of normal, healthy cells (MRC-5 cell line, MLEC and mouse macrophages) was not affected by treatment with 2-4, indicating high selectivity of the metallacarborane complexes towards tumour cell lines, compared to the unselective antitumour agent cisplatin and other potential RuII drugs. Moreover, flow cytometric analysis suggested that 4 induces cell death via a caspase-dependent apoptotic mechanism. DFT calculations of the frontier molecular orbitals showed that the HOMO-LUMO gap in 2-4 is smaller than in the corresponding cyclopentadienyl complexes 2-Cp-4-Cp (e.g. 5.47 (2) vs. 6.31 eV (2-Cp)). In order to assess the stability of 2-4, particularly the ruthenium-dicarbollide bond, energy decomposition analysis (EDA) of 2-4, together with the respective cyclopentadienyl analogues 2-Cp-4-Cp, was performed. EDA suggests that the ruthenium(ii)-dicarbollide bond in the three complexes is mostly ionic and far stronger than the ruthenium(ii)-arene bond.",
journal = "Dalton Transactions",
title = "Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines",
number = "36",
volume = "46",
doi = "10.1039/C7DT02027A",
pages = "12067-12080"
}

Gozzi, M., Schwarze, B., Sárosi, M., Lönnecke, P., Drača, D., Maksimović-Ivanić, D., Mijatović, S.,& Hey-Hawkins, E.. (2017). Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines. in Dalton Transactions, 46(36), 12067-12080.
https://doi.org/10.1039/C7DT02027A

Gozzi M, Schwarze B, Sárosi M, Lönnecke P, Drača D, Maksimović-Ivanić D, Mijatović S, Hey-Hawkins E. Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines. in Dalton Transactions. 2017;46(36):12067-12080.
doi:10.1039/C7DT02027A .

Gozzi, Marta, Schwarze, Benedikt, Sárosi, Menyhárt-Botond, Lönnecke, Peter, Drača, Dijana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Hey-Hawkins, Evamarie, "Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines" in Dalton Transactions, 46, no. 36 (2017):12067-12080,
https://doi.org/10.1039/C7DT02027A . .

TY  - GEN
AU  - Gozzi, Marta
AU  - Schwarze, Benedikt
AU  - Sárosi, Menyhárt-Botond
AU  - Lönnecke, Peter
AU  - Drača, Dijana
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Hey-Hawkins, Evamarie
PY  - 2017
UR  - http://xlink.rsc.org/?DOI=C7DT02027A
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2848
AB  - Three [(η6-arene)RuC2B9H11] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-C6H4 (4)) were synthesised according to modified literature procedures and fully characterised. 2–4 were found to be moderately active against two types of tumour cell lines (HCT116 and MCF7), with IC50 values in the low micromolar range. However, viability of normal, healthy cells (MRC-5 cell line, MLEC and mouse macrophages) was not affected by treatment with 2–4, indicating high selectivity of the metallacarborane complexes towards tumour cell lines, compared to the unselective antitumour agent cisplatin and other potential RuII drugs. Moreover, flow cytometric analysis suggested that 4 induces cell death via a caspase-dependent apoptotic mechanism. DFT calculations of the frontier molecular orbitals showed that the HOMO–LUMO gap in 2–4 is smaller than in the corresponding cyclopentadienyl complexes 2-Cp–4-Cp (e.g. 5.47 (2) vs. 6.31 eV (2-Cp)). In order to assess the stability of 2–4, particularly the ruthenium–dicarbollide bond, energy decomposition analysis (EDA) of 2–4, together with the respective cyclopentadienyl analogues 2-Cp–4-Cp, was performed. EDA suggests that the ruthenium(II)–dicarbollide bond in the three complexes is mostly ionic and far stronger than the ruthenium(II)–arene bond.
PB  - The Royal Society of Chemistry
T2  - Dalton Transactions
T1  - Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines
DO  - 10.1039/C7DT02027A
ER  - 

@misc{
author = "Gozzi, Marta and Schwarze, Benedikt and Sárosi, Menyhárt-Botond and Lönnecke, Peter and Drača, Dijana and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Hey-Hawkins, Evamarie",
year = "2017",
abstract = "Three [(η6-arene)RuC2B9H11] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-C6H4 (4)) were synthesised according to modified literature procedures and fully characterised. 2–4 were found to be moderately active against two types of tumour cell lines (HCT116 and MCF7), with IC50 values in the low micromolar range. However, viability of normal, healthy cells (MRC-5 cell line, MLEC and mouse macrophages) was not affected by treatment with 2–4, indicating high selectivity of the metallacarborane complexes towards tumour cell lines, compared to the unselective antitumour agent cisplatin and other potential RuII drugs. Moreover, flow cytometric analysis suggested that 4 induces cell death via a caspase-dependent apoptotic mechanism. DFT calculations of the frontier molecular orbitals showed that the HOMO–LUMO gap in 2–4 is smaller than in the corresponding cyclopentadienyl complexes 2-Cp–4-Cp (e.g. 5.47 (2) vs. 6.31 eV (2-Cp)). In order to assess the stability of 2–4, particularly the ruthenium–dicarbollide bond, energy decomposition analysis (EDA) of 2–4, together with the respective cyclopentadienyl analogues 2-Cp–4-Cp, was performed. EDA suggests that the ruthenium(II)–dicarbollide bond in the three complexes is mostly ionic and far stronger than the ruthenium(II)–arene bond.",
publisher = "The Royal Society of Chemistry",
journal = "Dalton Transactions",
title = "Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines",
doi = "10.1039/C7DT02027A"
}

Gozzi, M., Schwarze, B., Sárosi, M., Lönnecke, P., Drača, D., Maksimović-Ivanić, D., Mijatović, S.,& Hey-Hawkins, E.. (2017). Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines. in Dalton Transactions
The Royal Society of Chemistry..
https://doi.org/10.1039/C7DT02027A

Gozzi M, Schwarze B, Sárosi M, Lönnecke P, Drača D, Maksimović-Ivanić D, Mijatović S, Hey-Hawkins E. Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines. in Dalton Transactions. 2017;.
doi:10.1039/C7DT02027A .

Gozzi, Marta, Schwarze, Benedikt, Sárosi, Menyhárt-Botond, Lönnecke, Peter, Drača, Dijana, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Hey-Hawkins, Evamarie, "Antiproliferative activity of (η 6 -arene)ruthenacarborane sandwich complexes against HCT116 and MCF7 cell lines" in Dalton Transactions (2017),
https://doi.org/10.1039/C7DT02027A . .