TY  - JOUR
AU  - Kaluđerović, Goran
AU  - Miljković, Đorđe
AU  - Momčilović, Miljana
AU  - Đinović, Vesna
AU  - Mostarica Stojković, Marija
AU  - Sabo, Tibor
AU  - Trajković, Vladimir
PY  - 2005
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6014
AB  - The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy.
PB  - John Wiley and Sons
T2  - International Journal of Cancer
T1  - Novel platinum(IV) complexes induce rapid tumor cell death in vitro
IS  - 3
VL  - 116
DO  - 10.1002/ijc.21080
SP  - 479
EP  - 486
ER  - 

@article{
author = "Kaluđerović, Goran and Miljković, Đorđe and Momčilović, Miljana and Đinović, Vesna and Mostarica Stojković, Marija and Sabo, Tibor and Trajković, Vladimir",
year = "2005",
abstract = "The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)-based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum-based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)-based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine-N,N'-di-3-propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress-independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical-mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy.",
publisher = "John Wiley and Sons",
journal = "International Journal of Cancer",
title = "Novel platinum(IV) complexes induce rapid tumor cell death in vitro",
number = "3",
volume = "116",
doi = "10.1002/ijc.21080",
pages = "479-486"
}

Kaluđerović, G., Miljković, Đ., Momčilović, M., Đinović, V., Mostarica Stojković, M., Sabo, T.,& Trajković, V.. (2005). Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer
John Wiley and Sons., 116(3), 479-486.
https://doi.org/10.1002/ijc.21080

Kaluđerović G, Miljković Đ, Momčilović M, Đinović V, Mostarica Stojković M, Sabo T, Trajković V. Novel platinum(IV) complexes induce rapid tumor cell death in vitro. in International Journal of Cancer. 2005;116(3):479-486.
doi:10.1002/ijc.21080 .

Kaluđerović, Goran, Miljković, Đorđe, Momčilović, Miljana, Đinović, Vesna, Mostarica Stojković, Marija, Sabo, Tibor, Trajković, Vladimir, "Novel platinum(IV) complexes induce rapid tumor cell death in vitro" in International Journal of Cancer, 116, no. 3 (2005):479-486,
https://doi.org/10.1002/ijc.21080 . .