TY  - JOUR
AU  - Xie, Kan
AU  - Kapetanou, Marianna
AU  - Sidiropoulou, Kyriaki
AU  - Bano, Daniele
AU  - Gonos, Efstathios S.
AU  - Mladenović, Aleksandra
AU  - Ehninger, Dan
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/123456789/3912
AB  - Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.
PB  - Elsevier B.V.
T2  - Mechanisms of Ageing and Development
T1  - Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases
VL  - 192
DO  - 10.1016/j.mad.2020.111364
SP  - 111364
ER  - 

@article{
author = "Xie, Kan and Kapetanou, Marianna and Sidiropoulou, Kyriaki and Bano, Daniele and Gonos, Efstathios S. and Mladenović, Aleksandra and Ehninger, Dan",
year = "2020",
abstract = "Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.",
publisher = "Elsevier B.V.",
journal = "Mechanisms of Ageing and Development",
title = "Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases",
volume = "192",
doi = "10.1016/j.mad.2020.111364",
pages = "111364"
}

Xie, K., Kapetanou, M., Sidiropoulou, K., Bano, D., Gonos, E. S., Mladenović, A.,& Ehninger, D.. (2020). Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases. in Mechanisms of Ageing and Development
Elsevier B.V.., 192, 111364.
https://doi.org/10.1016/j.mad.2020.111364

Xie K, Kapetanou M, Sidiropoulou K, Bano D, Gonos ES, Mladenović A, Ehninger D. Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases. in Mechanisms of Ageing and Development. 2020;192:111364.
doi:10.1016/j.mad.2020.111364 .

Xie, Kan, Kapetanou, Marianna, Sidiropoulou, Kyriaki, Bano, Daniele, Gonos, Efstathios S., Mladenović, Aleksandra, Ehninger, Dan, "Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases" in Mechanisms of Ageing and Development, 192 (2020):111364,
https://doi.org/10.1016/j.mad.2020.111364 . .